• The active ingredient comprises plasma proteins such as albumin , immunoglobulins, other globulins, coagulation factors, complement proteins and protease inhibitors. (rxlist.com)
  • Examples include methotrexate (used in chemotherapy and in treating rheumatic arthritis ) and the protease inhibitors used to treat HIV/AIDS . (wikipedia.org)
  • The main active ingredient of Atazanavir (as sulfate)/Ritonavir 300 mg/100 mg Tablets is atazanavir, which belongs to a class of antiviral medicines called protease inhibitors. (who.int)
  • Opdivo is a type of drug known as an immune checkpoint inhibitor, that binds to the protein, PD-1, and blocks this protein, which helps the immune system effectively kill cancer cells, as defined by National Cancer Institute. (curetoday.com)
  • The treatment, called a checkpoint inhibitor, has promise to help a child's body effectively combat brain tumors when given a vaccine. (childrenscancer.org)
  • According to Dr. Moertel, the previous invention of the immune checkpoint inhibitor has already made a huge difference for thousands of people around the globe. (childrenscancer.org)
  • Shining brightest among these various immunotherapy approaches-at least for the time being-is the immune checkpoint inhibitor. (bumrungrad.com)
  • The immune checkpoint inhibitor thwarts this sneaky behavior by the cancer cells, allowing the immune system to effectively wipe the cancer out as it was designed to do naturally. (bumrungrad.com)
  • This is the target of the first immune checkpoint inhibitor medication approved, and now comes in variants to fight many different kinds of cancer. (bumrungrad.com)
  • The toxicity data of protein kinase inhibitors in humans is also well established [5]. (who.int)
  • More recent medications that doctors can use to treat TLS include B cell lymphoma-2 protein inhibitors and oral kinase inhibitors. (medicalnewstoday.com)
  • Chronic myeloid leukemia (CML) is currently treated with tyrosine kinase inhibitors, but these do not effectively eliminate the CML stem cells. (lu.se)
  • It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies. (wikipedia.org)
  • We previously developed a pan-coronavirus fusion inhibitor, EK1, which targeted the HR1 domain and could inhibit infection by divergent human coronaviruses tested, including SARS-CoV and MERS-CoV. (nature.com)
  • The investigators moved on to think about evaluating the therapeutic potential of pharmacologically inhibiting Cx32, using 2-aminoethoxy-dipenyl-borate (2APB), a compound previously shown to transiently inhibit Cx32 gap junctions in vitro, and which they confirmed was specific to the Cx32 gap junction protein. (genengnews.com)
  • In contrast, EX527 is an effective selective Sirt1 inhibitor, which can inhibit Sirt1 deacetylase activity effectively. (frontiersin.org)
  • Many drug molecules are enzyme inhibitors that inhibit an aberrant human enzyme or an enzyme critical for the survival of a pathogen such as a virus , bacterium or parasite . (wikipedia.org)
  • Medicinal enzyme inhibitors often have low dissociation constants , meaning that only a minute amount of the inhibitor is required to inhibit the enzyme. (wikipedia.org)
  • Small molecule inhibitors include essential primary metabolites that inhibit upstream enzymes that produce those metabolites. (wikipedia.org)
  • The PKCalpha inhibitor, Gö-6976, did not inhibit FLDE-stimulated IL-8 and IL-6 release. (cdc.gov)
  • Our results also show that acquired BRAF-inhibitor (BRAFi) resistance leads to increased expression of HuR and WNT5A in malignant melanoma cells, and simultaneous therapeutic inhibition of HuR function and WNT5A signaling could be an efficient treatment strategy to impair the invasive migration of BRAFi-resistant melanomas. (lu.se)
  • We also synthesize a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes which, upon activation, confer resistance to a BRAF inhibitor. (cdc.gov)
  • Further testing showed that dampening NGLY1 allowed a proteasome inhibitor to continue doing its work killing cancer cells without interference from Nrf1. (medicalxpress.com)
  • Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity, ACS Central Science (2017). (medicalxpress.com)
  • Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that catalyze post-translational deimination/citrullination of proteins, causing structural and functional changes in target proteins. (open.ac.uk)
