• At the final analysis of the study, there was not an improvement in OS for patients who received KEYTRUDA plus LENVIMA compared to docetaxel. (streetinsider.com)
  • Her treatment included Mohs paste application, together with chemotherapy (four cycles of 5-fluorouracil, epirubicin, and cyclophosphamide, and four cycles of docetaxel). (biomedcentral.com)
  • Scalp cooling has been evaluated mainly with regimens including anthracyclines (such as doxorubicin and epirubicin) and taxanes (such as paclitaxel and docet. (dignicap.com)
  • The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)
  • Results of two studies regarding adenocarcinomas have shown matuzumab to be well tolerated in combination with two standard chemotherapies - cisplatin, 5-fluorouracil and leucovorin (PFL) as well as epirubicin, cisplatin and capecitabine (ECX) - as a first line therapy. (wikipedia.org)
  • Etoposide plus cisplatin with or without the combination of 4'-epidoxorubicin plus cyclophosphamide in treatment of extensive small-cell lung cancer: A French Federation of Cancer Institutes multicenter phase III randomized study. (trillium.de)
  • Though studies have examined the cost-effectiveness of adjuvant goserelin with radiotherapy for locally advanced prostate cancer, few have compared the cost-effectiveness of adjuvant goserelin to adjuvant chemotherapy alone in premenopausal breast cancer. (biomedcentral.com)
  • In this retrospective study at one hospital, the records of 152 patients with stage Ia to IIIa ER + breast cancer who received goserelin or chemotherapy were reviewed. (biomedcentral.com)
  • Outcomes LXR ligands impact epirubicin response in TNBC cells in vitro To determine if the scOHC-LXR axis affects TNBC chemotherapy response, in vitro assays had been used to check how mixtures of epirubicin and LXR ligands modified tumor cell success and development. (sicollaborative.org)
  • LXR is associated with Pgp manifestation and function in TNBC individuals and in vitro The chemotherapy efflux pump Pgp was a solid applicant as the mediator of the LXR ligand induced level of resistance to epirubicin, since it offers previously been reported to become modulated by oxysterols in the bloodstream brain hurdle [21]. (sicollaborative.org)
  • Trials include participation in the national breast cancer study groups, ECOG and NSABP, as well as the development of new chemotherapy programs. (stanford.edu)
  • The study will also evaluate the toxic effects of the chemotherapy combination, including effects on the heart, and will determine survival and progression-free survival 5 years after treatment. (stanford.edu)
  • PURPOSE: Randomized phase III trial to determine the effectiveness of adjuvant chemotherapy in treating women who have undergone resection for local and/or regional relapsed breast cancer. (stanford.edu)
  • At the final analysis of the study, KEYTRUDA plus chemotherapy showed a statistically significant and clinically meaningful improvement in OS compared to chemotherapy alone in these patients. (merck.com)
  • The safety profile of KEYTRUDA in combination with chemotherapy in this study was consistent with previously reported studies. (merck.com)
  • The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
  • In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
  • By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)
  • Efficacy, effectiveness and safety of long-acting granulocyte colony-stimulating factors for prophylaxis of chemotherapy-induced neutropenia in patients with cancer: A systematic review. (trillium.de)
  • Thus, one mechanism of epirubicin combined TACE treatment for HCC was through induction of synergistic DNA damage. (nature.com)
  • The aim of this study was to assess the safety and effectiveness of PSE with TACE for patients with HCC and severe thrombocytopenia. (hindawi.com)
  • To evaluate the effectiveness of transarterial chemoembolization (TACE) combined with lenvatinib and sintilimab in treating patients with midstage hepatocellular carcinoma (HCC). (hindawi.com)
  • At present, both the European Association for the Study of the Liver (EASL) [ 2 ] and the American Association for the Study of Liver Diseases (AASLD) [ 3 ] recommend transarterial chemoembolization (TACE) as the standard treatment option for patients with intermediate-stage (BCLC stage B) HCC. (hindawi.com)
  • However, to date, TACE combined with lenvatinib plus sintilimab has not been studied for patients with BCLC B-stage HCC. (hindawi.com)
  • Therefore, we conducted this retrospective study to assess the efficacy and safety of TACE combined with lenvatinib plus sintilimab in BCLC B-stage HCC. (hindawi.com)
