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  • CCR7
  • Our results demonstrate that on activation, human CCR7 − CD62L − peripheral blood CD8 + and CD4 + T EM cells exhibit a dynamic differentiation, involving transient as well as stable changes to T CM phenotype and properties. (jimmunol.org)
  • These results suggest that T EM cells provide immediate effector function by a fraction of cells as well as self-renewal by others through up-regulation of CCR7 followed by either secondary peripheral effector function or long term maintenance of T CM -like properties. (jimmunol.org)
  • These intermediates retain expression of lymph node homing receptors such as CCR7 and CD62L and have initiated but not completed the remodeling events of genes involved in effector function (e.g. (jimmunol.org)
  • Similarly, stimulation of CD4 + T EM cells from healthy individuals induced a transient expression of CCR7 ( 12 ). (jimmunol.org)
  • genes
  • The aims will also resolve whether the predominant actions of Eomes in memory cells are on a unique set of genes or whether Eomes is controlling CD8+ T cell memory through interplay with T-bet at loci they regulate in common. (grantome.com)
  • Profiling active (H3K27ac) and repressed (H3K27me3) chromatin in naive, MP, and TE CD8+ T cells during viral infection revealed increased H3K27me3 deposition at numerous pro-memory and pro-survival genes in TE relative to MP cells, indicative of fate restriction, but permissive chromatin at both pro-memory and pro-effector genes in MP cells, indicative of multipotency. (ovid.com)
  • Abundant H3K27me3 deposition at pro-memory genes occurred late during TE cell development, probably from diminished transcription factor FOXO1 expression. (ovid.com)
  • These results outline a temporal model for loss of memory cell potential through selective epigenetic silencing of pro-memory genes in effector T cells. (ovid.com)
  • define a temporal model for how effector T cells lose memory cell potential through selective epigenetic silencing of pro-memory genes. (ovid.com)
  • Testing of each group of sorted cells showed that they induced divergent sets of genes. (uab.edu)
  • The IL-2-producing T cells induced genes known to be important in Tfh cell development and function. (uab.edu)
  • In contrast, the IL-2-non-producing T cells induced genes characteristic of non-Tfh effector cell differentiation. (uab.edu)
  • naive
  • We examined the tumor mass as a potential site of activation after adoptive transfer of naive tumor-specific CD8 T cells. (pubmedcentralcanada.ca)
  • Activated and proliferating tumor-infiltrating lymphocytes were evident in these mice 24 h and 4 d after naive cell transfer. (pubmedcentralcanada.ca)
  • We conclude that tumors support the infiltration, activation, and effector differentiation of naive CD8 T cells, despite the presence of immunosuppressive mechanisms. (pubmedcentralcanada.ca)
  • Thus, the potential for the tumor to serve as a site of naive T cell activation remains largely unexplored. (pubmedcentralcanada.ca)
  • However, it is not known whether intratumoral DCs/myeloid cells or tumor cells can activate naive CD8 T cells within the tumor mass. (pubmedcentralcanada.ca)
  • Therefore, a central question is whether naive T cells could access tumor masses in nonlymphoid tissues. (pubmedcentralcanada.ca)
  • However, despite relatively high mRNA expression levels of Id2 in mature CD8 + effector and memory cells and high Id3 in naive and long-lived memory cells ( 19 - 21 ), the role of these transcriptional regulators in CD8 + effector T cell differentiation is still not fully understood. (jimmunol.org)
  • Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM + and Transient IgG + Memory B Cells. (nih.gov)
  • Here we have demonstrated that as human viral antigen-specific CD8+ T cells differentiated from naive to effector cells, their surface expression of BTLA was gradually downregulated. (nih.gov)
  • a representative example demonstrates the narrow positive peak observed in phenotypic naive cells. (nih.gov)
  • E ) GMFI data, showing results compatible with those presented in D . Overall GMFI was determined by including the whole range from BTLA-negative to -positive cells, as shown in C . GMFI data were normalized to values determined in autologous naive CD8 + T cells. (nih.gov)
  • What does a naive T-cell turn into after encountering an antigen? (brainscape.com)
  • thymic
  • iNKT cells express a TCR of limited diversity and acquire their activated state and effector program during their thymic development. (rupress.org)
  • adaptive
  • Indeed, an increase in NE release in the spleen was described following the activation of Ag-specific Th cells and B cells, indicating that SNS activation occurs during an ongoing adaptive immune response and, thus, may influence its course ( 5 ). (jimmunol.org)
  • CD8 T cells are a crucial component of the adaptive immune response to malignancies. (pubmedcentralcanada.ca)
  • CD4+ T cells play a crucial in the adaptive immune system. (duke.edu)
  • Self-Renewal
  • Previously, we reported that the transcription factor Nanog, which maintains the self-renewal of embryonic stem cells (ESCs), promotes the osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 through a genome reprogramming process. (sigmaaldrich.com)
  • CD127
  • Numerous transcription factors have also been implicated in this cell-fate decision with T-bet, Blimp-1, and Id2 favoring shorter-lived, effector memory cells expressing high levels of KLRG1 and with Eomesodermin, Bcl-6, transcription factor-1, STAT3, and Id3 expression supporting the formation of long-lived memory precursors with high levels of CD127 and CXCR3 ( 4 , 11 - 22 ). (jimmunol.org)
  • Previously, we showed loss of Id2 resulted in a diminished CD8 + effector response and led to fewer remaining memory CD8 + T cells, which rapidly acquired a central memory (CD44 hi CD62L hi KLRG1 lo CD127 hi ) phenotype ( 19 , 20 ). (jimmunol.org)
  • secretion
  • Induction of chemokine secretion and enhancement of contact-dependent macrophage cytotoxicity by engineered expression of granulocyte-macrophage colony-stimulating factor in human colon cancer cells. (semanticscholar.org)
  • commitment
  • This inflammatory stimuli-mediated effector cell commitment into SLEC fate in the early expansion phase is regulated by transcription factor expression. (rupress.org)
  • Although IL-4 was not required at later times, CD8 T cell clones continued to lose surface CD8 expression with prolonged culture, suggesting commitment to the CD8 low phenotype. (jimmunol.org)
  • fate decision
  • As the incorporation of multiple distinct signals received by individual T cells likely triggers diverse transcriptional programs, it is important to discuss the key transcription factors that have been known to orchestrate CD8 T cell fate decision. (frontiersin.org)
  • Although the molecular mechanisms underlying this cell fate decision remain incompletely defined, substantial progress has been made, particularly with regards to CD8 + T cells. (frontiersin.org)
  • The first T cell fate decision occurs in the thymus, where CD4 + CD8 + (double positive) T cells selectively and stably down-regulate CD4 or CD8 before exiting the thymus as mature, single positive (CD4 + or CD8 + ), naïve T cells. (frontiersin.org)