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  • 2016
  • Plachta explained that after White joined his lab in 2016, she "mastered advanced imaging technologies, developed an impressive number of new molecular tools to follow the dynamics of cells in living mouse embryos, learned quantitative methods for image analysis, and established intensive and truly cross-disciplinary collaborations with multiple laboratories worldwide. (ascb.org)
  • mimics
  • The implementation of the Hox gene network over time, which mimics that of the embryo, particularly confirms the remarkably high level of self-organisation of gastruloids," explains Mehmet Girgin, co-first author of the study and PhD student at the Institute of Bioengineering at EPFL. (cam.ac.uk)
  • posterior
  • Vertebrate embryos are characterized by an elongated antero-posterior (AP) body axis, which forms by progressive cell deposition from a posterior growth zone in the embryo. (biomedsearch.com)
  • artificial
  • Thus, functional peculiarities of early embryos allow studying the nuclei under different transcriptional conditions without artificial inhibitors. (hindawi.com)
  • self-organization
  • Since improved methodologies like those employed by the cited authors became available, early embryonic pattern formation/self-organization appears to evolve now as a research topic of its own. (mdpi.com)
  • patterns
  • The study shows that gastruloids organise themselves with regard to the three main body axes, as they do in embryos, and follow similar patterns of gene expression. (cam.ac.uk)
  • research
  • The technique, reported today in the journal Nature , could reduce the use of mammalian embryos in research. (cam.ac.uk)
  • The researchers say that these pseudo-embryos will allow an alternative method to animal research, in accordance with the principle of the '3Rs' (the reduction, replacement and refinement of the use of animals in research). (cam.ac.uk)
  • method
  • Vector injection into the perivitelline space has emerged as the standard delivery method to transduce lentivirus to mammalian oocytes or one-cell embryos, but its application is limited by the need for high titers of lentivirus. (biomedsearch.com)
  • team
  • We were surprised to see how far gastruloids develop, their complex organisation and the presence of early-stage tissues and organ," says Professor Alfonso Martinez Arias, leader of the University of Cambridge team, at its Department of Genetics. (cam.ac.uk)