Effect of rotenone. Medical search. Frequent questions

mechanistically, rotenone-induced destruction of dopaminergic neurons has been attributed to its inhibition of the activity of neuronal mitochondrial complex I. However, the role of microglia, the resident brain immune cells in rotenone-induced neurodegeneration, has not been reported. (jneurosci.org)
Rotenone (ROT) is a specific inhibitor of mitochondrial complex I in the brain which leads to the generation of oxidative stress. (cranberryinstitute.org)
Correction of rat liver mitochondrial dysfunction under rotenone intoxication when treated with fixed combination meldonium with gamma-butyro-betaine. (ukrbiochemjournal.org)
The present investigation was an attempt to study the effect of low molecular weight sulfated chitosan (LMWSC) on in vitro rotenone model of Parkinson's disease (PD) by evaluating cell viability, oxidative stress, mitochondrial membrane potential, DNA fragmentation, and apoptosis. (elsevierpure.com)
Incubation of SH-SY5Y cells with 100 nm rotenone resulted in neuronal cell death, redox imbalanced mitochondrial dysfunction, DNA fragmentation, condensation, and apoptotic cellular morphology. (elsevierpure.com)
Reduction of the intracellular reactive oxygen species (ROS) levels ensued due to pretreatment of LMWSC along with consequent normalization of antioxidant enzymes, mitigation of rotenone induced mitochondrial dysfunction and apoptosis. (elsevierpure.com)
Our current findings suggested that LMWSC exhibit the pronounced neuroprotective effects, which could be due to its antioxidant, mitochondrial protection, and anti-apoptotic properties. (elsevierpure.com)
Hyperglycemia increased the formation of ROS-an effect linked to mitochondrial dysfunction and prevented by sulforaphane. (diabetesjournals.org)
Under HG conditions, reactive oxygen species release from monocytes was not inhibited by agents affecting mitochondrial metabolism but was inhibited in human endothelial cells. (diabetesjournals.org)

Biochemical and genetic mechanisms of oxidative stress (OS) developing in rat heart mitochondria were studied in a rotenone model of Parkinson's disease (PD), and the effect of Capicor (combination of meldonium dihydrate and gamma-butyrobetain dihydrate) on these mechanisms was evaluated. (ukrbiochemjournal.org)
Rotenone intoxication increased the intensity of lipid peroxidation, protein oxidative modification, and H 2 O 2 production. (ukrbiochemjournal.org)
The effect of Capicor on the protein markers of oxidative stress development in rat brain mitochondria under modeling of Parkinson's disease. (ukrbiochemjournal.org)
Oxidative stress and proteasomal dysfunction are implicated in the pathogenesis of PD but their interactions as well as their effect on aggregates formation are not yet clear. (unboundmedicine.com)
Naïve and transfected cells were exposed to oxidative stress induced by rotenone, SIN-I, FeCl(2,) and to proteasomal inhibition by lactacystin. (unboundmedicine.com)
Effect of β-cyfluthrin (synthetic pyrethroid) on learning, muscular coordination and oxidative stress in Swiss albino mice. (aaem.pl)
Moreover, AM also counteracted rotenone -induced behavioral deficits, oxidative stress , and degeneration of nigro-striatal dopaminergic neurons . (bvsalud.org)

Although little neurotoxicity was detected in neuron-enriched cultures after treatment for 8 d with up to 20 n m rotenone, significant and selective dopaminergic neurodegeneration was observed in neuron/glia cultures 2 d after treatment with 20 n m rotenone or 8 d after treatment with 1 n m rotenone. (jneurosci.org)
Furthermore, inhibition of NADPH oxidase or scavenging of superoxide significantly reduced the rotenone-induced neurotoxicity. (jneurosci.org)
This nanosystem crosses the blood-brain barrier in vitro and is effective against rotenone neurotoxicity in vivo. (au.dk)

