Effects of leptin. Medical search. Frequent questions

The combination of increased circulating leptin levels in obesity and transient reflux of gastric acid may promote oesophageal carcinogenesis by increasing proliferation and inhibiting apoptosis. (uea.ac.uk)
One of the five possible mechanisms of leptin resistance in human obesity is the defect in the leptin receptor (Ob-R). Evidence has accumulated that leptin-binding activity in human serum is related to a soluble form of the leptin receptor, and restriction of energy intake resulted a decrease in circulating leptin levels. (ui.ac.id)
Observational studies comparing circulating leptin levels between COPD patients and healthy controls were included. (karger.com)
Circulating leptin levels were correlated with the body mass index (BMI) as well as percent fat mass in stable COPD patients. (karger.com)
Most studies indicated that circulating leptin levels in stable COPD patients were not significantly different from those in healthy controls when adjusted for gender and BMI, whilst leptin levels tended to elevate in exacerbation groups. (karger.com)

The study reported that genetic modifications known to suppress leptin levels were more common in breastfed babies than formula-fed, and that these differences may play a role in the development of obesity. (bioscientifica.com)
Leptin is a hormone involved in regulating energy balance and higher levels are associated with obesity. (bioscientifica.com)
Previous research has indicated that breastfed children have a lower risk of obesity but how this may be related to epigenetic regulation of leptin has not been investigated. (bioscientifica.com)
Dr Omar states, "As we know that these genetic modifications in formula-fed babies reduce leptin levels, which is associated with obesity, these findings suggest that epigenetic mechanisms may play a role in the development of obesity. (bioscientifica.com)
The team plan to conduct larger, multicentre studies assessing the long-term role of genetic and environmental factors on epigenetic regulation of leptin, to put these data into context and explore possible therapeutic interventions that could be developed to prevent and treat childhood obesity. (bioscientifica.com)
In obesity, a decreased sensitivity to leptin occurs (similar to insulin resistance in type 2 diabetes), resulting in an inability to detect satiety despite high energy stores and high levels of leptin. (wikipedia.org)
Leptin receptor deficiency is a condition that causes severe obesity beginning in the first few months of life. (medlineplus.gov)
Leptin receptor deficiency is a rare cause of obesity. (medlineplus.gov)
Andiran N, Celik N, Andiran F. Homozygosity for two missense mutations in the leptin receptor gene (P316:W646C) in a Turkmenian girl with severe early-onset obesity. (medlineplus.gov)
Dubern B, Clement K. Leptin and leptin receptor-related monogenic obesity. (medlineplus.gov)
Leptin acts in the brain to prevent obesity. (nih.gov)
As POMC neurons prevent obesity, their disinhibition by leptin action on presynaptic GABAergic neurons probably mediates, at least in part, leptin's antiobesity effects. (nih.gov)
For instance, a 2015 study from China explored the effect of a high-protein diet in 156 adolescents with obesity . (medicalnewstoday.com)
Leptin is one of the major adipokines in obesity that indicates the severity of fat accumulation. (plos.org)
Aging has been demonstrated to aggravate obesity and to induce leptin resistance and hyperleptinemia. (plos.org)
We aimed to review the literature on the effects of training intervention on peripheral leptin level in obesity during aging, in order to evaluate the independent efficacy of this method. (plos.org)
The regulation of aldosterone secretion by leptin: implications in obesity-related cardiovascular disease. (ac.ir)
The present study was designed to follow up the effect of defined and standardized GTE in mice with obesity induced by monosodium L-glutamate. (olsztyn.pl)
Alarcon-Aguilar F.J., Zamilpa A., Perez-Garcia M.D., Almanza-Perez J.C., Romero-Nunez E., Campos-Sepulveda E.A., Vazquez-Carrillo L.I., Roman-Ramos R., Effect of Hibiscus sabdariffa on obesity in MSG mice. (olsztyn.pl)
Leptin molecules are fundamentally responsible for obesity and increase in cholesterol level. (womenfitness.net)
Different concentrations of hormones, such as ghrelin, leptin and insulin during foetal life raises the question whether or not they can be modulated, thereby avoiding obesity before birth. (aaem.pl)
Leptin is an adipocyte-derived hormone that controls energy balance by acting primarily in the CNS, but its action is lost in common forms of obesity due to central leptin resistance. (jneurosci.org)
Ample studies have confirmed the important role of Socs3 in leptin resistance and obesity. (jneurosci.org)
Leptin is an adipocyte-derived hormone that acts in the CNS to control energy homeostasis, but its effects are lost in common forms of obesity due to central leptin resistance ( Münzberg and Myers, 2005 ). (jneurosci.org)
Despite its important role in leptin resistance and obesity, the degree to which Socs3 participates in the regulation of energy homeostasis in nonobese animals is still largely unresolved. (jneurosci.org)
Studies have investigated the role of leptin in obesity, anorexia nervosa, insulin resistance, and hypertension. (thermofisher.com)
Severe hereditary obesity in rodents and humans can be caused by defects in leptin production. (thermofisher.com)
High levels of leptin and the accompanying leptin resistance can also decrease fertility, age you more quickly and contribute to obesity. (firstimpressionsbaby.com)
Dr. Heymsfield's research focuses primarily on human obesity, including energy balance regulation, weight loss treatments, co-morbidity effects, and development of related mathematical models. (pbrc.edu)
Body fat mass, a component of body weight, is an important measure of obesity, and a considerable evidence indicates that fat mass may have beneficial effects on bone [2]. (who.int)
Several studies have explored the effect of anthropometric risk ing central obesity, atherogenic dyslipidemia (ie, low high-density factors on metabolic syndrome. (cdc.gov)
However, no systematic effort has lipoprotein cholesterol [HDL-C], elevated triglycerides, and apoli- explored the effect of overweight and obesity on the prevalence of poprotein B-containing lipoproteins), elevated blood pressure, el- metabolic syndrome in India. (cdc.gov)
Hence, we under- and growing public health challenge worldwide resulting from took our meta-analysis to estimate the effect of anthropometric rapid urbanization, excessive energy intake, developing obesity, risk factors on the prevalence of metabolic syndrome to inform re- and sedentary lifestyle habits (2). (cdc.gov)

