• Stanley Paul Leibo studied the cryopreservation of embryos in the US in the twentieth century. (asu.edu)
  • Later, Leibo and his team accomplished one of the first successful births using previously-frozen mammalian embryos. (asu.edu)
  • The researchers used 4D OCT to obtain structural and Doppler hemodynamic imaging of the beating heart in live mouse embryos at embryonic day 9.25. (photonics.com)
  • Cell surface molecules expressed on embryos in a stage-specific manner appeared to play key roles in regulation of cell-cell interaction and cell sorting during early development. (nih.gov)
  • The paper "Formation of Genetically Mosaic Mouse Embryos and Early Development of Lethal (t 12 /t 12 )-Normal Mosaics," by Beatrice Mintz, describes a technique to fuse two mouse embryos into a single embryo. (asu.edu)
  • At early stages, embryos are surrounded by a protective layer named the zona pellicula that prevents two embryos from fusing. (asu.edu)
  • The development of a method for fusing two embryos has proved useful in many ways besides the direct study of the embryos. (asu.edu)
  • Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA methylation in pre-implantation rhesus monkey embryos as well as male and female gametes studied using an optimized tagmentation-based whole-genome bisulfite sequencing method. (nature.com)
  • Although the genome-wide DNA demethylation is believed to be a hallmark of mammalian embryogenesis, previous study also indicated that the somatic form of dnmt1 ( dnmt1s ) is actually expressed at each stage of pre-implantation embryos and plays a role in the maintenance of DNA imprinting 8 . (nature.com)
  • Furthermore, due to ethical and legal concerns, very limited techniques can be applied to human embryos to validate some of significant conclusions drawn from descriptive studies regarding human embryonic development. (nature.com)
  • When nonhuman mammalian development is compared with human development, the study subjects must be compared at the same developmental stage (fetal, perinatal, postnatal) When collected appropriately, data from experimental studies of nonhuman mammalian embryos elucidate important aspects of human facial development. (medscape.com)
  • These studies led to our discovery of a novel type of pluripotent epiblast stem cell (EpiSC) from the late epiblast layer of mouse and rat embryos. (qscience.com)
  • Pluripotent epiblast cells of early mammalian embryos give rise to all the lineages that make up a fetus. (cam.ac.uk)
  • Indeed, human and mouse embryos differ substantially during the period when the epiblast develops, and this seems to impact how embryonic lineages are determined. (cam.ac.uk)
  • At the cellular level, fibroblasts from Hat1 haploinsufficient embryos undergo early senescence and accumulate high levels of p21. (nih.gov)
  • In mammalian embryos, DNA methylation is initialized to maximum levels in the epiblast by the de novo DNA methyltransferases DNMT3A and DNMT3B before gastrulation diversifies it across regulatory regions. (bvsalud.org)
  • Self-organization of stem cells into embryos: A window on early mammalian development. (cam.ac.uk)
  • Although the precise developmental stage when production of these factors begins has not been established, the data suggest that these factors are released by cell types associated with early postimplantation embryos. (nebraska.edu)
  • This application proposes to address several important questions concerning TGF-like growth factors released by early mouse embryos: 1) What are their identities? (nebraska.edu)
  • We are very optimistic that this will allow us to study key events of this critical stage of human development without actually having to work on embryos. (cam.ac.uk)
  • We show that the conditional depletion of the m 6 A reader protein Ythdf2 in mice causes lethality at late embryonic developmental stages, with embryos characterized by compromised neural development. (biomedcentral.com)
  • Here, we establish an in vitro system to culture human embryos through implantation stages in the absence of maternal tissues and reveal the key events of early human morphogenesis. (futuristech.info)
  • Using human embryos and human pluripotent stem cells, we show that the reorganization of the embryonic lineage is mediated by cellular polarization leading to cavity formation. (futuristech.info)
  • Herceg, Z., Hulla W., Gell D., Cuenin C., Lleonart M., Jackson S. and Wang Z.Q. (2001) Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. (who.int)
  • Determining the functions of novel genes implicated in cell survival is directly relevant to our understanding of mammalian development and carcinogenesis. (monash.edu)
  • In vertebrates, the development of limbs and digits depends on the secretion of sonic hedgehog by the zone of polarizing activity, located on the posterior side of the embryonic limb bud. (wikipedia.org)
  • This protein sends short- and long-range signals to embryonic tissues to regulate development. (wikipedia.org)