These are toxicants that affect respiration by interfering with the electron transport chain in the mitochondria. (wikipedia.org)
Rotenone kills by inhibiting cellular respiration in mitochondria, which leads to reduced cellular uptake of oxygen. (noble.org)
During injury stimulation, the major effects on the cardiac function may be those involving mitochondria-dominated events along with potential nucleus-governed genetic/epigenetic alternations within the cardiomyocytes as well as the macrophage-led inflammation and T-cell-led immune responses underlying the myocardium-vessel interactive cascade. (hindawi.com)

Rotenone is the piscicide most often used to kill fish. (noble.org)
Liquid rotenone piscicide usually is available in a formulation with 5 percent active ingredient. (noble.org)
One gallon of 5 percent rotenone applied to 3 acre-feet of water volume gives 1 ppm concentration of bulk piscicide. (noble.org)
The removal of non-native fish is done with the use of the EPA-registered piscicide rotenone, an organic chemical that comes from a tropical legume (pea family) root that has been used by indigenous peoples to capture fish and has been used throughout the world for fish management projects. (co.us)

In this report, you will discover how the alpha lipoic acid benefits vital cellular energy while shielding against and possibly reversing the damaging effects of disorders that include diabetes, obesity, cardiovascular disease, neurodegeneration, and cancer. (lifeextension.com)

reported that chronic administration of a common herbicide, rotenone, resulted in a selective destruction of the nigrostriatal dopaminergic system, formation of cytoplasmic inclusions in nigral neurons, and induction of hypokinesia and rigidity in rats, reproducing the key features of human PD. (jneurosci.org)
Can cranberry juice protect against rotenone-induced toxicity in rats? (cranberryinstitute.org)
Thirty-two male rats were randomly divided into 4 groups, with 8 in each group: vehicle control (1 ml/kg/48 h for 12 days), rotenone (1.5 mg/kg/48 h, s.c. for 12 days), low-dose Caffeine-treated: (10 mg/kg IP. (edu.au)
Antihypertensive effect of giant embryo brown rice and pre-germinated giant embryo brown rice on spontaneously hypertensive rats. (greenmedinfo.com)
Cholesterol lowering and antioxidative effect of pregerminated brown rice in hypercholesterolemic rats. (greenmedinfo.com)
The estimation of the anti-neurotoxic effect of costus ethanolic extract against bifenthrin-intoxication in male rats. (aaem.pl)

It affects most aquatic gill-breathing animals such as fish, amphibians and insects. (noble.org)
Rotenone only affects gill breathing animals and invertebrates when used properly. (co.us)

These results suggest that caffeine has a dose-dependent neuroprotective effect. (edu.au)
Therefore, the present study aimed to investigate the neuroprotective activity of AM in the chronic rotenone mouse model of PD against rotenone -induced α-Syn accumulation and to dissect molecular mechanisms underlying the observed neuroprotection . (bvsalud.org)

In a checkerboard microplate method in vitro, furthermore, the most effective multidrug resistance (MDR) resistance modifiers, amorphigenin, formononetin, rotenone and chrysin, were assayed for their antiproliferative effects in combination with epirubicin. (iiarjournals.org)
Of note, an in-vitro study utilizing rat pheochromocytoma cells verified that AM conferred the neuroprotection only through AMPK activation, as the presence of inhibitors of AMPK (dorsomorphin) and autophagy (3-methyl adenine ) failed to mitigate rotenone -induced α-Syn accumulation. (bvsalud.org)

The effect of CJ on antioxidant enzymes was not consistent, however, in some organs, CJ reversed changes evoked by ROT. (cranberryinstitute.org)

Rotenone exposure enhanced the expression of preapoptotic (cytochrome C (cyto c), caspase-3, -8, -9, and Bax) and down-regulated the expression of anti-apoptotic (Bcl-2) markers. (elsevierpure.com)
Such misclassification, if nondifferential, will underestimate the true effect of the exposure. (cdc.gov)

To date, there are few data indicating that toxicity of ROT is not limited to the brain but can also affect other tissues. (cranberryinstitute.org)
The effects of mixture toxicity should be considered as well, even though mixture toxicity it's generally additive, chemicals with more than one mode of toxic action may contribute to toxicity. (wikipedia.org)

Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis. (logosbio.com)

At normal application rates, mammals, birds and reptiles are not affected because their skins inhibit absorption and enzymes in their digestive systems break down small amounts of rotenone into harmless products. (noble.org)

Derris is a relatively safe insecticide in that it does not affect warm-blooded animals and also breaks down into harmless substances with 24 hours of being used. (pfaf.org)

Pharmacology studies on P . oleracea have also showed its significant antibacterial effects on the enteropathogenic bacteria, which might reveal the treatment of P . oleracea in cases of bacillary dysentery to some extent. (mdpi.com)

The costs of developing a new insecticide and testing it for its usefulness, toxicology, and environmental effects are huge, equivalent to tens of millions of dollars. (encyclopedia.com)

Using primary neuron-enriched and neuron/glia cultures from the rat mesencephalon, we discovered an extraordinary feature for rotenone-induced degeneration of cultured dopaminergic neurons. (jneurosci.org)
This is the first report demonstrating that microglia play a pivotal role in rotenone-induced degeneration of dopaminergic neurons. (jneurosci.org)
Our study showed that the treatment with caffeine improved histopathological degeneration in the substantia nigra parts compacta (SNpc) neurons and hindered the reduction in dopamine concentration caused by rotenone. (edu.au)

In the rotarod test, CAF (40 mg/kg) potentiated the harmful impact of TEF (2.3 mg/kg) on motor coordination, while having no effect on two other pyrethroids. (aaem.pl)

The primary cellular pathways that mediate the longevity-extending effects of natural products involve nutrient-sensing pathways. (frontiersin.org)

Plants For A Future can not take any responsibility for any adverse effects from the use of plants. (pfaf.org)
The possible mechanisms by which hyperglycemia, in monocytes, can cause adverse effects is via the activation of diacylglycerol (DAG)-sensitive protein kinase C (PKC) ( 6 ). (diabetesjournals.org)
Koya and King ( 6 ) have shown that hyperglycemia may mediate adverse effects via PKC-β by activation of the DAG-PKC pathway, suggesting a role in diabetic complications. (diabetesjournals.org)
No adverse effects have been reported from its administration. (medscape.com)
Introduction The research of Hatch (1) has greatly increased our understand- ing of the use and potential limitations of biological markers for adverse reproductive effects. (cdc.gov)

AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin's neuroprotection in a rotenone-induced mouse model of Parkinson's disease. (bvsalud.org)

The target site and mechanism of toxic action through which narcosis affects organisms are still unclear, but there are hypotheses that support that it occurs through alterations in the cell membranes at specific sites of the membranes, such as the lipid layers or the proteins bound to the membranes. (wikipedia.org)
Enforcing cancer cell SCD expression or raising circulating lipid levels through a higher-fat CR diet confers resistance to the effects of CR. (nature.com)
Fig. 4: Low glycaemic diets impair tumour SCD, which interacts with changes in lipid availability to affect tumour growth. (nature.com)

Beneficial effects of pre-germinated brown rice treatment high-fat diet-induced metabolic syndrome. (greenmedinfo.com)
With the water level lowered, CPW will do a rotenone treatment on the reservoir to remove non-native brook trout with the objective of stocking native Rio Grande cutthroats in the summer of 2024. (co.us)
Potassium permanganate (KMnO4) is used in fish culture for disease treatment, water clarification, rotenone detoxification, and historically for oxygen depletion. (vin.com)
In conclusion, AM provided neuroprotection by ameliorating the rotenone -induced α-Syn accumulation through AMPK-dependent autophagy activation and it can be considered as a therapeutic agent which might be having a higher translational value in the treatment of PD. (bvsalud.org)

The findings showed that AM exerts neuroprotection against rotenone -induced α-Syn accumulation in the striatum and cortex by activating AMPK, upregulating autophagy (LC3II/I, Beclin-1 ), and lysosomal (TFEB) markers. (bvsalud.org)

