YS5, a human full-length IgG1 with high specificity for CD46, was identified to have high binding affinity for prostate cancer tissue. (wikipedia.org)
By the genetic recombination the viruses were conferred with high specificity against tumor cells without targeting normal tissues. (biomedcentral.com)
Medulloblastoma2
Established medulloblastoma (a malignant brain tumor common in childhood) specimens express CD46, and that medulloblastoma specimens removed from patients had a high level of CD46 expression. (wikipedia.org)
Therefore, a vaccine made of the Edmonston strain of measles virus could treat the medulloblastoma. (wikipedia.org)
Pathogens1
Measles computer virus (MV) is among the most widespread human pathogens causing approximately 1 million deaths worldwide each year mainly due to its immunosuppressive potential (for reviews see recommendations 4 11 and IDH-C227 37). (careersfromscience.org)
Oncolytic11
Oncolytic Virus to Target CD46 and SLC5A5 for Oncology is under clinical development by Vyriad and currently in Phase I for Atypical Teratoid Rhabdoid Tumor. (pharmaceutical-technology.com)
GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Oncolytic Virus to Target CD46 and SLC5A5 for Oncology LoA Report. (pharmaceutical-technology.com)
The virotherapy contains an attenuated oncolytic Edmonston (Ed) strain of measles virus encoding the human thyroidal sodium iodide symporter (MV-NIS) with the gene expression. (pharmaceutical-technology.com)
These noninvasive visualization systems provide real-time follow-up of viral progression within the cancer tissue by the ability of engineered oncolytic viruses (OVs) to encode reporter transgenes based on recombinant technology. (biomedcentral.com)
Oncolytic viruses (OVs) specifically induce cancer cells death by infection of and spreading on tumor cells through different mechanisms such as direct lysis effect or adjacent cells fusion. (biomedcentral.com)
On the other hand, the proliferation of oncolytic viruses into target cells and subsequent recognition of viral elements by pattern recognition receptors (PRRs) such as toll-like receptors can positively affect the development of the innate and adaptive immune responses against tumor cells (Fig. 1 ) [ 6 ]. (biomedcentral.com)
Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues. (biomedcentral.com)
OVT has its unique advantages and prospects, because oncolytic viruses (OVs) preferentially infect and replicate in tumor cells and destroy them, while leaving healthy cells largely untouched [ 7 ]. (biomedcentral.com)
Gene1
CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. (wikipedia.org)
19911
The first application of virotherapy with the engineered thymidine kinase (TK)-deficient herpes simplex viruses (HSV) was initiated in 1991 [ 10 ]. (biomedcentral.com)
Immune2
This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)
At that time, the application of tumor treatment with the spontaneous viruses or wild type viruses which quite often being scavenged by immune system, merely induces a subtle inhibition to tumor progression in patients. (biomedcentral.com)
Interact1
CD46 has been shown to interact with CD9, CD151 and CD29. (wikipedia.org)
Proliferation4
Although anti-SLAM and/or anti-CD46 antibodies stop virus binding they don't hinder the contact-mediated proliferation inhibition. (careersfromscience.org)
The info suggest that proliferation inhibition induced by MV get in touch with is in addition to the existence or absence of the virus-binding receptors SLAM and CD46. (careersfromscience.org)
One aspect of the viral immunosuppression is the proliferation inhibition in response to mitogens T-cell receptor cross-linking or recall antigens of IDH-C227 peripheral blood mononuclear cells (PBMC) isolated from patients (ex vivo) and in vitro. (careersfromscience.org)
We investigated the virus-mediated SLAM modulation and the effect of SLAM engagement around the viral contact-mediated proliferation inhibition of lymphocytes. (careersfromscience.org)
Tumor cells1
With the understanding particularly in the characteristics of viruses and tumor cells, numerous innovative OVs have been engineered to conquer cancers, such as Talimogene Laherparepvec (T-VEC) and tasadenoturev (DNX-2401). (biomedcentral.com)
Strategies1
Multilevel Implementation Strategies for Adolescent Human Papillomavirus Vaccine Uptake: A Cluster Randomized Clinical Trial. (mayo.edu)
Patients1
CD46 (3 16 23 It has been exhibited that MV can efficiently be isolated from patients using B-cell lines such as B95a (19) which lack a complete CD46 (15 28 indicating the presence of another receptor. (careersfromscience.org)
Human3
MV-NIS attacks cells expressing the human CD46 antigen and it also acts as an activator of human thyroidal sodium iodide symporter. (pharmaceutical-technology.com)
The encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6 (HHV-6), group B adenoviruses, and type IV pili of pathogenic Neisseria. (wikipedia.org)
Originally, viruses were known as the cause of human diseases, including some cancers [ 8 ]. (biomedcentral.com)
Cells6
SLAM is usually a glycoprotein belonging to the CD2 subset of the immunoglobulin (Ig) superfamily and is expressed on the surface of a proportion of primary B cells and Epstein-Barr computer virus (EBV)-transformed B cells activated T cells memory T cells T-cell clones and immature thymocytes (39). (careersfromscience.org)
40). For computer virus production cells were infected with a multiplicity of contamination (MOI) of. (careersfromscience.org)
Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)
Meanwhile, these non-engineered viruses sometimes inevitably infect and spread to normal tissues, indiscriminately killed both tumor and normal cells, causing a series of unpredicted side effects. (biomedcentral.com)
Treatment2
Recently, CD46 has emerged as a promising target for the treatment of both adenocarcinoma and neuroendocrine types of metastatic castration-resistant prostate cancer (mCRPC). (wikipedia.org)
The viruses originally used for treatment are usually spontaneous viruses. (biomedcentral.com)
Cancer1
It was not until early 1950s that the potential of viruses as anti-cancer agents had been recognized and applied [ 7 , 9 ]. (biomedcentral.com)
Receptor for measles virus2
also known as CDw150), a recently discovered membrane glycoprotein expressed on some T and B cells, is a cellular receptor for measles virus, including the Edmonston strain. (nih.gov)
The identification of SLAM as a receptor for measles virus opens the way to a better understanding of the pathogenesis of measles virus infection, especially the immunosuppression induced by measles virus. (nih.gov)
Molecule1
Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor. (nih.gov)
Cellular1
Among inactivated influenza vaccines, the whole virus particle vaccine (WPV) elicits superior priming responses to split virus vaccine (SV) in efficiently inducing humoral and cellular immunity. (hokudai.ac.jp)
Clinical3
however, most clinical isolates of measles virus cannot use CD46 as a receptor. (nih.gov)
The distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus. (nih.gov)
Thus, we propose that WPV with a reduced antigen dose should be evaluated for potential clinical usage, especially in naïve populations. (hokudai.ac.jp)
High2
Such a vaccine has already been tested in a number of trials involving other tumor types which have a high expression of CD46, including one type of adult brain tumor. (wikipedia.org)
YS5, a human full-length IgG1 with high specificity for CD46, was identified to have high binding affinity for prostate cancer tissue. (wikipedia.org)