• D.H.E. 45 (dihydroergotamine) ® is ergotamine hydrogenated in the 9, 10 position as the mesylate salt. (rxlist.com)
  • Dihydroergotamine (DHE) is a semi-synthetic form of ergotamine approved in the US in 1946. (wikipedia.org)
  • The main effect of ergotamine is to constrict blood vessels, sometimes so severely as to cause gangrene of fingers and toes. (britannica.com)
  • cobicistat will increase the level or effect of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • ergotamine decreases effects of glyceryl trinitrate pr by pharmacodynamic antagonism. (medscape.com)
  • ergotamine decreases effects of nitroglycerin IV by pharmacodynamic antagonism. (medscape.com)
  • A series of experiments were conducted to evaluate the effects of ergot alkaloids (dihydroergotamine, ergonovine, and ergotamine) on E. coli O157:H7 and Salmonella in both pure and mixed ruminal fluid culture. (usda.gov)
  • There was minimal, if any, affect on the growth of E. coli O157:H7 and Salmonella when exposed to dihydroergotamine, ergonovine, and ergotamine. (usda.gov)
  • You should not use Parlodel if you are allergic to bromocriptine or to an ergot medicine (dihydroergotamine, ergotamine, ergonovine, methylergonovine). (drugs.com)
  • There is the possibility of negative drug interactions between itraconazole EDTA nasal spray and other Rx or OTC medications, including avanafil / cisapride / eliglustat / irinotecan / isavuconazonium / methadone / naloxegol / ranolazine / ticagrelor / lurasidone / pimozide / lomitapide / lovastatin / simvastatin / dihydroergotamine / ergonovine / ergotamine / methylergonovine / eplerenone / felodipine / ivabradine / nisoldipine / disopyramide / dofetilide / dronedarone / triazolam. (canadapharmacy.com)
  • Ergotamine has alpha-adrenergic antagonist and serotonin antagonist effects and causes constriction of peripheral and cranial blood vessels. (medscape.com)
  • Clinicians should review the effects on CYP3A4 of other agents considered for concomitant use with ergotamine. (gpimedical.com)
  • When ergotamine or dihydroergotamine are concurrently administered with azithromycin ergot toxicity may occur. (entirelypetspharmacy.com)
  • D.H.E. 45 (dihydroergotamine mesylate) is an ergot alkaloid used to treat a migraine or cluster headache attack. (rxlist.com)
  • Our D.H.E. 45 (dihydroergotamine mesylate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • D.H.E. 45® (dihydroergotamine mesylate) Injection, USP is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes. (rxlist.com)
  • D.H.E. 45® (dihydroergotamine mesylate) Injection, USP should be administered in a dose of 1 mL intravenously, intramuscularly or subcutaneously. (rxlist.com)
  • Available as a clear, colorless, sterile solution in single 1 mL sterile ampuls containing 1 mg of dihydroergotamine mesylate per mL, in packages of 10 (NDC 0078-0041-01). (rxlist.com)
  • Serious cardiac events, including some that have been fatal, have occurred following use of D.H.E. 45® (dihydroergotamine mesylate) Injection, USP, but are extremely rare. (rxlist.com)
  • Each mL of injectable solution contains dihydroergotamine mesylate 1 mg. (medbroadcast.com)
  • D.H.E. 45® (dihydroergotamine mesylate) package insert. (gpimedical.com)
  • 4.D. H. E. 45 (dihydroergotamine mesylate) US prescribing information. (webmd.com)
  • One bottle of dihydroergotamine nasal spray contains 4 sprays. (medbroadcast.com)
  • If Itraconazole nasal spray side effects are experienced, you may want to discontinue use and talk to your doctor again regarding allergic fungal sinusitis treatment options. (canadapharmacy.com)
  • ORAL (Maxalt) side effects, medical uses, and drug interactions. (medicinenet.com)
  • 2.Barthel W, Glusa E, Koth W. Interactions of dihydroergotamine with etilefrine in human leg veins in vitro and in situ. (webmd.com)
  • The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. (webmd.com)
  • Ergonovine has much less effect on blood vessels but a stronger effect on the uterus. (britannica.com)
  • Finger ischemia secondary to the synergistic agonist effect of norepinephrine and ergonovine and in a burn patient. (webmd.com)
  • Dihydroergotamine is most effective if used at the first sign of a migraine headache with or without aura (warning signs that occur prior to the onset of a migraine headache). (medbroadcast.com)