The effects of sulforaphane on multiple pathways of biochemical dysfunction, increased reactive oxygen species (ROS) formation, hexosamine pathway, protein kinase C (PKC) pathway, and increased formation of methylglyoxal were assessed. (diabetesjournals.org)

Twenty-four hours after the last rotenone injection, animals were sacrificed and brains were sectioned and prepared for histopathological staining with hematoxylinand eosin, cresyl violet and Mallory's phosphotungestic acid haematoxylinand for immunohistochemical staining of tyrosine hydroxylase. (edu.au)
In addition to its herbicidal effects, PQ is highly toxic to mammalian lung, and in animals PQ has been shown to be neurotoxic. (cdc.gov)

Fpyn pattrs may measr cumulative effects asswell acurrent eqxu klveh The ness of these tests in epidemiologic udesof ei ental effects on repducthealth ha yet to be studied. (cdc.gov)

The beneficial effect of CJ on these parameters appeared only in the brain. (cranberryinstitute.org)
Several other promising scientific studies now show that lipoic acid has a beneficial effect on a number of the factors involved in metabolic syndrome: it reduces triglyceride levels, lowers cholesterol, improves fasting plasma glucose, and causes weight loss in rodent models of obesity. (lifeextension.com)

Epidemiological studies, however, report inconsistencies in rates of relative risk for those exposed to pesticides such as Rotenone, Maneb. (cdc.gov)

III - with rotenone/Capicor administration: after rotenone intoxication, capicor was injected intraperitoneally at dose 50 mg/kg per day along following 2 weeks. (ukrbiochemjournal.org)
Acute Administration of Caffeine: The Effect on Motor Coordination, Higher Brain Cognitive Functions, and the Social Behavior of BLC57 Mice. (aaem.pl)

The rotenone-water mixture can be mixed and temporarily stored in a washtub, sprayer tank or barrel. (noble.org)
People should avoid skin, mouth or eye contact with concentrated rotenone or the 1:10-15 mixture. (noble.org)
Fish often try to pipe (gulp a mixture of air and water from the surface) when stressed with rotenone. (noble.org)

There is limited data available on the mechanisms by which hyperglycemia mediates its effects in monocytes. (diabetesjournals.org)

Caffeine (CAF), a nonselective adenosine A1 and A2A receptor antagonist and commonly used psychoactive substance, may affect these disorders in a dose-dependent manner. (aaem.pl)

For many years, scientists have researched how lipoic acid affects insulin sensitivity and the severity of diabetes-related disorders, including heart disease, stroke, glaucoma, neuropathic pain, and kidney disease. (lifeextension.com)

Mechanistically, rotenone stimulated the release of superoxide from microglia that was attenuated by inhibitors of NADPH oxidase. (jneurosci.org)

Effect of caffeine on the anticonvulsant action of pregabalin against electroconvulsions in mice. (aaem.pl)

The interaction of TEF and CAF with the cholinergic system, resulting in a decrease in AChE activity in the brain, is not responsible for the effect observed in the rotarod. (aaem.pl)

A treated pond should be observed at dawn of the morning following a rotenone application to look for fish activity at the surface. (noble.org)
If any fish are still alive, the pond should be treated again with rotenone as soon as possible. (noble.org)
CPW, as well as other state fish and game agencies, have successfully used rotenone for more than 80 years to remove fish in controlled and targeted reaches of lakes and streams. (co.us)

A pond's water volume should be accurately measured to facilitate proper application of rotenone. (noble.org)
Immediately prior to application, rotenone should be diluted with about 10-15 times as much water. (noble.org)

The abundance and effects of almost all insect pests can be managed through the judicious use of insecticides. (encyclopedia.com)

A particular form of capsicum causes intense eye pain and other unpleasant effects when it comes in contact with the face. (medicinenet.com)