Leptin receptors are expressed by a variety of brain and peripheral cell types. (wikipedia.org)
Although regulation of fat stores is deemed to be the primary function of leptin, it also plays a role in other physiological processes, as evidenced by its many sites of synthesis other than fat cells, and the many cell types beyond hypothalamic cells that have leptin receptors. (wikipedia.org)
Mode of action Leptin acts directly on leptin receptors in the cell membrane of different types of cells in the human body in particular, and in vertebrates in general. (wikipedia.org)
Leptin receptors are expressed not only in the hypothalamus but also in other brain regions, particularly in the hippocampus. (wikipedia.org)
Thus some leptin receptors in the brain are classified as central (hypothalamic) and some as peripheral (non-hypothalamic). (wikipedia.org)
and peripheral leptin receptors on the beta-cells do not play a major role. (elsevierpure.com)
To address this, we and others have been removing leptin receptors from candidate first-order neurons. (nih.gov)
Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic receptors that regulate food intake and thermogenesis. (duke.edu)
Thus, in rats with normal leptin receptors but not in Zucker Diabetic Fatty rats, nonadipocytes and adipocytes esterify FFA, store them as TG, and later oxidize them intracellularly via an 'indirect pathway' of intracellular fatty acid metabolism controlled by leptin. (duke.edu)
Blockade of paraventricular melanocortin 3/4 receptors with SHU9119 or ionotropic glutamate receptors with kynurenate, alone or together, each partially reversed the effects of leptin, implicating increased activation of glutamate and melanocortin 3/4 receptors. (elsevierpure.com)
Conversely, although blockade of neuropeptide Y Y1 receptors in the paraventricular nucleus increased LSNA, mean arterial pressure, and heart rate, these responses were prevented by intracerebroventricular or arcuate nucleus injections of leptin, suggesting that, at least in part, leptin also increases sympathetic nerve activity by suppression of tonic neuropeptide Y inhibitory inputs from the arcuate nucleus. (elsevierpure.com)
Just like neurotransmitters and insulin, the leptin receptors become unresponsive when they are overtimulated on a continuous basis and leptin resistance develops. (holistichelp.net)
Additionally leptin has been found to target receptors on your tongue and serve as a modulator for sweets. (holistichelp.net)
When there is leptin resistance and the receptors are not responding, then cravings for sweets develop. (holistichelp.net)
Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells. (thermofisher.com)
Leptin is involved in regulating food intake, energy expenditure, and adiposity through hypothalamic leptin receptors. (thermofisher.com)
When scientists tested the ability of various tissues from leptin resistant animals to respond to leptin in vitro, most of the time leptin receptors isolated from the hypothalamus were still somewhat sensitive. (firstimpressionsbaby.com)

The goal of this study is to determine the effects of H. pylori infection on serum ghrelin and leptin levels and how these relates to body weight changes before and after H. pylori eradication. (karatay.edu.tr)
There was no significant difference in the serum leptin and ghrelin levels and BMI between those with or without H. pylori infection. (karatay.edu.tr)
Conclusion: However, no difference was detected in serum ghrelin and leptin levels between H. pylori infected patients and controls, ghrelin levels were decreased with H. pylori eradication, and these differences were correlated with differences in BMI. (karatay.edu.tr)
To evaluate this assumption, we investigated the effects of aerobic exercise training (AET), resistance exercise training (RET), and 4 weeks of de-training on serum leptin and TNF-α levels in diabetic rats. (biomedcentral.com)
Serum insulin, leptin, and TNF-α levels were assessed by commercial ELISA kits. (biomedcentral.com)
These findings indicate that both AET and RET are useful in reducing levels of serum adipocytokines (TNF-α, leptin) in diabetic and non-diabetic rats. (biomedcentral.com)
Training intervention leads to a decrease in leptin level of middle-aged or older, overweight or obese male and female groups, even without major weight loss, indicated by unchanged serum adiponectin levels. (plos.org)
Aim of this study is to examine the difference of serum soluble leptin receptor level and leptin receptor density in rat adipose tissue of adventitial aorta after four weeks treated with different restricted diets. (ui.ac.id)
The aim of the study was to assess the influence of the combined therapy with the angiotensin-converting enzyme inhibitor and aldosterone antagonist on insulin sensitivity and serum leptin concentration in patients with type 2 diabetes on a long-term angiotensin-converting enzyme inhibitor therapy. (viamedica.pl)
At baseline and after two 6-week long periods in which in a random order either spironolactone (25 mg/day) or placebo were given, serum levels of insulin, glucose, leptin, C-reactive protein, insulin sensitivity index (HOMA-S) and 24-hour blood pressure were assessed. (viamedica.pl)
Six weeks of spironolactone therapy induced a statistically significant increase of serum leptin concentration. (viamedica.pl)
Aim: To investigate the correlation of gender and serum leptin level with analgesic modulation of tramadol in high fat diet induced obese Wistar rats. (manipal.edu)
Conclusion: The present study revealed that obese female rats have more serum leptin concentration than obese male rats which could be one of the possible reasons for having more pain sensation to noxious stimuli in obese female rats compared to obese male rats. (manipal.edu)
Tramadol treatment at the dose of 10 mg/ kg for five days has decreased serum leptin level in rats which might be one of the additional analgesic mechanisms of action of tramadol. (manipal.edu)
Evaluation of serum biomarkers in mice at the end of spirulina intervention showed reduced the oxidative stress and the blood lipid levels and increased the level of appetite controlling hormone leptin in a dose-response manner, which exhibited the significant correlation with differentially abundant microbiota taxa in the cecum. (frontiersin.org)
Serum leptin levels are directly related to adipose tissue mass, which leads to increased leptin levels associated with the obese (OB) phenotype ( Al Maskari & Alnaqdy, 2006 ). (peerj.com)
Condition 1: Serum leptin. (who.int)
Serum leptin levels. (who.int)

