• The aim of this study is to investigate whether various flavonoids have synergistic effects with some antibiotics. (aaem.pl)
  • Certain naturally occurring flavonoids, such as luteolin, have anti-oxidant and anti-inflammatory effects, including inhibition of activated peripheral blood leukocytes from MS patients. (tufts.edu)
  • Moreover, luteolin and structurally similar flavonoids can inhibit experimental allergic allergic encephalomyelitis (EAE), an animal model of MS in rodents. (tufts.edu)
  • Many research studies have highlighted the positive effects of natural flavonoids on chronic diseases, including PCa. (mdpi.com)
  • Although previous research suggests that flavonoids like Luteolin have poor bioavailability, current research has found that, indeed, Luteolin can bind with proteins and carbohydrates increasing uptake, therefore, increasing antioxidative activity in our bodies. (nstchemicals.com)
  • Luteolin is one of the most common flavonoids and play an important role in the prevention and treatment of chronic disease. (testosteronejunkie.com)
  • Flavonoids, such as luteolin, are produced by plants as a cellular defense against microorganisms or UV radiation. (longevitylifehacks.me)
  • Recent studies have shown that certain flavonoids possess anti-inflammatory and neuroprotective properties distinct from their well-known anti-oxidant effects. (alstuttu.org)
  • METHODS: Cultured microglia, both N9 and primary derived lines, were treated with flavonoids in the presence of IFN-gamma and/or CD40 ligation to assess any anti-inflammatory effects and/or mechanisms. (alstuttu.org)
  • CONCLUSION: Our findings provide further support for apigenin and luteolin's anti-inflammatory effects and suggest that these flavonoids may have neuroprotective/disease-modifying properties in various neurodegenerative disorders, including Alzheimer's disease (AD). (alstuttu.org)
  • In the project 2, the mechanism of the protective effects of two flavonoids, namely luteolin and quercetin, on APAP induced hepatotoxicity was investigated in the in vitro settings using HLMs. (tufts.edu)
  • Chamomile owes its therapeutic effects to its unique combination of bioactive compounds, including flavonoids, terpenoids, and antioxidants. (naturalherbalism.com)
  • In our previous study, several compounds extracted from this herb, including luteolin‑4'‑O‑β‑D‑glucopyranoside (LGP), were revealed to exert inhibitory effects on adenosine diphosphate (ADP)‑induced platelet aggregation. (spandidos-publications.com)
  • Several studies have reviewed the effects of individual natural compounds on aging and aging-related diseases along with the underlying mechanisms. (frontiersin.org)
  • Celery juice contains luteolin and pyrroloquinoline quinone (PQQ), two plant compounds thought to reduce inflammation in your gut. (healthline.com)
  • Fermented or fresh, there's not enough evidence on luteolin, PQQ, or other compounds found in celery juice to determine how they may affect the gut. (healthline.com)
  • Of these compounds, luteolin showed the most potent inhibitory activity (IC(50)=1.5μg/mL). (greenmedinfo.com)
  • 60μM. Thus, some phenolic compounds have antioxidant capacity VOO and ACE inhibitors, suggesting its effect in reducing blood pressure. (tesisenred.net)
  • Luteolin exerted an inhibitory effect on transcription factor activity including nuclear factor κB (NF-κB), signal transducer and activator of transcription 1 (STAT1) and interferon regulatory factor 1 (IRF-1) in LPS/IFN-γ-activated BV-2 microglial cells. (alstuttu.org)
  • These inhibitory effects may be associated with its dual‑receptor inhibition on P2Y12 and TP receptors. (spandidos-publications.com)
  • Luteolin is the most active compound in the NO (48.19±0.18%) and AGEs (60.06±0.52%) inhibition, in function of a low torsion angle (16.3°) between the 3-OH moiety and C'6 carbon atom. (unict.it)
  • Replacement of 14 C-acetate by 14 C-mevalonate largely omitted the inhibiting effect of artichoke extracts indicating an inhibition at the level of hydroxymethylglutaryl-CoA-reductase. (aspetjournals.org)
  • However, no direct inhibition of this enzyme could be detected and no other enzymic steps later in the biosynthetic pathway for cholesterol seemed to be affected. (aspetjournals.org)
  • Screening of several known constituents of artichoke extracts revealed that cynaroside and particularly its aglycone luteolin were mainly responsible for inhibition, whereas chlorogenic acid was much less effective and caffeic acid, cynarin and other dicaffeoylquinic acids were without significant influence. (aspetjournals.org)
  • Moreover, chamomile extract showed potent inhibition against aldose reductase (ALR2), with an IC50 value of 16.9 microg/mL, and its components, umbelliferone (1), esculetin (3), luteolin (6), and quercetin (7), could significantly inhibit the accumulation of sorbitol in human erythrocytes. (nih.gov)
