CorticosteroidsKetorolac intranasalVaccineEfficacyInducesNasalCompared to intravenousVaccinesDrugsVaccinationDoseSteroidBioavailabilityRespiratoryInsulinTherapeuticAdministration routesSalineAlzheimer'sRoutesInteractionsDosingIncreasesDecreases effectsAcuteTalk with your doctor or pharmacistBrainPlaceboAllergyPATANASEOxytocinReductionDeliveryAvoidExtractsMiceClinicalExposureDiseasesAllergicSystemicViralCharacteristicsEffectorSignificantlyDrugSidePhysiological
Corticosteroids5
- We performed a systematic review and meta-analysis of the effects of intranasal corticosteroids on the symptoms of acute sinusitis. (annfammed.org)
- METHODS We searched MEDLINE, EMBASE, the Cochrane Central register of Controlled Trials (CENTRAL), and Centre for Reviews and Dissemination databases until February 2011 for studies comparing intranasal corticosteroids with placebo in children or adults having clinical symptoms and signs of acute sinusitis or rhinosinusitis in ambulatory settings. (annfammed.org)
- CONCLUSIONS Intranasal corticosteroids offer a small therapeutic benefit in acute sinusitis, which may be greater with high doses and with courses of 21 days' duration. (annfammed.org)
- b) Inhaled, intranasal, or topical corticosteroids are permitted. (moffitt.org)
- Ocular antihistamine drops (for eye symptoms), intranasal antihistamine sprays, intranasal cromolyn, intranasal anticholinergic sprays, and short courses of oral corticosteroids (reserved for severe, acute episodes only) may also provide relief. (medscape.com)
Ketorolac intranasal1
- probenecid increases levels of ketorolac intranasal by decreasing renal clearance. (medscape.com)
Vaccine4
- certolizumab pegol decreases effects of influenza virus vaccine quadrivalent, intranasal by pharmacodynamic antagonism. (medscape.com)
- Induction of effective immunity in the lungs should be a requisite for any vaccine designed to control the severe pathogenic effects generated by respiratory infectious agents. (nature.com)
- Many factors affect the success of a vaccination program, such as vaccine selection, storage and handling, syringe and needle selection, route of administration, nutritional and immunological status of the animals being vaccinated, environmental conditions and level of exposure. (cdc.gov)
- Even if a particular vaccine doesn't cause adverse health effects to the exposed individual, it is important for people handling vaccinations and other injections to understand that needles can transport more than just vaccines or medications. (cdc.gov)
Efficacy6
- Previous studies evaluated the efficacy of delivery therapeutics through intranasal route for brain diseases and mental health conditions. (wikipedia.org)
- There is evidence for the efficacy of intranasal delivery to treat Alzheimer's. (wikipedia.org)
- 0.05, n=4) in comparison to saline treated controls, demonstrating our intranasal delivery system's efficacy. (nih.gov)
- To compare the clinical efficacy of two routes of midazolam intranasal vs. intravenous, in relation to intravenous diazepam for control of seizures. (pediatriconcall.com)
- We conducted this study to evaluate the efficacy of intranasal midazolam vs. intravenous midazolam and intravenous diazepam in convulsing neonates and children. (pediatriconcall.com)
- Due to significant gastrointestinal side effects and lack of overall efficacy, this agent was not used as an oral anti-cancer agent. (cns.org)
Induces1
- They compete with histamine for histamine receptor type 1 (H1) receptor sites in the blood vessels, GI tract, and respiratory tract, which, in turn, inhibits physiologic effects that histamine normally induces at the H1 receptor sites. (medscape.com)
Nasal8
- Intranasal drug delivery occurs when particles are inhaled into the nasal cavity and transported directly into the nervous system. (wikipedia.org)
- Intranasal particles have to pass through the mucus layer, the first barrier, to then travel from nasal epithelium to brain. (wikipedia.org)
- Intranasal exposure to cadmium has been related to olfactory dysfunction in humans and to nasal epithelial damage and altered odorant-guided behavior in rodent models. (rutgers.edu)
- According to Persian Medicine texts, pumpkin ( Cucurbita pepo L.) oil has been suggested as a nasal drop for insomnia, but the hypnotic effect of pumpkin seed oil has not been studied despite recommendation by traditional medicine and general use. (jiitm.ir)
- The effect of nasal administration of the p210-CTB fusion protein on atherogenesis was compared with that of. (lu.se)
- The effect of nasal administration of the p210-CTB fusion protein on atherogenesis was compared with that of an ovalbumin peptide fused to CTB and with untreated controls. (lu.se)
- PATANASE(R) nasal spray was found to have an onset of action of 30 minutes and a 12 hour duration of affect after dosing, which was statistically significant compared to the placebo spray. (news-medical.net)