We investigated the role of circulating leptin in lactation by repleting leptin levels using miniosmotic pumps during the last 7 days of lactation in Brandt's voles (Lasiopodomys brandtii), a model small wild mammal we have extensively studied in the context of lactation energy demands. (elsevierpure.com)

Because hypogonadotropic hypogonadism occurs in leptin receptor deficiency, researchers suggest that leptin receptor signaling is also involved in regulating the body's response to hormones that control sexual development, and that this response is affected by LEPR gene mutations. (medlineplus.gov)
These data suggest that leptin- induced inhibition of food intake is mediated by an integrated network involving both the forebrain and hindbrain and that activation of NTS ObRb lowers the threshold for leptin responsiveness in the forebrain. (atsbio.com)
Taken together, these findings suggest that leptin deficiency affects cytokine gene expression differently in the brain compared to peripheral tissues with minimal interaction from acute SF. (peerj.com)

ABSTRACT To test the hypothesis that regional fat and not total body weight has a protective effect on bone mineral density (BMD) in postmenopausal women, a cross-sectional study was conducted during the period from March 2008 to June 2009 on 303 healthy postmenopausal women presenting to the osteoporosis unit for screening purposes. (who.int)

Objective: We investigated whether lifestyle intervention during pregnancy modifies pregnancy leptin and adiponectin levels, adipokines and their association with body mass index (BMI). (scirp.org)
Among adipokines, leptin and adiponectin are the most abundantly secreted peptides [ 11 ]. (plos.org)
An alternative hypothesis is that reducing fat leads to a reduction in circulating adipokines, such as leptin, that play a role in stimulating the hyperphagia of lactation. (elsevierpure.com)
However, the effects of PFAS on adipokines are not well understood. (cdc.gov)
Adipokines including leptin, soluble leptin receptor (sOB-R), free leptin index (FLI, the ratio of leptin to sOB-R), total and high molecular weight (HMW) adiponectin were assessed in 2002-2003. (cdc.gov)
We utilized multivariable linear regressions and Bayesian kernel machine regression (BKMR) to assess individual and overall joint effects of PFAS on adipokines with adjustment for age, race/ethnicity, study site, education, smoking status, physical activity, menopausal status, and waist circumference. (cdc.gov)

M. Matsubara, S. Maruoka and S. Katayose, "Inverse Relationship between Plasma Adiponectin and Leptin Concentrations in Normal-Weight and Obese Women," European Journal of Endocrinology, Vol. 147, No. 2, 2002, pp. 173-180. (scirp.org)
Plasma leptin, insulin, and neuropeptide Y concentrations in infants. (aaem.pl)

Y. B. Kim, S. Uotani, D. D. Pierroz, J. S. Flier and B. B. Kahn, "In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping But Distinct Pathways from Insulin," Endocrinology, Vol. 141, No. 7, 2000, pp. 2328-2339. (scirp.org)
Scholars@Duke publication: Direct antidiabetic effect of leptin through triglyceride depletion of tissues. (duke.edu)
Direct antidiabetic effect of leptin through triglyceride depletion of tissues. (duke.edu)
Questions: Studies in various cancer tissues have shown that Notch, IL-1 and leptin interaction (NILCO) play a role in the proliferation, migration and expression of proangogenic molecules. (istinye.edu.tr)
On the other hand, leptin receptor density in adipose tissues was higher in restricted diet group than control. (ui.ac.id)
It also results in natural release of adinopectin compound that counteracts the effects of leptin molecule present in our tissues. (womenfitness.net)
This suggests that excessive adiposity overrides the absence of leptin to promote a low-grade inflammatory environment in these tissues. (peerj.com)
Insulin has pleiotropic biological effects in virtually all tissues. (jci.org)

