• The work demonstrates that carbon nanobrushes can be dispersed within poloxamer gels, and that fibroblasts and myoctyes can proliferate within a poloxamer gel containing homogenously dispersed carbon nanobrushes. (asme.org)
  • Siafaka, P.I. Promising polymeric drug carriers for local delivery: The case of in situ gels. (eurekaselect.com)
  • The Bioscaffolder printer (Analytik, Cambridge, UK) and the Allevi 2 printer (Allevi, PA, USA) were used for printing the silicone and the poloxamer gels, respectively. (rheolution.com)
  • The present study aimed to evaluate the effect of surfactant composition on the physical properties of nanostructured lipid carriers (NLCs) containing wheat germ oil (WGO) and to investigate the influence of both surfactant composition and pH on the oxidative stability of WGO encapsulated within the NLCs. (ac.ir)
  • Lipid carriers include three groups of solid lipid nanoparticles (SLNs) with a solid lipid phase, emulsions with a fluid lipid phase and nanostructured lipid carriers (NLC) with a combination of solid and liquid lipids [8]. (ac.ir)
  • The lipid carriers can enhance the chemical stability of bioactive compounds through reducing interactions with reactive agents at the interface or surrounding aqueous phase [10]. (ac.ir)
  • This research includes comparative studies of the behavior of liposomes and nanostructured lipid-carriers in a series of well-structured in vitro tests that could assess their interactions with the hCMEC / D3 and SH - SY5Y cell lines as an in vitro model of the blood-brain barrier and neuronal function, respectively. (mdpi.com)
  • The developed nonionic surfactants-based microemulsions containing the optimal concentration of poloxamer 407 could be promising carriers for sustained regional delivery of ibuprofen via topical administration. (ac.rs)
  • In this trial Sodium Lauryl Sulfate, Poloxamer, Polyethylene Glycol (PEG)-6000, Tween 80 and Polyvinylpyrrolidone (PVP) K30 were used as solubilising agent. (ijpsr.com)
  • The present study shows that PEG 6000, Sodium Lauryl Sulfate, Poloxamer, Tween 80 and PVP K30 enhanced the release profile of capsule ibuprofen. (ijpsr.com)
  • Tween ® 80 and sodium deoxycholate, on (i) the physical, mechanical, and biological properties of ultradeformable vesicles, and (ii) the administration of naproxen sodium-loaded multidrug ultradeformable vesicles for the transdermal route in order to obtain therapeutically meaningful drug concentrations in the target tissues and to potentiate its anti-inflammatory effect by association with the antioxidant drug idebenone. (mdpi.com)
  • In the example given, poloxamer 181 (P181) = Pluronic L61 and Synperonic PE/L 61. (wikipedia.org)
  • These properties make this polymer suitable for use as a versatile drug carrier.Pluronic ® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and thermostability. (sigmaaldrich.com)
  • Two different F6H8-cEM were stabilized by the emulsifying agents Poloxamer 188 (Pluronic ® F68) or lecithin (S75). (scienceopen.com)
  • Furthermore SG-loaded solid lipid nanoparticles (SLNs) were prepared and the effect of this vehicle on SG permeation profi le was evaluated as well. (scconline.org)
  • Another new and very promising strategy is represented by the use of innovative carriers such as solid lipid nanoparticles (SLNs) (10). (scconline.org)
  • PN has been touted as a promising carrier for anticancer drugs among targeted drug delivery systems.We reviewed numerous ways for directing nanoparticles to a specific site and preparation processes, patent inventions, and prospects in this study. (pdfplayer.org)
  • An in vitro study was conducted to determine the effect of solid lipid nanoparticle on the human breast cancer cell lines (MCF-7 and MDA-MB231). (scialert.net)
  • The biological activity of Exo-Gel was evaluated in vitro, and the therapeutic effect of Exo-Gel on STOA was evaluated in vivo. (allergy-link.com)
  • Conclusion: The multifunctional DDS may prolong systemic circulation, continuously release drugs, increase the accumulation of drugs at the targeted site, enhance the anticancer effect, and reduce side effects both in vitro and in vivo. (eurekaselect.com)
  • To prevent adverse effects, the dosage should be individualized and increased cautiously. (medscape.com)
  • Aside from this, pharmaceutical technologists aim to develop drug formulations that can target specific organs and tissues, lowering the possibility of adverse effects. (eurekaselect.com)
  • drug resistance, and significant systemic adverse effects. (pdfplayer.org)
  • By addressing the limitations of conventional chemotherapy, such as poor biodistribution, cancer cell drug resistance, and significant systemic adverse effects, NPs hold great promise of drastically transforming the face of oncology[1-2]. (pdfplayer.org)
  • An attempt was taken to study the effect of surfactants and carriers in badly water soluble drug (Ibuprofen) by using solid solution method. (ijpsr.com)