- The most common side effects experienced with the use of PATANASE(R) include: bitter taste, headache, epistaxis, pharyngolaryngeal pain, post-nasal drip, cough, and urinary tract infection. (news-medical.net)
Compared to intravenous1
- Mean time from physician contact to drug administration was significantly shorter with intranasal midazolam as compared to intravenous midazolam and intravenous diazepam (0.40±0.10min vs. 1.06±0.40 min and 1.06±40 min) (p-0.03). (pediatriconcall.com)
Vaccines2
- Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of adverse effects (increased risk of infection). (medscape.com)
- Both injectable and intranasal vaccines may carry risks of allergic reactions and tissue damage. (cdc.gov)
Drugs5
- The Food and Drug Administration (FDA) tracks side effects of drugs they've approved. (medicalnewstoday.com)
- Like most drugs, Cimzia may cause mild or serious side effects. (healthline.com)
- Mild side effects of many drugs may go away within a few days or a couple of weeks. (healthline.com)
- An article from NIOSH researchers entitled "Health effects from unintentional occupational exposure to opioids among law enforcement officers: Two case investigations" published in the American Journal of Industrial Medicine seeks to characterize the risk associated with unintentional occupational exposure to drugs. (cdc.gov)
- The following two HHEs were conducted by NIOSH at the request of law enforcement agencies to evaluate incidents involving drugs where officers experienced health effects. (cdc.gov)
Vaccination1
- A successful vaccination program should reduce the incidence and limit the effects of disease in the herd while minimizing adverse health and production effects in vaccinated animals. (cdc.gov)
Dose6
- Intranasal cadmium chloride instillations reduced this sensory activity by up to 91% in a dose-dependent manner. (rutgers.edu)
- In this study optical imaging revealed significant reductions in odorant-evoked release from the olfactory nerve at a cadmium chloride dose two orders of magnitude less than that required to induce morphological changes in the nerve in the same animals, demonstrating that it is a more sensitive technique for assessing the consequences of intranasal neurotoxicant exposure. (rutgers.edu)
- A literature study was performed to evaluate dose-response relationships and no-effect levels for sensitization and elicitation in skin- and respiratory allergy. (cdc.gov)
- With respect to the skin, dose- response relationships and no-effect levels were found for both intradermal and topical induc- tion, as well as for intradermal and topical elicitation of allergenic responses in epidemiological, clinical, and animal studies. (cdc.gov)
- With respect to the respiratory tract, dose-response rela- tionships and no-effect levels for induction were found in several human as well as animal studies. (cdc.gov)
- Notwithstanding the observation of dose-response relationships and no-effect levels, due to a number of uncertainties, no definite conclusions can be drawn about absolute threshold values for allergens with respect to sensitization of and elicitation reactions in the skin and respiratory tract. (cdc.gov)
Steroid1
- Regular use of an intranasal steroid spray may be more appropriate for patients with chronic symptoms. (medscape.com)
Bioavailability3
- Intranasal administration is a potential route associated with high drug transfer from nose to brain and drug bioavailability. (wikipedia.org)
- The delivery systems between neutral to acidic pH is ideal for high drug bioavailability following intranasal administration. (wikipedia.org)
- The area under the curve of optimized formulation (F2) was 3.98 and 1.53 times more than oral drug solution and intranasal gel respectively, confirming improvement in bioavailability. (ijpsonline.com)
Respiratory2
- The intranasal route gained interest towards the end of the 20th century with treating cardiovascular and respiratory diseases. (wikipedia.org)
- To determine the effectiveness of intranasal (IN) naloxone compared with intramuscular (IM) naloxone for treatment of respiratory depression due to suspected opiate overdose in the prehospital setting. (mja.com.au)
Insulin4
- Intranasal insulin (INS) bypasses the blood-brain barrier, targets the brain, and improves synaptogenesis in rodent models, and memory in adult humans with Alzheimer's disease or type 2 diabetes, without altering the blood levels of insulin or glucose. (healthpartners.com)
- The acute effects on hippocampal neurochemical profile and transcript mRNA expression of insulin receptor (Insr), glucose transporters (Glut1, Glut4, and Glut8), and poly(ADP-ribose) polymerase-1 (Parp1, a marker of oxidative stress) were determined on P7 using in vivo 1H MR spectroscopy (MRS) and qPCR. (healthpartners.com)
