• The effects of age bias on neural correlates of successful and unsuccessful response inhibition in younger and older adults. (bvsalud.org)
  • It also correlates with a lower sensitivity of medial versus lateral IZ progenitors to the neurogenesis inhibition process that maintains the IZ pool. (biologists.com)
  • Response inhibition results in the emotional devaluation of faces: neural correlates as revealed by fMRI. (ox.ac.uk)
  • In the search for neuroanatomical correlates of this multifaceted disturbance, this study employs two distinct, well-defined tasks of close association tomotor inhibition and decision-making impulsivity, Go/ No Go and Delay discounting. (muni.cz)
  • 2003. Neural correlates of lexical access during visual word recognition. (degruyter.com)
  • 2014. Embodied language in first- and second-language speakers: Neural correlates of processing motor verbs. (degruyter.com)
  • Within the networks subserving successful and unsuccessful response inhibition, patterns of activity demonstrated distinct neural age bias effects in each age group . (bvsalud.org)
  • In the first paper published in Biological Psychiatry in December 2008, 'Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition' the researchers considered the effects of THC and CBD on brain function during a Go/No Go task which requires subjects to over-ride a regular button pressing response. (kcl.ac.uk)
  • They found that THC reduced activation in the part of the prefrontal cortex that is normally critical for this 'response inhibition' process. (kcl.ac.uk)
  • Although it is well established that prior experience with faces determines their subsequent social-emotional evaluation, recent work shows that top-down inhibitory mechanisms, including response inhibition, can lead to social devaluation after even a single, brief exposure. (ox.ac.uk)
  • In the present article, we review our current understanding of the developmental mechanisms patterning the balance between excitation and inhibition in the context of the neurobiology of autism. (neurotransmitter.net)
  • Our results suggest that neural decision-making mechanisms, involving not only signal enhancement but also non-signal inhibition, become inefficient with age. (frontiersin.org)
  • Neural sensorimotor gating mechanisms prevent the interruption of ongoing information processing routines by ensuing stimuli to permit mental integration and adaptive behavior. (erowid.org)
  • However, the neural mechanisms underlying this putative cognitive enhancing effect of green tea extract still remain unknown. (springer.com)
  • While studies have provided evidence for either increased excitation or reduced inhibition in ASD, the mechanisms driving those changes remain poorly understood. (sfari.org)
  • The present findings offer insights into the neural mechanisms linking inhibitory processes to affective responses. (ox.ac.uk)
  • Further research should investigate effects of lower intensity stretching, upper versus lower body stretching, different age groups, incorporate full warm-ups, and identify predominant mechanisms among others. (hartpury.ac.uk)
  • This group of flavonoids, flavonol, could be investigated further to discover the common mechanisms of inhibition of dengue virus replication. (who.int)
  • NICS targets the cerebellum, due to the high density of neurons at its superficial layer (the cerebellar cortex), the electrical properties, and network to neural circuits (involved in motor, cognitive, and emotional functions). (wikipedia.org)
  • MBAA was without a significant effect on NADHTR activity within any of the tissues with the exception of the Purkinje neurons. (cdc.gov)
  • DNQX, by blocking excitatory AMPA glutamate inputs, is hypothesized to produce relative inhibitions of NAc neurons. (jneurosci.org)
  • Increase of energy accumulation elicits leptin release and simultaneous inhibition of orexigenic neurons expressing neuropeptide Y (NPY) and agouti-related peptide (AgRP), as well as activation of the anorexigenic proopiomelanocortin (POMC) neurons within the hypothalamic arcuate nucleus (ARC). (frontiersin.org)
  • Neural stem cells (NSCs) serve as a source for new neurons in both the developing and adult brain. (elifesciences.org)
  • In an attempt to protect SN neurons from this inflammatory response we found that VAP-1 inhibition not only reduced neutrophil infiltration in the SN and striatum, but also reduced the associated striatal microglia and astrocyte response. (biomedcentral.com)