  • 4D OCT could potentially enable scientists to assess cardiac pumping over embryonic development as the heart tube remodels, which could reveal functional changes during early cardiogenesis that lead to congenital heart defects. (photonics.com)
  • Eyal Karzbrun is interested in understanding the collective cellular behaviors, which drive embryonic brain development. (ucsb.edu)
  • GSL expression during mouse early development was shown to shift rapidly from globo-series to neolacto/lacto-series, and then to ganglio-series. (nih.gov)
  • Similar shifting of GSL expression profiles from globo-series and neolacto/lacto-series to ganglio-series was observed during differentiation of human EC cells and embryonic stem (ES) cells, reflecting the essential role of cell surface glycoconjugates in early development. (nih.gov)
  • This technique was developed to study the t 12 mutation, which arrests development at the morula stage. (asu.edu)
  • The interest of the Institute in developmental biology is rooted back at the time when IGB researchers pioneered mouse genetics using gene targeting techniques to study mammalian embryonic development. (cnr.it)
  • The current research activity focuses at unravelling the genetic and the molecular basis of embryo development, with particular emphasis on the early stages of mammalian embryogenesis as well as on muscular, cardiovascular and neural differentiation. (cnr.it)
  • We therefore decided to investigate comprehensively the global and high-resolution DNA methylation dynamics during early development of a non-human primate (rhesus monkey, Macaca mulatta ). (nature.com)
  • Monkeys have served as one of the most valuable models for understanding DNA methylation dynamics during early embryogenesis in human due to their similarities in genetics and early embryonic development 17 , 18 . (nature.com)
  • The ectoderm is well around the stomodeum by the fourth week of embryonic development and contributes to the formation of the face and the nasal and oral cavities. (medscape.com)
  • At the early stages of embryonic development, the vertebrate face has a common plan. (medscape.com)
  • The worm benefits from many of the advantages of yeast as a genetically tractable organism for these kinds of studies while offering the unique opportunity to probe how these pathways have been extended and modified in the context of a multicellular animal undergoing development to produce diverse cell types such as muscles, nerves, and polarized epithelia. (wormbook.org)
  • We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
  • We previously reported that Hat1 is required for viability and important for mammalian development and genome stability. (nih.gov)
  • Embryonic development involves massive proliferation and differentiation of cell lineages. (bvsalud.org)
  • Embryonic development is orchestrated by robust and complex regulatory mechanisms acting at different scales of organization. (cam.ac.uk)
  • The roles of hormones and growth factors during the early stages of mammalian development are poorly understood. (nebraska.edu)
  • However, it has not been determined whether these factors are released at earlier stages of development. (nebraska.edu)
  • The work proposed in this application will help to clarify the roles of growth factors during early development and help determine whether further study of embryonic growth factors is likely to yield assays suitable for monitoring normal preimplantation development. (nebraska.edu)
  • We report that ARS2 is transcribed throughout embryonic development and is expressed ubiquitously in mouse and human tissues. (monash.edu)
  • These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process. (monash.edu)
  • Here, we describe the identification and cloning of their zebrafish homologues and demonstrate a novel role for the ligand, but not the receptor, in early vertebrate development. (ed.ac.uk)
  • Understanding the very early stages of embryo development is of interest because this knowledge may help explain why a significant number of human pregnancies fail at this time. (cam.ac.uk)
  • The particular stem cells that will eventually make the future body, the embryonic stem cells (ESCs) cluster together inside the embryo towards one end: this stage of development is known as the blastocyst. (cam.ac.uk)
  • This is because early embryo development requires the different types of cell to coordinate closely with each other. (cam.ac.uk)
  • However, in a study published today in the journal Science , Cambridge researchers describe how, using a combination of genetically-modified mouse ESCs and TSCs, together with a 3D scaffold known as an extracellular matrix, they were able to grow a structure capable of assembling itself and whose development and architecture very closely resembled the natural embryo. (cam.ac.uk)