  • While there are other important phytonutrients in PSE, these are the four we will focus on here for purposes of explanation, starting with the ingredient that has the most effect on histamine inhibition and working down to the least (which is still effective). (nhcherbs.com)
  • Luteolin also caused vasorelaxation in rat thoracic aorta smooth muscle by inhibiting intracellular Ca 2+ release, inhibition of sarcolemmal Ca 2+ channels, and activation of K + channels. (gastrores.org)
  • To explore whether an mPFC‐LHb circuit mediates the inhibitory effects of acupuncture on addictive behaviours, we examined the projection from mPFC to LHb, excitation of mPFC neurons during acupuncture stimulation, the effects of optogenetic modulation of mPFC‐LHb on HT7 inhibition of cocaine‐induced locomotion and the effect of mPFC lesion on HT7 inhibition of nucleus accumbens (NAc) dopamine release. (researchgate.net)
  • To examine the antiviral activity of luteolin against the influenza virus, the researchers infected several cell lines with two subtypes of the influenza A virus (IAV), A/Jiangxi/312/2006 (H3N2) and A/Fort Monmouth/1/1947 (H1N1). (naturalnews.com)
  • Cell studies also show that luteolin has antiviral activity against the flu virus (H1N1). (longevitylifehacks.me)
  • Luteolin, baicalein and quercetin inhibited the release of histamine, leukotrienes (LTs), prostaglandin D2 (PGD2), and granulocyte macrophage-colony stimulating factor (GM-CSF) from HCMC in a concentration-dependent manner. (alstuttu.org)
  • As concerns Ca2+ signalling, luteolin and quercetin inhibited Ca2+ influx strongly, although baicalein did slightly. (alstuttu.org)
  • With regard to PKC signalling, luteolin and quercetin inhibited PKC translocation and PKC activity strongly, although baicalein did slightly. (alstuttu.org)
  • In addition, although both luteolin and quercetin inhibited individually several UGT isoforms in vitro, they didn't inhibit the overall APAP glucuronidation. (tufts.edu)
  • Luteolin is a dietary flavonoid that has been researched due to its anti-cancer, antioxidant, and anti-inflammatory actions and is now being looked into for its supposed neuroprotective qualities. (cedfoundation.com)
  • Luteolin being a prime example of this compound class has shown an ability to act as an antioxidant. (nstchemicals.com)
  • In order to be a successful antioxidant, Luteolin has to be able to counteract several reactive molecules like reactive oxygen and nitrogen species. (nstchemicals.com)
  • 0.05) producing a synergistic antioxidant effect on LDL in vitro. (tesisenred.net)
  • Additionally, AuNPL were shown as more cytoprotective towards HaCaT cells then luteolin due to the more successful elimination of H2O2 induced intracellular ROS. (ac.rs)
  • In the present study, we investigated a combinatorial approach using two natural dietary polyphenols, luteolin and EGCG , and found that their combination at low doses (at which single agents induce minimal apoptosis) synergistically increased apoptosis (3-5-fold more than the additive level of apoptosis) in both head and neck and lung cancer cell lines . (cancertreatmentsresearch.com)
  • Based on these findings, the researchers concluded that the naturally occurring flavonoid, luteolin, is a potent antiviral against the influenza virus . (naturalnews.com)
  • Background: Although luteolin has been confirmed as potent anticancer agent, its potential application as therapeutic is limited by its water solubility. (ac.rs)
  • TY - JOUR AU - Matić, Ivana Z. AU - Mraković, Ana AU - Rakočević, Zlatko AU - Stoiljković, Milovan AU - Pavlović, Vladimir B. AU - Momić, Tatjana PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11544 AB - Background: Although luteolin has been confirmed as potent anticancer agent, its potential application as therapeutic is limited by its water solubility. (ac.rs)
  • Luteolin is considered to be an endocrine disruptor with potent estrogen agonist activity and potent progesterone antagonist activity. (gastrores.org)
  • In conclusion, SHE exerts potent anti-atopic and anti-inflammatory effects and should be considered for the clinical treatment of AD. (researchgate.net)
  • German chamomile is known for its potent anti-inflammatory properties, while Roman chamomile is often used for its calming effects. (naturalherbalism.com)
  • According to previous studies, luteolin, which is extracted from Chinese herbs, could inhibit the replication of the influenza virus in vitro. (naturalnews.com)
  • Novel luteolin capped gold nanoparticles (AuNPL) were synthesized and their anticancer effect towards human cervical adenocarcinoma HeLa cells was investigated in vitro. (ac.rs)
  • In vitro and in vivo studies have provided strong pharmacological evidences for wound healing effects of A. africana -derived extracts and phytochemicals. (hindawi.com)
