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CCAAT-Enhancer-Binding Protein-alphaCCAAT-Enhancer-Binding ProteinsCCAAT-Enhancer-Binding Protein-betaCCAAT-Enhancer-Binding Protein-deltaDNA-Binding ProteinsAdipocytesPromoter Regions, GeneticNuclear ProteinsTranscription FactorsAdipogenesisCell DifferentiationEnhancer Elements, Genetic3T3-L1 CellsGene Expression RegulationGranulocytesTranscriptional Activation3T3 CellsRNA, MessengerPPAR gammaGene Expression Regulation, LeukemicBase SequenceLeukemia, Myeloid, AcuteTranscription, GeneticCell LineLiverTranscription Factor CHOPMutationMolecular Sequence DataTransfectionElectrophoretic Mobility Shift AssayBinding SitesDown-RegulationProtein BindingAdipose TissueCells, CulturedResponse ElementsTranscription Factor AP-2Gene ExpressionCell NucleusMyelopoiesisSignal TransductionGTP-Binding Protein alpha SubunitsGenes, ReporterDNABlotting, WesternChromatin ImmunoprecipitationTrans-ActivatorsTumor Cells, CulturedUp-RegulationDNA PrimersMice, KnockoutLuciferasesGene Expression Regulation, EnzymologicLeucine ZippersProtein IsoformsEndrinRegulatory Sequences, Nucleic AcidHepatocyte Nuclear Factor 3-betaAmino Acid SequenceHeLa CellsReverse Transcriptase Polymerase Chain ReactionAcute-Phase ReactionNF-kappa B p50 SubunitMice, TransgenicMice, Inbred C57BLU937 CellsCarrier ProteinsCell Line, TumorDexamethasoneRNA Polymerase Sigma 54Cyclic AMP Response Element-Binding ProteinRecombinant Fusion ProteinsPhosphorylationReceptors, Cytoplasmic and NuclearNF-kappa BBlotting, NorthernGlucocorticoidsOligonucleotidesMutagenesis, Site-DirectedRNA, Small InterferingHL-60 CellsGene Expression Regulation, NeoplasticTranscription Factor AP-1HepatocytesEpithelial CellsEndoplasmic Reticulum StressRepressor ProteinsInterleukin-6ImmunohistochemistryMonocyte-Macrophage Precursor CellsApoptosisCloning, MolecularCell ProliferationProto-Oncogene ProteinsPlasmidsRecombinant ProteinsEndoplasmic ReticulumCell DivisionFibroblastsLipopolysaccharides
CEBPAPromoterGene
CEBPA2
  • The MTL-CEBPA is composed of a double-stranded RNA formulated into a SMARTICLES liposomal nanoparticle, and is intended to activate the CEBPA gene, which encodes the CCAAT / enhancer binding protein alpha (C/EBP-a). (clinicaltrialsarena.com)
  • 13. Combined testing for CCAAT/enhancer-binding protein alpha (CEBPA) mutations and promoter methylation in acute myeloid leukemia demonstrates shared phenotypic features. (nih.gov)
Promoter4
  • 5. Hypermethylation of the GATA binding protein 4 (GATA4) promoter in Chinese pediatric acute myeloid leukemia. (nih.gov)
  • 7. C/EBPA gene mutation and C/EBPA promoter hypermethylation in acute myeloid leukemia with normal cytogenetics. (nih.gov)
  • 10. Aberrant methylation of CCAAT/enhancer binding protein zeta promoter in acute myeloid leukemia. (nih.gov)
  • C/EBPΑ (CCAAT/enhancer binding protein (C/EBP) alpha), a protein encoded by the C/EBPΑ gene in humans, was originally identified 30 years ago as a transcription factor that binds both promoter and enhancer regions. (scientificarchives.com)
Gene2
  • Transcription factors are key regulators of these cells acting through their capacity to bind DNA and control gene transcription, which thus regulates the development of specific hematopoietic lineages from stem cells. (scientificarchives.com)
  • Several mediators are involved in lipid metabolism, including sterol regulatory element-binding protein-1c (SREBP-1c) and CCAAT/enhancer binding protein alpha (C/EBPα), which are important transcription factors involved in the regulation of lipogenic gene mRNA expression. (springer.com)