  • Both the embryonic and extra-embryonic cells start to talk to each other and become organised into a structure that looks like and behaves like an embryo," explains Professor Magdalena Zernicka-Goetz from the Department of Physiology, Development and Neuroscience, who led the research. (cam.ac.uk)
  • The first alpha-globulins to appear in mammalian sera during development of the embryo and the dominant serum proteins in early embryonic life. (curehunter.com)
  • 2) What are the requirements for DNA replication and transcription at the beginning of mammalian development? (nih.gov)
  • Implantation of the blastocyst is a developmental milestone in mammalian embryonic development. (futuristech.info)
  • Here we report the use of a novel in vitro system to study the post-implantation development of the human embryo. (futuristech.info)
  • Our findings highlight the species-specificity of these developmental events and provide a new understanding of early human embryonic development beyond the blastocyst stage. (futuristech.info)
  • In this study, we identified both temporal and localization changes in expression of DmFKBP12, a translational and transcriptional regulator of Drosophila RyR (DmRyR) and FKBP12, through embryonic development. (biomedcentral.com)
  • During embryonic development, the programmed death of certain cells plays an essential role in shaping organs and allowing proper growth. (phys.org)
  • While mechanisms of embryonic development are well conserved among mammals, the progression speed tends to be slower in larger species. (irbbarcelona.org)
  • We have recently recapitulated the segmentation clock, oscillatory gene expression during early development, from human and mouse pluripotent stem cells. (irbbarcelona.org)
  • This process informs animal model development to enhance scientific rigor during in vivo studies in experimental or naturally occurring disease models. (upenn.edu)
  • This study was conducted to evaluate in vivo and in vitro development of in vitro-matured equine oocytes fertilized by intracytoplasmic sperm injection. (bioone.org)
  • During early mammalian embryonic development, trophoblast cells play an essential role in establishing cell-cell interactions at the maternal-fetal interface to ensure a successful pregnancy. (edu.au)
  • Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
  • Followup study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic benzene exposure. (cdc.gov)
  • The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
  • 2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)
  • Specifically, we study the genetic, epigenetic and metabolic control of pluripotent and adult stem cells, and the molecular circuitries governing the decision between self-renewal and commitment to differentiation, both in physiology and disease. (cnr.it)
  • Our research focuses on understanding how pluripotent mammalian stem cells maintain their undifferentiated state and undergo differentiation in culture - this reflecting my enduring interest in the emergence of diversity during mouse gastrulation. (qscience.com)
  • These include segregation of the pluripotent embryonic and extra-embryonic lineages, and morphogenetic rearrangements leading to generation of a bilaminar disc, formation of a pro-amniotic cavity within the embryonic lineage, appearance of the prospective yolk sac, and trophoblast differentiation. (futuristech.info)
  • The data suggest that while fully committed embryonic lineages can rapidly acquire specific chromosomal conformations, most embryonic cells are showing plastic signatures driven by complex and intermixed enhancer landscapes. (bvsalud.org)
  • Among various stage-specific embryonic antigens (SSEAs), SSEA-1 was found to react with neolacto-series GSL Le x , while SSEA-3 and SSEA-4 reacted with globo-series Gb5 and monosialyl-Gb5, respectively. (nih.gov)
  • Stage-specific embryonic antigen. (nih.gov)
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
  • The stage-specific embryonic antigen 4 (SSEA4) is brain. (lu.se)
  • Changes of GSL expression profile were observed during mammalian embryogenesis. (nih.gov)
  • Most importantly, our DNA methyltransferase loss-of-function analysis indicates that DNA methylation influences early monkey embryogenesis. (nature.com)
  • However, probably due to technological limitations, no study has yet revealed genome-wide DNA remethylation during early embryogenesis. (nature.com)
  • The ligand exhibited an oscillating pattern of mRNA expression during the first 36 hours post fertilization, during which time gitr mRNA was not detected, and morpholino oligonucleotide-mediated knock-down of gitrl, but not of gitr, resulted in disruption of early embryogenesis, most clearly revealed during gastrulation, which corresponded to the earliest peak in gitrl mRNA expression (5.25-10 hpf). (ed.ac.uk)
  • For this purpose he develops three-dimensional cell-cultures, derived from mammalian stem-cells, which self-organize into brain resembling tissues. (ucsb.edu)
