Signal TransductionCells, CulturedApoptosisRats, Sprague-DawleyMice, Inbred C57BLDisease Models, AnimalCell Line, TumorTime FactorsCell ProliferationBlotting, WesternGene Expression RegulationPhosphorylationModels, BiologicalCell LineDown-RegulationRNA, MessengerMice, KnockoutDose-Response Relationship, DrugUp-RegulationOxidative StressReactive Oxygen SpeciesReverse Transcriptase Polymerase Chain ReactionNeuronsRats, WistarCalciumRNA, Small InterferingCell SurvivalProto-Oncogene Proteins c-aktMice, TransgenicMutationProtein BindingEnzyme ActivationExtracellular Signal-Regulated MAP KinasesEnzyme InhibitorsNitric OxideEndothelial CellsGene ExpressionNF-kappa BImmunohistochemistryInflammationRNA InterferenceCell DifferentiationCell MovementBrainHEK293 CellsMAP Kinase Signaling SystemAnalysis of VariancePromoter Regions, GeneticProtein TransportTransfectionReal-Time Polymerase Chain ReactionMolecular Sequence DataTranscription FactorsCaspase 3Transcription, GeneticGene Expression ProfilingMitochondriaGene Knockdown TechniquesMice, Inbred BALB CLiverMembrane ProteinsCytokinesGene Expression Regulation, NeoplasticPhenotypeMembrane Potential, MitochondrialTumor Necrosis Factor-alphaEndothelium, VascularMyocytes, CardiacCell CycleAntioxidantsHomeostasisGlucoseAnimals, NewbornMuscle, SkeletalAgingFlow CytometryDNA-Binding ProteinsMyocardiumProtein-Serine-Threonine KinasesEpithelial CellsPlant ExtractsInsulinMice, Nudep38 Mitogen-Activated Protein KinasesCalcium SignalingProto-Oncogene Proteins c-bcl-2Base SequenceStress, PhysiologicalCell DeathHippocampusMacrophagesMicroscopy, ConfocalAction PotentialsModels, AnimalBehavior, AnimalHuman Umbilical Vein Endothelial CellsNeuronal PlasticityAnoxiaCurcuminMyocytes, Smooth Muscle