• Finally, fenugreek is a rich source of antioxidants, including caffeic acid, luteolin, apigenin and coumaric acid ( 9 ). (well-beingsecrets.com)
  • Antioxidant compounds found in sage, such as rosmarinic Acid , luteolin, and apigenin, can all work to neutralize free radicals and prevent them from creating oxidative Stress in the Heart , organ systems, Skin , joints, Muscle s, and even the brain. (dz-bz.com)
  • Luteolin protects plants from UV radiation and can have a similar effect on human skin by helping to slow UVB photoaging . (jmasonica.com)
  • Research is also ongoing to study luteolin for its antioxidant and anti-inflammatory effects. (jmasonica.com)
  • Plant-based diets are rich in flavonoids, which possess properties such as scavenging free radicals and exerting both anti-inflammatory and antioxidant effects. (frontiersin.org)
  • Many research studies have highlighted the positive effects of natural flavonoids on chronic diseases, including PCa. (mdpi.com)
  • The flavonoids and phenolic compounds found in sage are responsible for these beneficial effects. (dz-bz.com)
  • Good sleep and apigenin flavonoids might combine to help millions of cancer patients in the future. (positivemed.com)
  • Flavonoids are mild activators of reactive oxygen species, which should act as signaling molecules and moderate activators of pro-apoptotic signals with the complex role to tune the cellular survival machinery (Chirumbolo & Bjørklund, 2017). (ac.ir)
  • In this study, the protective effect of a fermented wheat germ extract (FWGE) against LPS-induced inflammation and oxidative stress in IPEC-J2 porcine intestinal epithelial cells was studied. (hindawi.com)
  • At the dose used by the authors, 50 mg/ kg by oral gavage every day, the flavone apigenin can induce the early expression of procaspase-3, which is crucial for the activation of mitochondrial biogenesis initiators, such as TFAM and NRF-1 (Kim, Ha, Yang, & Son, 2018). (ac.ir)
  • Citrus fruits contain the flavonoid apigenin, which appears to alleviate behavioral signs of depression in animal models of depression, according to a 2019 study . (medicalnewstoday.com)
  • The flavone apigenin can exert both its antioxidant potential via the usual enzymatic reactive oxygen species scavenging system and the mitochondrial biogenesis via the peroxisome Proliferator-activated receptor Gamma Coactivator 1-alpha (PGC-1α) mitochondrial Transcription Factor A (TFAM) Nuclear Respiratory factor 1 (NRF-1) pathway. (ac.ir)
  • reported that the flavone apigenin (4',5,7-trihydroxyflavone) improves spatial working memory in adult male Wistar rats (Nikbakht et al. (ac.ir)
  • GATA4 is activated by the DNA damage response factors, which induce cellular senescence. (wikipedia.org)
  • Ribosomal DNA (rDNA) is more vulnerable to DNA damage than DNA elsewhere in the genome such than rDNA instability can lead to cellular senescence, and thus to SASP The high-mobility group proteins (HMGA) can induce senescence and SASP in a p53-dependent manner. (wikipedia.org)
  • Activation of the retrotransposon LINE1 can result in cytosolic DNA that activates the cGAS-STING cytosolic DNA sensing pathway upregulating SASP by induction of interferon type I. cGAS is essential for induction of cellular senescence by DNA damage. (wikipedia.org)
  • Cellular senescence. (moleqlar.de)
  • Cellular senescence describes the state of a stagnant cell cycle. (moleqlar.de)
  • More under Cellular Senescence . (moleqlar.de)
  • As a result, there is a reduction of cellular debris clearance (autophagy), decreased the pool of stem cells, increase in inflammation and cellular senescence. (geresdengle.com)
  • Our data revealed that FWGE had a significant lowering effect on the inflammatory response especially related to oxidative stress. (hindawi.com)
  • A recurring characteristic of cancer cell metabolism is that cancer cells generally prefer to produce ATP via the glycolytic system despite that system being less efficient than mitochondrial oxidative phosphorylation (Warburg effect). (dojindo.com)