AgRP neurons in the arcuate nucleus of the hypothalamus (ARC) coordinate homeostatic changes in appetite associated with fluctuations in food availability and leptin signaling. (biorxiv.org)
Cis-regulatory analysis of these integrated datasets enabled the identification of 28 putative hunger-promoting and 29 putative hunger-suppressing transcriptional regulators in AgRP neurons, 16 of which were predicted to be transcriptional effectors of leptin. (biorxiv.org)
Gain- and loss-of-function experiments in vivo confirm the role of IRF3 in mediating the acute satiety-evoking effects of leptin in AgRP neurons, while live-cell imaging in vitro indicate that leptin can activate neuronal IRF3 in a cell autonomous manner. (biorxiv.org)
Effects of leptin on pedunculopontine nucleus (PPN) neurons. (uams.edu)
Beck P, Urbano FJ, Williams DK, Garcia-Rill E. Effects of leptin on pedunculopontine nucleus (PPN) neurons. (uams.edu)
The underlying neurocircuitry responsible for this is poorly understood, in part because of incomplete knowledge regarding first-order, leptin-responsive neurons. (nih.gov)
While functionally relevant neurons have been identified, the observed effects have been small, suggesting that most first-order neurons remain unidentified. (nih.gov)
Leptin, working directly on presynaptic GABAergic neurons, many of which appear not to express AgRP, reduces inhibitory tone to postsynaptic POMC neurons. (nih.gov)
We reported that leptin has effects on somatosensory thalamic networks by decreasing GABAergic release from the thalamic reticular nucleus and the firing frequency of neurons in the Ventrobasal nucleus (VB). (saneurociencias.org.ar)
Therefore, we conclude that leptin increases LSNA in part via increased glutamatergic and α-melanocyte-stimulating hormone drive of paraventricular sympathoexcitatory neurons, the latter of which requires simultaneous withdrawal of tonic neuropeptide Y inhibition. (elsevierpure.com)
Lepr POA neurons respond heterogeneously to leptin. (elifesciences.org)
A-B ) Representative whole-cell current clamp recordings of Lepr POA neurons showing three different responses to puff application of leptin in the absence ( A ) and the presence ( B ) of synaptic transmission blockers. (elifesciences.org)
C-D ) Membrane potential changes of individual Lepr POA neurons in response to puff application of leptin in the absence (C, n = 23) and the presence (D, n = 25) of synaptic transmission blockers and the pie charts showing percetages of depolarization, hyperpolarization, and no change. (elifesciences.org)
Membrane potentials of individually recorded Lepr GFP neurons at baseline and following leptin treatment used to categorize leptin response profiles in Figure 1C,D and Figure 1-figure supplement 1A . (elifesciences.org)
Whole-cell current clamp of Lepr POA neurons in response to bath application of leptin. (elifesciences.org)
A ) Membrane potential changes of individual Lepr POA neurons in response to bath application of leptin in the absence of synaptic transmission blockers and the pie chart showing percentages of depolarization, hyperpolarization, and no change (n = 12). (elifesciences.org)
Leptin-Saporin (Lep-Sap) injections were used to delete ObR- expressing neurons in the NTS of 300g male Sprague Dawley rats. (atsbio.com)
FOXO1 exerts different effects in POMC and AgRP neurons. (jci.org)

However, we detected histone H3 methylation and acetylation in the leptin receptor gene, Lepr, following treatment with both drugs. (nih.gov)
In this study, Dr Omneya Magdy Omar and colleagues at Alexandria University Hospital Children's Hospital, Egypt, tested for epigenetic modifications to the leptin gene in 50, 6-month old babies, 25 of which were breastfed. (bioscientifica.com)
Leptin is coded for by the LEP gene. (wikipedia.org)
Leptin receptor deficiency is caused by mutations in the LEPR gene. (medlineplus.gov)
This gene provides instructions for making a protein called the leptin receptor, which is involved in the regulation of body weight. (medlineplus.gov)
LEPR gene mutations that cause leptin receptor deficiency prevent the receptor from responding to leptin, leading to the excessive hunger and weight gain associated with this disorder. (medlineplus.gov)
Conversely, leptin deficiency decreased pro-inflammatory cytokine gene expression in heart (IL-1β, TNF-α). (peerj.com)
Leptin is approximately 16 kDa in mass and encoded by the obese (ob) gene. (thermofisher.com)
Poor Jumbo has a mutation in the gene coding for leptin - he's totally missing it! (firstimpressionsbaby.com)

A fasting blood sample was obtained from each patient for total ghrelin and leptin analysis. (karatay.edu.tr)

However when you eat sugar and carbohydrates this results in insulin levels that are too high then you also have high levels of leptin. (holistichelp.net)
Obese people are found to have high levels of leptin in their blood, but it is not performing its job - leptin resistance. (holistichelp.net)

0.05) of leptin compared with ICV saline. (elsevierpure.com)
To test leptin responsiveness rats were food deprived for 5 hours and at 5 p.m. they received 3V injections of 0, 0.05, 0.1, 0.25 or 0.5 μg leptin. (atsbio.com)
0.05) and a 52% increase in the sensitivity of peripheral adipocytes to the inhibitory effects of insulin on lipolysis ( P = 0.04). (diabetesjournals.org)

Predominantly, the "energy expenditure hormone" leptin is made by adipose cells, and is thus labeled fat cell-specific. (wikipedia.org)
There was no significant effect of leptin treatment on daily energy expenditure, milk production or pup growth, but leptin repletion did result in a reversal of the suppression of uncoupling protein-1 levels in brown adipose tissue, indicating an additional role for reducing body fat and leptin during peak lacation. (elsevierpure.com)
Leptin is an important regulator of food intake and energy expenditure. (karger.com)
A-C ) 24 hr energy expenditure from PBS and leptin injections (5 ng/ml, total 0.5 pg) are overlaid for RT (22°C), warm (30°C), and cold (10°C) (n = 8 each). (elifesciences.org)
Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure. (thermofisher.com)