  • Enzymes are proteins that speed up chemical reactions necessary for life , in which substrate molecules are converted into products . (wikipedia.org)
  • [2] Enzyme inhibitors also control essential enzymes such as proteases or nucleases that, if left unchecked, may damage a cell. (wikipedia.org)
  • Many poisons produced by animals or plants are enzyme inhibitors that block the activity of crucial enzymes in prey or predators . (wikipedia.org)
  • The binding site of inhibitors on enzymes is most commonly the same site that binds the substrate of the enzyme. (wikipedia.org)
  • These structural insights suggest a general approach for developing new generations of antimalarial DHFR inhibitors that, by only occupying substrate space of the active site, would retain binding affinity with the mutant enzymes. (rcsb.org)
  • The fact that cycloheximide delays tepal senescence demonstrates the synthesis of particular proteins probably enzymes, responsible for degradation of cellular constituents, executes the cell death programme in flower tepals. (scialert.net)
  • Enzyme inhibitors may bind reversibly or irreversibly. (wikipedia.org)
  • Enzyme inhibitors play an important role in all cells, since they are generally specific to one enzyme each and serve to control that enzyme's activity. (wikipedia.org)
  • Hence the discovery and refinement of enzyme inhibitors is an active area of research in biochemistry and pharmacology . (wikipedia.org)
  • Enzyme inhibitors are a chemically diverse set of substances that range in size from organic small molecules to macromolecular proteins . (wikipedia.org)
  • [3] [2] Small molecule enzyme inhibitors also include secondary metabolites , which are not essential to the organism that produces them, but provide the organism with an evolutionary advantage, in that they can be used to repel predators or competing organisms or immobilize prey. (wikipedia.org)
  • In addition to small molecules, some proteins act as enzyme inhibitors. (wikipedia.org)
  • [7] A special case of protein enzyme inhibitors are zymogens that contain an autoinhibitory N-terminal peptide that binds to the active site of enzyme that intramolecularly blocks its activity as a protective mechanism against uncontrolled catalysis. (wikipedia.org)
  • The two-step washing stage effectively removes impurities and enzyme inhibitors. (blirt.eu)
  • Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM, about 241- and 149-fold more potent than the original EK1 peptide, respectively. (nature.com)
  • amyloid peptide, can be inhibited effectively using compounds anchored to cell membrane RAFTS. (healthnewstrack.com)
  • Concentrations as low as 100 nM of the anchored inhibitor were sufficient to completely block appearance of amyloid peptide. (healthnewstrack.com)
  • All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
  • This pD dependence is due to labile protein deuterons in acidic side-chains and surface peptide groups, which exchange rapidly with water deuterons. (lu.se)
  • In addition, we demonstrate that combined targeting of IL-6 signaling and WNT5A expression, using an anti-IL-6 antibody and a WNT5A antagonist peptide (Box5), respectively, more effectively reduces melanoma cell dissemination, as compared to each factor alone. (lu.se)
  • High-mobility group box 1 protein (HMGB1) has been reported to be a potent proangiogenic factor induced by inflammatory stress. (molvis.org)
  • Venetoclax (ABT-199) is a potent BCL-2 inhibitor that is FDA-approved for the treatment of CLL based on its remarkable single agent efficacy in this cancer type. (lls.org)
  • Potent, cell permeable and ATP-competitive inhibitor of DNA-PK, phosphoinositide 3-kinase (PI(3)K), the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. (enzolifesciences.com)
  • Aminoglycosides are a potent class of translation inhibitor antibiotics with a broad activity spectrum. (elifesciences.org)
  • C16 (PKRi, GW 506033X) is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). (wikipedia.org)
  • Novel selective inhibitors of nuclear export (SINE) have achieved outstanding preclinical results and are currently in Phase I trials. (massgeneral.org)
