• Positive inotropic and vasodilating effects of amrinone and milrinone in isolated canine heart. (ac.ir)
  • The drug inamrinone is a 5-amino-3,4′-bipyridine-6(1 H ) one that is used to treat patients with congestive heart failure [ 5 ], and milrinone (2-methyl-6-oxo-1,6-dihydro-3,4′-bipyridine-5-carbonitrile) is a phosphodiesterase 3 inhibitor that potentiates the effect of cyclic adenosine monophosphate (cAMP). (hindawi.com)
  • Pharmacokinetics of the bipyridines amrinone and milrinone. (derangedphysiology.com)
  • More recently, dopamine, dobutamine, and amrinone have been used to provide necessary inotropic support for the failing heart. (justia.com)
  • Amrinone also has beneficial effects during diastole in the left ventricle, including relaxation, compliance and filling in patients with congestive heart failure. (wikipedia.org)
  • Some serious side effects of long term administration included sustained ventricular tachycardia resulting in circulatory collapse, worsening myocardial ischemia, acute myocardial infarction, and worsening congestive heart failure. (wikipedia.org)
  • It may produce a water of Congestive functioning or it may understand cardiac to the effects of digital publication, often through heart to body. (worldclassbows.com)
  • Amrinone decreases the pulmonary capillary wedge pressure while increasing cardiac output, as it functions as an arterial vasodilator and increases venous capacitance while decreasing venous return. (wikipedia.org)
  • An IV administration of amrinone has been shown to increase cardiac output (CO) and stroke volume (SV), while concurrently reducing the filling pressure of the left ventricle and decreasing the resistance in the peripheral vasculature. (wikipedia.org)
  • Cause of its many beneficial effects, the use of LS in cardiac surgery arises. (ispub.com)
  • An increase in cAMP with the administration of amrinone in vascular smooth muscle produces vasodilation by facilitating calcium uptake by the sarcoplasmic reticulum (a special type of smooth ER) and decreasing the calcium available for contraction. (wikipedia.org)
  • Baicalin significantly increased the adipocyte response to physiological and pharmacological lipolytic stimuli (such as epinephrine - adrenergic agonist, DPCPX - adenosine A1 receptor antagonist, and amrinone - cAMP phosphodiesterase inhibitor). (bvsalud.org)
  • The stimulatory effects of baicalin on epinephrine-induced lipolysis were markedly diminished by insulin (activator of cAMP phosphodiesterases) and H-89 (PKA inhibitor). (bvsalud.org)
  • The drug, a member of a class of compounds known as phosphodiesterase (PDE) type I inhibitors, shows promising effects on dog and rabbit hearts, as well as on isolated rabbit heart cells, most notably an increase in the strength of the heart muscle's contractions, the researchers say. (news-medical.net)
  • In heart disease, PDE activity can limit the beneficial effects of cAMP or cGMP, so inhibitors have the potential to act as a therapy. (news-medical.net)
  • However, in mice the heart mostly has a different form of the PDE1 enzyme than found in humans, so PDE1 inhibitors likely affect mice differently than humans. (news-medical.net)
  • Amrinone, also known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor. (wikipedia.org)
  • phenylephrine decreases effects of iobenguane I 123 by receptor binding competition. (medscape.com)
  • Premarin: A collection N-sulfonyl-heterocyclyl-sulfonamide amrinone Receptor implicated by AHP( USA). (augenta.net)
  • Kinoshita M, Sakai K: Pharmacology and therapeutic effects of nicorandil. (karger.com)
  • There is a net decrease in myocardial wall tension, and O2 consumption when using amrinone. (wikipedia.org)
  • Effects of Amrinone on Regional Myocardial Function and Oxygen Balance in Stunned Myocardium in Dogs. (ekja.org)
  • The Ubiquitous effect has myocardial fibrin from the inhibitory browser and protects it to the stimuli through the prosthetic time. (siriuspixels.com)
  • The overall effect is an increase in intracellular Ca2+ which increases myocardial contractility. (derangedphysiology.com)
  • The relaxant mechanisms of nicorandil were examined by comparing its effects with those of sodium nitroprusside and cromakalim in bovine tracheal smooth muscle. (karger.com)
  • Cogolludo AL, Pérez-Vizcaíno F, Fajardo S, Ibarra M, Tamargo J: Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta. (karger.com)
  • However, these agents have not achieved worldwide use because of limited efficacy or unacceptable adverse effects. (keywen.com)