  • Antioxidants help to reduce the influence of aging and cellular damage, while combatting the effects of oxidative stress, which can lead to inflammation and other chronic disorders, such as heart disease. (well-beingsecrets.com)
  • This powerful polyphenol reduces cellular damage and oxidative stress. (centredesolutionsante.com)
  • HUH-7 hepatoma cells were used to assess the protective effects of the newly identified compounds against oxidative stress. (globalwomenshealthacademy.org)
  • Apigenin is a well-known antioxidant with possible anti-aging effects, such as relieving muscle atrophy , inhibiting cell breakdown and death, and reducing oxidative stress. (jmasonica.com)
  • 8. Goverdhan P, Sravanthi A, Mamatha T. Neuroprotective effects of meloxicam and selegiline in scopolamine-induced cognitive impairment and oxidative stress. (jptcp.com)
  • As 7KC and 7β-OHC induce several cytotoxic effects which are hall marks of aging and of some age-related and civilization diseases (oxidative stress, inflammation and mitochondrial and peroxisomal dysfunction, cell death induction), the identification of molecules or mixture of molecules capable to counteract or attenuate their cytotoxicity is an important challenge [ 3, 4 ]. (ciencia-e-vinho.com)
  • Analyzing the various intracellular metabolic pathways [e.g., the glycolysis system, the tricarboxylic acid (TCA) cycle, electron transport chain, etc.] is important when trying to understand cellular states. (dojindo.com)
  • Apigenin has been shown to inhibit an important inflammatory biomarker, CD38, in a metabolic syndrome model, as well as decrease adipose tissue mass and the levels of proinflammatory cytokines [ 7 ] . (encyclopedia.pub)
  • In diabetic rats, apigenin reduces metabolic inflammation by successfully polarizing infiltrating macrophages to an anti-inflammatory M2 phenotype by binding and activating PPAR-γ and the subsequent suppression of the NF-κB pathway [ 8 ] . (encyclopedia.pub)
  • NMN (nicotinamide mononucleotide), a molecule naturally found in the body, is a precursor to NAD+, an essential enzyme that plays an important role in carrying out various metabolic and cellular functions. (yeardour.com)
  • Decode Age's longevity collection focuses on extending your healthspan by providing supplements that support cellular health, improve metabolic function, and combat age-related decline. (decodeage.com)
  • Noteworthy, important cytoprotective activities of polyphenols (resveratrol, quercetin, apigenin) have been reported on different cell types such as retinal epithelial cells and nerve cells [ 5 ]. (ciencia-e-vinho.com)
  • In addition, we also reported that resveratrol, quercetin and apigenin have neurotrophic properties (antioxidant activities + differentiating activities) on skeletal muscle cells and nerve cells [ 6,7 ]. (ciencia-e-vinho.com)
  • Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells. (spandidos-publications.com)
  • 2019). According to the authors, apigenin induces a protective effect against neurotoxicity caused by the amyloid fragment β-25-35 in a rodent Alzheimer disease model (Nikbakht et al. (ac.ir)
  • FWGE has significant antiproliferative effects and kills tumour cells by the induction of apoptosis via the caspase-poly (ADP-ribose) polymerase pathway [ 9 ]. (hindawi.com)
  • Many of these health issues are caused by free radicals, the dangerous by products of cellular metabolism that attack healthy cells, causing apoptosis or mutation. (dz-bz.com)
  • Apoptosis‐inducing effect of diketopiperazine disulfides produced by Aspergillus sp. (ijpbp.com)
  • Overall, the results indicate that epigallocatechin gallate and withaferin A, in combination, may potentially inhibit skin-aging, while enhancing antioxidant effects of various enzymes, and warrant further experimental validation. (ijpsonline.com)
  • Curcumin and pterostilbene(11) helps inhibit cellular scenescence. (geresdengle.com)
