Efavirenz anti hiv agents. Medical search. Frequent questions

and efavirenz, emtricitabine, and tenofovir disoproxil fumarate. (nih.gov)
Gilead Sciences, Inc. today announced that the Antiviral Drugs Advisory Committee of the U.S. Food and Drug Administration (FDA) has voted 13 to 1 in support of approval of the Quad, a complete single tablet regimen of elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate, for the treatment of HIV-1 infection in treatment-naïve adults. (news-medical.net)
Gilead Sciences, Inc. today announced that the Antiviral Drugs Advisory Committee of the U.S. Food and Drug Administration (FDA) has voted to support approval of once-daily oral Truvada(emtricitabine and tenofovir disoproxil fumarate) to reduce the risk of HIV-1 infection among uninfected adults, an HIV prevention strategy called pre-exposure prophylaxis or PrEP. (news-medical.net)
Gilead Sciences, Inc. announced today that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for marketing approval of the "Quad", a complete single-tablet regimen of elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate for the treatment of HIV-1 infection in adults. (news-medical.net)
For HIV programs operating in countries such as India, fixed-dose combinations containing Efavirenz (Tenofovir-Lamivudine-Efavirenz) are less affordable than those containing Nevirapine [ 16 ]. (biomedcentral.com)
Several antiretroviral agents, such as emtricitabine (FTC), lamivudine (3TC), and tenofovir, have activity against HIV and HBV, whereasile others, such as entecavir , have limited activity against HIV but lead to the development of HIV-resistant strains if used alone. (medscape.com)
[ 16 ] Tenofovir is considered a first-line agent in patients with chronic HBV infection because the virologic efficacy is high and the risk for HBV resistance is low. (medscape.com)
Guidelines issued by the U.S. Department of Health and Human Services (DHHS) list emtricitabine and tenofovir disoproxil fumarate as preferred agents for use as part of a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen in appropriate patients who have never taken anti-HIV medicines before. (gilead.com)
MK-8504 and MK-8583 (Tenofovir Prodrugs) Single-Dose PK and Antiviral Activity in HIV Infection. (natap.org)
Severe acute exacerbations of HBV have been reported in patients who are coinfected with HIV-1 and HBV and have discontinued products containing lamivudine or tenofovir disoproxil fumarate (TDF), which are components of DELSTRIGO. (natap.org)
Offering you a complete choice of products which include trustiva - tenofovir 300 mg + emtricitabine 200 mg + efavirenz 600 mg tablet, hetero tenof em, avonza tablets (lamivudine (300mg) tenofovir (300mg) efavirenz (400mg) mylan), taficita tablets, mylan, taffic tablets hetero treatment hiv and albavir tablets (abacavir 600mg, lamivudine 300mg ) mylan pharmaceutcals ltd. (pmaoverseas.com)
TANGO is a phase III, randomised, open-label, active-controlled, multicentre, parallel-group study comparing dolutegravir plus lamivudine once daily against continuation of a ≥3-drug tenofovir alafenamide (TAF)-based regimen over 48-weeks in HIV-1 infected, antiretroviral treatment-experienced, virally suppressed subjects. (gsk.com)
50 copies per millilitre (c/mL), a standard measure of HIV control, at week 48 when compared to a three-drug regimen of dolutegravir and two nucleoside reverse transcriptase inhibitors (NRTIs), tenofovir disoproxil fumarate/emtricitabine (TDF/FTC), in treatment-naïve, HIV-1 infected adults. (gsk.com)
Not recommended with ATRIPLA, which contains efavirenz, emtricitabine, and tenofovir disoproxil fumarate, unless needed for dose adjustment when coadministered with rifampin. (nih.gov)
We detected host cell surface markers on the HIV envelope to determine the cellular source of HIV in participants on the first line regimen of efavirenz, emtricitabine, and tenofovir. (cam.ac.uk)
Comment: Elvitegravir/cobicistat/emtricitabine/tenofovir is a complete regimen for HIV and should not be administered with other antiretrovirals. (medscape.com)

