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  • exposure
  • Adult rats exposed to cranial irradiation (10 Gy) showed significant declines in performance of hippocampal-dependent cognitive function tasks [novel place recognition, novel object recognition (NOR), and contextual fear conditioning (FC)] 1 month after exposure to ionizing radiation using a clinically relevant regimen. (frontiersin.org)
  • The lognormal damage model is then extended to the case of radiochemotherapy using the concept of additive damage, which we previously developed for drugs with two mechanisms, and then applied to combination exposure. (aacrjournals.org)
  • Hyperthermia
  • In another approach, called hyperthermia perfusion, a warmed solution containing anticancer drugs is used to bathe, or is passed through the blood vessels of, the tissue or organ containing the tumor. (cancercompass.com)
  • 5 . A method as in claim 4 , wherein applying hyperthermia comprises applying an oscillating magnetic field to the region of the cells, wherein the oscillating magnetic field generates heat by its effect on the nanoparticle/feature conjugates. (google.de)
  • tumors
  • Furthermore, individual cells of malignant tumors growing in animals or in humans exhibit marked biochemical heterogeneity, as reflected in their cell surface composition, enzyme levels, immunogenicity, response to anticancer drugs, and so on. (nih.gov)
  • Currently, radiation may be directly targeted at liver tumors with the radioembolization technique. (hindawi.com)
  • Phycocyanin (PC), a marine natural extract, has been studied for its anti-cancer effect on malignant solid tumors [ 5 ]. (jcancer.org)
  • MICE
  • In experiments, which were conducted in mice, the scientists found that the body s internal biological clock affects the survival of immune cells that are targets of the anti-cancer drug cyclophosphamide (CY). (innovations-report.com)
  • They discovered that Clock-mutant and Bmal1-knockout mice showed high sensitivity to the drug at any time it was administered - as if the drug were administered early in the morning or late at night. (innovations-report.com)
  • In contrast, the Cryptochrome knockout mice showed more resistance to the drug at all times than did normal mice. (innovations-report.com)
  • Patients
  • Sirtris Pharmaceuticals, a company founded by Dr. David Sinclair, leader of the Harvard resveratrol study, is conducting a clinical trial to evaluate resveratrol's effects in controlling blood sugar in patients with diabetes. (bobsnaturalfoods.com)
  • It is also due to the simple fact that long-term aspirin use is already widely practised among patients for the prevention of cardiovascular events such as thrombosis and neurovascular events such as stroke, thus providing a convenient opportunity for researchers to study its other long-term chemopreventive effects. (hindawi.com)
  • exert
  • These results confirm an astrocyte-mediated mechanism where preservation of extracellular adenosine can exert neuroprotection against radiation-induced pathology. (frontiersin.org)
  • Epidemiological, clinical, and experimental evidence strongly indicates that NSAIDs exert a significant chemopreventive, antiproliferative effect on several types of cancer cells (see Table 1 ). (hindawi.com)
  • Antioxidant
  • These include its potent antioxidant effects, ability to enhance cellular energy production, and ability to influence patterns of gene expression in a manner similar to caloric restriction (the best-documented method of extending life span in animals). (bobsnaturalfoods.com)
  • In laboratory studies, resveratrol's antioxidant effect has been shown to protect against nerve cell damage caused by beta-amyloid peptide, which accumulates in the brains of Alzheimer's sufferers. (bobsnaturalfoods.com)
  • pathways
  • This strategy involves delivering the drug via transdermal pathways, resulting in the death of cancerous cells. (hindawi.com)
  • The primary advantages of the Drosophila system for use in anti‐cancer drug screening are the conservation of cancer genes/pathways between flies and mammals, its suitability for rapid phenotypic screening of chemicals for anti‐cancer effects in vivo in a high‐throughput and cost‐effective manner and its use in identifying drugs that can specifically target tumours in vivo . (els.net)
  • In this review, the various proapoptotic pathways induced by traditional and novel NSAIDs such as phospho-NSAIDs, hydrogen sulfide-releasing NSAIDs and nitric oxide-releasing NSAIDs in mammalian cell lines are discussed, as well as the proapoptotic effects of NSAIDs on budding yeast which retains the hallmarks of mammalian apoptosis. (hindawi.com)
  • liver
  • We thought that the liver might be activating the drug more strongly at some times, or detoxifying it less effectively, or both. (innovations-report.com)
  • It has been reported that phycocyanin has anti-oxidative function, anti-inflammatory activity, anti-cancer function, immune enhancement function, liver and kidney protection pharmacological effects. (jcancer.org)
  • cognitive
  • Since ionizing radiation causes microglial and astroglial activation, we hypothesized that maladaptive changes in astrocyte function might be implicated in radiation-induced cognitive dysfunction. (frontiersin.org)
