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Multipotent Stem CellsEctodermStem CellsGerm CellsCell DifferentiationSea UrchinsGastrulaCell LineageNeoplasms, Germ Cell and EmbryonalAdult Stem CellsEmbryonic InductionGene Expression Regulation, DevelopmentalStem Cell TransplantationHematopoietic Stem CellsMesenchymal Stromal CellsEndodermMesodermHydraAdipogenesisCells, CulturedEmbryonic Stem CellsHair FollicleNestinRegenerationCell ProliferationCell Culture TechniquesSOXB1 Transcription FactorsTestisXenopusCell SeparationPluripotent Stem CellsSpermatogenesisBone Marrow CellsTranscription FactorsTesticular NeoplasmsMice, TransgenicImmunohistochemistryOsteogenesisSpermatogoniaNeuronsStem Cell NicheNeural Stem CellsHematopoietic Stem Cell TransplantationBiological MarkersMice, Inbred C57BLPhenotypeGene Expression ProfilingReverse Transcriptase Polymerase Chain ReactionFlow CytometryInduced Pluripotent Stem CellsGerm LayersSpermatozoaMesenchymal Stem Cell TransplantationClone CellsCell MovementGerminomaNeural CrestGene Expression RegulationHomeodomain ProteinsCell DivisionSertoli CellsSeminiferous TubulesStem Cell FactorNerve Tissue ProteinsSignal TransductionEmbryo, NonmammalianGonadsEpithelial CellsWheat Germ AgglutininsCell LineSpermatocytesOctamer Transcription Factor-3SpermatidsEmbryo, MammalianIn Situ HybridizationAdipose TissueSeminomaTeratomaFetal Stem CellsBody PatterningTissue EngineeringMolecular Sequence DataMeiosisStem Cell ResearchRNA, MessengerBone Morphogenetic ProteinsBone Morphogenetic Protein 4Nervous SystemChick EmbryoChimeraTooth GermXenopus ProteinsOogenesisProto-Oncogene Proteins c-kitPlant StemsMorphogenesisHematopoiesisOvaryBase SequenceEmbryonic Development
EndodermPluripotent stemAbility to differentiateHematopoieticProgenitor cellsDorsal ectodermEmbryosAdultTissuesStromal cellsSelf-renewalDivide and differentiateMesenchymal stemProliferationPluripotencyEarly embryoDifferentiation potentialTherapyOrganismEctodermalSomatic cellsZygoteRegenerativePopulationsMesodermalIPSCsESCsNeuronsHuman stem cellsLineageEmbryonic developmentTissueVitroRegenerationBody'sMammalianFateBoneMultipotencyCharacterizationResearchGenesOsteoblastsNature of stem cellsLineagesDevelopmental biologyMolecularPotential of stem cellsMurineBlastocystVertebrateVivoDerivationTypesRegenerateOrgansClustersMechanisms
Endoderm6
Pluripotent stem23
Ability to differentiate5
Hematopoietic6
  • For instance, the bone marrow's hematopoietic stem cells may give birth to several types of blood cells. (suzermedclinic.com)
  • For instance, mesenchymal stem cells can develop into bone, cartilage, and fat cells, while hematopoietic stem cells in the bone marrow can produce several types of blood cells. (suzermedclinic.com)
  • Support for the immunological System: Specific stem cells, including hematopoietic stem cells found in the bone marrow, are in charge of producing various blood cells, including white blood cells that are essential for the immunological response. (suzermedclinic.com)
  • We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)
  • The hematopoietic retrodifferentiated stem cells have been shown to engraft an animal host in two proofs of principle clinical studies, demonstrating long-term engraftment and safety in acquired aplastic anaemia, while transient amelioration of beta thalassemia major was also observed. (eurekaselect.com)
  • Examples include hematopoietic (adult) stem cells that can become red and white blood cells or platelets. (asapclinics.com)
Progenitor cells3
  • Adult stem cells can be used to accelerate bone or tendon healing , and they can induce cartilage progenitor cells to produce a better matrix and repair cartilage damage . (thefutureofthings.com)
  • Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture. (sigmaaldrich.com)
  • To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)
Dorsal ectoderm2
Embryos7
  • Embryonic stem cells: Only a few days old embryos are the source of these stem cells. (suzermedclinic.com)
  • Embryonic stem cells (ESCs): These stem cells are commonly collected through in vitro fertilization (IVF) clinics and are derived from embryos at the blastocyst stage. (suzermedclinic.com)
  • Fetal stem cells are isolated from older embryos or fetuses (five to nine weeks old) that have miscarried, or they are harvested after termination of pregnancy. (understanding-stemcells.info)
  • For research purposes, embryonic stem cells from surplus, artificially inseminated embryos (in vitro fertilization) are currently being harvested in various countries, for example in Belgium and the United Kingdom. (understanding-stemcells.info)