Pregnant women (aged ≥18 years) with confirmed HIV-1 infection and at 14-28 weeks' gestation were eligible. (nih.gov)
HA392 trade name] is indicated in combination with another antiretroviral agent for the treatment of human immunodeficiency virus (HIV) infection in adults, adolescents and children weighing over 25 kg. (who.int)
Consideration should be given to official treatment guidelines for HIV-1 infection (e.g. those of the WHO). (who.int)
Therapy should be initiated by a health care provider experienced in the management of HIV infection. (who.int)
Etravirine, in combination with other anti-retrovirals, is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment-experienced adult patients, who have evidence of viral replication and HIV-1 strains resistant to a non-nucleoside reverse transcriptase inhibitor (NNRTI) and other antiretroviral agents. (wikipedia.org)
Efavirenz was approved by the FDA on September 17, 1998, for use with other antiretroviral agents in the treatment of HIV infection in adults and children ages 3 and older. (news-medical.net)
This medicine does not cure HIV infection or AIDS and does not reduce the risk of passing the virus to other people. (news-medical.net)
Using a mathematical formula that carefully measures the degree to which HIV infection of immune system cells is stalled by antiretroviral therapy, AIDS experts at Johns Hopkins have calculated precisely how well dozens of such anti-HIV drugs work, alone or in any of 857 likely combinations, in suppressing the virus. (news-medical.net)
Gilead Sciences, Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved Viread in combination with other antiretroviral agents for the treatment of HIV-1 infection in pediatric patients ages 2-12. (news-medical.net)
Globally, there were an estimated 1.1 million deaths due to HIV in 2015, including 0.4 million deaths due to TB co-infection. (biomedcentral.com)
5. The hemisulfate salt or solvate as claimed in claim 1, for use in the treatment of an HIV or HBV infection. (gc.ca)
HIV or HBV infection. (gc.ca)
7. The solvate of claim 3, for use in the treatment of an HIV or HBV infection. (gc.ca)
8. The hydrate of claim 4, for use in the treatment of an HIV or HBV infection. (gc.ca)
9. Use of a hemisulfate salt or solvate as claimed in claim 1, in the manufacture of a medicament for the treatment of an HIV or HBV infection. (gc.ca)
Infection with human immunodeficiency virus (HIV) can result in immunosuppression, allowing opportunistic pathogens to cause disease. (medscape.com)
[ 1 , 2 , 3 ] These opportunistic infections were a major source of morbidity and mortality in patients with HIV infection before the development of effective antiretroviral therapy (ART) and still occur today, mostly in infected individuals who are not receiving ART. (medscape.com)
Please see HIV Infection and AIDS . (medscape.com)
Patients with HIV infection are at a greater risk for hepatitis B virus (HBV) infection, due to the common route of transmission. (medscape.com)
Patients with HIV infection are at a higher risk of developing cirrhosis , hepatic decompensation, and hepatocellular carcinoma than patients diagnosed with only chronic HBV infection. (medscape.com)
Treatment of HIV infection may improve the virologic, histologic, and clinical evolution of chronic HBV infection. (medscape.com)
however, the immune response to HBV vaccine is lower in patients with HIV infection than in uninfected patients, and postvaccination HBsAg must be tested to document immunity. (medscape.com)
In patients with HIV and HBV coinfection, HBV infection should be treated only in conjunction with HIV infection. (medscape.com)
Treatment of HBV infection alone without addressing the HIV infection will lead to emergence of HIV strains that are resistant to nucleoside reverse-transcriptase inhibitors (NRTI). (medscape.com)
It is important that patients be aware that individual HIV medications must be taken as part of combination regimens, and that they do not cure HIV infection or prevent transmitting HIV to other people. (gilead.com)
It is prescribed to treat HIV (human immunodeficiency virus) infection. (pranonnehc.com)
T- lamirenz Tablet restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual.It is prescribed to treat HIV (human immunodeficiency virus) infection. (pranonnehc.com)
It helps to control HIV infection so your immune system can work better. (pranonnehc.com)
ISENTRESS 600 mg film-coated tablets is indicated in combination with other anti-retroviral medicinal products for the treatment of human immunodeficiency virus (HIV-1) infection in adults, and paediatric patients weighing at least 40 kg (see sections 4.2, 4.4, 5.1 and 5.2). (medicines.org.uk)
Therapy should be initiated by a physician experienced in the management of HIV infection. (medicines.org.uk)
Efavirenz is part of a nifty group of medications known as NNRTIs (Non-Nucleoside Reverse Transcriptase Inhibitors), used in the management of HIV infection. (abpharmacies.com)
PIFELTRO is indicated in combination with other antiretroviral (ARV) agents for the treatment of HIV-1 infection in adult patients with no prior ARV treatment history or to replace the current ARV regimen in those who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable ARV regimen with no history of treatment failure and no known substitutions associated with resistance to doravirine. (natap.org)
Effective antiretroviral therapy is the most important intervention in terms of improving longevity and preventing opportunistic infections in patients with human immunodeficiency virus (HIV) infection. (medscape.com)
For more information, see Pediatric HIV Infection . (medscape.com)
It may also be used to prevent HIV infection in some people at high risk. (pmaoverseas.com)
This guideline addresses initial treatment of HIV-1 infection with ART in nonpregnant adults . (hivguidelines.org)
For recommendations regarding the treatment of HIV-2 infection, see the NYSDOH AI guideline Diagnosis and Management of HIV-2 in Adults . (hivguidelines.org)
TROGARZO, a CD4-directed post-attachment HIV-1 inhibitor, in combination with other antiretroviral(s), is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in heavily treatment-experienced adults with multidrug resistant HIV-1 infection failing their current antiretroviral regimen. (nih.gov)
TROGARZO, in combination with other antiretroviral(s), is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in heavily treatment-experienced adults with multidrug resistant HIV-1 infection failing their current antiretroviral regimen. (nih.gov)
Prezcobix (darunavir and cobicistat) is a combination of a human immunodeficiency virus ( HIV -1) protease inhibitor and a CYP3A inhibitor and is indicated for the treatment of HIV-1 infection in adult patients. (rxlist.com)
The BRIGHTE study is a two-cohort (randomised and non-randomised), phase III clinical trial evaluating the safety and efficacy of the HIV-1 attachment inhibitor fostemsavir in heavily treatment-experienced adults with HIV-1 infection. (gsk.com)
ViiV Healthcare, the global specialist HIV company, majority owned by GlaxoSmithKline, with Pfizer Inc. and Shionogi Limited as shareholders, today announced that the European Commission has granted Marketing Authorisation for Dovato (dolutegravir/lamivudine) for the treatment of HIV-1 infection in adults and adolescents above 12 years of age weighing at least 40 kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine. (gsk.com)
Dovato (dolutegravir 50 mg/ lamivudine 300 mg tablets) is authorised in the EU for the treatment of HIV-1 infection in adults and adolescents above 12 years of age weighing at least 40 kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine. (gsk.com)
In the US the Food and Drug Administration (FDA) authorised Dovato, a complete, once-daily, single-tablet regimen of dolutegravir (DTG) 50 mg and lamivudine (3TC) 300 mg for the treatment of HIV-1 infection in adults with no antiretroviral (ARV) treatment history and with no known resistance to either DTG or 3TC. (gsk.com)
SELZENTRY will not cure HIV infection. (viivhealthcare.com)
Ricovir 300mg Tablet is used to treat HIV infection and chronic hepatitis B virus (HBV) infection in combination with other anti-HIV medicines. (medvay.com)
As a complete regimen for the treatment of HIV-1 infection in adults and children weighing ≥40kg. (renalandurologynews.com)
Efavirenz is a non-nucleoside reverse transcriptase inhibitor indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus type 1 infection in adults and in pediatric patients at least 3 months old and weighing at least 3.5 kg. (nih.gov)
London, UK 27 November 2017 - Today ViiV Healthcare, the global specialist HIV company majority owned by GSK, with Pfizer Inc. and Shionogi Limited as shareholders, announced the start of a phase III study with a two-drug regimen of long-acting, injectable cabotegravir (ViiV Healthcare) and long-acting injectable rilpivirine (Janssen Sciences Ireland UC) in virally suppressed adults with HIV-1 infection. (viivhealthcare.com)
This study follows the phase III ATLAS 1 (virally suppressed patients) and FLAIR 2 (treatment-naïve patients) studies of monthly dosing with long-acting cabotegravir and long-acting rilpivirine for the treatment of HIV-1 infection. (viivhealthcare.com)
The rapid destruction of these cells due to HIV-1 infection makes the infected individual immune-compromised and prone to several opportunistic infections. (openaccesspub.org)
Coadministration with other antiretroviral medications for treating HIV-1 infection is not recommended. (medscape.com)
This report modifies and expands the list of antiretroviral human immunodeficiency virus (HIV) infection, appropri- medications that can be considered for use as PEP. (cdc.gov)
Human immunodeficiency virus (HIV) infection is caused by the retrovirus HIV-1 (and less commonly by the related retrovirus HIV-2). (msdmanuals.com)
Інфекція вірусом імунодефіциту людини (ВІЛ) Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
Психосоціальний підхід до дітей із ВІЛ-інфекцією Human immunodeficiency virus (HIV) infection is caused by the retrovirus HIV-1 (and less commonly by the related retrovirus HIV-2). (msdmanuals.com)
In the United States, since HIV infection was first recognized, more than 10,000 cases have been reported in children and young adolescents, but this number represents only 1% of total cases. (msdmanuals.com)
Since 1996, with the advent and introduction of highly active antiretroviral therapy (HAART), a profound impact on the natural history of HIV infection was observed, with a remarkable increase in the survival of HIV-infected individuals, transforming the panorama of the disease. (bvsalud.org)
HIV-1 infection, documented by any licensed rapid HIV test or HIV-1 E/CIA test kit at any time prior to entry and confirmed by a licensed Western blot or a second antibody test by a method other than the initial rapid HIV and/or E/CIA, or by HIV-1 antigen or plasma HIV-1 RNA viral load. (who.int)

Etravirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), designed to be active against HIV with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs, mutation K103N for efavirenz and Y181C for nevirapine. (wikipedia.org)
We hypothesize that Nevirapine is a cheaper alternative that possesses equal efficacy as Efavirenz in HIV-Tuberculosis (TB) co-infected patients. (biomedcentral.com)
Those who were ART-naïve and co-infected with TB were randomized to receive either Nevirapine (Group 1)- or Efavirenz (Group 2)-based ART along with Rifampicin-based ATT. (biomedcentral.com)
A total of 284 patients (mean age 36.7 ± 8.1 years) were randomized in a 1:1 ratio to receive either Nevirapine ( n = 144)- or Efavirenz ( n = 140)-based ART after a median ATT-ART gap of 27 days. (biomedcentral.com)
Composite unfavourable outcome in HIV-TB co-infected patients who were ART-naïve showed no statistically significant difference in the Nevirapine or Efavirenz groups. (biomedcentral.com)
Therefore, Nevirapine-based ART is a reasonable alternative to Efavirenz in resource-limited settings. (biomedcentral.com)
Virologic Response to First-line Efavirenz- or Nevirapine-based Antiretroviral Therapy in HIV-infected African Children. (ox.ac.uk)
BACKGROUND: Poorer virologic response to nevirapine- versus efavirenz-based antiretroviral therapy (ART) has been reported in adult systematic reviews and pediatric studies. (ox.ac.uk)
METHODS: We compared drug discontinuation and viral load (VL) response in ART-naïve Ugandan/Zimbabwean children ≥3 years of age initiating ART with clinician-chosen nevirapine versus efavirenz in the ARROW trial. (ox.ac.uk)
RESULTS: A total of 445 (53%) children received efavirenz and 391 (47%) nevirapine. (ox.ac.uk)
CONCLUSION: Short-term VL suppression favored efavirenz, but long-term relative performance was age dependent, with better suppression in older children with nevirapine, supporting World Health Organization recommendation that nevirapine remains an alternative NNRTI. (ox.ac.uk)
In contrast to the disappointing cross-resistance news with 1592, DuPont-Merck's new non-nucleoside reverse transcriptase inhibitor (NNRTI) DMP-266 (now with the generic name "efavirenz" and trade name "Sustiva"), seems to be active against the most common resistance mutation (Y181) associated with use of nevirapine and delavirdine, the two commercially available NNRTIs. (treatmentactiongroup.org)

