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  • circulation
  • This paper provides an overview of the gut microflora and its significance, a focus on the mechanisms employed by bacteria to gain access to the systemic circulation, and how critical illness creates a hostile environment in the gut and alters the microflora favoring the growth of pathogens that promote bacterial translocation. (hindawi.com)
  • heme
  • Pectin Esterification Degree in the Bioavailability of Non-heme Iron in Women. (bioportfolio.com)
  • Iron is found in the diet in two forms-heme iron, which is well absorbed, and nonheme iron, which is poorly absorbed. (healthjade.com)
  • Foods rich in vitamin C (e.g., citrus fruits and fresh vegetables), eaten with small amounts of heme iron-containing foods, such as meat, may increase the amount of nonheme iron absorbed from cereals, beans, and other vegetables. (healthjade.com)
  • induce
  • Unabsorbed gut iron due to malaria could induce enteric infections, accounting for the increased administration of antibiotics and antifungals in the iron-supplemented arm. (beds.ac.uk)
  • trials
  • In the field, we are undertaking large randomised controlled trials of iron interventions in rural Bangladesh (infants) and Malawi (pregnant women). (edu.au)
  • There have been no previous randomised trials assessing whether vaginal infections are influenced by host iron status. (beds.ac.uk)
  • ofloxacin
  • FLOXIN® (ofloxacin) Tablets contain the following inactive ingredients: anhydrous lactose, modified corn starch, hydroxypropyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, polysorbate 80, sodium starch glycolate, titanium dioxide and may also contain synthetic yellow iron oxide. (rxlist.com)
  • What are the possible side effects of ofloxacin (Floxin)? (rxlist.com)
  • metabolic
  • and b) a need for additional safety data, including absorption and metabolic studies in man, short-term feeding studies, and a multigeneration reproduction study. (inchem.org)
  • The Committee considered that if data from adequate absorption/metabolic studies and short-term feeding studies demonstrated that there was no bioaccumulation of aluminium in the tissues, there would be no need for a multigeneration reproduction study. (inchem.org)
  • Iron deficiency is a well-known and common nutritional complication of metabolic surgery. (bariatrictimes.com)
  • The most well-known and prevalent nutritional concern is the effect of metabolic surgery on iron nutrition. (bariatrictimes.com)
  • The purpose of this review is to summarize the current knowledge related to obesity, metabolic surgery, and iron nutrition and to suggest opportunities for quality improvement. (bariatrictimes.com)
  • 3 The major reduction in gastric acid and lack of food contact with the duodenum and proximal jejunum explain, in part, the pathogenesis of iron deficiency complicating metabolic surgery. (bariatrictimes.com)
  • Critically
  • Critically important to the overall understanding of iron balance is the recent discovery of erythroferrone-with potential implications for treating multiple blood disorders and diseases. (nih.gov)
  • evidence
  • Based on the evidence discussed here, we suggest a synergistic use of iron-chelators and anti-inflammatories as putative anti-brain aging therapies to counteract pathological aging in neurodegenerative diseases. (frontiersin.org)
  • Nonetheless, knowledge of free radical chemistry in vitro combined with accumulating circumstantial evidence e.g., use of iron chelators (see below), suggest a role for Fenton chemistry in free radical-mediated pathology. (frontiersin.org)
  • A large body of evidence now points to a strong relationship between body iron stores and diabetes risk, and diabetes is a major problem especially in the aging veteran population. (grantome.com)
  • excess
  • Consequently, the homeostatic neuroregulation of iron is tightly controlled for this reason, this "goldilocks" mineral can lead to perturbations in neuronal function if deficient or in excess. (frontiersin.org)
  • Because excess iron damages tissues, total body iron is carefully regulated, with most of it being constantly recycled. (nih.gov)
  • Unfortunately, the human body does not seem to have an efficient or regulated way to rid itself of excess iron. (nih.gov)
  • Magnetic resonance imaging potentially provides a useful and widely available technique for examining the three- dimensional distribution of excess iron in the body, but further research is needed to develop a way to make measurements quantitative. (nih.gov)
  • Regardless of the cause, progressive iron accumulation eventually overwhelms the body's capacity for safe sequestration of the excess, resulting in a variety of pathologies. (nih.gov)
  • dose
  • In the first study, 40 women were randomly assigned to either 60 mg of oral iron (as FeSO4) administered each morning for 14 days, or the same dose on alternate days for 28 days. (hematology.org)
  • The most common dose-limiting side effects include α-adrenoceptor antagonist. (imagenenaccion.org)
  • tissue
  • Currently, biomagnetic susceptometry (SQUID) provides the only non-invasive method for measurement of tissue iron stores that has been calibrated, validated and used in clinical studies. (nih.gov)
  • Among conclusions reached, the workshop participants recommended further investigation of magnetic resonance imaging as a method for quantitative determinations of tissue iron, especially in liver, heart and brain. (nih.gov)
  • mechanisms
  • We propose to study the mechanisms for these associations in animal models because it is crucial to understand the ramifications of altering body iron stores to ameliorate diabetes risk. (grantome.com)
  • Most of the mechanisms and details underlying the relationship of iron to diabetes risk, however, remain unknown, and it is crucial to understand the basis for these relationships as we set out to reverse them. (grantome.com)
  • study of the biochemical and physiological effects of drugs and the molecular mechanisms by which those effects are produced - what drugs do to the body and how they do it. (studystack.com)
  • Proposed mechanisms include estrogenic and antiestrogenic effects, induction of cancer cell differentiation, inhibition of tyrosine kinase and DNA topoisomerase activities, suppression of angiogenesis, and antioxidant effects. (t-nation.com)
  • Warnings and Precautions
  • Because XENICAL has been shown to reduce the absorption of some fat-soluble vitamins and betacarotene, patients should be counseled to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition [see WARNINGS AND PRECAUTIONS ]. (rxlist.com)
  • bone
  • The cellular sequestration of iron leaves less available for transport to the bone marrow. (nih.gov)