  • Whereas such naive pluripotency has been well demonstrated in rodents, poor chimerism has been achieved in other species including non-human primates due to the inability of the donor cells to match the developmental state of the host embryos. (bvsalud.org)
  • After becoming chief pathologist at the University of Wisconsin-Madison Wisconsin Regional Primate Center in 1995, James A. Thomson began his pioneering work in deriving embryonic stem cells from isolated embryos. (asu.edu)
  • Efficient generation of embryonic stem cells from single blastomeres of cryopreserved mouse embryos in the presence of signalling modulators. (axonmedchem.com)
Adult17
Tissues7
  • In addition to their ability to supply cells at the turnover rate of their respective tissues, they can be stimulated to repair injured tissue caused by liver damage, skin abrasions and blood loss. (thefutureofthings.com)
  • Growth and Development: Stem cells divide and differentiate into specialized cell types during embryonic development, resulting in the formation of the body's many tissues and organs. (suzermedclinic.com)
  • They maintain the lifetime and functionality of tissues and organs by regularly diluting and differentiating new cells to replace aging, injured, or dead ones. (suzermedclinic.com)
  • Body cells that can make copies of themselves and differentiate into different cell types or tissues are generally referred to as stem cells. (understanding-stemcells.info)
  • Conditional knockout (cKO) is a genetic technique to inactivate gene expression in specific tissues or cell types in a temporally regulated manner. (bvsalud.org)
  • A stringent characterization pipeline demonstrated that donor cells efficiently (up to 90%) incorporated into various tissues (including the gonads and placenta) of the chimeric monkeys. (bvsalud.org)
  • The progressive generation of chick and mouse axial tissues - the spinal cord, skeleton and musculature of the body - has long been proposed to depend on the activity of multipotent stem cells. (silverchair.com)
Stromal cells2
Self-renewal8
  • Given the considerable interest in using stem cells for modeling and treating disease, it is essential to understand what regulates self-renewal and differentiation. (uib.no)
  • The self-renewal and proliferative nature of stem cells raised the hope to fight against various diseases. (biomedcentral.com)
  • The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. (axonmedchem.com)
  • Octamer-binding transcription factor-4 (Oct4), a transcription factor belongs to the POU transcription factor family Class V, is fundamental for maintaining self-renewal ability and pluripotency of stem cells. (biomedcentral.com)
  • Colony formation assay, sphere-forming ability assay, alkaline phosphatase (AP) activity assay and teratoma-formation assay were used to assess the role of modaline sulfate (MDLS) in promoting self-renewal and reinforcing pluripotency of P19 cells. (biomedcentral.com)
  • Moreover, MDLS significantly promoted the self-renewal capacity of P19 cells. (biomedcentral.com)
  • These findings demonstrated, for the first time, that MDLS could maintain self-renewal and pluripotency of stem cells. (biomedcentral.com)
  • We used conjugated polymers to develop a novel neural stem cell culture substrate with anchored growth factors to promote cell self-renewal. (5dok.org)
Divide and differentiate2
  • What better way to see how cells divide and differentiate than with an unspecialized stem cell? (medium.com)
  • At the top of the list comes the zygote-a fertilized egg, which of course has the ability to divide and differentiate into all cell types in the body and create a new organism. (thefutureofthings.com)
Mesenchymal stem2
  • Information about mesenchyme, specifically mesenchymal stem cell procotols. (sigmaaldrich.com)
  • Step-by-step cell culture protocols for mesenchymal stem cell (MSC) isolation, expansion and differentiation. (sigmaaldrich.com)
Proliferation7
  • In this study, we identified a glutamatergic transmission circuit in ES cells that operates through an autocrine mechanism and regulates cell proliferation. (bvsalud.org)
  • We directly quantified the released glutamate signal using microdialysis-high performance liquid chromatography-tandem mass spectrometry (MD-HPLC-MS-MS). Pharmacological inhibition of endogenous glutamate release and the resulting tonic activation of NMDA receptors significantly affected ES cell proliferation, suggesting that ES cells establish a glutamatergic autocrine niche via releasing and responding to the transmitter for their own regulation. (bvsalud.org)