Unlike the currently available agents in the class, resistance to other NNRTIs does not seem to confer resistance to etravirine. (wikipedia.org)
NNRTIs block reverse transcriptase, a protein that HIV needs to make more copies of itself. (news-medical.net)
The aim of Efavirenz, like all NNRTIs, is to inhibit the action of 'reverse transcriptase', an enzyme crucial for the replication of HIV. (abpharmacies.com)

Methods: HIV-infected, treatment-naïve adults were randomized to receive rilpivirine (RPV) or efavirenz (EFV), plus a background regimen. (eurekaselect.com)
In treatment-naive patients with HIV/HBV coinfection, a regimen containing TDF plus FTC or TDF plus 3TC should be used as the backbone of HIV therapy. (medscape.com)
As part of traditional approval, the U.S. prescribing information for Viread and Truvada now include 48-week data from Study 934, a Phase III open-label trial comparing a once-daily regimen of Viread, Emtriva and efavirenz to twice-daily Combivir(R) (lamivudine/zidovudine) and once-daily efavirenz in treatment-naive patients. (gilead.com)
If approved by the FDA, the new product would be the first and only complete Highly Active Antiretroviral Therapy (HAART) regimen for HIV available in a single once-daily fixed-dose tablet. (gilead.com)
The U.S. joint venture to develop and commercialize the fixed-dose regimen of Truvada and efavirenz is the first of its kind in the field of HIV treatment. (gilead.com)
Due to cross resistance, at least one of the new products isn't expected to work in people with extensive prior nucleoside experience, and it may be difficult to cobble together a regimen from the two remaining new agents that can reasonably be expected to produce sufficient virologic suppression. (treatmentactiongroup.org)
Deborah Waterhouse, CEO, ViiV Healthcare, said: "For many years, the standard of care for treatment-naïve people living with HIV in Europe has been a three-drug regimen. (gsk.com)
The data from our dolutegravir-based two-drug regimen development programme challenges this, and with the authorisation of Dovato, people living with HIV can for the first time start treatment on a once-daily, single-pill, two-drug regimen with the knowledge that efficacy is non-inferior to a three-drug regimen whilst containing fewer antiretrovirals. (gsk.com)
Do not use as a single agent or add on as a sole agent to a failing regimen. (nih.gov)

Etravirine (ETR, brand name Intelence, formerly known as TMC125) is a drug used for the treatment of HIV. (wikipedia.org)

Efavirenz, also known as EFV or Sustiva, is a type of medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). (news-medical.net)
Joseph Gathe from Therapeutic Concepts in Houston, Texas, described findings from Study 202, an ongoing, phase IIb study on cenicriviroc versus efavirenz ( Sustiva or Stocrin ). (aidsmap.com)
RDEA806, at least in test tube studies, is active against HIV strains resistant to the NNRTI Sustiva (efavirenz), according to Graeme Moyle, MD, who presented the new data at ICAAC/IDSA. (poz.com)

A new once-daily pill combining three antiretrovirals and a booster molecule is a safe and effective alternative to two widely used drug regimens for newly diagnosed HIV-positive adults who have had no previous treatment. (news-medical.net)
The NYSDOH AI Medical Care Criteria Committee recommendations for prescribing ART regimens for treatment-naive, nonpregnant adults (age ≥18 years) with HIV-1 and without acquired resistance are based on a comprehensive review of available clinical trial data. (hivguidelines.org)
HIV treatment regimens that do not require daily dosing could be an important part of making HIV feel like a smaller part of patients' lives and with the ATLAS-2M study, we are evaluating the possibility of maintaining viral suppression with six treatments per year of long-acting cabotegravir and long-acting rilpivirine. (viivhealthcare.com)
In addition, the negative influence of antiHIV-1 regimens on certain host factors involved in telomerase function may enhance aging. (openaccesspub.org)
Although the principles of exposure management remain unchanged, recommended HIV postexposure prophylaxis (PEP) regimens have been changed. (cdc.gov)
HIV PEP regimens and other medications, consultation with these recommendations have been updated twice ( 1-3 ). (cdc.gov)