  • This preliminary study was aimed at evaluating the effectiveness of TACE combined with lenvatinib and sintilimab in treating patients with midstage HCC. (hindawi.com)
  • However, a 2012 study revealed that the rate of local recurrence in patients treated with miriplatin was significantly higher than that in patients treated with epirubicin with mitomycin (Miyayama et al. (springeropen.com)
  • The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)
  • This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. (nature.com)
  • Recent studies had shown that tumors can tolerate immune cells through multiple strategies, including tumor-induced macrophage reprogramming, T cells inactivation, production of B cells pathogenic antibodies and activation of regulatory T cells to promote tumor colonization, growth, and metastasis in lymph nodes. (bvsalud.org)
  • Doctors prescribe epirubicin alongside other medications to treat breast cancer in people who have already had surgery to remove the tumor. (medicalnewstoday.com)
  • Results from the present study demonstrate that treatment with an HDAC inhibitor caused reduced activation of ATM-mediated DNA damage signaling in various tumor cell types. (roma2024.com)
  • Also, the study will look at whether there are gene expression profiles in the tumor tissue that can predict pathologic complete response. (stanford.edu)
  • Merck and Eisai are studying the KEYTRUDA plus LENVIMA combination through the LEAP (LEnvatinib And Pembrolizumab) clinical program in various tumor types, including but not limited to endometrial carcinoma, hepatocellular carcinoma, RCC, head and neck cancer, gastric cancer and esophageal cancer across multiple clinical trials. (streetinsider.com)
  • Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)
  • Therefore, we have conducted a retrospective study to evaluate the safety and effectiveness of ultrasound-guided percutaneous brachytherapy for the treatment of HCC with PVBTT. (biomedcentral.com)
  • In this retrospective study, we reviewed the records of 235 patients collected from the institutional database of interventional radiology from the last 5 years (2015-2019) who had HCC complicated with PVTT. (biomedcentral.com)
  • METHOD: We conducted a retrospective, multicenter study to explore the effectiveness of ICI in patients with pUC or vUC in Taiwan. (bvsalud.org)
  • At the conference of the American Society of Clinical Oncology (ASCO) in May 2005, the following results from clinical phase II studies with matuzumab were presented: Mutations in the kinase domain of the EGFR are observed with approximately 2 to 25% of non-small cell lung carcinoma (NSCLC) patients. (wikipedia.org)
  • The effectiveness of immune checkpoint inhibitors (ICI) in patients with vUC remains uncertain and necessitates additional research. (bvsalud.org)
  • The patients with locally advanced or metastatic leiomyosarcoma who are inoperable are enrolled, aiming at the effectiveness and safety of temozolomide for injection combined with epirubicin as the first-line treatment for advanced leiomyosarcoma. (inclinicaltrials.com)
  • Only three drugs-epirubicin, ifosfamide and dacarbazine (DTIC) have effective activity in patients with soft tissue sarcoma, and the response rate is about 20%3-4 in the second phase study. (inclinicaltrials.com)
  • A Phase II clinical study on the efficacy and toxicity of temozolomide in patients with unresectable or metastatic soft tissue sarcoma. (inclinicaltrials.com)
  • Hideyuki Akazan A randomized controlled study was conducted in patients with superficial bladder cancer in order to investigate the safety of an orally administered (3 g/day) Lactobacillus preparation, biolactis powder (BLP), and its preventive effect on the recurrence after. (karger.com)
  • O'Brien C, Fogarty E, Walsh C, Dempsey O, Barry M, Kennedy MJ, McCullagh L, , The cost of the inpatient management of febile neutropenia in cancer patients - a micro-costing study in the Irish healthcare setting. (tcd.ie)
  • 13. Zhang H, Shen WS, Gao CH, Deng LC, and Shen D. Protective effects of salidroside on epirubicin-induced early left ventricular regional systolic dysfunction in patients with breast cancer. (ac.ir)
  • Sixty-two patients with midstage HCC were enrolled in this study. (hindawi.com)
  • Clinical studies have demonstrated a benefit in some patients by adding HDAC inhibitors to therapeutic regimens that induce DNA damage (24). (roma2024.com)
  • Yes, 66.3% of patients in the multi-center clinical study kept at least 50% of their hair. (dignicap.com)
  • Moxifloxacin prophylaxis for chemoembolization or embolization in patients with previous biliary interventions: a pilot study. (thieme-connect.com)