  • targets
  • We are also planning additional studies to discover the molecular signals from the circadian machinery to the immune system that might prove to be useful drug targets. (innovations-report.com)
  • Human cancer cell targets of the proapoptotic effects of prominent traditional and modified NSAIDs. (hindawi.com)
  • mechanisms
  • Through these mechanisms, resveratrol may enhance the anti-cancer effects of chemotherapeutic drugs and radiation. (bobsnaturalfoods.com)
  • As detailed studies on ACPs mechanisms of action are crucial for optimizing drug development, in this review we provide an overview of the literature concerning peptides' structure, modes of action, selectivity, and efficacy and also summarize some of the many ACPs studied and/or developed for targeting different solid and hematologic malignancies with special emphasis on the first group. (frontiersin.org)
  • studies
  • So far, there are more and more studies have shown that phycocyanin has the anti-cancer effect, which can block the proliferation of cancer cells and kill cancer cells. (jcancer.org)
  • Aspirin's affordability and ease of access, together with its relatively reduced side effects with respect to other traditional NSAIDs [ 5 ], have also helped to increase its appeal as a potential chemopreventive agent and target in anticancer studies. (hindawi.com)
  • substance
  • Cannabis is not a substance, not a drug, not a herb -- simply a food and, as with all superfoods, it has healing properties. (cancertutor.com)
  • The traditional word for the API is pharmacon or pharmakon which originally denoted a magical substance or drug. (reportsnreports.com)
  • human
  • Gonias, S. L., Oakley, A. C., Walther, P. J., and Pizzo, S. V. (1984) Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human alpha-2-macroglobulin by cis-diamminedichloroplatinum (II). (springer.com)
  • As human cancer remains a cause of high morbidity and mortality worldwide, an urgent need of new, selective, and more efficient drugs is evident. (frontiersin.org)
  • involves
  • The most promising approach so far has been radiation, which involves sending a tiny string of irradiated beads, via catheter, to the stent site for a fixed period of time. (psu.edu)
  • bone
  • Radiopharmaceutical drugs usually relieve pain from bone metastases. (malecare.org)
  • Rosiglitazone, an insulin-sensitizing drug, had no significant effect on bone marrow cellularity. (osti.gov)
  • Journal
  • To receive news and publication updates for Journal of Drug Delivery, enter your email address in the box below. (hindawi.com)
  • Delivery
  • 8 . A method as in claim 7 , wherein the inhibitor comprises a coating that encapsulates the drug, and wherein treating the patient so that the inhibitor is overcome comprises applying a magnetic field such that the delivery packages generate heat, motion, or a combination thereof sufficient to disrupt the inhibitory function of the coating. (google.de)
  • Type 1: Th e microcapsules are subcutaneously injected in the area surrounding the tumor, followed by delivery of radiations. (omicsonline.org)
  • immune
  • Immunoregulatory drugs (IL-2, denileukin diftitox, thalidomide and lenalidomide, IFN-α, alemtuzumab) and immune checkpoint inhibitors (anti-CTLA4 and anti-PD-1 monoclonal antibodies) mainly promote thyroid autoimmunity. (springer.com)
  • inhibitor
  • b4) treating the patient such that the inhibitor is overcome and drug acts on the cells characteristic of the disease. (google.de)
  • cells
  • The effect of nanoparticles on magnetic fields can be used to determine the location of a disease, and a measure of the number of cells characteristic of the disease. (google.de)
  • 11 . A method as in claim 1 , further comprising (c) determining a measure of the number of cells characteristic of the disease by the magnetic effect of nanoparticles introduced into the cells, (d) repeating steps (b) and (c) until the number cells characteristic of the disease is below a threshold value, wherein the number of cells characteristic of the disease remaining is determined from a plurality of measurements. (google.de)
  • Thus
  • Thus, defects in Clock or Bmal1 genes, which essentially damp the cycles of the internal clock may produce very different effect when compared to defects in Cryptochrome gene, which, in contrast, `jams the circadian clock at the most active point in its cycle. (innovations-report.com)
  • Thus, this paper gives us specific mechanistic insight into the role of circadian rhythms in sensitivity to such drugs," said Takahashi. (innovations-report.com)
  • Thus, phycocyanin has an important development and utilization as a potential drug, and phycocyanin has become a new hot spot in the field of drug research. (jcancer.org)
  • function
  • Several drugs and supplements may interfere, at different levels, with regulation of thyroid function. (springer.com)
  • This chapter reviews drugs that significantly affect thyroid function. (springer.com)
  • response
  • Overall, the model provides a framework for understanding the complex effects of schedule and dose, as well as a method to potentially predict combination or fractionated dose-response from knowledge of a drug's perturbations to the cell cycle phase distribution. (aacrjournals.org)