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  • antigen-prese
  • The antigen-presenting cells that initiate and maintain MHC class II-associated organ-specific autoimmune diseases are poorly defined. (pnas.org)
  • The antigen-presenting cells (APCs) that drive the various phases of MHC class II-dependent organ-specific autoimmune diseases, such as insulin-dependent diabetes mellitus, experimental allergic encephalitis, and thyroiditis, are not fully identified. (pnas.org)
  • Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. (nih.gov)
  • In addition Astrocytes produce several immunosuppressive molecules for example prostaglandin E2 (PGE2) or transforming growth factor-β (TGF-β) (Aloisi Ria & Adorini 2000 Astrocytes represent the non-professional class of CNS-resident antigen presenting cells (APCs) (Constantinescu et al. (cylch.org)
  • mice
  • We previously generated keratin 14 (K14)-A β b mice expressing MHC class II only on thymic cortical epithelium. (pnas.org)
  • Interestingly, a significant number of mice that express both the K14-A β b transgene and the autoreactive 2-2-3 TCR spontaneously develop inflammatory skin disease with mononuclear infiltrates, induction of MHC class II expression on keratinocytes, and T helper 1 cytokines. (pnas.org)
  • MHC class II-deficient mice fail to develop cellular and humoral immune responses to AChR and clinical EAMG ( 4 ). (jimmunol.org)
  • immune
  • HLA-DQβ and HLA-DR3 polymorphisms have been linked to myasthenia gravis ( 5 ) and MHC class II has been shown to restrict immune response to AChR in humans as well ( 6 ). (jimmunol.org)
  • mediate
  • Recent work shows that the cysteine protease cathepsin S (Cat S) is required for the terminal step in CLIP formation in B cells and most dendritic cells (DCs), and in vitro can mediate all steps of digestion of class II-Ii complexes ( 20 , 21 , 22 , 23 , 24 , 25 ). (jimmunol.org)
  • social
  • Moment, Michelle Garcia Winner, the founder of Social Thinking, shares a lesson she used in a treatment session with a 15-year-old boy with social anxiety, depression, and late diagnosis of ASD. (socialthinking.com)
  • In this free 12 minute video, Social Thinking founder Michelle Garcia Winner shares what she learned when helping a client with social anxiety talk more in class-and the other factors she discovered that likely make the social anxiety more profound. (socialthinking.com)
  • The Mass General Psychiatry Academy was launched in 2005 to bring high quality continuing medical education to psychiatrists, primary care doctors, psychologists, social workers, and other health professionals around the world through live programming and the Internet. (massgeneral.org)
  • Being male and belonging to a low social class were independently associated with the likelihood of working while studying. (who.int)
  • state
  • Ag presentation by APC requires both Ag processing and maturation of MHC class II αβ heterodimers to a functional state. (jimmunol.org)
  • school
  • The commission will consist of trained martial arts professionals, medical and emergency health care professionals, sports education experts, and school administration professionals, all working to create a positive environment through the maintenance of training logs, injury logs, and insurance coverage protection. (nysenate.gov)
  • Week
  • You may also be interested in our drop-in dance & fitness classes offered 7 days a week such a Zumba®, Feldenkrais®, Gentle Yoga, and other low impact conditioning classes, or beginning ballet and barre classes. (balletaustin.org)
  • cells
  • Cellular analysis has revealed that AChR-specific lymphocyte proliferation following immunization with AChR depends on MHC class II-restricted CD4 + Th cells and APC ( 3 ). (jimmunol.org)
  • however MHC class II expression can be induced with Interferon (IFN)-γ and further modulated by TNF-α (Dong & Benveniste 2001 In vitro activated astrocytes can stimulate autoreactive T cells and it has been suggested that astrocytes may promote CNS inflammation (Kort et al. (cylch.org)
  • series
  • The Accounting Technician II is a journey-level and specialized class in the paraprofessional accounting series that performs a variety of technical duties in support of the City's Accounts Payable (A/P) and Accounts Receivable (A/R) systems. (calopps.org)
  • Ballet Austin has developed a series of classes and workshops for men and women in their 50's and beyond to promote an active and healthy life. (balletaustin.org)
  • child
  • There are real obstacles to continuing education: parenting responsibilities, financial costs, child care arrangements, and a general scarcity of time. (prospect.org)
  • develop
  • Techniques used during lessons are designed to develop a holistic understanding of music through aural, visual, and tactile cues. (takelessons.com)
  • family
  • Her parents favored a European type of education and as a young girl Roberta and her family lived in Rome, experiencing the culture of Italy, and then traveling throughout Europe. (how2heroes.com)
  • The Massachusetts General Hospital Department of Psychiatry invites you to attend the Patient and Family Education Evening: Behavioral Health and the Launch from Adolescence to Young Adulthood. (massgeneral.org)
  • center
  • Chef McDang plates his sour coconut and galangal soup with the help of Chef David Gilbert, left, and Chef Stephan Pyles, center, during his "Principles of Thai Cookery" class at Sustenio, Saturday, May 19, 2012. (mysanantonio.com)
  • important
  • Evidence from protease inhibitor studies and in vitro digestion of purified class II-Ii complexes implicates endosomal cysteine proteases as important in Ii degradation. (jimmunol.org)