  • In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
  • Amputation-induced proliferation occurred predominantly within the epidermal and intestinal epithelium, as well as wound-adjacent muscle fibers, where clusters of cells at the same stage of the cell cycle were found. (mdpi.com)
  • This complete characterization of hASCs cultivated in pooled allogeneic human serum, a suitable xeno-free approach, shows that pooled allogeneic human serum provides a high proliferation rate, which can be attributed for the first time to C-MYC protein expression, and showed cell stability for safe clinical applications in compliance with good manufacturing practice. (biomedcentral.com)
  • FGF-10 immunostaining could be related to cell proliferation in epithelium and cell differentiation in epithelium and ectomesenchyme. (bvsalud.org)
  • Eph/ephrin signaling is a cell-to-cell communication pathway, which regulates cell migration and proliferation. (5dok.org)
Pluripotency3
  • Remodeling of mitochondria and metabolism, with the shift from glycolysis to oxidative phosphorylation (OXPHOS), plays a fundamental role in maintaining pluripotency and stem cell fate. (uib.no)
  • In addition, we found that in the presence of LIF, MDLS could replace feeder cells to maintain the undifferentiated state of OG2-mES cells (Oct4-GFP reporter gene mouse embryonic stem cell line), and the MDLS-expanded OG2-mES cells showed an elevated expression levels of pluripotency markers in vitro. (biomedcentral.com)
  • Therefore, finding a way to effectively maintain the pluripotency of stem cells cultured in vitro is important for the application of stem cells. (biomedcentral.com)
Early embryo1
  • Germ cells are cells that form the germ line and are already predetermined for development of the next cell generation in the early embryo. (understanding-stemcells.info)
Differentiation potential3
  • This general definition includes a wide variety of cells with varying degrees of differentiation potential. (thefutureofthings.com)
  • Since suboptimal media may change the differentiation potential of stem cells, it is vital to select the correct stem cell-validated media and reagents at the start of your research process. (sigmaaldrich.com)
  • Furthermore, MDLS could promote teratoma formation and enhanced differentiation potential of P19 cells in vivo. (biomedcentral.com)
Therapy8
  • Avant-garde approaches to stem-cell therapy may be the first stepping-stones to a bright new future of stem-cell medicine and are emerging in leading laboratories worldwide. (thefutureofthings.com)
  • Cell invasion is a crucial step of tumor metastasis , finding new regulators of which offers potential drug targets for cancer therapy. (sdbonline.org)
  • It includes the possible stem cell therapy mechanisms involved and outcomes recorded so far, the limitations of using these regenerative medicines, and the progressive improvement in stem cell therapy by adopting approaches like PiggyBac, Sleeping Beauty, and the Sendai virus. (biomedcentral.com)
  • Fetal bovine serum is the supplement most widely used for cell culture, but it has disadvantages and it is not safe for cell therapy due to the risks of pathogen transmission and immune reaction. (biomedcentral.com)
  • However, one of the bottlenecks in the stem cell therapy is that stem cells tend to differentiate into other types of cells during culture in vitro. (biomedcentral.com)
  • STEM CELL THERAPY IN UKRAINE AND RUSSIA Recently, there have been changes in stem cells treatment laws in Ukraine and Russia. (nbscience.com)
  • The goal for stem cell therapy is to use healthy stem cells found in the body to replace or activate your body's own stem cells at an injured site. (asapclinics.com)
  • Stem Cell Therapy introduces large amounts of regenerative factors to the injured tissue to substantially increase your body's healing potential and ability. (asapclinics.com)
Organism4
  • The term ontogeny has also been used in cell biology to describe the development of various cell types within an organism. (wikipedia.org)
  • The first three divisions of the zygote give birth to eight totipotent cells, each of which also has the ability to become an entire organism. (thefutureofthings.com)
  • Embryonic stem cells are isolated from the internal cell mass (embryoblast), from which the whole organism develops during natural embryonic development. (understanding-stemcells.info)