- Moreover, it has been shown that insulin, melanocyte-stimulating hormone and vasopressin can all cross the BBB and increase cerebrospinal fluid (CSF) as well as blood concentrations within 15-30 min after intranasal administration 8 . (nature.com)
- Intranasal delivery of insulin showed greater memory improvement in patients with Alzheimer's than in healthy individuals. (wikipedia.org)
Therapeutic2
- Increasingly, clinical studies have generated unprecedented interest in the therapeutic targets and potential benefits of intranasal OXT application for neuropsychiatric disorders characterised by social dysfunction, such as social anxiety, autism and schizophrenia 4 . (nature.com)
- The effect produced by some therapeutic measures on the different forms of leucocytes in pulmonary tuberculosis. (jameslindlibrary.org)
Administration routes1
- Consequently, the most convincing animal studies of functional effects of OXT have therefore used intracerebroventricular or intracerebral administration routes. (nature.com)
Saline2
- Young adult male C57BL/6 J mice subjected to 30 min of middle cerebral artery occlusion (MCAO) were administered intranasal preparations of E2-GNPs, water soluble E2, or saline as control 1 h after reperfusion. (nih.gov)
- Once clear DA signals were evoked and recorded, rats were exposed to intranasal OXT (n=3) or saline (n=3) and OXTinduced changes DA signaling was monitored for 1 h. (ewu.edu)
Alzheimer's1
- TLSA ) ("Tiziana" or the "Company"), a biotechnology company developing breakthrough immunomodulation therapies via novel routes of drug delivery, today announced that the U.S. Food and Drug Administration (FDA) has cleared the Investigational New Drug (IND) application for intranasal foralumab to be studied in Alzheimer's disease. (itbusinessnet.com)
Routes2
- When utilizing other routes of administration to target the brain, drug adsorption is low due to issues with systemic circulation effects and blood brain barrier. (wikipedia.org)
- Various alternative routes of administration are intranasal, rectal, sublingual and buccal. (pediatriconcall.com)
Interactions1
- This information does not contain all possible interactions or adverse effects. (rxlist.com)
Dosing1
- Effect of Multiple Dosing on the ApoE2 Expression in Mice Brain. (bvsalud.org)
Increases4
- There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. (nature.com)
- In addition, intranasal OXT increases DA neurotransmission, elucidating a potential mechanism for a modulatory role of OXT in learning and memory. (ewu.edu)
- We used a drug along with chemical anesthesia that increases its effectiveness and does not have significant side effects and eliminates the need for high doses of anesthesia. (jiitm.ir)
- Conclusions: Co-administration of ciprofloxacin with riluzole increases the systemic levels of riluzole and thereby the oral pharmacokinetic properties of riluzole while co-administration of grapefruit juice with riluzole has no significant effect. (researchgate.net)
Decreases effects1
- aspirin decreases effects of probenecid by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
Acute2
- BestBets: Should intranasal lidocaine be used in patients with acute cluster headache? (bestbets.org)
- Acute psychological and physiological effects of MDMA ('Ecstasy') afte. (erowid.org)
Talk with your doctor or pharmacist2
- For more information on the possible side effects of Ocrevus, talk with your doctor or pharmacist. (medicalnewstoday.com)
- To learn about other mild side effects, talk with your doctor or pharmacist, or read Cimzia's medication guide . (healthline.com)
Brain4
- Moreover, intranasally delivered OXT may cause some of its central effects by stimulating the endogenous OXT system, which secretes OXT into the peripheral circulation but also distributes it within the brain - via targeted synaptic/dendritic release as well as less targeted long-distance diffusion from hypothalamic release sites 2 . (nature.com)
- During the late 1980s, William Frey II studied the intranasal route for treating brain diseases. (wikipedia.org)
- We have developed a gelatin nanoparticle-mediated intranasal drug delivery system as an efficient, non-invasive method for delivering 17β-estradiol (E2) specifically to the brain, enhancing neuroprotection, and limiting systemic side effects. (nih.gov)
- In such case, intranasal route may be a viable alternative as it has advantage of targeting the drug to the brain. (ijpsonline.com)
Placebo2
- Participants higher in self-criticism, lower in self-reassurance, social safeness, and attachment security had less positive experiences of CFI under oxytocin than placebo, indicating that the effects of oxytocin on affiliation may depend on attachment and self-evaluative styles. (derby.ac.uk)
- Kalman, D. S., Heimer, M., Valdeon, A., Schwartz, H., and Sheldon, E. Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. (webmd.com)