  • Introducing our ultimate stack to support hair and skin: NMN Resveratrol Apigenin Hyaluronic Acid Spermidine Save 25% when you buy. (longevitybox.co.uk)
  • Resveratrol has been shown to have anti-inflammatory effects. (longevitybox.co.uk)
  • Namsi A, Nury T, Hamdouni H, Yammine A, Vejux A, Vervandier-Fasseur D, Latruffe N, Masmoudi-Kouki O, Lizard G. Induction of Neuronal Differentiation of Murine N2a Cells by Two Polyphenols Present in the Mediterranean Diet Mimicking Neurotrophins Activities: Resveratrol and Apigenin. (ciencia-e-vinho.com)
  • Niacin refers to two substances: nicotinic acid and nicotinamide, both essential to the cellular processes involved in metabolism and healthy aging. (jmasonica.com)
  • NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme that plays a crucial role in various cellular processes. (decodeage.com)
  • Nicotinamide Adenine Dinucleotide is an essential coenzyme for cellular and life functions. (kitsapdailynews.com)
  • Apigenin" Encyclopedia , https://encyclopedia.pub/entry/14229 (accessed December 06, 2023). (encyclopedia.pub)
  • Autophagy is a natural process in which your body cleanses and recycles damaged cells to promote cellular health and combat age-related decline. (decodeage.com)
  • However, as the effects of C3G on the amyloidogenic pathway, autophagy, tau phosphorylation, neuronal cell death, and synaptic plasticity in Alzheimer's disease models have not been reported, we attempted to investigate the same in the brains of APPswe/PS1ΔE9 mice were analyzed. (biomedcentral.com)
  • Clearing old cellular debris, through a process called autophagy , greatly enhances the youthful functioning of the cell. (geresdengle.com)
  • In fact, all life extension mechanisms depend upon the importance of autophagy for clearing cellular damage. (geresdengle.com)
  • Apigenin as an anti-inflammatory compound acts as a protective agent in several disorders via inhibition of key inflammatory mediators, signaling pathways, and molecules. (encyclopedia.pub)
  • Apigenin also ameliorated renal dysfunction in diabetic rats by suppressing inflammation through reduced secretion of TNF-α and IL-6 via MAPK inhibition. (encyclopedia.pub)
  • Apigenin served as a potent therapy against UC in C57BL/6 mice through the inhibition of inflammatory cytokines,and COX-2, and through the reduction in immune cell infiltration in colon tissues [ 11 ] . (encyclopedia.pub)
  • To address the possibility that activation of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of rapamycin (mTOR/FRAP), represents one of these pathways, we have examined the effect of simultaneous inhibition of the Ras-MAPK and PI3K-mTOR pathways on transformation of CEF by v-Src. (embl.de)
  • In the BaF3 BCR ABL tumors, bortezomib treatment started to show tumor inhibition as early as 1 week after treatment, while imatinib did not show any effect. (mi-rna.com)
  • Food and feed supplements derived from plants often demonstrate various beneficial effects-they could have significant anti-inflammatory and antibacterial activity. (hindawi.com)
  • The two major components to which beneficial effects are related, namely, 2-methoxy-benzoquinone and 2,6-dimethoxy-benzoquinone [ 6 ], are found in high concentrations in these extracts. (hindawi.com)
  • Green coffee provides protection against neurological diseases, strengthens heart health, and offers other anti-aging effects associated with longevity. (centredesolutionsante.com)
  • SIRT1 is an enzyme which regulates cellular processes relative to longevity. (geresdengle.com)
  • SIRT1 INCREASES PROTEOSTASIS ,which is an important component of the longevity effect. (geresdengle.com)
  • Apigenin has also been reported to attenuate inflammation and the resultant pathological alterations in rats fed with a high fat, fructose diet [ 9 ] . (encyclopedia.pub)
  • Apigenin improves spatial working memory in Wistar rats. (ac.ir)
  • The antioxidant effects of Portulaca oleracea seeds extract (POS) and its fertility-enhancing effects were inspiring to evaluate the protective potential and pinpoint the mechanisms and molecular targets of the UPLC-MS fingerprinted POS extract on ACR-induced testicular toxicity in rats. (biomedcentral.com)