  • Effectiveness of an aggressive antibiotic regimen for chemoembolization in patients with previous biliary intervention. (thieme-connect.com)
  • There have been few treatment advances for patients with malignant pleural mesothelioma, which can be challenging to treat through surgery and radiation alone," said Dr. Quincy Chu, CCTG's study chair of the IND.227 trial/KEYNOTE-483 trial. (merck.com)
  • This study details the functions of more mature patients with the anxiety that passed on simply by suicide in comparison with younger sufferers. (e3ligasesignal.com)
  • The safety and effectiveness of KEYTRUDA in pediatric patients with MSI-H central nervous system cancers have not been established. (businesswire.com)
  • KEYNOTE-158 (ClinicalTrials.gov, NCT02628067 ) is an ongoing global, open-label, non-randomized, multi-cohort, multi-center, Phase 2 study evaluating KEYTRUDA in patients with multiple types of advanced solid tumors - including endometrial carcinoma - that have progressed on standard of care therapy. (businesswire.com)
  • All inpatient encounters from patients aged ≤18 years with a primary or secondary discharge diagnosis of International Classification of Diseases, Tenth Revision, Clinical Modification code G06.0 (intracranial abscess and granuloma) or G06.2 (extradural and subdural abscess, unspecified) during the study period were included. (medscape.com)
  • A multicenter, phase II/III Study in Patients with known or suspected brain metastases. (radiol-osaka-u.com)
  • Fig.1C)1C) we noticed significant save of colony formation set alongside the epirubicin alone (ideals were calculated using paired check. (sicollaborative.org)
  • In both the LEAP-006 and LEAP-008 trials, the safety profiles of the KEYTRUDA plus LENVIMA-based treatment regimens were consistent with that observed in previously reported studies evaluating the combination. (streetinsider.com)
  • After determining the pharmacokinetic characteristics in a phase I study, several phase II studies investigating the treatment of advanced stomach carcinoma were conducted. (wikipedia.org)
  • Results showed that TIGAR was increased and relocated to the nucleus after epirubicin or hypoxia treatment in cancer cells. (nature.com)
  • DNA damage in HepG2 cells after TIGAR knockdown with or without treatment of epirubicin or CoCl 2 was detected by Comet assay. (nature.com)
  • EMEND has not been studied for treatment of established nausea and vomiting. (nih.gov)
  • tests for evaluations between epirubicin treated cells with and without pre-treatment with LXR ligands, or one-way ANOVA after modification for multiple tests when you compare all treatments simultaneously. (sicollaborative.org)
  • When LXR agonists GW3965, 24OHC, or 26OHC had been coupled with epirubicin treatment (Fig. (sicollaborative.org)
  • There is inadequate information to document the effectiveness of PEI as an alternative to surgical resection for the treatment of hepatic metastases. (aetna.com)
  • Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. (nature.com)
  • Colonies measuring at least 50 cells were counted and normalized to plating effectiveness (27). (roma2024.com)
  • OBJECTIVE: To evaluate pembrolizumab plus either lenvatinib or placebo as first-line therapy for advanced UC in the phase 3 LEAP-011 study. (bvsalud.org)
  • In this study, we aimed to evaluate the effect of salidroside on the activities of the different drug-metabolizing enzymes CYP1A2, CYP2B6, CYP2C9, CYP2D6 and CYP3A4 in rats, in which a specific probe drug was used for each enzyme. (ac.ir)
  • Studies involving mechanism of emodin, an herbal extract, has revealed its potential as anti-inflammatory, antioxidant and anti-cancer agent. (longdom.org)
  • A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. (ac.ir)
  • Dexamethasone prophylaxis to alleviate postembolization syndrome after transarterial chemoembolization for hepatocellular carcinoma: a randomized, double-blinded, placebo-controlled study. (thieme-connect.com)
  • 11. Hung SK, Perry R, and Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. (ac.ir)
  • Accordingly, most sp Teren American studies, the initiation of studies of postoperative thrombosis and thus creates its efficacy and safety. (syksignaling.com)
  • However, analyzes the RESTRICTIONS Website will, for all the meta-analyzes or systematic reviews, and special meaning for them, that such studies are not an indication of the relative efficacy and safety of both strategies. (syksignaling.com)
  • All compounds have a higher IC50 value compared to epirubicin-HCl and napradox-50 (IC50 0.55 ± 0.2 and 0.35 ± 0.03 μM, respectively), indicating that all samples have lower activity than the positive controls. (japsonline.com)