Allergy2
- FARE (Food Allergy Research & Education) acknowledges the U.S. Food and Drug Administration's (FDA) decision to extend the Prescription Drug User Fee Act (PDUFA) target action date for the New Drug Application (NDA) of neffy® (Intranasal (IN) Epinephrine) by three months to September 19, 2023. (foodallergy.org)
- According to the American College of Allergy, Asthma & Immunology (ACAAI), allergies affect an estimated 40 to 50 million people in the United States. (news-medical.net)
PATANASE1
- PATANASE(R) is intended only for intranasal administration. (news-medical.net)
Oxytocin6
- However, whereas oxytocin plasma concentrations peaked at 15 min after intranasal administration and decreased after 75 min, CSF concentrations took up to 75 min to reach a significant level. (nature.com)
- Effects of intranasal oxytocin on compassion focused imagery. (derby.ac.uk)
- This study explored the effects of oxytocin on Compassion Focused Imagery (CFI), that is, imagining another "mind" being deeply compassionate to oneself, and the interaction of these effects with self-criticism and feeling socially safe with others. (derby.ac.uk)
- In this study, we tested the effects of the neuropeptide oxytocin on ANS reactivity during couple conflict in a standardized laboratory paradigm. (edu.au)
- Our results imply sex-specific effects of oxytocin on sympathetic activity, to negative couple interaction, with the neuropeptide reducing sAA responses and emotional arousal in women while increasing them in men. (edu.au)
- Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions. (bvsalud.org)
Reduction6
- Glycopyrrolate is a prescription medication used during Surgery for preoperative reduction of saliva , intraoperative reduction of cholinergic effects, Reversal of Neuromuscular Blockade and as an Adjunct to Treatment of Peptic Ulcer . (rxlist.com)
- Effects of (R)-ketamine, (S)-ketamine, and their metabolites on MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced reduction of dopamine transporter (DAT) and tyrosine hydroxylase (TH) in the mouse striatum and substantia nigra (SNr) were examined. (unboundmedicine.com)
- MPTP-induced reduction of DAT in the striatum was attenuated by subsequent repeated intranasal administration of both enantiomers of ketamine although (R)-ketamine was more potent than (S)-ketamine. (unboundmedicine.com)
- Interestingly, MPTP-induced reduction of DAT in the striatum was also attenuated by a single intranasal administration of (R)-ketamine. (unboundmedicine.com)
- In contrast, MPTP-induced reduction of DAT in the striatum was not attenuated by repeated intranasal administration of two enantiomers of norketamine. (unboundmedicine.com)
- Skin damage or irritation may result in a significant reduction of the no-effect level for a specific compound. (cdc.gov)
Delivery4
- Thus present study concludes that flexible liposome enriched thermoreversible, mucoadhesive in situ intranasal gel of rizatriptan benzoate is a safe and effective drug delivery system for treatment of migraine. (ijpsonline.com)
- Intranasal delivery of POH was conducted in nude mice. (cns.org)
- To demonstrate whether intranasal delivery of POH is effective in treating gliomas, animals bearing intracranial tumors were treated intranasally with POH. (cns.org)
- The intranasal delivery of POH had no toxicity, and demonstrated a decrease in tumor growth,increase in survival, and increased GRP78 in tumor tissue. (cns.org)
Avoid1
- The newer, second-generation (ie, nonsedating) antihistamines are usually preferable to avoid sedation and other adverse effects associated with the older, first-generation antihistamines. (medscape.com)
Extracts1
- Zwei weitere ergographische Versuchsreihen über die Wirkung orchistischen Extraktes [Two further ergographic experimental series on the effects of testicular extracts]. (jameslindlibrary.org)
Mice1
- After intranasal cadmium exposure, mice were unable to detect the target odor. (rutgers.edu)
Clinical2
- Tiziana's lead candidate, intranasal foralumab, which is the only fully human anti-CD3 mAb, has demonstrated a favorable safety profile and clinical response in patients in studies to date. (itbusinessnet.com)
- Clinical effects of "natural" and "synthetic" sodium salicylate. (jameslindlibrary.org)
Exposure2
- There is uncertainty surrounding law enforcement officers' exposure to and health effects from opioids encountered while at work protecting the public. (cdc.gov)
- Chemicals (including disinfection byproducts) in drinking water or in recreational water that cause health effects either through water exposure or by volatilization leading to poor air quality are included. (cdc.gov)
Diseases1