  • The authors begin the paper by noting their desire to find a method for inducing somatic cells of patients to return to a pluripotent state, a state from which the cell can differentiate into any type of tissue but cannot form an entire organism. (asu.edu)
Ectodermal2
  • Thus, our work highlights similarities in mitochondrial remodeling during the transition from pluripotent to multipotent state in ectodermal and mesodermal lineages, while at the same time demonstrating cell-lineage-specific adaptations upon further differentiation. (uib.no)
  • Resting on this archetypal chordate body plan, unique populations of cells, the neural crest and the ectodermal placodes, evolved in craniates (referred to here as 'vertebrates' for simplicity). (biomedcentral.com)
Somatic cells1
  • In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
Zygote2
  • Cells that can do this are found when the zygote first starts to divide in the uterus. (medium.com)
  • Examples are the zygote formed at egg fertilization and the first few cells that result from the division of the zygote. (asapclinics.com)
Regenerative5
  • Stem cells and their potential for regenerative medicine, including the treatment of illnesses, injuries, and hereditary problems, are now the subject of ongoing research. (suzermedclinic.com)
  • Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
  • Atta-ur-Rahman, Shazia Anjum , " Frontiers in Stem Cell and Regenerative Medicine Research ", Bentham Science Publishers (2017). (eurekaselect.com)
  • Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases. (biomedcentral.com)
  • 1 Institute for Stem Cell Research and MRC Centre for Regenerative Medicine,University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JQ,UK. (silverchair.com)
Populations6
  • Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)
  • Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
  • Thus, to understand the origin of the vertebrates is to understand how these cell populations became developmentally and evolutionarily coupled in our earliest vertebrate ancestors. (frontiersin.org)
  • Here, we present a multimodal -omics platform for the comprehensive study of cell populations in complex tissue, which has allowed us to characterize the cells involved in wound healing across both time and space. (stanford.edu)
  • Here, we address these questions by analyzing the effects of targeted signaling manipulations in differentiating stem cell populations at single-cell resolution. (biologists.com)
  • Although the main cell-cell communication systems that drive and coordinate differentiation in cell populations have been identified, how these systems interact in signaling networks is still not well understood. (biologists.com)
Mesodermal1
  • The BMP, Wnt and Nodal signaling requirements for the differentiation of specific mesoderm subtypes in mammals have been mapped in detail, but how FGF shapes mesodermal cell type diversity is not precisely known. (biologists.com)
IPSCs3
  • iPSCs can develop into distinct cell types as a result of this. (suzermedclinic.com)
  • The advantage of iPSCs is that they do not raise the ethical issues raised by embryonic stem cells. (suzermedclinic.com)
  • We offer a large collection of cell culture media, supplements, bioactive small molecules, and growth factors used to control the cell fate of human iPSCs. (sigmaaldrich.com)
ESCs2
Neurons4
  • For example, your nerve cells, aka your neurons, have long connections that help them transmit messages throughout our nervous system. (medium.com)
  • A particular field encouraged by the foundation is stem-cell research, with the great hope that it will result in the ability to get cells to differentiate into neurons and support cells to bridge the gap of a spinal cord injury. (thefutureofthings.com)
  • They have the capacity to develop into the three cell types necessary for the maintenance and repair of the nervous system: neurons, astrocytes, and oligodendrocytes. (suzermedclinic.com)
  • ReNcell neural progenitors are immortalized human neural stem cell lines that can differentiate into neurons, astrocytes sand oligodendrocytes. (sigmaaldrich.com)
Human stem cells2
Lineage8
  • In Drosophila with depleted RACK1 in all muscle cells or, specifically, in SC lineage resulted in a delayed recovery of skeletal muscle after physical damage as well as the low presence of active SC in the wound area. (sdbonline.org)
  • The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
  • This requirement strongly limits the number of solutions or entiation and lineage-specification, programmed cell death, and ``states'' for the system. (lu.se)
  • 2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
  • Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
  • During this process, leukocytes lose lineage-associated markers home and undergo homocytic aggregation, upregulate expression of stem cell antigens, and subsequently redifferentiate to give rise original tissue or, transdifferentiate into a different tissue altogether. (eurekaselect.com)
  • A remarkable proportion of the new neural crest genes encode soluble ligands that control neural crest precursor specification into each cell lineage, including pigmented, neural, glial, and skeletal derivatives. (biomedcentral.com)
  • We propose that the evolution of the neural crest is linked not only to the recruitment of ancestral regulatory genes but also to the emergence of signaling peptides that control the increasingly complex lineage diversification of this plastic cell population. (biomedcentral.com)
Embryonic development2
Tissue21
  • Replace the damaged tissue with stem cells that will develop into healthy heart cells. (medium.com)
  • A unique class of cells in the body called stem cells has the extraordinary capacity to differentiate into many cell and tissue types. (suzermedclinic.com)
  • Stem cells have the capacity to replace ill or damaged body cells in tissue repair and regeneration. (suzermedclinic.com)
  • These stem cells have a potential that in the transition between embryonic and tissue stem cells. (understanding-stemcells.info)
  • However, they still grow faster than tissue stem cells, which are already defined as cell types of a particular tissue. (understanding-stemcells.info)
  • Mesenchymal stem cells (MSC) are tissue stem cells originating in the mesoderm germ layer. (understanding-stemcells.info)
  • It has been demonstrated that MSC can differentiate into chondrocytes (cartilage-forming cells), osteoblasts (bone-forming cells) and adipocytes (adipose tissue cells). (understanding-stemcells.info)
  • Bone cell' Bone cells', which are found within the bone tissue, are responsible for the make-up of the skeleton of vertebrates. (patsnap.com)
  • They are made up of different bone cells: there is the compact tissue which is the hard outer part of the bone, the cancellous tissue which is all the spongy tissue inside of the compact tissue, and the subchondral tissue which is the smooth tissue at the end of each bone. (patsnap.com)
  • The ability to expand pluripotent cells in vitro and subject them to direct differentiation to produce specific cell types is crucial to the development of cell-based therapies to replace or restore tissue that has been damaged by disease or injury. (sigmaaldrich.com)
  • The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
  • GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
  • Human adipose tissue-derived stem cells (hASCs) are attractive cells for therapeutic applications and are currently being evaluated in multiple clinical trials. (biomedcentral.com)
  • and (2) through the paracrine release of trophic factors to induce tissue repair by endogenous cells [ 6 ]. (biomedcentral.com)
  • The robustness and efficacy of the retrodifferentiation process in generating unprecedented quantities of stem cells belonging to the three germ layers will enable organ and tissue reconstruction ex vivo, using bio-printing and various scaffold materials. (eurekaselect.com)
  • Epimorphic regeneration and retrodifferentiation both have the capacity to recreate and reconstruct tissue with precise positional integration of cells in such a way that will enable us to heal without scars and to understand how to maintain tissue integrity and architecture in the face of a hostile environment. (eurekaselect.com)
  • The postcranial axis (i.e. tissue caudal to the head) is then generated over an extended period in a rostral-to-caudal sequence by cells that are derived from the primitive streak and the adjacent epiblast cells, which together eventually form the tail bud. (silverchair.com)
  • These cells don't carry out specialized functions like brain, red, or white blood cells, but they are the most vital component in repairing and replacing damaged or torn tissue. (asapclinics.com)
  • When you have damaged tissue anywhere in your body, the damaged tissue signals to your body's own stem cells. (asapclinics.com)
  • This injection of stem cells and various other growth factors is believed to activate your body's own stem cells to start healing the injured tissue. (asapclinics.com)
  • ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. (thermofisher.com)
Vitro5
  • Differentiation is triggered by various factors in vivo , some of which can be replicated in in vitro stem cell cultures. (sigmaaldrich.com)