  • Despite extensively available in vitro and in vivo information on effects of rifampicin and isoniazid on human CYPs, there is limited published data regarding the inhibitory effects of other anti-TB drugs on human CYPs and UGTs. (tufts.edu)
  • Celery contains a flavonoid called luteolin. (medicalnewstoday.com)
  • One study looked at the effect of celery seed extracts on blood pressure in rats that either had normal blood pressure and or artificially induced hypertension . (medicalnewstoday.com)
  • Luteolin is a commonly found natural chemical that can be found in several plant species like carrots, peppers, celery, cucumbers and many more. (nstchemicals.com)
  • Celery juice may affect the gut in several ways. (healthline.com)
  • If you experience digestive side effects after drinking celery juice, it's likely best to avoid it. (healthline.com)
  • This study aimed to assess the effects of green vegetable cocktail juice (GVCJ) made of carrot, beetroot, celery, and radish on benzene-induced hematologic and immunologic disorders in rats. (springer.com)
  • It was also found that LGP exhibited marked inhibitory effects on the activation of αIIbβ3 integrin, the secretion of serotonin from granules, and the synthesis of thromboxane A2. (spandidos-publications.com)
  • Inhibitory effects of adlay bran Coix lachryma-jobi L. var. (greenmedinfo.com)
  • The epinephrine-induced inhibitory effects on GP IIb/IIIa and primary hemostasis are similar to, though less robust than those associated with the use of low dose (81 mg) aspirin. (raysahelian.com)
  • These results suggest the mediation of mPFC‐LHb circuit in the inhibitory effects of acupuncture on cocaine psychomotor activity in rats. (researchgate.net)
  • Biochemical and pharmacological studies revealed that the anti-inflammatory effect of luteolin was accompanied by down-regulation of extracellular signal-regulated kinase (ERK), p38, c-Jun N-terminal kinase (JNK), Akt and Src. (alstuttu.org)
  • Already known from folk medicine, extracts containing luteolin have been used to treat epilepsy. (nstchemicals.com)
  • Interestingly, ellagic acid, as well as extracts that are rich in ellagic acid, has demonstrated significant effects on the airways. (hindawi.com)
  • Luteolin or its glycosides from artichoke extracts may have an ameliorating effect on irritable bowel syndrome. (gastrores.org)
  • Considering the adverse effects produced by synthetic depigmenting actives, the search for new therapeutic options is desirable, and plant extracts are possible candidates for hyperpigmentation treatment. (bvsalud.org)
  • I also wanted to point out that histamine is an alerting neurotransmitter, so it makes sense that if luteolin decreases high histamine levels it may help some with sleep. (longevitylifehacks.me)
  • Luteolin also inhibits mast cells, as well as mast cell-dependent T cell activation, recently implicated in MS pathogenesis. (tufts.edu)
  • Animal studies show luteolin inhibits neuroinflammation by controlling microglia activation. (longevitylifehacks.me)
  • Luteolin is able to do this because this flavanoids interferes with the production of estrogens. (testosteronejunkie.com)
  • This study found that although luteolin does have some neuroprotective benefits it also has harmful side effects on neuronal development. (cedfoundation.com)
  • Using the cytopathic effect reduction method, qRT-PCR, immunofluorescence and Western blot assays, they found that luteolin suppressed the replication of IAV. (naturalnews.com)
  • In addition, the researchers found that luteolin suppressed the expression of coat protein I complex (COPI), which is related to influenza virus entry and the endocytic pathway. (naturalnews.com)
  • New research has found IL-6 to be an anti-inflammatory cytokine with multiple beneficial effects when released by contracting muscle as a myokine. (wikipedia.org)
  • Luteolin is also found in many fruits and vegetables like broccoli, peppers, and spinach. (healthline.com)
  • Luteolin is a flavanoid that is commonly found in a variety of plants, fruits and vegetables which have been used for centuries in Chinese medicine. (testosteronejunkie.com)
  • The good herb: Buckwheat liquor helps cells clean house - Science Daily, 8/16/21 - 'When the researchers looked more closely at specific components of tartary buckwheat extract, they found that one component, quercetin, had the same effects as the extract. (qualitycounts.com)
  • Previous studies have found anti-inflammatory effects of luteolin. (secondopinionnewsletter.com)
  • Other studies suggest more positive effects of luteolin like improving cardiomyocyte function, regulates nitric oxide production and prevents damage from its free radicals, improves cardiac functions in case of heart failure and more. (nstchemicals.com)