Soluble leptin receptor level was measured by ELISA and leptin receptor density by using immuno-histochemistry. (ui.ac.id)
Plasma levels of neuropeptide Y and leptin were analyzed using validated ELISA kits. (ac.ir)
Sandwich ELISA: To detect Rat Leptin by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.5-2.0 µg/mL of this antibody is required. (thermofisher.com)
Method of measurement: ELISA method using Leptin ELISA kit by Mercodia. (who.int)

Non-hypothalamic targets of leptin are referred to as peripheral targets. (wikipedia.org)
There is a different relative importance of central and peripheral leptin interactions under different physiologic states, and variations between species. (wikipedia.org)
As some of the effects of leptin have been elicited through both peripheral and central mechanisms, we assessed whether leptin modulates insulin secretion also through the central nervous system. (elsevierpure.com)
Loss of NTS ObR was confirmed with RNAScope in situ hybridization and pSTAT3 response to peripheral leptin in representative Lep- Sap rats. (atsbio.com)
We examined the effect of three months of rosiglitazone treatment (4 mg b.i.d.) on whole-body insulin sensitivity and in vivo peripheral adipocyte insulin sensitivity as assessed by glycerol release in microdialysis from subcutaneous fat during a two-step (20 and 120 mU · m −2 · min −1 ) hyperinsulinemic-euglycemic clamp in nine type 2 diabetic subjects. (diabetesjournals.org)

Location of action The central location of action (effect) of the fat cell-specific hormone leptin is the hypothalamus, a part of the brain, which is a part of the central nervous system. (wikipedia.org)
Function The primary function of the hormone leptin is the regulation of adipose tissue mass through central hypothalamus mediated effects on hunger, food energy use, physical exercise and energy balance. (wikipedia.org)
The primary effect of leptins is in the hypothalamus, a part of the central nervous system. (wikipedia.org)
In the hypothalamus, the binding of leptin to its receptor triggers a series of chemical signals that affect hunger and help produce a feeling of fullness (satiety). (medlineplus.gov)
Leptin is secreted by adipose tissue, where it then circulates to the hypothalamus to act as a satiety hormone. (peerj.com)
Insulin's orexigenic effect in the arcuate nucleus of the hypothalamus can be a major modulator of foetal development. (aaem.pl)
Leptin is a hormone that is produced in the fat cells and helps regulate hunger by providing us with feelings of satiation after we eat via the hypothalamus. (holistichelp.net)
His fat cells can't properly communicate with his hypothalamus because he has no leptin. (firstimpressionsbaby.com)
Leptin is naturally produced in the fat cells and works to regulate energy balance by signaling to the brain and hypothalamus when an individual has eaten enough. (firstimpressionsbaby.com)
The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus. (bvsalud.org)

Our aim was to study the localization of LPL and its endothelial anchoring protein glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) in mouse pancreas, and effects of diet and leptin deficiency on their expression patterns. (columbia.edu)
As scientifically known so far, the general effects of leptin in the central nervous system are: Deficiency of leptin has been shown to alter brain proteins and neuronal functions of obese mice which can be restored by leptin injection. (wikipedia.org)
People with leptin receptor deficiency also have hypogonadotropic hypogonadism, which is a condition caused by reduced production of hormones that direct sexual development. (medlineplus.gov)

The soluble leptin receptor in group treated with 40% of normal daily calori diet was found significantly lower than control (p = 0.02). (ui.ac.id)
Diet of 40 % normal daily calorie for 4 weeks decreased soluble leptin receptor level, but increased adipocyte leptin receptor density of the adipose tissue of rat adventitial aorta. (ui.ac.id)

Just like insulin resistance, the key to preventing or reversing leptin resistance lies primarily in the foods you eat. (holistichelp.net)