  • This study has revealed the potency of cupressuflavone and amentoflavone-derived compounds that potentially developed further as active constituents in cancer medication. (japsonline.com)
  • Pharmacokinetic studies and tissue distributions were performed and detected by an ultra-high performance liquid chromatography/mass spectrometry system. (dovepress.com)
  • In August 2007, Merck Serono announced that the preliminary results of the colorectal cancer study were less than promising, and that further trials for treating this type of cancer may be abandoned. (wikipedia.org)
  • The primary endpoint of the study is OS, and secondary endpoints include progression-free survival (PFS) and objective response rate (ORR) as assessed by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 modified for mesothelioma, safety and quality of life. (merck.com)
  • Results The dosage regimen of temozolomide used in the study was well tolerated and had moderate activity against unresectable or metastatic leiomyosarcoma of uterus and non-uterus. (inclinicaltrials.com)
  • Materials and Methods Chemicals Entinostat (MS-275) was obtained from Selleck Chemicals LLC, epirubicin from Calbiochem (EMD Chemical), dimethyl sulfoxide (DMSO) from MP Biomedicals LLC. (roma2024.com)
  • The half-life Phenoxodiol of intra-cellular epirubicin sign was established using dissociation one stage exponential decay as well as the manifestation of Pgp in affected person tumors that got suffered a meeting compared with those that hadn't was evaluated using MannCWhitney testing. (sicollaborative.org)
  • This study is a single-center, prospective, one-arm clinical study, which is planned to be carried out in Cancer Hospital of Chinese Academy of Medical Sciences. (inclinicaltrials.com)
  • Those preliminary findings need validation in larger studies, with a prospective design and longer follow-up. (hindawi.com)
  • The association between the single nucleotide polymorphisms of interleukin-6 and n-3 polyunsaturated acids-A prospective cohort study. (kmu.edu.tw)
  • Merck has an extensive clinical development program in lung cancer and is advancing multiple registration-enabling studies, with research directed at earlier stages of disease and novel combinations. (merck.com)
  • Similarly studies with Emodin and Aloe emodin derivatives have also revealed greater therapeutic potential, DNA intercalation property, and reactive oxygen species generation and thereby induction of apoptosis in cancer cells [ 12 ]. (longdom.org)
  • For experiments, cells were treated for 48 hours with an DL-Methionine HDAC inhibitor or vehicle (DMSO) before epirubicin (0.5 M). DNA Damage Detection Assay Expression of -H2AX was detected using the Accuri 6 flow cytometer (BD Biosciences). (roma2024.com)
  • Cells treated with vehicle or VPA (2mM) for SPP1 48 hours before the addition of epirubicin (0.5 M) for 4 hours. (roma2024.com)
  • Cells were either collected immediately, or washed to remove epirubicin, and allowed to recover for 12 hours. (roma2024.com)
  • Cells were then treated with vehicle or vorinostat (1.0 M) and epirubicin (50 nM) for up to 14 days. (roma2024.com)
  • Further studies with pharmacological and genetic approaches revealed that TIGAR regulated the phosphorylation of ATM, a key protein in DDR, through Cdk5. (nature.com)
  • In order to increase the effectiveness of emodin, it has been subjected to various modification and numerous derivatives have been successfully synthesized with the goal of achieving better therapeutic effects. (longdom.org)
  • We review the evidence on the effects and effectiveness of these systems, which are making their way into routine clinical practice. (actasdermo.org)
  • There may be some value in considering an alkaline diet in reducing morbidity and mortality from chronic diseases and further studies are warranted in this area of medicine. (pranaon.com)
  • In February 2008, the development was halted because of disappointing study results. (wikipedia.org)
  • On August 27, 2007 Merck announced that matuzumab will not be used for intestinal cancer due to negative results in phase II studies. (wikipedia.org)
  • The publication of study results is an essential mandate of the ABCSG. (abcsg.org)
  • The aim of the present study was to reveal the relationship between changes of arterial flow in HCC nodules under balloon occlusion and local TE by means of CTHA. (springeropen.com)
  • This study was approved by the Research Ethics Committee of Graduate School of Medicine, Chiba University. (hindawi.com)
  • Our research can provide the basis for the study of related herb-drug interactions in clinic. (ac.ir)