- Although a large body of research, ranging from rodents to humans, has reported on the effects of OXT and AVP administration on affiliative and trust behaviors, and has highlighted the genetic contributions of OXT and AVP receptor polymorphisms to both social behaviors and to diseases related to social deficits, the consequences of peptide administration on psychiatric symptoms, and the impact of receptor polymorphisms on receptor function, are still unclear. (frontiersin.org)
Allergic1
- We encourage individuals and families affected by food allergies to remain informed, stay connected to their healthcare providers, and continue to follow the prescribed management plans for allergic reactions, including carrying and utilizing currently approved epinephrine auto-injectors as recommended by their healthcare professionals. (foodallergy.org)
Systemic1
- Epinephrine is the first medication that should be used to reverse effects of systemic vasodilation and increased vasopermeability observed with anaphylaxis. (medscape.com)
Viral1
- The antiviral effect appeared similarly strong when the viral challenge was carried out 3 months after boosting, and associated with the persistence of N-specific CD8 + T-resident memory lymphocytes. (nature.com)
Characteristics1
- Despite extensive research and very promising results, however, little is known about the pharmacokinetic characteristics of intranasal OXT application. (nature.com)
Effector1
- This effect was accompanied by induction of regulatory T cells that markedly suppressed effector T cells rechallenged with apoB-100 and increased numbers of interleukin (IL)-10(+) CD4(+) T cells. (lu.se)
Significantly1
- The rise correlated significantly with rises in minimum temperature and the maximum atmospheric humidity in the greater Cairo area over the same period (after exclusion of the effect of the maximum atmospheric temperature). (who.int)
Drug5
- These properties affect drug diffusion. (wikipedia.org)
- You may wonder how often certain side effects occur with this drug or whether certain side effects pertain to it. (medicalnewstoday.com)
- Here's some detail on some of the side effects this drug may or may not cause. (medicalnewstoday.com)
- This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. (rxlist.com)
- aceclofenac will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. (medscape.com)
Side26
- Ocrevus can cause mild or serious side effects. (medicalnewstoday.com)
- The following lists contain some of the key side effects that may occur while taking Ocrevus. (medicalnewstoday.com)
- These lists do not include all possible side effects. (medicalnewstoday.com)
- They can give you tips on how to deal with any side effects that may be bothersome. (medicalnewstoday.com)
- If you would like to report to the FDA a side effect you've had with Ocrevus, you can do so through MedWatch . (medicalnewstoday.com)
- Most of these side effects may go away within a few days or a couple of weeks. (medicalnewstoday.com)
- Serious side effects from Ocrevus aren't common, but they can occur. (medicalnewstoday.com)
- Call your doctor right away if you have serious side effects. (medicalnewstoday.com)
- Other serious side effects are explained below in "Side effect details. (medicalnewstoday.com)
- We agree that, absent systematic ascertainment, the actual incidence of this troublesome side effect is likely to be underestimated. (psychiatrist.com)
- Lurie and Hosmer report that they have had success in treating this side effect with oxybutynin. (psychiatrist.com)
- What Are Side Effects Associated with Using Etodolac? (rxlist.com)
- This document does not contain all possible side effects and others may occur. (rxlist.com)
- Check with your physician for additional information about side effects. (rxlist.com)
- Call your doctor for medical advice about serious side effects or adverse reactions. (rxlist.com)
- You may report side effects or health problems to FDA at 1-800-FDA-1088. (rxlist.com)
- Report a suspected side effect or falsified product to the MHRA Yellow Card scheme. (medicines.org.uk)
- What are Cimzia's side effects? (healthline.com)
- The lists below describe some of the more common side effects that Cimzia may cause. (healthline.com)
- Your doctor or pharmacist can tell you more about the potential side effects of Cimzia. (healthline.com)
- They can also suggest ways to help reduce side effects. (healthline.com)
- Here's a short list of some of the mild side effects that Cimzia can cause. (healthline.com)
- For more information on this side effect, see the "Side effect focus" section below. (healthline.com)
- Learn more about some of the side effects Cimzia may cause. (healthline.com)
- Side effects if give dog sulfametoxazol-trimetroprim? (vetinfo.com)
- She was placed on Rimadyl about a week ago for a tail injury, could this be a side effect? (vetinfo.com)
Physiological1
- The psychological and physiological effects of MDMA on normal voluntee. (erowid.org)