  • We found VAP-1 inhibition protected dopamine neurons in the SN, their projections to the striatum and promoted the functional recovery of habit learning. (biomedcentral.com)
  • Neuronal production in the midbrain-hindbrain domain (MH) of the vertebrate embryonic neural tube depends on a progenitor pool called the `intervening zone' (IZ), located at the midbrain-hindbrain boundary. (biologists.com)
  • Among those, several candidate genes have been shown to control the early patterning and/or the late synaptic maturation of specific neuronal subpopulations controlling the balance between excitation and inhibition in the developing cortex and cerebellum. (neurotransmitter.net)
  • We have previously utilised an NT2.D1 neurosphere based model of neuronal differentiation to study the effects of a variety of compounds on neural development [7] . (plos.org)
  • However, given potential alternative explanations, it is not known whether neuronal inhibition is in fact necessary for NAc DNQX microinjections to generate motivations. (jneurosci.org)
  • Here we provide a direct test of whether local neuronal inhibition in NAc is necessary for DNQX microinjections to produce either desire or dread. (jneurosci.org)
  • We used optogenetic channelrhodopsin (ChR2) excitations at the same local sites in NAc as DNQX microinjections to oppose relative neuronal inhibitions induced by DNQX in female and male rats. (jneurosci.org)
  • SIGNIFICANCE STATEMENT A major hypothesis posits neuronal inhibitions in nucleus accumbens generate intense motivation. (jneurosci.org)
  • Is neuronal inhibition in nucleus accumbens required for such pharmacologically-induced motivations? (jneurosci.org)
  • Here we demonstrate that neuronal inhibition is necessary to generate appetitive or defensive motivations, using local optogenetic excitations to oppose putative DNQX-induced inhibitions. (jneurosci.org)
  • The proteins activate after neural signals begin, and mark the end of a signal when brain cells have (by neuronal terms) long since moved on to something else, Wang said. (princeton.edu)
  • Changes in dopaminergic neural function can be induced by an acute inflammatory state that, by altering the integrity of the neurovasculature, induces neuronal stress, cell death and causes functional deficits. (biomedcentral.com)
  • Effectively blocking these effects of inflammation could, therefore, reduce both neuronal and functional decline. (biomedcentral.com)
  • We propose the hypothesis that the features of autism associated with weak central coherence result from a reduction in the integration of specialized local neural networks in the brain caused by a deficit in temporal binding. (neurotransmitter.net)
  • The author concludes the data support the hypothesis that specific inhibition of neural NADHTR activity by AA is the primary cause of neuropathy. (cdc.gov)
  • On May 15, 2018, behavioral, cognitive and computational neuroscientists convened at a workshop organized by SFARI on the so-called 'excitation/inhibition (E/I) hypothesis' of autism spectrum disorders (ASD). (sfari.org)
  • Originally proposed by John Rubenstein and Michael Merzenich in 2003 1 , the E/I hypothesis postulates that an imbalance in excitation and inhibition disrupts the activity of neural circuits in individuals with the disorder. (sfari.org)
  • Based on the fact that seizure activity is frequently associated with autism and that abnormal evoked potentials have been observed in autistic individuals in response to tasks that require attention, several investigators have recently proposed that autism might be caused by an imbalance between excitation and inhibition in key neural systems including the cortex. (neurotransmitter.net)
  • This suggestion is consistent with the neurophysiological evidence of inefficient visual cortical inhibition in aging. (frontiersin.org)
  • In the second paper published in the Archives of General Psychiatry (12 January 2009) 'Distinct Effects of _9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing' the researchers investigated the neurophysiological basis of the effects of cannabis on anxiety, using faces that had fearful expressions. (kcl.ac.uk)
  • Vertebrate neurogenesis requires inhibition of endogenous bone morphogenetic protein (BMP) signals in the ectoderm. (molcells.org)