  • The recommended dose of dihydroergotamine is one spray in each nostril (total of 2 sprays) at the first sign or symptom of a migraine headache, or as early as possible after the onset of migraine headache pain. (medbroadcast.com)
  • Dihydroergotamine belongs to a family of medications called ergot alkaloids . (medbroadcast.com)
  • Many medications can cause side effects. (medbroadcast.com)
  • Your doctor may need to change the doses of your medications or monitor you carefully for side effects. (medlineplus.gov)
  • OTC medications are also generally cheaper than prescription medications and typically have fewer and less severe side effects. (medicalnewstoday.com)
  • Generic medications are significantly discounted copies of brand name medication that have the same active ingredients, intended use, dosage, side effects, effects, and route of administration as the original brand name medication. (universaldrugstore.com)
  • In other words, generic medications have the same pharmacological effects as their brand-name counterparts. (universaldrugstore.com)
  • These medications have anti-inflammatory effects and are thought to narrow the blood vessels in your brain, helping to ease pain. (healthline.com)
  • These fluids also help prevent side effects from the medications included in the migraine cocktail. (healthline.com)
  • Each of the medications that may be included in a migraine cocktail has its own side effects. (healthline.com)
  • During this consultation, the patient can be advised about the possible risks associated with her condition during pregnancy and about the possible teratogenic effects of her medications. (medscape.com)
  • Black boxed warnings alert doctors and patients about drug effects that may be dangerous. (medicalnewstoday.com)
  • Nausea is a common side effect. (wikipedia.org)
  • Nausea is a common side effect of IV administration and less common in other modes. (wikipedia.org)
  • Common side effects include diarrhea, rash, and nausea. (rxwiki.com)
  • Tell your doctor right away if you have any serious side effects, including: nausea/vomiting that doesn't stop, increased thirst, increased urination, confusion, stomach/abdominal pain, yellowing eyes/skin, dark urine. (imedix.com)
  • Common side effects of cimetidine include headaches, dizziness, and diarrhea. (rxwiki.com)
  • Gastrointestinal side effects may include vomiting, diarrhea, or abdominal pain. (entirelypetspharmacy.com)
  • concomitant use can increase the risk of side effects. (azurewebsites.net)
  • concomitant use with azithromycin may increase the effect of these medicinal products. (azurewebsites.net)
  • Tell your doctor if you experience serious side effects of D.H.E. 45 including slow/fast/irregular heartbeat, tingling/pain/coldness in the fingers or toes, whitish fingers/toes/nails, loss of feeling in the fingers or toes, bluish hands or feet, muscle pain or weakness in the arms or legs, severe stomach or abdominal pain, lower back pain , or little or no urine. (rxlist.com)
  • Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: blue fingers/toes/nails, cold hands / feet , hearing changes, mental/ mood changes .Chest/jaw/neck tightness can commonly occur soon after using rizatriptan. (medicinenet.com)
  • Because CYP 3A4 inhibition elevates the serum levels of DIHYDROERGOTAMINE, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. (rxlist.com)
  • Three concentrations of dihydroergotamine (DHE) were injected into embryos of 3 treatment groups (1μg/ml, 0.1 μg/ml, and 0.01μg/ml), at 1ml each. (ualberta.ca)
  • Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of DIHYDROERGOTAMINE with potent CYP 3A4 inhibitors including protease inhibitors and macrolide antibiotics. (rxlist.com)
  • Monoamine oxidase inhibitors or MAOIs , for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine ( Matulane ), may reduce the breakdown of sumatriptan in the liver , leading to increased blood levels and side effects of sumatriptan. (hdkino.org)
  • Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. (mayoclinic.org)
  • Using Zembrace SymTouch with certain other medicines can affect each other, causing serious side effects. (medicine.com)
  • These medicines may interact and cause very harmful effects. (webmd.com)
  • When these two medicines are given together, the effects of one or both may increase. (webmd.com)
  • Dihydroergotamine has alpha-adrenergic antagonist and serotonin antagonist effects. (medscape.com)