  • Induction of P450s can be demonstrated using one or more of a combination of different endpoints: mRNA, protein via Western blotting, and activity using a selective substrate. (aspetjournals.org)
  • By contrast, reversible inhibitors bind non-covalently and may spontaneously leave the enzyme, allowing the enzyme to resume its function. (wikipedia.org)
  • Reversible inhibitors produce different types of inhibition depending on whether they bind to the enzyme, the enzyme-substrate complex, or both. (wikipedia.org)
  • enzyme (E) accelerates conversion of substrates (S) to products (P). Bottom: by binding to the enzyme, inhibitor (I) blocks binding of substrate. (wikipedia.org)
  • Binding site shown in blue checkerboard, substrate as black rectangle, and inhibitor as green rounded rectangle. (wikipedia.org)
  • An enzyme inhibitor stops ("inhibits") this process, either by binding to the enzyme's active site (thus preventing the substrate itself from binding) or by binding to another site on the enzyme such that the enzyme's catalysis of the reaction is blocked. (wikipedia.org)
  • secretase is internalized from the cell membrane into intracellular compartments (endosomes) where it cleaves its substrate, Amyloid Precursor Protein (APP). (healthnewstrack.com)
  • Using a substrate-cassette approach, P450 activities were determined after incubation with the prototypic inhibitors tienilic acid (CYP2C9), erythromycin, troleandomycin, and fluoxetine (CYP3A4). (aspetjournals.org)
  • Mechanism-based P450 inhibitors can be characterized as displaying NADPH-, concentration-, and time-dependent quasi-irreversible or irreversible inactivation because of chemical modification of the heme and/or protein, and the inactivation rate is diminished in the presence of a competing substrate ( Silverman, 1998 ). (aspetjournals.org)
  • Kinetic analysis of enzyme inactivation in hepatocytes was used to describe the effect of these time-dependent inhibitors and derive the inhibition parameters k inact and K I , which generally were in good agreement with the values derived using recombinant P450s and human liver microsomes (HLMs). (aspetjournals.org)
  • The expression of HMGB1, c-Jun N-terminal kinase (JNK), extracellular-signal-regulated kinase (ERK), and p38 mitogen-activated protein kinase (p38 MAPK) was assessed with immunofluorescence and western blot analysis. (molvis.org)
  • The anti-inflammatory effects of SHE treatment involved blocking of the mitogen-activated protein kinase and signal transducer and activator of transcription 1 signaling pathways. (researchgate.net)
  • Finding alternative strategies to effectively re-engage BCL-2 proteins can potentially circumvent resistance. (lls.org)
  • But the drugs have been limited by cancer cells ability to development resistance, as well as the inhibitors inability to fight solid tumors effectively. (medicalxpress.com)
  • Studies have suggested that resistance could be linked to a protein called Nrf1. (medicalxpress.com)
  • However, Janjigian and Cytryn noted that adding Stivarga to the current treatment combination "may be able to shrink the tumor more effectively, extend the time before the tumor develops resistance to treatment and ultimately extend a patient's life beyond what nivolumab and chemotherapy can do without regorafenib. (curetoday.com)
  • Because of the widespread resistance to the M2 class of drugs, the two neuraminidase inhibitors, Tamiflu and Relenza, are now the most commonly prescribed anti-flu medications. (cdc.gov)
  • The fact that XPO1 and other essential nucleo-cytoplasmatic transport proteins are over expressed in cancer, specifically in melanoma, offers the opportunity to treat cancer by modulating this transport system. (massgeneral.org)
  • Moreover, we show that the RNA-binding protein human antigen R (HuR) drives melanoma cell motility, and targeting HuR with a specific HuR inhibitor, MS-444, significantly reduces melanoma cell migration. (lu.se)
  • The menin-PRMT5 complex binds to the promoter of the Gas1 gene, where PRMT5 (an enzyme that adds methyl groups to histone proteins) functions as an epigenetic inhibitor, tamping down gene transcription. (medindia.net)
  • An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity . (wikipedia.org)
  • An increase in total sugar, phenolic and soluble protein content was observed with a concomitant decrease in α-amino acid content. (scialert.net)