  • Early neurogenesis is initiated by inhibition of BMP signaling in the ectoderm by BMP antagonists expressed in Spemann's organizer region, resulting in anterior neural tissue formation ( Hemmati-Brivanlou and Melton, 1994 ). (molcells.org)
  • We also demonstrate that lateral inhibition, a ubiquitous characteristic of neural circuitry, can effect target-size tuning, improving detection specifically of small targets. (sandia.gov)
  • Thus, the lateral hypothalamus-ventral tegmental area-nucleus accumbens neural circuitry is reexamined in order to interrogate the functional interplay between ghrelin, dopamine, orexin, and endocannabinoid signaling. (frontiersin.org)
  • the EST, which assesses the effects of compounds on the differentiation of mouse embryonic stem cells into contracting cardiomyocytes, can be used to rank the potency of chemicals within a series of alkoxyacetic acid metabolites formed from The implementation of the European REACH (Registration, glycol ethers. (cdc.gov)
  • Airan's approach employs noninvasive pharmacological methods to achieve similar control of neural activity. (stanford.edu)
  • This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. (plos.org)
  • Experiments in mice with similar neurofibromas confirmed the inhibition of the MEK protein function in the tumors. (highlighthealth.com)
  • Taken together, our results, besides providing further evidence that VPA may represent a promising therapeutic strategy in cancer treatment, may help in the design of new protocols geared at the treatment of neural crest-derived tumors. (iiarjournals.org)
  • Genetic studies have clarified that most microcephaly genes encode ubiquitous proteins involved in mitosis and in maintenance of genomic stability, but the effects of their inactivation are particularly strong in neural progenitors. (cancerindex.org)
  • Moreover, NO effects were mimicked by 8BrcGMP and by Zaprinast, an inhibitor of Phosphodiesterase 5. (nih.gov)
  • Removal of inhibitor partially rescues these defects, while simultaneous treatment with both SERCA inhibitor and PKC activator remarkably rescues tracheal and neural development. (caltech.edu)
  • This being said, there are also four commonly seen irrational cognitive patterns involved in social inhibition. (wikipedia.org)
  • The development of transcranial magnetic stimulation (TMS) in the 1980s opened new possibilities for the application NICS, and brain imaging techniques developed in the latter half of the 20th century later revealed the effects of cerebellum stimulation on higher cognitive functions such as language, emotion and attention. (wikipedia.org)
  • This paper presents the results of a retrospective study that investigates the cognitive effects of learning a foreign language in late adulthood. (researchgate.net)
  • Our findings provide first evidence for the putative beneficial effect of green tea on cognitive functioning, in particular, on working memory processing at the neural system level by suggesting changes in short-term plasticity of parieto-frontal brain connections. (springer.com)
  • Doxorubicin, a brain-impermeable chemotherapeutic agent, is also readily and selectively uptaken by NSCs and reduces their proliferation, which might explain its problematic anti-neurogenic or cognitive side-effect. (elifesciences.org)
  • The effect of acrylamide (79061) (AA) and methylene-bisacrylamide (110269) (MBAA) on NADH-tetrazolium-reductase (NADHTR) activity in neural and nonneural tissues was studied in rats. (cdc.gov)
  • AA decreased the NADHTR activity in neural tissues without significantly decreasing enzyme activity in the nonneural tissues. (cdc.gov)
  • Chronic inflammation can result in edema, wallerian degeneration, and fibrotic changes to the neural tissues. (medscape.com)
  • Blocking of BMPs in animal cap explants causes the formation of anterior neural tissues as a default fate. (molcells.org)
  • Outside the canonical hypothalamic feeding circuits involved in energy homeostasis and the notion of "feeding center," we focused on lateral hypothalamus as neural substrate able to confront food-associated homeostatic information with food salience, motivation to eat, reward-seeking, and development of compulsive eating. (frontiersin.org)