  • The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for furosemide and any potential adverse effects on the breastfed infant from furosemide or from the underlying maternal condition. (pfizermedicalinformation.com)
  • LS also exhibits vasodilator effect through the activation of adenosine triphosphate-dependent potassium (K + ) channels [ 5 6 ]. (ispub.com)
  • We also investigated the mechanism of action (MoA) involved with the antileishmanial activity of fendiline and the in vitro effect of its combination with antileishmanial standard drugs. (hindawi.com)
  • A variety of drugs including simple AV nodal blocking agents like beta-blockers and verapamil , as well as antiarrhythmics may be used, usually with good effect, although the risks of these therapies need to be weighed against the potential benefits. (wikidoc.org)
  • Blood Vessels- Has direct vasoconstrictor effect, there is no prominent effect on BP as it is secondary to the improvement in circulation. (pharmanotes.org)
  • The positive inotropic effect of amrinone is mediated by the selective enhancement of high-gain CICR, which contributes to the contraction of myocytes by phosphorylation through cAMP dependent protein kinase A (PKA) and Ca2+ calmodulin kinase pathways. (wikipedia.org)
  • this results in an inotropic effect. (wikipedia.org)
  • Definition According to dictionary definition Asthma is a chronic disease that causes inflammation and narrowing of the air passage of the lungs (bronchi) obstructing the airflow and making breathing difficult.Asthma affects both adults and children. (medicscientist.com)
  • Heart failure affects about 5.7 million U.S. adults, according to the Centers for Disease Control and Prevention, and contributes to an estimated one in nine deaths. (news-medical.net)
  • Their relaxant effects on high K + -contracted preparations were smaller than those on methacholine-contracted muscle. (karger.com)
  • Nicorandil may also activate Maxi K + channels, possibly through the NO-cGMP pathway, and the interaction of K ATP channels and Maxi K + channels may affect the relaxant effect of nicorandil in bovine tracheal smooth muscle. (karger.com)
  • 11. Boskabady MH, Kiani S, Rakhshandeh H. Relaxant effects of Rosa damascena on guinea pig tracheal chains. (ac.ir)
  • 13. Boskabady MH, Ramazani M, Tabei T. Relaxant effects of different fractions of essential oil from carum copticum on guinea pig tracheal chains. (ac.ir)
  • Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. (medscape.com)
  • Antiarrhythmic and Inotropic Effects of Selective Na+/Ca2+ Exchanger Inhibition: What Can We Learn from the Pharmacological Studies? (unideb.hu)
  • Rodent studies have shown that baicalin treatment positively affects fat tissue, however, data on the direct influence of this compound on adipocyte metabolism is lacking. (bvsalud.org)
  • Furthermore, PKA phosphorylates and deactivates the phospholambans that inhibit SERCA, which is an enzymatic pump that, to terminate the contraction, removes the Ca2+ from the cytoplasm, stores it back in the sarcoplasmic reticulum and promotes the subsequent arterial relaxation as well, producing a lusitropic effect. (wikipedia.org)
  • In the present study, the effects of aqueous-ethanolic extract from Rosa damascena on heart rate and contractility were examined. (ac.ir)
  • Thrombocytopenia is the most prominent and dose-related side effect, but it is transient and asymptomatic. (wikipedia.org)
  • active shop molecular biology of the lung volume( also viewed in demographics per development) alters to the radioactive heart, whereas potential restoration widens to the high effect of the genes, in which isoform suppression with the Shah is support. (siriuspixels.com)
  • Kukovetz WR, Holzmann S, Braida C, Poch G: Dual mechanism of the relaxing effect of nicorandil by stimulation of cyclic GMP formation and by hyperpolarization. (karger.com)
  • However, a doubt was expressed regarding the level of the toxic effects of orellanine, a toxin from the mushroom C. orellanus , compared with other bipyridines [ 4 ]. (hindawi.com)
  • Early studies in patients with heart failure showed that amrinone produced short-term hemodynamic improvement, but had limited long-term clinical benefit. (wikipedia.org)
  • For this, the in vitro activity of four non-dihydropyridine agents (amrinone, fendiline, mibefradil, and lidoflazine) was tested against different Leishmania species and their cytotoxicity to mammalian cells was evaluated. (hindawi.com)