  • Get medical help right away if you have any very serious side effects, including: symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating), severe dizziness, fainting, slow/fast/irregular heartbeat. (imedix.com)
  • This document does not contain all possible side effects and others may occur. (rxlist.com)
  • Their data, which assessed the impact of the infusion rate of intravenous DHE-in either 60 minutes or 90 to 120 minutes—on inpatient treatment outcomes, suggest that prolonging the infusion time to manage cramping led to an improvement of adverse effects without interfering with efficacy. (neurologylive.com)
  • If you have side effects from this medication, talk with your doctor or pharmacist before stopping it. (medbroadcast.com)
  • If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. (medicinenet.com)
  • If any of these effects last or get worse, tell your doctor or pharmacist promptly. (imedix.com)
  • If you notice other effects not listed above, contact your doctor or pharmacist. (imedix.com)
  • Below are a few examples of reports where side effects / adverse reactions may be related to Keflex (Cephalexin). (druglib.com)
  • This is not a complete list of azithromycin side effects. (rxwiki.com)
  • It will assess the effect of eptinezumab compared with intravenous lignocaine in aborting status migrainosus, with the primary outcome of time from infusion until resolution of pain. (bmj.com)
  • He/she may also direct you to take your first dose of this medication in the office/clinic to monitor for serious side effects (such as chest pain ). (medicinenet.com)
  • If therapy is terminated due to unfavourable side effects, restart it at 300 mg daily or a dose lower than that which prompted the stoppage. (emedz.net)
  • The most common side effect of Botox for migraines is neck soreness and pain. (emedicinehealth.com)
  • The most common side effect of onabotulinumtoxinA (Botox) is neck soreness and pain. (emedicinehealth.com)
  • Exercise, mind-body interventions, and behavioral treatments (including cognitive behavioral therapy and mindfulness practices) can encourage active patient participation in the care plan and help address the effects of pain in the patient's life. (cdc.gov)
  • Our Prezcobix (darunavir and cobicistat) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • The following side effects have been reported by at least 1% of people taking this medication. (medbroadcast.com)
  • Appropriate studies have not been performed on the relationship of age to the effects of nitroglycerin transdermal in the pediatric population. (mayoclinic.org)
  • Fludrocortisone should not be used in persons with congestive heart failure due to its effect on sodium retention. (scireproject.com)
  • This effect can happen at any time while taking Sumatriptan Succinate/Naproxen Sodium but is more likely if you take it for a long time. (universaldrugstore.com)
  • unfortunately, since outcomes specific to this group were not described, the specific effects of fludrocortisone could not be discerned. (scireproject.com)
  • It will explore several secondary measures including change in health resource utilisation, effect on patient reported outcomes of migraine disability and the safety and tolerability of each medication. (bmj.com)
  • Your pharmacist may be able to advise you on managing side effects. (medbroadcast.com)
  • Discuss the risks and benefits of treatment with your doctor, as well as the possible use of exercise to reduce this side effect. (imedix.com)
  • Dihydroergotamine (DHE) has been used in the treatment of migraine for quite a long period of time, and in recent years, the interest in attempting to optimize this oft used but somewhat unchanged therapy has increased. (neurologylive.com)
  • This article will take a closer look at what's in a migraine cocktail, the possible side effects, and other migraine treatment options. (healthline.com)
  • Generally speaking, it takes about an hour or longer for the effects of this treatment to start working and to feel symptom relief. (healthline.com)
  • If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. (medbroadcast.com)
  • Many of these side effects can be managed, and some may go away on their own over time. (medbroadcast.com)
  • Most of these side effects do not require medical attention and gradually resolve over time. (apollopharmacy.in)
  • Korlym (mifepristone) blocks the actions of a hormone called cortisol, which can reduce certain side effects caused by excess cortisol in the body. (benefitsexplorer.com)