  • A variety of glycoconjugates, including glycosphingolipids (GSLs), expressed in mammalian tissues and cells were isolated and characterized in early biochemical studies. (nih.gov)
  • 4) Are these factors produced by specific embryonic tissues? (nebraska.edu)
  • At this time, a coordinated program of lineage diversification, cell-fate specification, and morphogenetic movements establishes the generation of extra-embryonic tissues and the embryo proper, and determines the conditions for successful pregnancy and gastrulation. (futuristech.info)
  • The requirement of Sin1 in cell survival, and in particular in neuronal survival, has not been established due to the early embryonic lethality of mice with a targeted deletion of the Sin1 gene. (bl.uk)
  • The other two types of stem cell in the blastocyst are the extra-embryonic trophoblast stem cells (TSCs), which will form the placenta, and primitive endoderm stem cells that will form the so-called yolk sac, ensuring that the foetus's organs develop properly and providing essential nutrients. (cam.ac.uk)
  • In a recent study, we showed that human fibroblasts can be reprogrammed into induced trophoblast stem (iTS) cells by transcription factor-mediated nuclear reprogramming using the Yamanaka factors OCT4, KLF4, SOX2 and c-MYC (OKSM) and a selection of TS cell culture conditions. (edu.au)
  • Our protocol allows researchers to generate patient-specific iTS cells to interrogate the trophoblast and placenta biology as well as their interactions with embryonic cells in health and diseases. (edu.au)
  • We think that it will be possible to mimic a lot of the developmental events occurring before 14 days using human embryonic and extra-embryonic stem cells using a similar approach to our technique using mouse stem cells," she says. (cam.ac.uk)
  • Zygotic mutants develop to pupal stages, but do not eclose, whereas maternal mutants display severe defects in early embryonic patterning (Veraksa, 2002). (sdbonline.org)
  • Defects observed in Hat1 +/- mice are consistent with an early-onset aging phenotype. (nih.gov)
  • Consistently, further studies show that Hat1 -/- MEFs exhibit mitochondrial defects suggesting a critical role for Hat1 in mitochondrial function. (nih.gov)
  • Methylation of mammalian DNA and histone residues are known to regulate transcription, and the discovery of demethylases that remove methylation in DNA and histones provide a basis for the understanding of dynamic regulation of mammalian gene expression. (cmbn.no)
  • Our study provides the first comprehensive illustration of the 'wax and wane' phases of DNA methylation dynamics. (nature.com)
  • During preimplantation stages, differentiation occurs between precursors of embryonic and extraembryonic structures. (medscape.com)
  • This work reveals the importance of BRACHYURY and CDX2 genes as key mediators of embryonic and extraembryonic lineage differentiation in hESCs and EpiSCs. (qscience.com)
  • This signaling molecule is key in regulating embryonic morphogenesis in all animals. (wikipedia.org)
  • Later studies of virus-transformed fibroblasts demonstrated the association of GSL expression profiles with cell phenotypes. (nih.gov)
  • Hat1 +/- mouse embryonic fibroblasts (MEFs) display modest increases in endogenous DNA damage but have significantly higher levels of reactive oxygen species (ROS). (nih.gov)
  • Our focus on mesoderm leads us on to molecular pathways for early human cardiomyocyte differentiation, with a goal of understanding the transcriptional networks responsible for cardiomyocyte identity and using this to generate more homogeneous cardiomyocyte populations for therapeutic applications and drug discovery. (qscience.com)
  • We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
  • Here we use single cell Hi-C to map chromosomal conformations in post-gastrulation mouse embryo cells and study their distributions and correlations with matching embryonic transcriptional atlases. (bvsalud.org)
  • Early in his career, Leibo collaborated with other scientists to study why cells were oftentimes injured during freezing. (asu.edu)
  • Beatrice Mintz conducted a previous study that examined a reproductive disorder characterized by two distinct populations of germ cells in heterozygous mice. (asu.edu)
  • Mintz thought there might be a way to use dual populations of cells to study the action of the mutant cells. (asu.edu)
  • This review summarizes recent work elucidating endocytic pathways, primarily in the worm germ line and coelomocytes, and also touches on diverse studies of secretion, especially in ectodermal cells of epithelial character. (wormbook.org)
  • Control of geometry, modulation of the physical environment, and priming with chemical signals reveal the intrinsic capacity of embryonic stem cells to make patterns. (cam.ac.uk)
  • Once a mammalian egg has been fertilised by a sperm, it divides multiple times to generate a small, free-floating ball of stem cells. (cam.ac.uk)