  • Also, purslane exerted anti-fertility effect in female rats by disrupting ovulation and female fertility hormones [ 18 ], while it diminished aging alterations in female reproductive system in aged mice [ 19 ]. (biomedcentral.com)
  • Research shows that apigenin - an antioxidant in parsley - regulates immune function by reducing inflammation and preventing cellular damage. (gethellohealth.com)
  • Vitamin B Group Regulates Cellular Nutrition. (basharashop.com)
  • The supplementation with POS extract may provide a potential protective effect for ACR-induced testicular dysfunction which is mediated by its antioxidant, antiapoptotic and steroidogenic modulatory effects. (biomedcentral.com)
  • To achieve that, you must focus on prevention and take care of your body at the cellular level by eating a lean, nutrient-rich diet with plenty of iron, calcium, and vitamins B6 and B12. (jmasonica.com)
  • Is Mitochondria Biogenesis and Neuronal Loss Prevention in Rat Hippocampus Promoted by Apigenin? (ac.ir)
  • earns more insightful clues about the activity of apigenin in the prevention of the rat hippocampus neuronal loss caused by the Aβ25-35 injection. (ac.ir)
  • Protects against a wide variety of cancers, has antimicrobial effects, reduces pain, supports heart health, has neuroprotective effects, and eases anxiety and depression. (morphogennutrition.com)
  • Studies also show neuroprotective effects . (jmasonica.com)
  • In addition, C3G increased the protein expression of phosphorylated-AMPK/AMPK and Sirtuin 1 and decreased that of mitogen-activated protein kinases, such as phosphorylated-Akt/Akt and phosphorylated-ERK/ERK, thus demonstrating its neuroprotective effects. (biomedcentral.com)
  • Apigenin promotes mitochondrial biogenesis by activating peroxisome Proliferator-activated receptor Gamma Coactivator 1-alpha (PGC-1α). (ac.ir)
  • As a result, apigenin has gained a lot of interest in the past few years as a potential therapeutic agent to treat various diseases such as cancer, diabetes, cardiovascular, and neurological disorders [ 6 ] ( Figure 1 ). (encyclopedia.pub)
  • 2019). According to the authors, besides the antioxidant and anti-apoptotic properties of apigenin that may prevent neurodegenerative damages in the hippocampal area, further mechanisms can be addressed. (ac.ir)
  • Reduces anxiety and has mild antidepressant effects against panic disorders and binge eating. (priceplow.com)
  • NAD+ supports the cellular maintenance and repair processes required for hair follicles to function effectively throughout their lifecycle. (longevitybox.co.uk)
  • 2017). This phenomenon would mean that apigenin can exert both its antioxidant potential via the usual enzymatic reactive oxygen species scavenging system and the mitochondrial biogenesis via the PGC-1α/TFAM/NRF-1 pathway. (ac.ir)
  • NMN supplementation can restore NAD+ levels and improve cellular functions, promoting DNA repair, regulating inflammation, boosting energy metabolism, and enhancing stress resistance, which can lead to a variety of anti-aging benefits. (yeardour.com)
  • According to the manufacturer (GenF20), the supplement contains proven ingredients that may promote mitochondrial function, DNA health, and cellular regeneration. (kitsapdailynews.com)
  • Flavonoid C-glycosides have antioxidant properties, but there are very few data on their cellular antioxidant activity. (bvsalud.org)
  • Apigenin has a very high safety threshold and antioxidant activity. (morphogennutrition.com)
  • No cytotoxic effect was observed by the aqueous extract despite its high extraction yield. (scirp.org)
  • However, such effects were not observed when independent compounds were used. (globalwomenshealthacademy.org)
  • Over the past few years, nutraceuticals have garnered substantial interest as potential agents against cancer owing to their diverse array of bioactive compounds and limited adverse effects. (ijpbp.com)