Rotenone is a naturally occurring compound derived from the roots of certain tropical and subtropical legume plants. (noble.org)
They include nicotine extracted from tobacco (usually applied as nicotine sulphate), pyrethrum extracted from daisylike plants, and rotenone from several tropical shrubs. (encyclopedia.com)
The U.S. Virgin Islands and the British Virgin Islands are affected by Tropical Storm Philippe and now there's Rina. (yahoo.com)
In the United States, a tropical storm warning was in effect for a 230-mile stretch from Portsmouth, New Hampshire, to the eastern end of Maine. (yahoo.com)
A tropical storm warning was in effect for much of New Brunswick and all of Nova Scotia and Prince Edward Island, along with a hurricane watch for parts of New Brunswick and Nova Scotia. (yahoo.com)

This change is effective June 15, 2023 and will remain in effect until August 28, 2023. (utah.gov)

This area of research has lagged con- siderably behind the field of developing new effect markers, such as semen analysis and early pregnancy loss. (cdc.gov)

The high polyphenols content of cranberry accounts for its strong antioxidant activity underlying the beneficial health effects of this fruit. (cranberryinstitute.org)

The effect of NLP-Ba on αSN fibrillation/cytotoxicity is attributed to a combination of free baicalein and empty NLPs. (au.dk)

Chrysin and amorphigenin on the mouse lymphoma cell line and formononetin on the MDA-MB-231 cell line synergistically enhanced the effect of epirubicin. (iiarjournals.org)

In a community with an environmental factr suspected of adversely affecting reproductive outcome, *Division of Reproductive Health, Centers for Disease Control, Atlanta, GA 30333. (cdc.gov)

All these features permit to delimit the spatial effects of urban sewages, mining effluents, agricultural wastes, watershed deforestation or road building. (springer.com)

These are chemicals that cause an inflammatory effect on living tissue by chemical action at the site of contact. (wikipedia.org)

The greatly enhanced neurodegenerative ability of rotenone was attributed to the presence of glia, especially microglia, because the addition of microglia to neuron-enriched cultures markedly increased their susceptibility to rotenone. (jneurosci.org)
To further evaluate the effects of the overexpression of the Bcl-2 homologue Buffy , this study analysed lifespan and climbing ability in both parkin -RNAi- and Pink1 -RNAi-expressing flies. (sdbonline.org)
In addition to its anti-diabetic effects, lipoic acid has a known ability to help combat obesity. (lifeextension.com)

The resulting effect of irritants is an increase in the volume of cells due to a change in size (hypertrophy) or an increase in the number of cells (hyperplasia). (wikipedia.org)

Fig. 2: Comparison of the effect size of differentially expressed IRGs among neuropsychiatric disease pairs. (nature.com)

This also abolished the counteracting effect of sulforaphane, suggesting mediation by nrf2 and related increase of transketolase expression. (diabetesjournals.org)
In comparing the effect of PQ on gene expression in the ventral midbrain, one PQ-susceptible strain showed changes in more than 300 transcripts whereas one resistant strain showed changes in fewer than one dozen transcripts. (cdc.gov)

However, no studies evidenced the effect of AM on AMPK-dependent autophagy activation in the PD. (bvsalud.org)

Anatomy3

Diseases3

Chemicals and Drugs32

Phenomena and Processes5

Information Science1

Health Care1

Mitochondrial9

Oxidative7

Neurotoxicity3

Mitochondria3

Piscicide4

Neurodegeneration1

Rats6

Gill-breathi2

Neuroprotective2

Vitro2

Antioxidant enzymes1

Exposure2

Toxicity2

Apoptosis1

Enzymes1

Substances1

Pharmacology1

Toxicology1

Degeneration3

Pyrethroids1

Cellular1

Adverse5

Model1

Lipid3

Treatment4

Findings1

Oxygen1

Animals2

Epidemiologic1

Beneficial effect2

Pesticides1

Administration2

Mixture3

Hyperglycemia1

Dose-dependent1

Disorders1

Inhibitors1

Caffeine1

Brain1

Fish3

Water2

Insect1

Capsicum1

Tropical5

Effective1

Markers1

Activity1

Combination1

Mouse1

Control1

Agricultural1

Chemical1

Ability3

Cells1

Disease1

Expression2

Studies1