  • Finally, type-1 cannabinoid receptor-dependent inhibition of GABA-ergic release and relapse to reward-associated stimuli is linked to ghrelin and orexin signaling in the lateral hypothalamus-ventral tegmental area-nucleus accumbens network to highlight its pathological potential for food addiction-like behavior. (frontiersin.org)
  • The purpose of this study was to determine the effects of insulin and of endurance exercise on skeletal muscle sorbitol levels in streptozotocin-induced diabetic rats. (hindawi.com)
  • The main purpose of this study was to determine the effect of insulin treatment in STZ-induced diabetes on skeletal muscle sorbitol values. (hindawi.com)
  • Mainly in the ileum, isoamylamine (3 mM) elicited acute effects modified by TTX, atropine and propranolol, and suppressed by spermine (3 mM), not being localized at the smooth muscle level. (foodandnutritionresearch.net)
  • We establish, therefore, that VAP-1 inhibition has an anti-inflammatory profile that may be beneficial in the treatment of dopamine neuron dysfunction caused by an acute inflammatory state in the brain. (biomedcentral.com)
  • During successful inhibition, the older adult group demonstrated significantly increased activity to other-age faces , whereas unsuccessful inhibition in the younger group produced significantly enhanced activity to other-age faces . (bvsalud.org)
  • The model also suggests that the different effects of flexor muscle nerve afferent stimulation observed experimentally (phase prolongation versus resetting) result from opposing influences of flexor group I and II afferents on the PF and RG circuits controlling the activity of flexor and extensor motoneurones. (nih.gov)
  • 2) NICS can induce variations in plasticity (ability of nervous system to adapt its activity in response to stimuli), which create long-lasting effects behaviour and cognition. (wikipedia.org)
  • The drug went to work immediately, reducing neural activity in the targeted area - but only while the ultrasound device was active and only where the ultrasound intensity exceeded a certain threshold. (stanford.edu)
  • By turning up the ultrasound intensity and monitoring brainwide metabolic activity, the researchers could also observe the drug's secondary effects on distant downstream brain regions receiving input from the targeted area, said Raag Airan , MD, PhD, an assistant professor of neuroradiology. (stanford.edu)
  • To examine the role of protein kinase C as a chronic regulator of proximal tubule Na/H antiporter activity, the effect of phorbol 12-myristate 13-acetate (PMA) on the Na/H antiporter was studied in cultured proximal tubule cells. (jci.org)
  • This latter effect may mediate increased Na/H antiporter activity in a number of chronic conditions. (jci.org)
  • Vessel sprouting recovers upon removal of inhibition and restoration of pump activity. (caltech.edu)
  • The effect of VPA on cell growth, apoptotic activity and invasive ability were evaluated. (iiarjournals.org)
  • Firstly, VPA induced cell growth inhibition and apoptotic activity, as demonstrated by sulforhodamine B protein assay, annexin V assay and by Western blot analysis for Bcl2 and Bax expression levels, in all three cell lines. (iiarjournals.org)
  • The effectiveness of HDAC inhibitors, expecially VPA, in neuroblastoma cells, prompted us to investigate the anticancer activity of VPA in other neural crest-derived malignancies, such as glioblastoma, melanoma and Askin tumor. (iiarjournals.org)
  • In this study, we investigated the effect of VPA on cell proliferation, apoptotic activity and invasive ability in glioblastoma (U87MG), melanoma (G361) and Askin (SKNMC) tumor cells. (iiarjournals.org)
  • To date, neural oscillations are still the most prominent electrophysiological signature of human brain activity. (biorxiv.org)
  • The Princeton GCaMPs respond more quickly to changes in calcium so that changes in neural activity are seen more immediately, Wang said. (princeton.edu)
  • The researchers also tweaked certain GCaMPs to be sensitive to different types of calcium ion concentrations, meaning that high rates of neural activity can be better explored. (princeton.edu)
  • Here, we used an optogenetic approach to study the effect of 5-HT on single-unit activity in the mouse primary olfactory (anterior piriform) cortex. (jneurosci.org)
  • These results identify a new role for serotonergic modulation in dynamically regulating the balance between different sources of neural activity in sensory systems, suggesting a possible role for 5-HT in perceptual inference. (jneurosci.org)