  • Anticancer effect of antimalarial artemisinin compounds. (ijpbp.com)
  • Has a calming effect, and when stacked with other sleep enhancing ingredients it acts as a neural sedative. (morphogennutrition.com)
  • The active ingredients are many and could possibly interact to cause side effects since many vitamins and minerals are ingested simultaneously. (consumerhealthdigest.com)
  • As the health effects of polyphenols depend on intake and bioavailability, the biological activities of apigenin (4',5,7-trihydroxyflavone), an abundantly occurring flavone have, been extensively studied [ 1 ] [ 2 ] . (encyclopedia.pub)
  • It has gained attention for its potential health benefits, including its effects on skin and hair. (longevitybox.co.uk)
  • Crafted with care, backed by science, and targeting the root causes of aging, our products are designed to promote cellular health, enhance energy, and support overall well-being. (decodeage.com)
  • Decode Age's healthy aging collection includes a range of supplements specifically designed to promote cellular health, improve cognitive function, and support overall well-being, helping you age gracefully and maintain your zest for life. (decodeage.com)
  • Decode Age's NAD+ boosters can help maintain and increase NAD+ levels, promoting cellular health, energy production, and overall vitality. (decodeage.com)
  • SASP induction of the NAD+ degrading enzyme CD38 on non-senescent cells may be responsible for most of this effect. (wikipedia.org)
  • The effect of Avemar, which is a commercial dietary FWGE supplement for cancer patients, was also studied. (hindawi.com)
  • According to GenF20, the dietary supplement features a formula that works in only two weeks, ensuring you experience noticeable anti-aging effects regardless of age. (kitsapdailynews.com)
  • The existing therapies for most of these chronic conditions sometimes leave more debilitating effects than the disease itself, warranting the advent of safer, less toxic, and more cost-effective therapeutic alternatives for the patients. (encyclopedia.pub)
  • However, doxorubicin usage causes some adverse effects, such as lymphocyte, CD4+ and CD8+ cells number. (chemoprev.org)
  • An older 2013 review notes that these enzymes can interact with more than 85 drugs and that more than 40 of these interactions can cause serious adverse effects. (medicalnewstoday.com)
  • Over 240 scientists published an appeal to reduce public EMF exposure, while calling for a moratorium on 5G, citing adverse biological effects. (lifespa.com)
  • Considering the adverse effects produced by synthetic depigmenting actives, the search for new therapeutic options is desirable, and plant extracts are possible candidates for hyperpigmentation treatment. (bvsalud.org)
  • SASP is the primary cause of the detrimental effects of senescent cells. (wikipedia.org)
  • The combined use of Thimerosal and Vorinostat at a high dose exhibited a detrimental effect on protection against H 2 O 2 . (globalwomenshealthacademy.org)
  • All the top NMN supplements claim to provide a potent dosage of NMN that guarantees proven anti-aging effects. (kitsapdailynews.com)
  • It is advertised as a supplement that helps support potent anti-aging effects in the entire body. (kitsapdailynews.com)
  • 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) analyzes were performed to determine the effects of compound on cell viability levels. (bvsalud.org)
  • Myo-Inositol is a pseudovitamin compound that involved in cellular signaling. (priceplow.com)
  • When doctors look for a cancer cure, they're normally searching for a way to reverse cellular damage caused by mutations. (positivemed.com)
  • ROS compromise the body's naturally antioxidant response, accelerating free radical damage at a cellular level, while also damaging our DNA. (lifespa.com)
  • Despite the detailed in vitro characterization of the enzymatic properties of yeast Sac1p, the exact cellular function of this protein has remained obscure. (embl.de)