dead link] "First New NNRTI in Nearly a Decade to Benefit Canadians with HIV/AIDS" (PDF) (Press release). (wikipedia.org)
A Johns Hopkins expert in the drug treatment of HIV disease and AIDS is spearheading an international effort to radically shift the manufacturing and prescribing of combination therapies widely credited in the last decade for keeping the disease in check for 8 million of the 34 million infected people worldwide. (news-medical.net)
The government of Thailand has said it plans to buy more generic HIV/AIDS drugs from India because it cannot obtain acceptable discounts from the manufacturers of the patented products. (pharmatimes.com)
According to World Health Organization (WHO) guidelines, which have also been adopted by the National AIDS Control Organization (NACO), India, Efavirenz-based Anti-Retroviral Therapy (ART) is better in Human-Immunodeficiency-Virus (HIV)-infected patients who are also being treated with Rifampicin-based Anti-Tuberculous Therapy (ATT). (biomedcentral.com)
The first cases of HIV/AIDS were reported by the U.S. Centers for Disease Control and Prevention (CDC) in the June 5, 1981 issue of the Morbidity and Mortality Weekly Report (MMWR). (gilead.com)
Today, CDC estimates that more than one million Americans are infected with HIV, the virus that causes AIDS. (gilead.com)
It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome). (pranonnehc.com)
This case-based review aims to describe the clinical findings, treatment, and outcome of an HIV/AIDS patient with psoriatic arthritis (PsA) who received four anti-TNF agents and review case reports concerning this rare clinical association. (infectiousjournal.com)
A growing body of evidence indicates that chronic inflammation plays a role in a variety of non-AIDS-related conditions that help explain why HIV-positive people still have higher mortality than age-matched HIV-negative people. (aidsmap.com)
It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). (pmaoverseas.com)
Tenof EM Tablet is not a cure for HIV/AIDS and only helps to decrease the amount of HIV in your body. (pmaoverseas.com)
Some people put on weight while taking medicines to treat HIV/AIDS. (pmaoverseas.com)
This is a conservative estimate as these surveys do not include sufficient detail on several conditions that would have been declinable before the ACA (such as HIV/AIDS, or hepatitis C). Additionally, millions more have other conditions that could be either declinable by some insurers based on their pre-ACA underwriting guidelines or grounds for higher premiums, exclusions, or limitations under pre-ACA underwriting practices. (kff.org)
This guideline was developed by the New York State Department of Health AIDS Institute (NYSDOH AI) for primary care providers and other practitioners who are initiating therapy in nonpregnant, antiretroviral therapy (ART)-naive adults with HIV. (hivguidelines.org)
This is an exploratory, qualitative content analysis of 50 vivid dream and nightmare narratives posted to an online forum by people living with HIV/AIDS and taking the anti-HIV drug Efavirenz. (smith.edu)
It examines thematic connections among the dreams with consideration of how these themes might be linked to and reflective of complex subjective experiences of living with HIV/AIDS. (smith.edu)
This thesis demonstrates that the phenomenon of vivid dreams and nightmares as purported side effects of Efavirenz is of substantial interest to people living with HIV/AIDS. (smith.edu)
Furthermore, it argues that vivid dreams and nightmares experienced by people living with HIV/AIDS and taking Efavirenz are not simply medication side effects, but are meaningful experiences that are potentially useful in clinical social work with this population. (smith.edu)
Women who have HIV/ AIDS should not breastfeed due to the potential for HIV transmission and the potential for serious adverse reactions in nursing infants. (rxlist.com)
London, 15 July 2019 - ViiV Healthcare, the global specialist HIV company majority-owned by GSK, with Pfizer Inc. and Shionogi Limited as shareholders, announced today that 20 abstracts from its portfolio of late-stage pipeline and authorised HIV treatments will be presented at the 10th International AIDS Society Conference on HIV Science (IAS 2019) in Mexico City , 21-24 July, in Mexico City, Mexico. (gsk.com)
We are ViiV Healthcare: 100% dedicated to HIV medicines and research and completely focused on people affected by HIV and AIDS. (viivhealthcare.com)
We work actively with communities affected by HIV and AIDS around the world. (viivhealthcare.com)
We are the only pharmaceutical company solely focused on curing HIV and AIDS, but of course, none of what we do can be achieved alone - we believe in the power of partnership. (viivhealthcare.com)
Our aim is to take a deeper and broader interest in HIV/AIDS than any company has done before and take a new approach to deliver effective and new HIV medicines as well as support communities affected by HIV. (viivhealthcare.com)
Belgrade, Serbia, (October 13, 2011) - Tibotec Pharmaceuticals, one of the Janssen Pharmaceutical Companies (Janssen), presented new data across their HIV portfolio at the 13th annual European Aids Conference (EACS) demonstrating the company's commitment to exploring and developing new HIV treatment options which could help improve treatment for patients at every stage of the disease. (jnj.com)
Journal of Clinical Research In HIV AIDS And Prevention - 3(4):20-27. (openaccesspub.org)
It is the etiologic agent of the acquired immunodeficiency syndrome (AIDS) that targets the CD4 + T-lymphocyte cells of the human immune system 1 . (openaccesspub.org)
According to the National AIDS Control Organisation (NACO), there are two high risk groups of HIV-1 infected individuals, which include sex workers (SW) and those men who do sex with men (MSM). (openaccesspub.org)
To assess the prevalence of oral manifestations in HIV/AIDS patients and a possible correlation of the development of diabetes mellitus due to highly active antiretroviral therapy (HAART). (bvsalud.org)
AIDS, HIV, diabetes mellitus. (bvsalud.org)
Acquired immunodeficiency syndrome (AIDS) was first described in 1981 in the United States, and its causative agent is the human immunodeficiency virus (HIV). (bvsalud.org)

Other diarylpyrimidine-analogues are currently being used as anti-HIV agents, notably rilpivirine. (wikipedia.org)
The Antiretroviral Therapy as Long Acting Suppression every 2 Months (ATLAS-2M) study is designed to demonstrate the non-inferior antiviral activity and safety of long-acting cabotegravir and long-acting rilpivirine administered every 8 weeks (Q8W) compared with long-acting cabotegravir and long-acting rilpivirine administered every 4 weeks (Q4W) over a 48-week treatment period in adult HIV-1-infected participants. (viivhealthcare.com)
Pooled data from ECHO and THRIVE show rilpivirine demonstrated sustained efficacy over 96 weeks and was non-inferior to efavirenz (77.6% vs 77.6% respectively), with a more favourable tolerability profile. (jnj.com)
There were fewer AEs leading to discontinuation with rilpivirine compared to efavirenz. (jnj.com)
The virologic failure rate was higher with rilpivirine than with efavirenz up to 48 weeks (9.0% vs. 4.8% respectively). (jnj.com)
At 96 weeks, the overall virologic failure rate was 14.0% with rilpivirine and 7.6% with efavirenz. (jnj.com)
ECHO and THRIVE are two pivotal Phase 3 clinical trials which evaluated the efficacy and safety of rilpivirine in 1,368 antiretroviral treatment-naïve HIV-1-infected adults with plasma HIV-1 RNA ≥ 5000 copies/mL. (jnj.com)
Improvement of lipid profile after switching from efavirenz or ritonavir-boosted protease inhibitors to rilpivirine or once-daily integrase inhibitors: results from a large observational cohort study (SCOLTA). (cdc.gov)