  • Asaad WF, Rainer G, Miller EK (1998) Neural activity in the primate prefrontal cortex during associative learning. (yale.edu)
  • 3) NICS induces selectivity of the activation and/or inhibition of specific neural circuits within the cerebellum. (wikipedia.org)
  • In recent years, considerable efforts have been devoted to study neural circuits, and to identify potential factors responsible for the derangement of homeostatic eating toward hedonic eating and addiction-like feeding behavior. (frontiersin.org)
  • Yarczower and Daruns' study about social inhibition of expression defined inhibition of expression as a suppression of one's facial behavior in the presences of someone or a perceived anxious situation. (wikipedia.org)
  • Isoamylamine and spermine in colon relaxed KCl (100 mM)-elicited tonic contractions, suggesting an effect on smooth muscle, but did not justify the suppression of motility caused by spermine and isoamylamine. (foodandnutritionresearch.net)
  • Our data suggest that force and central drive to the muscle are not determinants of fatigue induced by short-lasting un-resisted repetitive finger movements, even in the presence of increased inhibition of the motor cortex. (nature.com)
  • Psarrou M, Stefanou SS, Papoutsi A, Tzilivaki A, Cutsuridis V, Poirazi P. (2014) A simulation study on the effects of dendritic morphology on layer V prefrontal pyramidal cell firing behavior. (forth.gr)
  • Thus, the role of midbrain dopamine is positioned at the intersection between selected hormonal signals involved in food reward information processing (namely, leptin, ghrelin, and insulin), and lipid-derived neural mediators such as endocannabinoids. (frontiersin.org)
  • N2 - The phenomenon of impulsivity in Parkinson's disease appears as an arduous side effect of dopaminergic therapy with potentially detrimental consequences for the life of the patients. (muni.cz)
  • In a lab study conducted by Buck and colleagues, social inhibition in everyday life was reviewed. (wikipedia.org)
  • The results of the study revealed that being with a stranger had inhibitory effects on communication, whereas being with a friend had facilitative effects with some stimuli and inhibitory effects with others. (wikipedia.org)
  • Consequently, the findings of the study confirm that neural responses to successful and unsuccessful inhibition can be contingent on the stimulus-specific attribute of age in both younger and older adults . (bvsalud.org)
  • Sensory afferents have been incorporated in the model to study the effects of afferent stimulation on locomotor phase switching and step cycle period and on the firing patterns of flexor and extensor motoneurones. (nih.gov)
  • In the 1990s, researchers began to study the effects of TMS in humans. (wikipedia.org)
  • In the present study we ask whether aging also reduces decoding, i.e., selecting the neural representations of target orientation while discarding those conflicting with it. (frontiersin.org)
  • In this study we treated differentiating NT2.D1 neurospheres with LiCl or VPA in order to determine their effects using a toxicogenomic and phenotypic anchoring approach. (plos.org)
  • Purpose of the study: To evaluate the effects of a stretching protocol on function, muscle length, and scapular kinematics in subjects with and without shoulder pain. (researchgate.net)
  • In this study, the anticancer properties of VPA on neural crest-derived human tumor cell lines G361 melanoma, U87MG glioblastoma and SKNMC Askin tumor cells were investigated. (iiarjournals.org)
  • This study used functional magnetic resonance imaging (fMRI) to investigate the neural mechanism mediating the relationship between inhibitory control and emotional devaluation. (ox.ac.uk)
  • This study examined the reinforcement omission effects on behavioral repertoire of rats with lesions in the central nucleus and basolateral complex of the amygdala, using classical conditioning and non-contingent reinforcement schemes. (bvsalud.org)
  • According to a generally accepted mechanism, inhibition of BMP signaling generates anterior neural tissue as a default pathway ( Nieuwkoop, 1952 ). (molcells.org)
  • The proposed mechanism for closing the gate is inhibition of the C-fiber nociception by impulses in activated myelinated fibers. (medscape.com)
  • Blood vessels (BVs) are considered an integral component of neural stem cells (NSCs) niches. (elifesciences.org)