  • Cytotoxic effects detected by lactate dehydrogenase leakage and the 3-[4,5-dimethylthiazol-2-yl]-2,5-dephenyl tetrazolium bromide-assay were restricted to higher concentrations. (aspetjournals.org)
  • Epigallocatechin gallate and luteolin especially showed synergistic interaction with antibiotics in many microorganisms. (aaem.pl)
  • However, as we've mentioned, most of the clinical studies haven't recorded any adverse effects. (spotmebro.com)
  • The goal here is to simply present a balanced view of the studies and clinical trials on luteolin as a supplement. (longevitylifehacks.me)
  • Clinical similarity, transitivity, and consistency tests were conducted, followed by a random-effects frequentist network meta-analysis (NMA). (researchgate.net)
  • The primary cellular pathways that mediate the longevity-extending effects of natural products involve nutrient-sensing pathways. (frontiersin.org)
  • The anti-inflammatory effects of SHE treatment involved blocking of the mitogen-activated protein kinase and signal transducer and activator of transcription 1 signaling pathways. (researchgate.net)
  • Luteolin is an interesting naturally occurring bioflavinoid. (alstuttu.org)
  • In summary, luteolin is an interesting naturally occurring bioflavinoid that has been shown to have a myriad of functions in various models that could potentially be useful in slowing progression in patients with ALS. (alstuttu.org)
  • parenterally and have a variety of adverse effects. (tufts.edu)
  • Additionally, some research shows that luteolin may help to stop the proliferation of certain cancer cells. (longevitylifehacks.me)
  • Additionally, luteolin increased sleep time and non-REM sleep. (longevitylifehacks.me)
  • Luteolin can additionally reverse epithelial mesenchymal transition (EMT) through a mechanism that involves cytoskeleton shrinkage, induction of the epithelial biomarker E-cadherin expression, and by down-regulation of the mesenchymal biomarkers N-cad herin, snail, and vimentin. (stiftung-plantafood.de)
  • Taking it with other supplements with similar effects might lower blood sugar too much. (medlineplus.gov)
  • Examples of supplements with this effect include bishop's weed, chlorophyll, khella, and St. John's wort. (medlineplus.gov)
  • To ascertain if PKC mediated the luteolin-induced relaxation, the PKC inhibitors bisindolymaleimide IV and chelerythrine Cl - were used together. (gastrores.org)
  • For testosterone to exert its effects, free testosterone must bind to receptors in target tissues. (lifeextension.com)
  • We investigated the effects of chamomile hot water extract and its major components on the prevention of hyperglycemia and the protection or improvement of diabetic complications in diabetes mellitus. (nih.gov)
  • Numerous studies have investigated the effects of chamomile on sleep quality. (naturalherbalism.com)
  • The aim of present study was to confirm these antiplatelet effects and elucidate the potential mechanisms. (spandidos-publications.com)
  • A recent study has revealed the detrimental effects of the flavonoid luteolin on neuronal differentiation in embryonic stem cells. (cedfoundation.com)
  • In this study, Chinese researchers explored the underlying mechanism of luteolin's effect on influenza virus-infected cells. (naturalnews.com)
  • The purpose of this study was to determine if luteolin had an effect on gallbladder motility. (gastrores.org)
  • An appropriate luteolin formulation that permits sufficient absorption and reduces its metabolism could be a useful adjuvant to IFN-β for MS therapy. (tufts.edu)
  • Luteolin has been quite extensively studied for its neuroprotective properties. (nstchemicals.com)
  • However, while the anti-inflammatory effects of dexamethasone treatment were due to the reduced activation of NF- κ B and AP-1, the ellagic acid treatment led to reduced BALF levels of IL-6 and increased levels of IL-10. (hindawi.com)
  • The primary flavonols of PSE that effect allergy are the rosmanaric acid, luteolin, chrysoeriol, and apigenin. (nhcherbs.com)
  • Anti-IL-6 therapies should therefore take into consideration the (beneficial) anti-inflammatory effects of myokines generally, including the now-established multiple benefits of muscle-derived Interleukin 6. (wikipedia.org)
  • Thus, the beneficial effects of luteolin and quercetin against APAP induced hepatotoxicity possibly result from their properties of being able to partially block the CYP-mediated oxidation and to drive the reaction via APAP glucuronidation. (tufts.edu)
  • Luteolin as a therapeutic option for multiple sclerosis. (tufts.edu)
  • As we discussed, the antioxidative potential of Luteolin could be a great factor for it to be a tool as an anticancer prevention tool and therapeutic agent. (nstchemicals.com)
  • Luteolin relaxed cholecystokinin- or KCl-induced tension by blocking extracellular Ca 2+ entry as well as intracellular Ca 2+ release. (gastrores.org)