  • Tucatinib (Tukysa) is a tyrosine kinase inhibitor used to treat metastatic, HER2-postive breast cancer . (lbbc.org)
  • Tucatinib is a small molecule tyrosine kinase inhibitor, or TKI. (lbbc.org)
  • Certain proteins, called tyrosine kinases, tell breast cancer cells to multiply. (lbbc.org)
  • Likewise, WIKI4 also effectively inhibits the Wnt/β-catenin pathway-dependent growth of DLD1 (by 67% in 10 days;1μM). (fishersci.com)
  • Pyr20 still effectively inhibits both the wild-type and SP21 proteins, and the x-ray structures of these complexes show how Pyr20 fits into both active sites without steric strain. (rcsb.org)
  • We performed molecular docking simulation with six different inhibitors (ligand), which includes DTNB, NSC695265, thionitrobenzoic acid, 2-nitro-5-thiocyanobenzoic acid, 2-nitro-5-sulfo-sulfonyl-benzoic acid and NSC517871 into the redox-active site [C37-G38-H39-C40] of the PDI enzyme and the activity was inferred by redox inhibitory models. (biomedcentral.com)
  • We demonstrated that in silico docking experiment can be effectively carried out to recognize the redox inhibitory models of PDI with inhibitor molecules. (biomedcentral.com)
  • secretase inhibitor to the membrane would confer inhibitory activity upon it by bringing it to the right compartment. (healthnewstrack.com)
  • This work demonstrates that caution is warranted in the interpretation of enzyme induction studies with metabolically stable, weak time-dependent inhibitors, which may have dramatic inhibitory effects on P450 activity in this system. (aspetjournals.org)
  • Glycation, the result of a protein or lipid molecule bonding with sugar molecules, is a consequence of the aging process. (molvis.org)
  • The compound is an inhibitor of mammalian protein kinase and has been applied topically for the treatment of skin metastasis showing good local tolerability [5]. (who.int)
  • They found that inhibiting proteins in the Hedgehog network using drugs reduces growth of tumors in an animal model of human MEN1 syndrome. (medindia.net)
  • A low concentration of the enzyme inhibitor reduces the risk for liver and kidney damage and other adverse drug reactions in humans. (wikipedia.org)
  • The STAT3 Inhibitor Galiellalactone Effectively Reduces Tumor Growth and Metastatic Spread in an Orthotopic Xenograft Mouse Model of Prostate Cancer. (lu.se)
  • Interestingly we found that number of docked clusters with each ligand varies in the range of five to eight and conveys that the binding specificity of each inhibitor varies for PDI. (biomedcentral.com)
  • A class of compounds called proteasome inhibitors that include bortezomib and carfilzomib-both approved by the U.S. Food and Drug Administration-have been effective at treating certain types of blood cancers . (medicalxpress.com)
  • The interactions between proteases and their inhibitors have been linked to modulation of cell death processes in plants and in certain cut flowers. (scialert.net)
  • Therefore, we herein established a SARS-CoV-2 spike (S) protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV. (nature.com)
  • Non-infected (-) and infected (+) BHK-21 whole cell extracts (5 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with Dengue virus Envelope protein antibody (GTX127277) diluted at 1:25000. (genetex.com)
  • Studies on sortases, membrane-anchored transpeptidases that cleave surface proteins were described. (cdc.gov)
  • Background The neddylation pathway conjugates NEDD8 to cullin-RING ligases and controls the proteasomal degradation of specific proteins involved in essential cell processes. (nih.gov)
  • Protein degradation. (nih.gov)
  • Administration of the anti-PTHrP antibody, but not of alendronate, effectively reduced the blood calcium of the animals that developed elcatonin-refractory HHM. (unboundmedicine.com)
  • This antibody was raised against Dengue virus 2 Envelope protein, which may cross react with Envelope protein of Dengue virus 3 but does not recignize with Envelope protein of JEV. (genetex.com)
  • Dengue virus Envelope protein antibody detects Dengue virus Envelope protein protein at cytoplasm by immunohistochemical analysis. (genetex.com)
  • Green: Dengue virus Envelope protein stained by Dengue virus Envelope protein antibody (GTX127277) diluted at 1:1000. (genetex.com)