  • Within the developing CNS, SOX1 maintains neural cells in an undifferentiated state and has been used as a marker for neural stem cells. (novusbio.com)
  • Scientists have used the sensors to observe brain signals in real time, and to delve into previously obscure neural networks such as those in the cerebellum. (princeton.edu)
  • Conclusion: The limited literature examining non-local effects of prolonged SS revealed that both the stretched and contralateral, non-stretched, limbs of young adults demonstrate small magnitude force deficits. (hartpury.ac.uk)
  • The radicular LBP caused by spinal stenosis is probably related to the inhibition of normal nerve root vascular flow with resultant nerve root nutrition, nerve root edema, and nerve root dysfunction. (medscape.com)
  • Professor Philip McGuire concludes, 'These studies show that THC and CBD have distinct effects on brain function in humans, and these may underlie their correspondingly different effects on cognition and psychiatric symptoms. (kcl.ac.uk)
  • Since the invasion process involves a complex system of tightly regulated proteases, matrix metalloproteinases (MMPs) and their tissue-specific inhibitors (TIMPs), the effect of VPA on MMP and TIMP expressions was analysed. (iiarjournals.org)
  • Depletion of xCyp26c by morpholino-oligonucleotides suppressed the normal formation of the axis and head, indicating that xCyp26c plays a critical role in the specification of anterior neural tissue in whole embryos. (molcells.org)
  • In animal cap explants, however, xCyp26c morpholinos did not alter anterior-to-posterior neural tissue formation. (molcells.org)
  • However, it is unclear whether anterior neural tissue produced by inhibition of BMP is simply generated by a default pathway of pre-existing intracellular molecules or by the newly expressed posterior modifier inhibition molecules. (molcells.org)
  • Although tissue culture (TC) rabies vaccines (e.g., human diploid cell rabies vaccine (HDCV)) are more immunogenic and less likely to cause adverse effects than neural tissue rabies vaccine (NTV), the routine use of TC vaccine is cost-prohibitive in many developing countries. (cdc.gov)
  • Increased Physiological GDNF Levels Have No Effect on Dopamine Neuron Protection and Restoration in a Proteasome Inhibition Mouse Model of Parkinson's Disease OPEN ACCESS eNeuro. (lu.se)
  • Emotions, experienced in higher brain centers, may exert downstream effects on the PMC, which is why some people can experience incontinence with excitment or fear. (medscape.com)
  • However, these drugs have potential developmental effects that are not fully understood. (plos.org)
  • In human psychophysics, decision making in a binary orientation discrimination task requires a neural decoding operation ( Gold and Ding, 2013 ) to select which of two alternative presented stimuli is the target. (frontiersin.org)
  • reported that in-vivo BMP inhibition triggered at stage 5 not only expands the neural plate but also represses the neural crest marker. (molcells.org)
  • Participants were also measured on the behavioral activation system and the behavioral inhibition system. (wikipedia.org)
  • The results revealed that individuals with more sensitivity on the behavioral inhibition system reported having more negative effects from daily events. (wikipedia.org)
  • The authors suggested that there is a behavioral facilitation after N due to a frustration effect, and explained this effect as reï¬ ecting motivational reaction of behavior induced by a surprising non-reward. (bvsalud.org)
  • Social inhibition can range from normal reactions to social situations to a pathological level, associated with psychological disorders like social anxiety or social phobia. (wikipedia.org)
  • Cannabis is the world's most widely used illicit drug and has a wide range of psychological and symptomatic effects. (kcl.ac.uk)
  • There is not yet sufficient evidence of the therapeutic effects of cerebellar TMS, although some successful results have been reported in other clinical studies of TMS used to treat the frontal lobe. (wikipedia.org)
  • Yet, the stronger inhibition of mature GC results in a higher temporal fidelity compared to that of immature GC. (elifesciences.org)
  • Together, these results suggest that xCyp26c plays a specific role in anterior-posterior (A-P) neural patterning of Xenopus embryos. (molcells.org)