  • Our current research now focuses on two basic, interrelated questions: (1) How do mammalian cells decide where and when to initiate DNA replication? (nih.gov)
  • Failure of mammalian cells to regulate their proliferation cycle leads to cancer. (nih.gov)
  • Finally, our work will also assist in the rational design of differentiation protocols of human embryonic stem cells to specific cell types for disease modelling and cell replacement therapy. (futuristech.info)
  • Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • Nikolai Ivanovich Vavilov proposed theories of plant genetic diversity and participated in the political debate about genetics in Soviet Russia in the early twentieth century. (asu.edu)
  • Altogether, this study defines the repertoire of transcription factors that regulate developmental myofiber growth and the role of Gsk3/Deaf1/glycolysis in this process. (sdbonline.org)
  • In a collaborative study, Dahl (Picture) and colleagues, together with collaborators at the University of Chicago and Beijing, show that ALKBH5 is a second demethylase for 6meA in mRNA (see figure below) and that mice lacking this demethylase are infertile. (cmbn.no)
  • We employ a variety of experimental systems for our studies ranging from molecular biology to transgenic and knockout mice. (stanford.edu)
  • In this fashion, mice or other laboratory animals that exhibit particular traits can be created for specialized studies, or herds of farm animals (such as goats, sheep or cows) can be created that produce pharmaceutically useful proteins in their milk. (who.int)
  • Immunohisto- have been used for positive selection of NSCs from em- chemistry on human embryonic central nervous system bryonic mice (Nagato et al. (lu.se)
  • He has been a fellow (2001-2004) and a special fellow (2004-present) of the Leukemia and Lymphoma Society of America and conducted his postdoctoral studies at the Salk Institute for Biological Studies, La Jolla, California. (a-star.edu.sg)
  • Together with Professors Sebastian Streichan and Boris Shraiman he is developing new experimental and theoretical tools, to examine how shape, fate and function emerge during early developmental stages. (ucsb.edu)
  • DmFKBP12 is first expressed at the syncytial blastoderm stage and undergoes increased expression during the cellular blastoderm and early gastrulation stages. (biomedcentral.com)
  • Although Drosophila chimeras had previously been produced, mammalian chimeras were not successful until Mintz developed a reliable technique for the production of embryonic fusions. (asu.edu)
  • Deformed epidermal autoregulatory factor-1 (DEAF-1) is a transcription factor that was originally shown to bind the autoregulatory enhancer of the Deformed ( Dfd ) Hox gene, which is activated in embryonic head segments of Drosophila (Gross, 1996). (sdbonline.org)
  • Although DmFKBP12 is distributed evenly between the anterior to posterior poles of the blastoderm egg, the protein is expressed more strongly in the cortex of the early Drosophila gastrula with the highest concentration found in the basement membrane of the cellular blastoderm. (biomedcentral.com)
  • Fertilized egg, through the profile as under-membrane cortex distribution concentering onto basement at cellular blastoderm, to the profile as three-gem layer localization in primitive neuronal and digestion architecture of early Drosophila gastrula. (biomedcentral.com)
  • Further study on the differences between mammalian RyR-FKBP12 and Drosophila DmRyR-FKBP12 can be exploited to develop safe pesticides. (biomedcentral.com)
  • Here we show that DNMT3A and DNMT3B are differentially regulated during endoderm and mesoderm bifurcation and study the implications in vivo and in meso-endoderm embryoid bodies. (bvsalud.org)
  • In vivo studies are particularly challenging for mammals after implantation, owing to the small size and inaccessibility of the embryo. (cam.ac.uk)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • The CPG field is one area of study that sets the standard on how basic cellular neurophysiology determines biological function. (degruyter.com)
  • not unique for the embryonic system but are shared by other ogenesis regulation must consider different scales of multi-cellular modeling areas. (lu.se)
  • Taken together, these studies should significantly accelerate the progression from basic stem cell research to clinical applications. (qscience.com)
  • Comparative analysis of temporal differentiation models provides a basis for studying the evolution of gastrulation dynamics across mammals. (bvsalud.org)
  • We find that embryonic chromosomes show a remarkably strong cell cycle signature. (bvsalud.org)
  • In 1973, I continued these studies on the replication and structure of SV40 chromosomes at Harvard Medical School where they culminated in promotion to Full Professor with tenure in 1985. (nih.gov)