  • A number of proteins are associated with the replication fork which helps in terms of the initiation and continuation of DNA synthesis. (wn.com)
  • Unlike many cancer-associated proteins, menin is neither an enzyme nor a signaling receptor. (medindia.net)
  • Entry of HIV-1 into human lymphoid requires activities of viral envelope glycoproteins gp120 and gp41, and two host-cell proteins, the primary receptor CD4 and a chemokine co-receptor. (biomedcentral.com)
  • Platelets express a receptor/binding protein for factor IXa that promotes assembly of the IXa/VIIIa complex. (medscape.com)
  • What's more, treating a mouse model of human MEN1 syndrome with a Hedgehog pathway inhibitor called Erivedge (FDA-approved in 2012 for metastatic or locally advanced basal cell carcinoma) reduced proliferation of tumor cells and blood insulin levels. (medindia.net)
  • Herein, we demonstrate apabetalone, the most clinical advanced BET inhibitor, downregulates expression of cell surface receptors involved in SARS-CoV-2 entry, including angiotensin-converting enzyme 2 (ACE2) and dipeptidyl-peptidase 4 (DPP4 or CD26) in SARS-CoV-2 permissive cells. (biorxiv.org)
  • Rosiglitazone, a PPAR γ agonist, could increase PON2 expression in A10 cells, while the PPAR γ inhibitor prevented the effect of fisetin on PON2. (hindawi.com)
  • Expression of cell cycle inhibitors, P21 and P27, and activation of apoptosis executer enzyme, caspase-3, were also induced by TCEE. (hindawi.com)
  • The GAS1 protein promotes Hedgehog signaling, and thus by inhibiting Gas1 expression, menin and PRMT5 effectively dial down the pathway's tendency towards cell proliferation. (medindia.net)
  • Heterologous expression of an ATPase inhibitor completely eliminated bactericidal activity, while loss of the F-ATPase reduced the electrophysiological response to aminoglycosides. (elifesciences.org)
  • The results indicated increased expression of genes encoding proteins involved in stress, hypoxic responses, immune and inflammatory responses, responses to tissue injury and tissue repair, cytokines, and chemokines. (cdc.gov)
  • Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
  • At this stage all the cellular membranes and proteins are degraded. (blirt.eu)
  • Our data provide proof-of principle of a new approach for directing small molecule inhibitors to disease causing RAFT targets in cellular membranes. (healthnewstrack.com)
  • We also identified that Cys37 of the enzyme plays an important role in hydrogen bonding with inhibitors. (biomedcentral.com)
  • A quantitative justification hydrogen isotopes 1H and 2H in aqueous protein of this point of view, however, has not been solutions has been used extensively during the past presented. (lu.se)
  • All globular proteins contain large numbers of interaction, in particular, its dynamic aspects labile hydrogen atoms that can exchange with the (Daszkiewicz et al . (lu.se)
  • A potential submicrosecond for solvent-accessible carboxyl complication in such studies is the exchange of groups to years for deeply buried amide hydrogen hydrogen nuclei between water and protein. (lu.se)
  • Hydrogen exchange in protein solutions hydrogen atoms. (lu.se)
  • Protein transport between the nuclear and the cytoplasmic compartment is a key factor for cell viability and proliferation. (massgeneral.org)
  • Microgravity-induced bone loss in space, can be reduced by systemic delivery of NELL-1, a protein required for bone growth and its maintenance. (medindia.net)
  • Here we show phylogenetically conserved pathways of PAD-mediated OMV/MV release in bacteria and describe deiminated/citrullinated proteins in E. coli and their derived OMV/MVs. (open.ac.uk)
  • Gap junction protein inhibitor protects mice from death and liver damage after hepatotoxic drug challenge. (genengnews.com)
  • Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)
  • The VEGF-A protein and mRNA levels in conditioned medium of RGC-5 cells incubated with AGE-modified BSA (AGE-BSA) were examined with real-time PCR and enzyme-linked immunosorbent assay (ELISA), and BSA-treated cells were used as controls. (molvis.org)
  • Compared with the BSA controls, the RGC-5 cells incubated with AGE-BSA showed a dose- and time-dependent increase in VEGF-A mRNA and VEGF-A protein secretion in the supernatant, with the highest levels achieved at 24 h. (molvis.org)