Shionogi-ViiV Healthcare LLC today announced that initial results have been received from the Phase III SINGLE (ING114467) study of the investigational integrase inhibitor dolutegravir in treatment-naive adults with HIV-1. (news-medical.net)
SARS-CoV-2 main protease inhibitor + HIV-1 protease inhibitor/CYP3A inhibitor. (oncologynurseadvisor.com)
A CCR5 inhibitor is an antiretroviral medication that blocks the CCR5 co-receptor and prevents HIV from entering the cell. (aidsmap.com)
Darunavir is an inhibitor of the human immunodeficiency virus ( HIV -1) protease . (rxlist.com)
Once-daily RDEA806, an experimental non-nucleoside reverse transcriptase inhibitor ( NNRTI ) being developed by Ardea Biosciences, appears highly active against HIV, is unlikely to have significant interactions with other meds and may have a useful side effect-reducing uric acid levels. (poz.com)
SELZENTRY ® (maraviroc) is a first-in-class oral CCR5 entry inhibitor approved in the U.S. for both treatment-naïve and treatment-experienced adult patients with CCR5-tropic HIV-1 virus in combination with other anti-HIV medicines. (viivhealthcare.com)
9. The first non-nucleoside inhibitor of reverse transcriptase drug ever used was a. efavirenz. (remixeducation.in)
Individualized Protease Inhibitor Monotherapy: The Role of Pharmacokinetics and Pharmacogenetics in an Aged and Heavily Treated HIV-Infected Patient. (cdc.gov)
Insulin resistance (IR) is common in HIV-seropositive patients, particularly among those receiving protease inhibitor (PI) and is more prevalent among those with lipoatrophy or fat accumulation in the visceral region. (bvsalud.org)

Concomitant rifampin (≥50kg): give additional 200mg/day of efavirenz. (renalandurologynews.com)

The chewable tablets and the granules for oral suspension have not been studied in HIV-infected adolescents (12 to 18 years) or adults. (medicines.org.uk)
London, United Kingdom, 4th March, 2011 - ViiV Healthcare LLC announced today that it has submitted a Type II Variation to the European Medicines Agency (EMEA) and a Supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) for once daily administration of Celsentri/Selzentry ® (maraviroc) 150 mg tablets in treatment-experienced patients infected with CCR5-tropic HIV-1. (viivhealthcare.com)
These highlights do not include all the information needed to use EFAVIRENZ TABLETS safely and effectively. (nih.gov)
See full prescribing information for EFAVIRENZ TABLETS. (nih.gov)
Efavirenz tablets should be taken orally once daily on an empty stomach, preferably at bedtime. (nih.gov)
Efavirenz tablets are not recommended for patients with moderate or severe hepatic impairment. (nih.gov)

Efavirenz may also be used with other antiretroviral medications to prevent HIV in people who have been exposed to the virus in the work place, such as health care providers who come in contact with HIV infected blood through an accidental needle stick. (news-medical.net)
Consider alternatives to efavirenz in patients taking other medications with a known risk of Torsade de Pointes or in patients at higher risk of Torsade de Pointes. (nih.gov)

Both studies in treatment-experienced patients were conducted in clinically advanced, 3-class antiretroviral-experienced (NRTI, NNRTI, PI, or enfuvirtide) adults with evidence of HIV-1 replication despite ongoing antiretroviral therapy. (viivhealthcare.com)

Darunavir is not currently approved for use as monotherapy in Europe and U.S. Darunavir is currently approved for use in combination with ritonavir and other ARV agents. (jnj.com)
Low-dose ritonavir-boosted darunavir in virologically suppressed HIV-1-infected adults: an open-label trial (ANRS 165 Darulight). (cdc.gov)