  • From this effort it is possible to increase the release of ibuprofen by using surfactants and carriers. (ijpsr.com)
  • Furthermore, NLCs prepared with the surfactant of poloxamer as a non-ionic surfactant had greater oxidative stability at high pH, and NLC prepared with sodium dodecyl sulfate (SDS) as an ionic surfactant had greater oxidative stability at low pH. (ac.ir)
  • Recently, NLCs containing PUFAs have been prepared and findings showed significant protective effects for PUFAs against oxidization by using this encapsulation method [12]. (ac.ir)
  • Moreover, there is limited understanding of the effect of both type and concentration of surfactant as well as pH on the oxidative stability of NLCs incorporating PUFAs. (ac.ir)
  • With the considering the enhanced effect of the water-oil interface in lipid oxidation, bulk oil oxidation is mechanistically different from the emulsified oil in oxidation process so various factors like free fatty acids content, pH, the polarity of the aqueous phase, antioxidant content and lipid droplet properties have a considerable effect on the vulnerable emulsified lipid [13]. (ac.ir)
  • Fig. 3: Poloxamer scaffolds (bulk, 47.0 %, and 43.0 %) printed inside the ElastoSens™ Bio' sample holders. (rheolution.com)
  • Several studies report that GLP-1R agonists had anti-inflammatory effects in multiple disorders including T2D. (justia.com)
  • Thus, Delivery of PRP-Exo incorporated in thermosensitive Gel provides a novel approach of cell-free therapy and has therapeutic effect on STOA. (allergy-link.com)
  • Herein, it seems to be a promising strategy for improving the therapeutic effect on iron(III)-overload patients. (encyclopedia.pub)
  • Despite numerous studies conducted on these carriers, their safety and efficacy still cannot be guaranteed, taking into consideration all aspects from their physical-chemical and biopharmaceutical properties to all the biological characteristics of living organisms. (mdpi.com)
  • Aleem O, Kuchekar B, Pore Y, Late S. Effect of β-cyclodextrin and hydroxypropyl β-cyclodextrin complexation on physicochemical properties and antimicrobial activity of cefdinir. (setpublisher.com)
  • Some chemical characteristics of poloxamers such as temperature-dependent self-assembly and thermo-reversible behavior along with biocompatibility and physiochemical properties make poloxamer-based biomaterials. (mostwiedzy.pl)
  • An important characteristic of poloxamer solutions is their temperature dependent self-assembling and thermo-gelling behavior. (wikipedia.org)
  • Since its clumsy pharmacokinetic behavior (plasma half-life of about 20 min) and several side effects, the clinical use of DFO is progressively decreasing. (encyclopedia.pub)
  • These strategies have focused on improving DFO's half-life reducing the administration frequency, and minimizing the side effects [ 2 ] . (encyclopedia.pub)
  • Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. (toothpastetop.com)
  • The standard drugs such as piperazine citrate, albendazole, mebendazole and thiabendazole possess some side effects such as nausea, vomiting, stomach and abdominal pain, headache, dizziness, and temporary hair loss etc. (iajpr.com)
  • But the herbal drug shows fewer side effects. (iajpr.com)
  • New research has found that the active ingredients in several common spices prevent platelet aggregation and blood clot formation without the side effects. (iajpr.com)
  • Traditional chemotherapy is nonspecific in its targeting of malignant cells, leaving normal healthy cells vulnerable to the drug's side effects. (pdfplayer.org)
  • The aim of this work was to evaluate the effect of two chemically different edge activators, i.e. (mdpi.com)
  • Plasma triglyceride-rich lipoproteins (TRLs), including chylomicrons and very low-density lipoprotein (VLDL), were collected via ultracentrifugation to evaluate their cytotoxic effects on primary pancreatic acinar cells (PACs). (omicsdi.org)
  • This method, which was later termed solid dispersion, involved the formation of eutectic mixtures of drugs with water-soluble carriers by the melting of their physical mixtures. (ijpsr.com)
  • Here we present data on the effects of CNTs on chondrocyte viability and biochemical deposition examined in composite materials of hydrogels + CNTs mixtures. (asme.org)
  • The drug along with the excipients (surfactants and carriers) was heated first and then hardened by cooling to room temperatures. (ijpsr.com)
  • In either case, once the solid dispersion was exposed to aqueous media and the carrier dissolved, the drug was released as very fine, colloidal particles. (ijpsr.com)
  • In passive mechanism, diffusion of drug through close junctions of epithelial cells occurs depending on its size and charge while in active transport, uptake of drug is mediated by carrier i.e. active proteins [ 3 - 5 ]. (omicsonline.org)
  • The maximum drug release rate (3.55%h(-1)) was from the microemulsion M3 comprising 16%, w/w of poloxamer 407. (ac.rs)