  • These protocols, such as organoid cell culture methods, have provided more predictive in vitro cellular "Disease-in-a-Dish" models. (sigmaaldrich.com)
  • Un rôle majeur des prostaglandines dans l'hématopoïèse, ainsi mis en évidence, a pu être étendu à la souris chez qui un traitement par la prostaglandine PGE2 provoque la multiplication des CSH in vivo et in vitro, un résultat qui génerera très probablement des applications cliniques. (hypotheses.org)
  • However, the limited amount of stem cells and their tendency to undergo spontaneous differentiation upon extended propagation in vitro restrict their practical application. (biomedcentral.com)
  • Using biologically relevant elastic substrates to study cell function in vitro has proven beneficial, as the in vivo microenvironment usually is much softer than rigid plastic dishes. (5dok.org)
Regeneration3
Body's1
  • Cells also contain the body's hereditary material and can make copies of themselves. (asapclinics.com)
Mammalian1
  • The early mammalian embryo consists of the extra-embryonic cell layers-the trophoblast and a body of cells called the inner cell mass (ICM), which eventually become the embryo proper. (thefutureofthings.com)
Fate6
  • The cells of the ICM are no longer omnipotent, because they no longer share the fate of the trophoblast, and they have committed themselves to an embryonic fate with the ability to become any cell in the body (but not the trophoblast). (thefutureofthings.com)
  • A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
  • In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)
  • SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. (axonmedchem.com)
  • Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions. (axonmedchem.com)
  • This signaling pathway is a highly conserved cell-to-cell communication system that regulates cell fate in development and disease. (5dok.org)
Bone6
  • They have the capacity to develop into several cell types, including fat, cartilage, and bone cells. (suzermedclinic.com)
  • Bone cells all work together inside of the bones to help keep up the skeletal system. (patsnap.com)
  • The bone cells do many things for the skeletal system such as the development of new bones, the maintenance of bones, and the regulation of minerals in the body. (patsnap.com)
  • Types There are four main categories of bone cells which include: lining cells, which protect the boneOursler, Merry J., and Teresita Bellido Bellido. (patsnap.com)
  • while the subchondral bone region enhances the environment for cells which migrate into that region's macrostructure and which differentiate into osteoblasts. (patsnap.com)
  • Both have potential to differentiate into different cell types (such as skin, muscle, bone, etc. (asapclinics.com)
Multipotency1
Characterization1
Research10
  • Another way stem cells are useful are their potential to aid research. (medium.com)
  • Stem cells are at the forefront of medical research and incite some of the most controversial ethical and religious debates worldwide. (thefutureofthings.com)
  • While regarded by many top scientists as the Holy Grail of medicine, others consider embryonic stem-cell research sacrilegious. (thefutureofthings.com)
  • Recent advances in the field of stem-cell research are giving hope to millions. (thefutureofthings.com)
  • Importing hES cells for research purposes is also generally prohibited but may be allowed under certain conditions. (understanding-stemcells.info)
  • This lawsuit was filed in hopes of gaining injunctive relief against a moratorium on the federal funding of stem cell research. (asu.edu)
  • The plaintiffs in the case were seven prominent scientists who performed embryonic stem cell research and three patients: James Thomson, Roger Pedersen, John Gearhart, Douglas Melton, Dan Kaufman, Alan Trounson, Martin Pera, Christopher Reeve, James Cordy, and James Tyree. (asu.edu)
  • Recent advances in the realm of stem cell research are due to the advent of CRISPR genome editing technology and more advanced 3D cell culture techniques. (sigmaaldrich.com)
  • So as a new therapeutic approach, stem cells are under research with a focus on reducing the burden of several kidney diseases. (biomedcentral.com)
  • The ease by which various stem cell types can be generated from human peripheral blood has allowed the design of various kits to guarantee the specificity, sterility and efficacy of stem cells production for various clinical and research applications. (eurekaselect.com)
Genes6