Objectives: Increasing life expectancy of HIV-1-infected patients raises interest in how trial results apply to older patients. (eurekaselect.com)
In January 2008, the Food and Drug Administration approved its use for patients with established resistance to other drugs, making it the 30th anti-HIV drug approved in the United States and the first to be approved in 2008. (wikipedia.org)
All patients with HBV/HIV coinfection must be assessed for hepatitis A virus (HAV) immunity and vaccinated if negative. (medscape.com)
Eighty-four percent of patients in the Viread/Emtriva group compared to 73 percent of patients in the Combivir group achieved and maintained HIV RNA less than 400 copies/mL through week 48. (gilead.com)
In addition, 80 and 70 percent of patients in the Viread/Emtriva group and the Combivir group, respectively, achieved and maintained HIV RNA less than 50 copies/mL. (gilead.com)
Telura Tablet is a combination medicine used to treat human immunodeficiency virus (HIV) infections in adult patients. (pranonnehc.com)
PsA patients with HIV without advanced disease. (infectiousjournal.com)
Patients should be advised that current anti-retroviral therapy does not cure HIV and has not been proven to prevent the transmission of HIV to others through blood contact. (medicines.org.uk)
Warning: Posttreatment Acute Exacerbation of Hepatitis B (HBV) All patients with HIV-1 should be tested for the presence of HBV before initiating ARV therapy. (natap.org)
Patients coinfected with HIV-1 and HBV who discontinue DELSTRIGO should be monitored with both clinical and laboratory follow-up for at least several months after stopping DELSTRIGO. (natap.org)
A group of new anti-HIV therapies are about to enter expanded access programs, but heavily pre-treated patients aren't out of the woods yet. (treatmentactiongroup.org)
Early study results suggested as much as a 2 log reduction in plasma HIV RNA when treatment naïve patients were treated with 1592. (treatmentactiongroup.org)
Encourage clinicians to seek the assistance of an experienced HIV care provider when treating patients with extensive comorbidities. (hivguidelines.org)
Use of SELZENTRY in patients with dual/mixed or CXCR4-tropic HIV-1 is not recommended. (viivhealthcare.com)
SELZENTRY, in combination with other antiretroviral agents, is indicated for adult patients infected with only CCR5-tropic HIV-1. (viivhealthcare.com)
This indication is based on analyses of plasma HIV-1 RNA levels in two controlled studies of SELZENTRY in treatment-experienced patients and one study in treatment-naive patients. (viivhealthcare.com)
Using prices published in the UK, the results showed based on 20,000 HIV-1 infected patients meeting the entry criteria for MONET, a switch to DRV/r monotherapy could cut the three year cost of HIV treatment from £412 million to £248 million per year (20,000 HIV infected patients meeting entry criteria for MONET trial out of estimated 50,000 HIV patients on standard combination treatment). (jnj.com)
Pharmacokinetic Changes during Pregnancy According to Genetic Variants: a Prospective Study in HIV-Infected Patients Receiving Atazanavir-Ritonavir. (cdc.gov)
56 patients were examined, divided into two groups, Group 1, the HIV group, with 28 patients known to be HIV+, who developed diabetes mellitus due to HAART, and Group 2, the control group, with 28 patients with HIV- diagnosed with diabetes mellitus. (bvsalud.org)
The occurrence of diabetes is four times greater in HIVseropositive patients than in HIV-seronegative patients matched by age and body mass 10,13-16 . (bvsalud.org)

It may be prescribed alone or in combination with other HIV medicines. (pmaoverseas.com)
Taking these medicines regularly at the right time greatly increases their effectiveness and reduces the chances of HIV becoming resistant to them. (pmaoverseas.com)
The data presented at IAS 2019 further build upon the company's innovative approach to research and development by investigating treatments that have the potential to reduce the number of medicines people living with HIV take during their lifetime and provide a range of options that meet their diverse and evolving needs. (gsk.com)
With our pipeline of innovative medicines, we are aiming to make a difference in the lives of people living with HIV. (gsk.com)
ViiV Healthcare's ambition and innovative R&D programme aims to reduce the number of HIV drugs people living with HIV take over a lifetime and Dovato is an important addition to our portfolio of medicines to support this aim. (gsk.com)
It is used in combination with other anti-HIV medicines. (medvay.com)

Cenicriviroc, which blocks both CCR5 and CCR2 receptors on immune cells, is effective against HIV, better tolerated than current antiretrovirals and has immunomodulatory activity that may reduce inflammation, according to a presentation yesterday at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) in Atlanta. (aidsmap.com)
The drug also has a very limited effect on CYP450, the enzyme system responsible for breaking down many of the commonly used antiretrovirals (ARVs), meaning that RDEA806 can likely be used with other HIV meds without concerns of drug-drug interactions. (poz.com)
Though there is no exact information available on this issue, intensive efforts are needed to explore regulation of telomerase expression in HIV infected individuals and particularly those receiving antiretrovirals. (openaccesspub.org)
The antiretrovirals approved by FDA-USA being prescribed to the doctors to treat the HIV infected individuals are over two dozen in number. (openaccesspub.org)

[ 9 ] Antiretroviral drug classes and agents within each class are listed in Table 1, below (see individual medication tables for more detail). (medscape.com)

Trustiva Tablet restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual. (pmaoverseas.com)
This helps to lower your risk of getting HIV-related complications and improves your lifespan. (pmaoverseas.com)

ISENTRESS is also available as a 400 mg tablet for twice daily use in HIV infected adults or children and adolescents at least 25 kg. (medicines.org.uk)

Antimicrobial agents can be active against the vaccine strains in the oral typhoid and cholera vaccines and might prevent adequate immune response to these vaccines. (cdc.gov)

He received the HIV diagnosis in 1998, initially treated with lamivudine, zidovudine, and efavirenz. (infectiousjournal.com)

Since its inception 10 years ago, as the only pharmaceutical company solely focused on HIV, ViiV Healthcare continues its industry-leading commitment by delivering scientific advances that address the needs of the HIV community. (gsk.com)
John C. Pottage, Jr, M.D. Chief Scientific and Medical Officer, ViiV Healthcare said: "The Marketing Authorisation of Dovato in Europe marks a significant development for people living with HIV. (gsk.com)
ViiV Healthcare is a global specialist HIV company established in November 2009 by GlaxoSmithKline (NYSE: GSK) and Pfizer (NYSE: PFE) dedicated to delivering advances in treatment and care for people living with HIV. (viivhealthcare.com)
John C Pottage, Jr, MD, Chief Scientific and Medical Officer, ViiV Healthcare said: "We have a patient-centred approach to innovation that seeks to transform how HIV is treated. (viivhealthcare.com)