  • We demonstrate that neural stem/progenitor cell (NSPC) self-renewal and spatiotemporal generation of neurons and other cell types are severely impacted by the loss of Ythdf2 in embryonic neocortex. (biomedcentral.com)
  • genital malformations which occur due to This case-control study was conducted at abnormalities in neural tube formation [ 1 ]. (who.int)
  • The mammalian target of rapamycin complex 2 (mTORC2) has been implicated in the regulation of cell survival by phosphorylating the protein kinase Akt. (bl.uk)
  • Policies were coded by setting [i.e., early care and education (ECE) also known as child care, school, community], jurisdictional level (i.e., state or local) and policy type (i.e., legislation or regulation). (cdc.gov)
  • Dr. Beard's hypothesis developed out of his study of the mammalian placenta, the connection between the growing embryo and the mother's blood supply. (fleetwoodonsite.com)
  • In its earliest incarnation, Beard realized, the placenta behaves much as a malignant tumor, invading into the uterus while creating a complex blood supply. (fleetwoodonsite.com)
  • But the placenta differs from a cancerous tumor in that at some point its growth ceases, a change Beard attributed to the embryonic production of pancreatic enzymes. (fleetwoodonsite.com)
  • The results from large-scale proteomics experiments are in line with evidence from cross-species conservation, human population variation studies, and investigations into the relative effect of gene expression and alternative splicing. (blogspot.com)
  • In the past, our research focused on viral genomes as models for DNA replication in mammalian cell nuclei. (nih.gov)
  • We find human-specific molecular signatures of early cell lineage, timing, and architecture. (futuristech.info)
  • This prospective study was conducted with 96 spent CM from patients undergoing IVF cycle, in order to determine relationships of Cell-free DNA levels in embryo CM with embryo cleavage quality on day 3. (who.int)
  • The sonic hedgehog transcription pathway has also been linked to the formation of specific kinds of cancerous tumors, including the embryonic cerebellar tumor and medulloblastoma, as well as the progression of prostate cancer tumours. (wikipedia.org)
  • For his multiple ground breaking discoveries in the study of the virulence factors and basic biology of the human fungal pathogen Candida albicans, Dr Wang was awarded the President's Science Award 2012. (a-star.edu.sg)
  • To study differences in time between species, my group uses in vitro systems. (irbbarcelona.org)
  • Tumour necrosis factor ligand and receptor superfamily (TNFSF and TNFRSF) members have diverse and well-studied functions in the immune system. (ed.ac.uk)
  • GITRL and its receptor GITR are well-described as co-regulators of the mammalian immune response. (ed.ac.uk)
  • One important model for mechanistic studies of endocytosis in C. elegans focuses on oocytes, which internalize huge quantities of yolk proteins and their associated lipids by clathrin-mediated endocytosis ( Grant and Hirsh, 1999 ). (wormbook.org)
  • Taken together, the results presented in this study show a key role of the scaffold protein Sin1 in regulating neuronal survival. (bl.uk)
  • Although he reported a novel approach to embryonic fusions, his technique was inefficient and the sole mouse that survived long enough to observe the coat color did not show evidence of chimerism. (asu.edu)
  • Studies undertaken in this laboratory virus isolation, Western blot, and reverse transcription- have demonstrated some histopathologic similarities, in PCR (RT-PCR). (cdc.gov)
  • 4D OCT allowed them to investigate the functional relation between blood flow and heart wall dynamics within different regions of the embryonic heart at a level of detail not currently accessible by other methods. (photonics.com)
  • The analysis of data from several independent protein-protein interaction studies in mammals, combined with functional studies of its Arabidopsis ortholog, SERRATE, suggests that this essential process is related to RNA metabolism. (monash.edu)
  • This study, more importantly, provided a successful model for the use of chimeras in experimental research. (asu.edu)
  • Yet it has remained mysterious because of the experimental hurdles that beset the study of this developmental phase. (futuristech.info)
  • We and others have synthesized light-activatable cMOs that allow spatiotemporal control of RNA splicing or translation, complementing the use of conditional knockouts to study stage- and tissue-specific differences in gene function. (cdc.gov)
  • Now we are extending this approach of cross-species comparison to other mammalian species, including cows and rhinos, and other developmental processes. (irbbarcelona.org)
  • Scientists Shang Wang at Stevens Institute and Irina Larina at Baylor hope their approach will inspire new ideas and designs in imaging and measurement techniques to assess embryonic cardiac biomechanics. (photonics.com)