  • Scientists may "reprogram" mature cells, such skin cells, to behave like embryonic stem cells by inserting particular genes. (suzermedclinic.com)
  • In 2006, the Japanese scientist Shinya Yamanaka used viruses to introduce the genes Oct4, Sox2, cMyc and Klf4 into mouse body cells for the first time, activating quiescent developmental genes. (understanding-stemcells.info)
  • However, Yaf2 knockout promotes neural differentiation and leads to redistribution of RYBP binding, increases enrichment of RYBP and H2AK119ub on the RYBP-YAF2 cotargeted genes, and prevents ectopic derepression of nonneuroectoderm-associated genes in neural-differentiated cells. (bvsalud.org)
  • explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)
  • Immunofluorescence, RT-PCR, and western blotting were used to measure expression changes of stem-related genes and activation of related signaling pathways. (biomedcentral.com)
  • The identification of neural crest specification genes expressed in the neural plate of basal chordates, in addition to the discovery of pigmented migratory cells in ascidians, has challenged this hypothesis. (biomedcentral.com)
Osteoblasts1
  • In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts. (patsnap.com)
Nature of stem cells1
Lineages1
  • Cell viability and differentiation capacity toward the mesenchymal lineages were assessed, along with immunophenotype. (biomedcentral.com)
Developmental biology1
  • Frontiers in Cell and Developmental Biology. (uib.no)
Molecular3
  • Molecular Cell , 82 (1), 190-208. (axonmedchem.com)
  • Molecular cell, 82(1), 106-122. (axonmedchem.com)
  • We also review the location and molecular characteristics of these putative stem cells, along with their evolutionary conservation in vertebrates and the signalling mechanisms that regulate and arrest axis extension. (silverchair.com)
Potential of stem cells1
  • The biological properties and clinical potential of stem cells elicit that are generated must not be unduly sensitive to small fluctu- continued scientific, commercial, and public interest. (lu.se)
Murine1
Blastocyst1
Vertebrate1
  • This cell population is considered a vertebrate innovation and, accordingly, chordate ancestors lacked neural crest counterparts. (biomedcentral.com)
Vivo1
  • Prior to their clinical application, hASCs must be expanded ex vivo to obtain the required number of cells for transplantation. (biomedcentral.com)
Derivation1
  • That same year, Thomson published his first paper, "Isolation of a Primate Embryonic Stem Cell Line," in Proceedings of the National Academy of Sciences of the United States of America, detailing the first derivation of primate embryonic stem cells. (asu.edu)
Types6
  • The higher the potency, the more types of cells that the stem cell can differentiate into. (medium.com)
  • Based on their place of origin and capacity for development, several stem cell types are divided into categories. (suzermedclinic.com)
  • Stem cells have the unique ability to self-renew or to differentiate into various cell types in response to appropriate signals. (sigmaaldrich.com)
  • Each cell population has its own distinct developmental features and generates unique cell types. (frontiersin.org)
  • Shortly after their dorsal specification, neural crest cells undergo an epithelial-to-mesenchymal transition, migrate, and finally, upon arrival at their destination, they give rise to a variety of cell types. (biomedcentral.com)
  • Stem cells are categorized by their potential to differentiate into other types of cells. (asapclinics.com)
Regenerate1
  • The ability of stem cells to proliferate and regenerate themselves over a lengthy period of time makes it possible for them to replenish other cells in the body. (suzermedclinic.com)
Organs3
  • Another goal is to grow functioning organs from stem cells that match the patient's immune system to prevent complications. (medium.com)
  • During the development of multicellular organisms, precursor cells for specialized organs need to differentiate in reproducible proportions and in spatially coherent domains. (biologists.com)
  • The emergence of these pluripotent cells is linked to the evolution of more sophisticated sensory and predatory organs (for instance, jaws). (biomedcentral.com)
Clusters1
  • The NASA comprehensive germ VEGF found clusters that begin conducted NASA SBIR or STTR struts to be in the AGATE Alliance as Advanced cookies. (need4speed.com)
Mechanisms1
  • While much is known about biochemical signaling, many of the mechanisms that drive cell outcome in response to biophysical influences remain to be uncovered. (5dok.org)