  • These results highlight the possible global (non-local) effects of prolonged SS. (hartpury.ac.uk)
  • The results of laboratory studies suggest that electrical stimulation delivered by a TENS unit reduces pain through nociceptive inhibition at the presynaptic level in the dorsal horn, thus limiting its central transmission. (medscape.com)
  • The results showed that all groups responded to the omission and only the Basolateral group showed effect in the "Rearing" category, in the period after the omission. (bvsalud.org)
  • These results highlight the need to consider the involvement of a more complex neural network for evaluation of these effects. (bvsalud.org)
  • This is due to contingent conclusions regarding NICS effects. (wikipedia.org)
  • Beneficial effect on dendrites in neural cells was detectable already before any aggregates or fibrils were detectable. (lu.se)
  • Muscle fatigue induced by sustained contractions may develop at the muscle but also at neural levels (i.e., central fatigue) 1 . (nature.com)
  • Neural specificity of acrylamide action upon enzymes associated with oxidative energy-producing pathways. (cdc.gov)
  • For these reasons, we suggest that force and central drive to the muscle might not be key elements of neural adaptations of fatiguing repetitive movements. (nature.com)
  • Objective: The objective of this review was to describe the effects of unilateral SS on contralateral, non-stretched, muscle force and identify gaps in the literature. (hartpury.ac.uk)
  • Protein kinase inhibitors antagonized cGMP effects. (nih.gov)
  • This latter effect was due to protein kinase C activation in that it was inhibited by sphingosine and was not seen with 4 alpha-PMA, an inactive analogue. (jci.org)
  • Inhibition of the MEK protein diminished as early as two hours after drug administration. (highlighthealth.com)
  • The majority of patients are still continuing with therapy, some for as long as five years, and the long-term treatment has had no observed adverse effect on their development or overall health. (highlighthealth.com)
  • Talking about the latest research published by the Institute of Psychiatry at King's College London, into the effects of cannabis, Professor Philip McGuire one of the authors said: 'The Institute has been at the forefront of research into the adverse psychiatric effects of cannabis use. (kcl.ac.uk)
  • To identify genes involved in the anterior neural specification, we analyzed gene expression profiles using a Xenopus Affymetrix Gene Chip after BMP-4 inhibition in animal cap explants. (molcells.org)
  • No direct neural connection exists between the hypothalamus and the anterior pituitary. (msdmanuals.com)
  • Some hormones exert an effect on cells of the organ from which they were released (paracrine effect), some even on the same cell type (autocrine effect). (msdmanuals.com)
  • Related processes that deal with social inhibition are social evaluation concerns, anxiety in social interaction, social avoidance, and withdrawal. (wikipedia.org)
  • It is key for neutrophil extravasation in vivo and, when the function of VAP-1 is inhibited, the net effect is the impairment of neutrophil migration into areas of inflammation [ 22 ]. (biomedcentral.com)
  • Also in high level cases of social inhibition, other social disorders can emerge through development, such as social anxiety disorder and social phobia. (wikipedia.org)
  • Richardson R , 2015 , 'The development of fear and its inhibition: Knowledge gained from preclinical models. (edu.au)
  • The development of the central nervous system (CNS) begins when the ectoderm gives rise to the neural plate. (molcells.org)
  • NICS is a neural modulation technique, showing capability to rehabilitate the brain functions of patients undergoing a plethora of neurological or psychiatric diseases. (wikipedia.org)
  • Working memory effect on effective connectivity between frontal and parietal brain regions was evaluated using dynamic causal modeling. (springer.com)
  • Scientists use this fluorescence to trace the path of neural signals throughout the brain as they happen. (princeton.edu)
  • It is therefore conceivable that the inhibition of the function of these genes may specifically affect the proliferation and survival of brain tumor cells. (cancerindex.org)
  • Overexpression of xCyp26c weakly induced neural genes in animal cap explants. (molcells.org)