  • Amrinone has been shown to increase the contractions initiated in the heart by high-gain calcium induced calcium release (CICR). (wikipedia.org)
  • Depending on its degree of expression, a varicocele affects fertility (fertility) via various mechanisms (including an increase in body temperature in the area of ​​the testicles) and is the most common cause of sterility (infertility) in men many cases can be restored. (healthandmedicineinfo.com)
  • The preventive effect of iberiotoxin was markedly enhanced under the blockade of K ATP channels with glibenclamide. (karger.com)
  • In the present research, the short-term effects of 25, 50, and 100 µM baicalin on glucose transport, conversion to lipids, and oxidation, and also on lipolysis in primary rat adipocytes were explored. (bvsalud.org)
  • 8. Maleev A, Neshtev G, Stoianov S, Sheikov N.The ulcer protective and antiinflamatory effect of Bulgarian Rose oil. (ac.ir)
  • Both inotropic and lusitropic effects justify the use of amrinone to treat heart failure. (wikipedia.org)
  • For their experiments, the researchers used six dogs surgically outfitted with sensors and heart pacemakers, and tested ITI-214's effects on them before and after inducing heart failure by running the pacemaker rapidly for approximately three weeks. (news-medical.net)
  • 9. Hosseini M, Rakhshandah H, Shafieenic R, Dolati K. Analgesic effect of Rosa damascena on mice. (ac.ir)
  • The effects of furosemide on embryonic and fetal development and on pregnant dams were studied in mice, rats and rabbits. (pfizermedicalinformation.com)
  • Except for amrinone, our results demonstrated antiprotozoal activity for fendiline, mibefradil, and lidoflazine, with IC 50 values in a range between 2 and 16 μ M and Selectivity Index between 4 and 10. (hindawi.com)
  • Our results suggest that CORT, EPI, bisphenols, and their combinations impact cellular, immune, and metabolic homeostasis in marine mammal blubber, which may affect the ability of marine mammals to sustain prolonged fasting during reproduction and migration, renew tissues, and mount appropriate responses to immune challenges and additional stressors. (bvsalud.org)
  • The administration of the racemic mixture results in the overall β1 agonism responsible for its activity and also its mild β2 agonist effect. (derangedphysiology.com)
  • Cromakalim relaxed methacholine-contracted preparations, whereas it had no effect on high K + -contracted muscle. (karger.com)
  • isocarboxazid increases effects of phenylephrine by pharmacodynamic synergism. (medscape.com)
  • linezolid increases effects of phenylephrine by pharmacodynamic synergism. (medscape.com)
  • selegiline transdermal increases effects of phenylephrine by pharmacodynamic synergism. (medscape.com)
  • It was shown that 100 µM baicalin reduced glucose oxidation but at any concentration did not affect glucose transport and lipogenesis. (bvsalud.org)
  • Most of these patients were using the only effective drug then available, bromide, which had terrible side effects and limited efficacy. (keywen.com)
  • This study showed no significant differences in efficacy or side effects between amitriptyline and gabapentin. (keywen.com)
  • Factors Affecting the Difference between Radial and Femoral Arterial Pressure after Cardiopulmonary Bypass in Patients Undergoing Valvular ReplacementFactors Affecting the Difference between Radial and Femoral Arterial Pressure after. (ekja.org)
  • CNS Effect- These include disorientation, hallucination (in elderly), visual disturbance and aberrations of colour perception. (pharmanotes.org)
  • RNA) or ebook chairman of important heart shuttling stress( building or effect failure). (ajw-service.de)
  • derivatives: effects that are treatment from the levels to the Summary. (siriuspixels.com)
  • A Comparison of the Effects of Isoflurane Verus Propofol Anesthesia on Blood Gas Parameters during One Lung Ventilation for Lung Surgery. (ekja.org)
  • It affects 12 million people in 98 countries and territories and is mainly associated with poverty in developing nations. (hindawi.com)
  • Top ocean predators such as marine mammals are threatened by intensifying anthropogenic activity, and understanding the combined effects of multiple stressors on their physiology is critical for conservation efforts. (bvsalud.org)
  • 20. England PJ, Shahid M. Effects of forskolin on contractile response and protein phosphorylation in the isolated perfused rat heart. (ac.ir)
  • The gastrointestinal system was the most frequently (27.5%) affected system. (researchsquare.com)