Results: Pre-pregnancy BMI correlated with baseline (p = 0.023 and p = 0.079) and end leptin levels (p = 0.128 and p (scirp.org)
Similarly, gestational weight gain correlated with both baseline (p = 0.009 and p = 0.046) and end leptin levels (p = 0.065 and p = 0.011). (scirp.org)
BMI at the end of pregnancy correlated with the end leptin levels, but the correlation was weaker in the control (p = 0.043) than intervention women (p (scirp.org)
Control women having the highest pre-pregnancy BMI tended to exhibit the lowest increase in leptin levels during pregnancy (p = 0.10), whilst in the intervention group, women who had the highest pre-pregnancy BMI exhibited the highest increase in pregnancy leptin (p = 0.058). (scirp.org)
Conclusions: In contrast to the control group, women in the life-style intervention group exhibited a stronger association between gestational weight gain and leptin levels, indicating that they maintained insulin sensitivity. (scirp.org)
L. Hilakivi-Clarke, S. Assis, J. Raitanen and R. Luoto, "Effects of Dietary and Physical Activity Intervention during Pregnancy on Circulating Leptin and Adiponectin Levels," Food and Nutrition Sciences , Vol. 3 No. 4, 2012, pp. 556-567. (scirp.org)
Epigenetic modifications that decrease leptin levels were significantly more common in formula-fed babies, and one of these modifications was also associated with higher body weight in the non-breastfed infants. (bioscientifica.com)
Also, we did not measure leptin levels or follow what happens as the babies grow. (bioscientifica.com)
As one of the major signals of energy status, leptin levels influence appetite, satiety, and motivated behaviors oriented towards the maintenance of energy reserves (e.g., feeding, foraging behaviors). (wikipedia.org)
High leptin levels are interpreted by the brain that energy reserves are high, whereas low leptin levels indicate that energy reserves are low, in the process adapting the organism to starvation through a variety of metabolic, endocrine, neurobiochemical, and behavioral changes. (wikipedia.org)
The effect of 20 ng leptin ICV was replicated by intravenous (IV) leptin infusion that achieved physiological leptin levels of approximately 17 ng/ml (n=5). (elsevierpure.com)
When the melanocortin (MC) pathway was blocked with a nonselective MC-3/4 antagonist SHU 9119 administered ICV, and either saline or leptin (n=12) was infused IV, intravenous leptin failed to produce a decrease in glucose-stimulated insulin levels. (elsevierpure.com)
Previously, some studies showed that H. pylori colonization had been associated with circulating leptin and ghrelin levels, but the certain relationship is still uncertain. (karatay.edu.tr)
Leptin receptor protein levels were unchanged by acid exposure. (uea.ac.uk)
The COX-2 inhibitor NS 398 blocked the effects of acid and leptin but while both acid and leptin individually significantly increased PGE2 production and COX-2 mRNA levels, the combination was not more effective than either stimulant alone. (uea.ac.uk)
Here we demonstrate direct extraneural effects of leptin to deplete fat content of both adipocytes and nonadipocytes to levels far below those of pairfed controls. (duke.edu)
Leptin levels increase during the biological night and peak during the biological morning. (ac.ir)
The finding of this study indicated that eight weeks of aerobic training intervention in morning and evening caused to significant decrease in plasma levels of leptin (p=0.03) and significant increase in plasma levels of neuropeptide Y (p=0.0001).In comparison between morning and evening training, the changes of Leptin levels (p=0.02) and neuropeptide Y levels (p=0.0001) was more in evening training. (ac.ir)
A positive correlation between leptin and tumor necrosis factor (TNF)-α levels was found in COPD exacerbations, while it disappeared in patients with stable disease. (karger.com)
Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR. (frontiersin.org)
Increasing dietary calcium suppresses adipocyte calcitriol levels and puts leptin-resistant fat cells back into "fat-burning" mode. (firstimpressionsbaby.com)
Learn More Researchers at the Mayo Clinic studied two African tribes' leptin levels. (firstimpressionsbaby.com)
In some studies, for instance, low-fat meals seemed to result in higher levels of circulating leptin than high-fat meals. (firstimpressionsbaby.com)
Conclusion: Some PFAS may alter circulating levels of leptin. (cdc.gov)

The structural and functional similarity of leptin with IL-6 has led to the leptin receptor regulates the expression of certain genes that also target IL-6 signaling, which indicates a certain amount of interaction between the two molecules [ 11 ]. (biomedcentral.com)
Leptin also has thermogenic actions and regulates enzymes of fatty acid oxidation. (thermofisher.com)

To conduct a meta-analysis to determine whether the level of leptin is related to the disease status of COPD. (karger.com)
Animal studies have found that it could significantly reduce the level of leptin resistance as well as insulin resistance caused by having a high-fat diet. (firstimpressionsbaby.com)

A vicious cycle ensues, sugar and carbohydrates lead to leptin resistance and insulin resistance which results in more cravings for sugar and carbs, which leads to more insulin and leptin resistance. (holistichelp.net)
Since it is sugar and all the foods that break down into sugar that cause a rise in an insulin and leptin, then it is these foods that must be eliminated. (holistichelp.net)
Particular emphasis is placed on the controversial current debate about the similarities and differences between hypothalamic insulin and leptin signaling at the molecular level. (jci.org)
Insulin and leptin increase expression of POMC and decrease expression of AgRP. (jci.org)

This study tested the impact of ObRb activity in the nucleus of the solitary tract (NTS) on sensitivity to leptin in the forebrain. (atsbio.com)

Studies in transgenic mouse models of Alzheimer's disease have shown that chronic administration of leptin can ameliorate brain pathology and improve cognitive performance, by reducing b-amyloid and hyperphosphorylated Tau, two hallmarks of Alzheimer's pathology. (wikipedia.org)

Leptin is a peptide hormone produced by adipocytes that has anorexigenic effects upon appetite while regulating immunity. (peerj.com)
Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body. (thermofisher.com)

Resistance training appears to be more efficient in reducing blood leptin level than aerobic training alone. (plos.org)
One potential mechanism for such leptin resistance is an increased hypothalamic expression of Suppressor of cytokine signaling 3 (Socs3), a feedback inhibitor of the Jak-Stat pathway that prevents Stat3 activation. (jneurosci.org)
What is Leptin Resistance and Why Should You Care? (holistichelp.net)
Leptin resistance is similar to insulin resistance and they go hand in hand. (holistichelp.net)
According to the author of this product, the famous researcher Morgan Hurst, weight gain occurs due to leptin resistance, which is triggered by viruses and toxins in the body. (firstimpressionsbaby.com)
All these natural ingredients work together to remove the leptin resistance toxins from your body and to help you lose the extra weight in a matter of weeks. (firstimpressionsbaby.com)

