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  • Egr1
  • in primary cultures of glioma stemlike cells that EGR1 contributes to stemness marker expression and proliferation by orchestrating a PDGFA-dependent growth-stimulatory loop. (nih.gov)
  • In nucleus pulposus cells early transcriptional programming initiated by EGR1 is essentially restrained by the cells' epigenome as it was determined during development and differentiation. (nih.gov)
  • Results of preclinical studies by MUSC investigators reported in the July 2016 issue of PLOS One , demonstrate for the first time that the transcription factor KLF12 promotes CRC cell growth, in part, by activating EGR1. (scienmag.com)
  • They found that the EGR1 promoter contains two possible KLF12 DNA-binding motifs located at -1488bp (motif 1) and -808bp (motif 2) relative to the transcription start site. (scienmag.com)
  • Using ChIP assay, the MUSC researcher team found that KLF12 does, indeed, bind strongly to the EGR1 promoter motif 2 but not to motif 1. (scienmag.com)
  • In vitro experiments demonstrated that, at both the mRNA and protein levels, CRC cells with undetectable levels of KLF12 expressed the lowest levels of EGR1 compared to cells expressing high levels of KLF12. (scienmag.com)
  • Early growth response-1 (EGR1) is a multifunctional transcription factor that regulates diverse biological functions, including inflammation, apoptosis, differentiation, tumorigenesis, and even viral infection. (sigmaaldrich.com)
  • We demonstrate that EV71 activates EGR1 expression during infection by stimulating the protein kinase A/protein kinase Cɛ/phosphoinositide 3-kinase/Akt (PKA/PKCɛ/PI3K/Akt) cascade. (sigmaaldrich.com)
  • Moreover, EGR1 protein co-localizes with EV71 RNA in the cytoplasm of infected cells to facilitate viral replication. (sigmaaldrich.com)
  • survival
  • Thus, this set of experiments indicates that KLF12 promotes CRC growth by enhancing cancer cell proliferation and/or survival. (scienmag.com)
  • inflammation
  • With the exception of inferior oxygenation, a sustained inflation targeting delivery to preterm lambs of 15 mL/kg volume by 5 s did not influence physiological variables or early markers of lung inflammation and injury at 15 min compared to a standard pressure-limited sustained inflation. (biomedcentral.com)
  • Peroxisome proliferator-activated receptor delta promotes colonic inflammation and tumor growth. (mayo.edu)
  • 2017
  • 2017) Neuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthma. (plos.org)
  • mice
  • In primary macrophages isolated form C57/BL6 male mice, we identify mitochondrial ROS formation by CO as the upstream trigger for the observed effects on Egr-1 in part through uncoupling protein 2 (UCP2). (biomedsearch.com)
  • nuclear
  • Here we demonstrate that the expression of hepatocyte nuclear factor 1 homeobox A antisense RNA 1 (HNF1A-AS1) is significantly upregulated in gastric cancer (GC) tissues. (aacrjournals.org)
  • simulations
  • Investigating the effect of key mutations on the conformational dynamics of Toll-like receptor dimers through molecular dynamics simulations and protein structure networks. (ncbs.res.in)
  • regulate
  • A new role for wilms tumor protein 1: differential activities of + KTS and -KTS variants to regulate LHβ transcription. (nih.gov)
  • Specific oligonucleotides were used as a method to down-regulate vascular Egr-1 expression in the PAH model. (rug.nl)
  • Involves
  • 2015). 'Early Growth Response Protein-1 Involves in Transforming Growth factor-β1 Induced Epithelial-Mesenchymal Transition and Inhibits Migration of Non-Small-Cell Lung Cancer Cells', Asian Pacific Journal of Cancer Prevention , 16(9), pp. 4137-4142. (waocp.org)
  • expression
  • Western blotting was alsoused to observe changes of the expression of EGR 1. (waocp.org)
  • The lentivirus-mediated EGR 1 vector was used to increaseEGR1 expression. (waocp.org)
  • These cells also had lower EGR 1 protein expression. (waocp.org)
  • A study of gene expression in leukemia cells has identified an RNA binding protein that plays an important role in driving the development of cancer. (medicalxpress.com)
  • Expression of a PPARγ-K77R mutant did not impair the effect of CO. In addition to PPARγ SUMOylation, CO-activated p38 MAPK was responsible for Egr-1 repression. (biomedsearch.com)
  • The spatiotemporal analysis of Egr-1 expression in this PAH model reveals that Egr-1 is up-regulated in the pulmonary arteries directly after induction of increased flow, but also later in the disease process. (rug.nl)
  • Patients with PAH associated with CHD were studied, and pulmonary vascular Egr-1 expression was specifically increased in neointimal remodeling compared to medial hypertrophy remodeling in hypoxic PH and control vessels. (rug.nl)
  • mediators
  • Besides its role as physical barrier towards invading pathogens and irritants, epithelium also affects the outcome of the immune response by the production of various pro-inflammatory mediators. (biomedcentral.com)
  • Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs. (nih.gov)
  • mutations
  • Mutations in the coding region of the mouse Atp2b2 gene indicate a narrow window for tolerated dysfunction of the ATP2B2 protein, specifically in the auditory system. (biomedcentral.com)
  • epithelial cells
  • We have previously shown that nasal epithelial cells are able to respond to exposure to house dust mite (HDM) allergen and that this response is different for epithelial cells isolated from healthy or from allergic individuals. (biomedcentral.com)
  • Additional proapoptotic mechanisms in epithelial cells that may need to be considered include latent viral infections and acquired defects in protein processing and trafficking (not depicted- see text for details). (nih.gov)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • Brain
  • We are also using a combination of cortical evoked potential responses to laser pulsed pain stimuli as well as functional magnetic resonance imaging (fMRI) of the brain of volunteers (and eventually patients) to determine the cortical representation of these A-delta and C fiber mediated pain. (stanford.edu)
  • antioxidant
  • Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses. (abcam.com)
  • Objective: To determine whether the early administration of albumin as an expander and antioxidant would improve survival on the 28th day for septic shock patients. (bioportfolio.com)
  • Furthermore
  • Furthermore, the high degree of overlap between the poly(I:C) and the HDM response suggests a potential mechanism of viral induced allergic exacerbations. (biomedcentral.com)
  • annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)