In 2015, there were 0.1 million new cases of TB in PLHIV (people living with HIV) in India, with TB being responsible for approximately 15-18% of all deaths among PLHIV [ 3 ]. (biomedcentral.com)
35 means we can empower more people living with HIV to challenge stigma with our information workshops, videos and broadcasts. (aidsmap.com)
Merck's commitment to HIV spans exploratory research to Phase 3 trials and is fueled by our goal to develop meaningful scientific innovations that someday may help people living with HIV," said Dr. George Hanna, vice president and therapeutic area head of infectious diseases, Global Clinical Development, Merck Research Laboratories. (natap.org)
For guidelines specific to treatment of adolescents with HIV, please consult the DHHS Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV ). (hivguidelines.org)
Dovato strengthens ViiV Healthcare's industry-leading portfolio of innovative treatment approaches for people living with HIV. (gsk.com)
With around 25,000 new HIV diagnoses in Europe [*] every year [2] , and the fact that today HIV is considered a chronic condition which requires people living with HIV (PLHIV) to remain on antiretroviral (ARV) treatment for life, it is ever more important to provide innovative treatment options. (gsk.com)
200/µl or lower than this is considered According to an estimate of UNAIDS, there were approximately 33 million people worldwide living with HIV-1 and an emerging newly infected 2.7 million individuals 2 . (openaccesspub.org)
India inhabits 2.1 million HIV-1 infected people equivalent to the third largest population in the world living with HIV-1. (openaccesspub.org)

Certain opportunistic infections (OIs) are associated with increases in viral load, which may accelerate HIV progression or increase transmission of HIV. (medscape.com)
KENILWORTH, N.J.--(BUSINESS WIRE)--Merck (NYSE: MRK), known as MSD outside the United States and Canada, announced today the presentation of new data from its ongoing HIV research programs at the Conference on Retroviruses and Opportunistic Infections (CROI 2020) taking place March 8 - 11, 2020 in Boston, Massachusetts. (natap.org)
4. Which antifungal agent is NOT indicated for use in fungal infections of the skin and nails? (remixeducation.in)

Live attenuated vaccines generally should be avoided in immunocompromised travelers, including those taking antimetabolites, calcineurin inhibitors, cytotoxic agents, immunomodulators, and high-dose steroids (see Table 3-04 ). (cdc.gov)
Gilead and Bristol-Myers Squibb have established a U.S. joint venture to produce a once-daily fixed-dose product containing Truvada and efavirenz and expect to file a new drug application with the FDA in the second quarter of this year. (gilead.com)

The best treatment of HIV-inflammation is antiretroviral therapy. (aidsmap.com)
If appropriate, initiation of anti-HBV therapy may be warranted. (natap.org)
T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy. (cam.ac.uk)
HIV cerebrospinal fluid (CSF) escape, where HIV is suppressed in blood but detectable in CSF, occurs when HIV persists in the CNS despite antiretroviral therapy (ART). (cam.ac.uk)

Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. (wikipedia.org)
Many of the antiretroviral drugs that have been approved for HIV-infected adults and adolescents are gaining FDA approval for use in younger children. (medscape.com)

11. Which anti-human immunodeficiency virus drug hinders the final assembly of new viruses? (remixeducation.in)
Human Immunodeficiency Virus Type-1 (HIV-1) belongs to the retroviridae family and to the Lentivirus genus. (openaccesspub.org)
have occupational exposure to blood and other body fluids that might contain human immunodeficiency virus (HIV). (cdc.gov)

6. The antiviral agent, amantadine, inhibits the replication of which strain of virus? (remixeducation.in)

Coadministration of efavirenz with elbasvir/grazoprevir. (nih.gov)
Coadministration of efavirenz can alter the concentrations of other drugs and other drugs may alter the concentrations of efavirenz. (nih.gov)

5 allows us to reach millions of people globally with accurate and reliable resources about HIV prevention and treatment. (aidsmap.com)

We observed that 28% of participants with an undetectable HIV blood viral load showed CSF escape. (cam.ac.uk)

HAART changes the landscape of the disease by progressively decreasing the progression of HIV-1, but exerts prolonged adverse effects on the telomerase function. (openaccesspub.org)
The HIV group and the control group were diagnosed with diabetes, but this condition in the HIV group presented earlier than in the control group, suggesting a possible association with HAART. (bvsalud.org)

Anatomy1

Organisms1

Diseases4

Chemicals and Drugs27

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Psychiatry and Psychology1

Phenomena and Processes5

Anthropology, Education, Sociology and Social Phenomena1

Information Science1

Health Care1

Geographicals2

Tenofovir16

Infection59

Nevirapine12

NNRTIs3

Regimen9

Etravirine1

Sustiva3

Regimens6

AIDS31

Rilpivirine8

Inhibitor9

200mg1

Tablets6

Medications2

NNRTI1

Darunavir2

Patients20

Medicines6

Antiretrovirals4

Medication1

Risk of getting HIV-related compl2

Tablet1

Strains1

19981

ViiV Healthcare4

Living with HIV8

Infections3

Dose2

Therapy4

Adolescents2

Human immu3

Antiviral1

Coadministration2

Prevention1

Viral load1

HAART2