Repletion of leptin resulted in a dose-dependent reduction of body mass and food intake in lactating voles. (elsevierpure.com)
POA leptin signaling suppresses food intake. (elifesciences.org)
B ) Experimental scheme of testing POA leptin effect on food intake with BioDAQ. (elifesciences.org)
C ) Leptin injection into the POA suppressed dark-onset food intake for the first 3 hr after the injection (n = 8). (elifesciences.org)
D ) POA leptin effect on food intake lasted only for the first 3 hr after the injection (n = 8). (elifesciences.org)
Raw hourly food intake data over 13 hr and cumulative food intake data for time bins following intra-POA injections of PBS and leptin used to generate Figure 2C,D,E . (elifesciences.org)
There was a dose-dependent inhibition of food intake in Blk-Sap rats, but only 0.5 μg leptin inhibited intake of Lep-Sap rats. (atsbio.com)
This provides an anatomical substrate for the effect of leptin on meal size, and more generally, a mechanism for how the brain controls short-term food intake as a function of the energetic stores available in the organism to maintain energy homeostasis. (jneurosci.org)

Thus, oxytocin signaling likely mediates the effect of hypothalamic leptin on satiety circuits of the caudal brainstem. (jneurosci.org)

Summary: We previously reported that fourth ventricle infusions of leptin that cause weight loss are associated with an increase in hypothalamic phosphorylation of signal transducer and activator of transcription 3 (pSTAT3), a marker of leptin receptor (ObRb) activation, implying an integrated response to central leptin. (atsbio.com)

So in other words, ghrelin is your hunger hormone, leptin is your satiety hormone. (holistichelp.net)

Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. (elsevierpure.com)
Leptin has been shown to decrease glucose-stimulated insulin secretion in both in vivo and in vitro studies. (elsevierpure.com)

Results: Twelve weeks water-based rhythmic exercise training significantly reduced leptin (P = 0.001), aldosterone (P = 0.001), systolic blood pressure (P = 0.001) and diastolic blood pressure (P = 0.031) in obese postmenopausal women with metabolic syndrome. (ac.ir)
There was a significant treatment effect during this period (repeated measures ANOVA, p=0.001). (elifesciences.org)

While palmitate oxidation increased normally in isolated soleii from WT animals when treated with leptin, leptin's ability to stimulate palmitate oxidation was impaired in the FAT/CD36 null soleii. (uoguelph.ca)
Inhibition of the paraventricular nucleus with muscimol completely reversed leptin's effects. (elsevierpure.com)

Therefore ever time you eat sugar and carbohydrates then insulin stimulates leptin. (holistichelp.net)

The aim of this research was to study effect of circadian rhythm on response of neuropeptide Y and leptin to eight weeks of aerobic training with moderate intensity in non-athlete obese young men. (ac.ir)
Reduced leptin in lactation may, in part, cause lactational hyperphagia via stimulatory effects on hypothalamic orexigenic neuropeptides (neuropeptide Y and agouti-related peptide) and inhibition of the anorexigenic neuropeptide (proopiomelanocortin). (elsevierpure.com)

Ghrelin is a peptide that plays an important role in short-term appetite regulation, whereas leptin is a factor that controls long-term energy balance and is considered as a satiety hormone. (firstimpressionsbaby.com)

For this, immunofluorescence microscopy was used on pancreatic tissue from C57BL/6 mouse embryos (E18), adult mice on normal or high-fat diet, and adult ob/ob-mice treated or not with leptin. (columbia.edu)
Leptin treatment of ob/ob mice for 12 days reversed this pattern, so that most of the islets expressed LPL in beta cells. (columbia.edu)
Effect of leptin on mechanical sensitivity in Ob/Ob and WT mice. (saneurociencias.org.ar)
Electrophysiological recordings in the obese Ob/Ob mice supported that the development of the thalamocortical system in the absence of endogenous leptin decreases the functional expression of the HCN channel (H current) in the VB. (saneurociencias.org.ar)
In Ob/Ob mice, although they lack circulating leptin, the receptor remains functional. (saneurociencias.org.ar)
Bartikova H., Skalova L., Valentova K., Matouskova P., Szotakova B., Martin J., Kvita V., Bousova I., Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo. (olsztyn.pl)
Herein, we studied the dose effects of widely used food supplement, microalgae spirulina ( Arthrospira platensis ), on the colonic microbiota and physiological responses in healthy male Balb/c mice. (frontiersin.org)
A ) Injection sites for all mice used for the intra-POA leptin injection study. (elifesciences.org)
Male C57BL/6j (lean) and ob/ob mice (leptin-deficient mice exhibiting obese phenotype) were subjected to SF or control conditions for 24 h using an automated SF chamber. (peerj.com)

In islets of obese Zucker Diabetic Fatty rats with leptin receptor mutations, leptin had no effect in vivo or in vitro. (duke.edu)

For example, one 2014 study investigated the effect of excessive water intake in women who were overweight. (medicalnewstoday.com)

Leptin decreases the production of ghrelin and tells you your full. (holistichelp.net)
Insulin decreases ghrelin and increases leptin. (holistichelp.net)

Consequently, insulin de-inhibits and leptin activates the POMC promoter. (jci.org)

While leptin appears to be involved in the regulation of T lymphocytes, IL-6 activity may specifically lead to the proliferation and differentiation of macrophages, which are involved in both inflammation and tissue repair [ 11 ]. (biomedcentral.com)
Numerous studies have been performed on the effect of aerobic exercise on weight loss and improvement of some neuro-hormonal factors affecting the regulation of energy balance, but in many of these studies there are conflicting results. (ac.ir)

