• EBNA3C is an EBV-encoded nuclear protein, essential for proliferation of EBV infected B-lymphocytes. (scienceopen.com)
  • When both proteins are overexpressed, Gadd34 can interact with EBNA3C in both nuclear and cytoplasmic compartments. (scienceopen.com)
  • One such gene is the EBV nuclear antigen EBNA3C. (pennmedicine.org)
  • EBNA3C is a large nuclear transcription factor involved in modulating transcription activated by a cellular repressor RBP-Jkappa and other transcription factors. (pennmedicine.org)
  • Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA3C) is one of the essential latent antigens for primary B-cell transformation. (interleukinreceptor.com)
  • Previous studies established that EBNA3C facilitates degradation of several vital cell cycle regulators, including the retinoblastoma (pRb) and p27(KIP) proteins, by recruitment of the SCF(Skp2) E3 ubiquitin ligase complex. (interleukinreceptor.com)
  • Various mechanisms have been proposed for the proliferative effects, including the up-regulation of cyclin D2 by the viral EBNA-2 and EBNA-LP proteins, direct binding of EBNA3C to the retinoblastoma protein (pRb), and down-regulation of the p16(INK4A) tumour suppressor by the viral LIMP1 product. (figshare.com)
  • These mimic external growth signals (LMP1 and LMP2) Clemastine fumarate or directly regulate gene manifestation (EBNA2 EBNA3c) therefore driving the infected cell into proliferation [7]. (colinsbraincancer.com)
  • Furthermore, interaction is lost with a mutant of EBNA3C ( 509 DVIEVID 515 →AVIAVIA), that abolishes EBNA3C coactivation ability as well as SUMO interaction[ 1 ]. (scienceopen.com)
  • Using EBNA3C amino acids 365-545 in a yeast two hybrid screen, we found an interaction with the Growth Arrest and DNA-damage protein, Gadd34. (scienceopen.com)
  • Our results provide novel insights into the function of EBNA3C on cell progression by regulating the cyclin D2 protein and raise the possibility of the development of new anticancer therapies against EBV-associated cancers. (cusabio.cn)
  • 3. Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP. (nih.gov)
  • Dr. Sample has investigated the function of the latency-associated EBNA3A and EBNA3C that are essential for EBV-driven proliferation and demonstrated that these are transcription factors that function through a cellular intermediate, the CSL protein, which is the intracellular signaling protein of the Notch pathway. (psu.edu)
  • During his Ph.D in the laboratory of Professor Martin Allday, Dr. Kalchschmidt investigated the molecular mechanisms by which Epstein-Barr virus nuclear antigen 3C (EBNA3C) regulates host gene expression. (nih.gov)
  • 20. Epstein-Barr virus nuclear antigen 3A partially coincides with EBNA3C genome-wide and is tethered to DNA through BATF complexes. (nih.gov)
  • Furthermore, unexpected recruitment of the DNA-binding transcription factor RBPJ at EBNA3C binding sites was detected only when EBNA3C was functional. (nih.gov)
  • This challenged existing models of how RBPJ, a repressive transcription factor of the Notch signaling pathway, functions in EBNA3C-mediated gene regulation. (nih.gov)
  • Importantly, there were 15 nonsynonymous variations, including 8 in the latent cycle gene EBNA3C that were associated with the development of PTLD. (nih.gov)
  • Intrigued by the fact that EBNA3C can act as either activator or repressor of its target genes, he chose to study the most upregulated gene ( AICDA ) and the three most repressed genes ( COBLL1 , ADAM28, and ADAMDEC1 ). (nih.gov)
  • Changes to histone modifications at these loci correlated well with gene expression and indicated a two-step mechanism for EBNA3C-mediated repression. (nih.gov)
  • Surprisingly, recruitment of a Polycomb protein, generally linked to gene repression, was observed at all four genes, irrespective of being activated or repressed by EBNA3C. (nih.gov)
  • 16. Epstein-Barr virus essential antigen EBNA3C attenuates H2AX expression. (nih.gov)