  • 2. Pandey S. Srivastava V. An Overview on Invasomes: Novel Vesicular Carrier for Transdermal Drug Delivery. (rjptonline.org)
  • Cefdinir is a poorly- water-soluble drug, it belongs to Biopharmaceutical Classification System class IV, which shows that it may have limited therapeutic effects due to its low solubility and poor bioavailability. (setpublisher.com)
  • Lipid-based carriers can be used for encapsulation and delivery of hydrophobic compounds in food, pharmaceutical, and cosmetic industries [7]. (ac.ir)
  • His study in Perovskite is interdisciplinary in nature, drawing from both Chemical physics, Charge carrier, Hybrid solar cell, Polymer and Photoexcitation. (research.com)
  • hydrogel in exerting antihyperalgesic effects in prophylactic topical treatment, whereas they were comparable in therapeutic treatment as well as in producing antiedematous effect in both protocols. (ac.rs)
  • In a rat model of inflammation, the microemulsion M3 was significantly more efficacious than the reference hydrogel in exerting antihyperalgesic effects in prophylactic topical treatment, whereas they were comparable in therapeutic treatment as well as in producing antiedematous effect in both protocols. (ac.rs)
  • The objective of this work is to study the effect of carbon nanobrushes embedded within hydrogel composites on tissue engineering. (asme.org)
  • The effect of ultrasonic treatment on the structure, morphology and antioxidant activity of highland barley ß-glucan (HBG) was investigated. (bvsalud.org)
  • In recent years, an unmeasured number of research papers have been published describing the use of lipid based carriers for cosmetic application. (scconline.org)
  • Additionally, the oxidative stability of the NLC with the poloxamer-to-lipid ratio of 2:1 (Polox-NLC-2) looked promising. (ac.ir)
  • The composite is comprised of carbon nanobrushes embedded in a biocompatible poloxamer gel. (asme.org)
  • Moreover it has protective effect against cancer by their effect on signal transduction in cell proliferation and angiogenesis. (iajpr.com)
  • as a delivery system for a peptide to the wound site to study the effect of the peptide on wound healing in mice. (sigmaaldrich.com)
  • For the generic term poloxamer, these copolymers are commonly named with the letter P (for poloxamer) followed by three digits: the first two digits multiplied by 100 give the approximate molecular mass of the polyoxypropylene core, and the last digit multiplied by 10 gives the percentage polyoxyethylene content (e.g. (wikipedia.org)
  • P407 = poloxamer with a polyoxypropylene molecular mass of 4000 g/mol and a 70% polyoxyethylene content). (wikipedia.org)
  • Unlike apoav-/- mice, injection of apoA-V rHDL into gpihbp1-/- mice had no effect on plasma TG levels, and apoA-V remained associated with plasma VLDL.Intravenously injected apoA-V rHDL significantly lowers plasma TG in an apoA-V deficient mouse model. (omicsdi.org)
  • However, ApoC3-tg mice with the same triglyceride levels did not develop large areas of pancreatic necrosis, even upon the administration of poloxamer 407 to further increase triglyceride levels. (omicsdi.org)
  • However, no studies have reported the effect of GLP-1R agonists on lung IL-33 expression or release, the effect of GLP-1R agonists on the innate allergic inflammatory response that is mediated by ILC2, or the effect of GLP-1R agonists on respiratory syncytial virus (RSV) infection. (justia.com)
  • The beneficial effects of hydrogen sulfide (H2S) on wound healing have previously been demonstrated in healthy or diabetic animal models. (fabad.org.tr)
  • When this antibacterial agent is formulated with poloxamer 188, the silver sulfadiazine can be washed easily from the wound because of its water solubility, making dressing changes considerably more comfortable. (medscape.com)
  • Lecithin-stabilized F6H8-cEM could be tested for preclinical studies as a carrier system for lipophilic agents. (scienceopen.com)
  • Several approaches, such as loading nanocarriers or functionalizing biopolymers with DFO, have been proposed to enhance the therapeutic effects of deferoxamine [ 1 ] . (encyclopedia.pub)
  • The current formulation contains a lipid-soluble carrier, polypropylene glycol, which has certain disadvantages, including pseudoeschar formation. (medscape.com)
  • For the poloxamer scaffolds, the storage modulus also decreased when porosity increased as a direct consequence of the lower amount of polymer present in the construct (Fig. 5) (lower volume fraction). (rheolution.com)
  • The cytotoxicity of the components of the SLN formulation was low: SLN with 1% oleyl alcohol displayed no significant cytotoxicity effect on breast cancer cells. (scialert.net)
  • Synthesized nano-siderite (FeCO 3 -NPs) was applied on chickpea and displayed high effectiveness in preventing iron chlorosis by an excessive residual effect [16]. (jchemrev.com)