The pituitary gland produces the largest number of different hormones and, therefore, has the widest range of effects on the body's functions. (medscape.com)

The leptin receptor is turned on (activated) by a hormone called leptin that attaches (binds) to the receptor, fitting into it like a key into a lock. (medlineplus.gov)
Leptin binds to its receptor, leading to recruitment of JAKs, which phosphorylate the receptor. (jci.org)
The STAT3 monomer binds to the activated leptin receptor and is phosphorylated by JAKs. (jci.org)

Sugar acts directly in the brain to inhibit the effect of leptin and increased appetite so you never feel full. (holistichelp.net)
Overweight, large appetite and craving carbs are signs you're Leptin Resistant. (firstimpressionsbaby.com)

Ghrelin and leptin peptides play a crucial role in the homeostasis of the human body. (karatay.edu.tr)
Empirical research papers were eligible provided that they reported data of middle-aged or older (above 45 years of age) overweight or obese (body mass index above 25) individuals and included physical training intervention or at least fitness status of groups together with corresponding blood leptin values. (plos.org)
Lep-Sap had no effect on body weight. (atsbio.com)
Clinical trials of curcumin on weight- and body mass index (BMI)-lowering effect have not been systematically evaluated, and the results are inconsistent. (frontiersin.org)
Leptin also tells your body when to burn more fat and reduce storage of fat. (holistichelp.net)
Leptin is a 167 amino acid long protein hormone with important effects in regulating body weight, metabolism and reproductive function. (thermofisher.com)
Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. (pbrc.edu)
To corroborate the reported data that regional fat topography may influence the bone mass independently of total adiposity [6], this study aimed to test the hypothesis that regional fat and not total body weight has a protective effect on BMD in postmenopausal women. (who.int)
Body mass index (BMI) was the disease may become larger in de- other drugs with known effect on bone calculated as weight (kg)/height (m)². (who.int)
nificance of individual coefficients in the en, bone mineral status is much more Daily routine calibration was done model was assessed by the Hosmer- closely associated with total body fat using the standard phantom supplied Lemeshow test for goodness of fit and [4] and in a multivariate model total fat by the manufacturer. (who.int)

For this purpose, we studied the effect of NILCO and related angiogenic/proinflammatory molecules on xenograft colorectal cancer (CRC). (istinye.edu.tr)

We infused leptin or saline through implanted intracerebro-ventricular (ICV) catheters to chronically catheterized, conscious rats (n=15), 2 h after initiation of hyperglycemic (approximately 11 mM) clamp. (elsevierpure.com)

It is for this reason that by applying exogenous leptin, we expected to see a modification in the neuronal signals that relay somatosensory information (mechanical sensitivity, pain, itch) to the cortex. (saneurociencias.org.ar)

Leptin (from Greek λεπτός leptos, "thin" or "light" or "small") is a protein hormone predominantly made by adipose cells and its primary role is likely to regulate long-term energy balance. (wikipedia.org)

The physiological features of this response suggest a possible role for leptin in the evolution of diabetes in overweight individuals. (elsevierpure.com)

Here we generated AgRP neuron-specific transcriptomic and chromatin accessibility profiles during opposing states of fasting-induced hunger and leptin-induced hunger suppression. (biorxiv.org)
Thus, our findings identify AgRP neuron-expressed IRF3 as a key transcriptional effector of the hunger-suppressing effects of leptin. (biorxiv.org)
Insulin deactivates and leptin inhibits the AgRP promoter. (jci.org)

Therefore, the aim of this study was to determine the effect of water-based rhythmic exercise training on leptin, aldosterone and blood pressure in obese postmenopausal women with metabolic syndrome. (ac.ir)
Conclusion: It seems that water-based rhythmic exercise training have a positive effect on leptin, aldosterone and blood pressure on Obese postmenopausal women with metabolic syndrome. (ac.ir)
Amiot M.J., Riva C., Vinet A., Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. (olsztyn.pl)
Accessible Version: www.cdc.gov/pcd/issues/2022/21_0231.htm to estimate the effect of anthropometric risk factors on the preval- ence of metabolic syndrome. (cdc.gov)

Anatomy4

Organisms3

Diseases4

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Psychiatry and Psychology1

Phenomena and Processes9

Health Care1

Circulating leptin levels5

Obesity33

Receptors17

Serum18

Role of circul1

Suggest that leptin3

Abstract1

Adipokines6

Concentrations2

Tissues8

Neurons18

Gene9

Total ghrelin and leptin1

High levels of leptin2

0.053

Energy expenditure5

ELISA4

Peripheral5

Hypothalamus10

Deficiency3

Soluble leptin receptor2

Reversing leptin resistance1

Levels24

Regulates2

Level of leptin2

Insulin and leptin4

Sensitivity to leptin1

Administration of leptin1

Adipocytes2

Resistance6

Food intake8

Hypothalamic leptin1

Central leptin1

Hormone leptin1

Secretion2

0.0012

Leptin's2

Stimulates1

Neuropeptide2

Satiety hormone1

Mice9

Vitro1

Intake1

Decreases2

POMC1

Regulation2

Hormones1

Binds3

Appetite2

Body10

Molecules1

Rats1

Neuronal1

Predominantly1

Overweight1

AgRP3

Metabolic syndrome4