  • Therefore, in addition to enzyme activity, mRNA and/or protein levels should be measured to fully evaluate the P450 induction potential of a drug candidate. (aspetjournals.org)
  • Their experiments demonstrated that treating mice with a small molecule inhibitor that specifically target the hepatic gap junction protein connexion 32 (Cx32) provides significant protection against liver damage and death resulting from subsequent or simultaneous challenge with known hepatotoxic drugs such as acetaminophen. (genengnews.com)
  • Dr. Olin discovered that brain tumors sometimes shield themselves with a protein called CD200, preventing a child's immune system and treatment from attacking it. (childrenscancer.org)
  • His goal was to "turn off" this shielding CD200 protein, allowing a previously developed vaccine and the child's immune system a chance to eradicate the brain tumor. (childrenscancer.org)
  • Since anti-pathogen inhibitors generally target only one enzyme, such drugs are highly specific and generally produce few side effects in humans, provided that no analogous enzyme is found in humans. (wikipedia.org)
  • [6] Another class of inhibitor proteins is the ribonuclease inhibitors , which bind to ribonucleases in one of the tightest known protein-protein interactions . (wikipedia.org)
  • Previous research has found that a mutation in a protein called menin causes a hereditary cancer syndrome called MEN1 (multiple endocrine neoplasia type 1). (medindia.net)
  • They found that NGLY1 is responsible for activating Nrf1, the protein that is suspected of weakening proteasome inhibitors' effectiveness against cancer. (medicalxpress.com)
  • Stivarga is a type of kinase (a type of enzyme) inhibitor that blocks certain proteins, which can ultimately prevent cancer cells from growing, according to National Cancer Institute. (curetoday.com)
  • Tucatinib blocks these proteins from working to help keep cancer from growing. (lbbc.org)
  • This protein exists on the surface of cancer cells. (bumrungrad.com)
  • When the PDL-1 protein pairs up with the PD-1 protein above, it switches off the checkpoint that would otherwise activate the body's T-cells. (bumrungrad.com)
  • Several agents have been developed to target these key regulatory proteins that are essential for HIV replication. (biomedcentral.com)
  • We solved the X-ray crystal structure of six-helical bundle (6-HB) core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit, revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain. (nature.com)
  • A protein called Nrf1 (shown in white in these mouse cells) can hamper promising drugs for blood cancers, but now researchers have found a possible workaround to shut Nrf1 down. (medicalxpress.com)
  • When proteasome inhibitors go into action, Nrf1 is spurred into overdrive to restore the cells' normal activities and keep them alive. (medicalxpress.com)
  • Immune "checkpoints" are proteins in T-cells (a type of white blood cells) that are activated or inactivated the T-cells response to the foreign cells. (bumrungrad.com)
  • Inhibiting the PD-L1 protein allows the T-cells to do their job. (bumrungrad.com)
  • When the protein is inhibited the T-cells will start working continuously. (bumrungrad.com)
  • Feedlot dust stimulation of interleukin-6 and -8 requires protein kinase Cepsilon in human bronchial epithelial cells. (cdc.gov)
  • We previously found that exposure of bronchial epithelial cells to hog barn dusts resulted in a protein kinase C (PKC)-dependent increase in IL-6 and IL-8 release. (cdc.gov)
  • Chimeric monoclonal antibodies activate antigen-presenting cells (APCs) and T cells more effectively than murine monoclonal antibodies but can still induce production of human anti-chimeric antibodies. (msdmanuals.com)
  • K I 30 μM and k inact 0.02 min -1 ) effectively abolished CYP2C9 activity over 24 h at low (micromolar) concentrations in primary cultured human hepatocytes. (aspetjournals.org)
  • The translated protein has a molecular weight of about 60 kD and exhibits NAD + -dependent deacetylase activity. (frontiersin.org)
  • Because sortases of Staphylococcus aureus are required for animal infections, inhibitors that disrupt the activity of sortases may be therapeutically useful. (cdc.gov)