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  • papilla
  • Cultured human and rat tooth papilla cells induce hair follicle regeneration and fiber growth. (dur.ac.uk)
  • Adult human and juvenile rat tooth papilla cells were implanted into surgically inactivated hair follicles within two different microenvironments. (dur.ac.uk)
  • Taken together, this study reveals that cultured dental papilla cells from postnatal mammals (adult, juvenile, and newborn) retain inductive molecular signals that must be common to both hair and teeth follicles. (dur.ac.uk)
  • appendage
  • Here, we review what is known of the molecular and cellular mechanisms controlling early steps in the development of these organs, attempt to unravel both common themes and unique aspects that can begin to explain the diversity of appendage formation, and discuss human genetic diseases that affect appendage morphogenesis. (springer.com)
  • Moreover, the finding that hair follicle and dental placodes do not form in p63 Brdm2/Brdm2 mice demonstrates that appendage development does not initiate in p63 Brdm2/Brdm2 mice ( 7 ). (pubmedcentralcanada.ca)
  • It highlights the stem cell-like qualities and morphogenetic abilities of tooth and hair follicle cells from mature humans, and their capacity for cross-appendage and interspecies communication and interaction. (dur.ac.uk)
  • 1998
  • Like JAK/STAT, Notch signaling is also required for the expression of slbo in anterior follicle cells ( Gonzalez-Reyes and St Johnston, 1998 ), indicating that Notch signaling might be crucial for BC specification and migration. (biologists.org)
  • epithelium
  • In each case the first morphological sign of development is a localized thickening in the surface epithelium that subsequently invaginates to form a mammary, hair follicle or tooth bud. (springer.com)
  • The human cells interacted with follicle epithelium to regenerate new end bulbs and create multiple differentiated hair fibers. (dur.ac.uk)
  • The development of teeth is the result of interactions between competent mesenchyme and epithelium, both of which undergo extensive morphogenesis. (biomedcentral.com)
  • eccrine glands
  • Alongside hair follicles, eccrine glands are found throughout human skin and are indispensible for thermoregulation. (pnas.org)
  • This work uncovers a previously unidentified biological factor that specifically promotes the development of eccrine glands when these organs are interspersed with hair follicles, and has the potential to inform efforts to elucidate the genetic basis for the evolution of increased eccrine gland density in humans. (pnas.org)
  • Differential and allelic expression analysis of the genes within this interval coupled with subsequent functional studies demonstrated that the level of En1 activity directs the relative numbers of eccrine glands and hair follicles. (pnas.org)
  • placodes
  • To identify additional NF-κB target genes we developed a novel method to isolate and transcriptionally profile primary hair follicle placodes with active NF-κB signaling. (biologists.org)
  • In addition to corroborating established NF-κB functions, these analyses uncovered novel NF-κB target genes with potential roles in priming hair follicle placodes for down-growth. (biologists.org)
  • Tooth
  • The mesenchymal-epithelial interactions that characterize the early stages of tooth and hair follicle morphogenesis share certain similarities, and there is increasing evidence that mesenchymal cells derived from both mature structures retain interactive and stem cell-like properties. (dur.ac.uk)
  • Sox2 + cells became restricted to the labial cervical loop during tooth morphogenesis, and they contributed to the renewal of enamel-producing ameloblasts as well as all other epithelial cell lineages of the tooth. (pubmedcentralcanada.ca)
  • The importance of cell adhesion molecules in morphogenesis has long been acknowledged but remarkably few studies have focused on the distribution and function of these molecules in tooth development. (biomedcentral.com)
  • Replacement of zebrafish first-generation teeth starts early, between 3 and 4 dpf for the first tooth (position 4V). (biomedcentral.com)
  • stages
  • NF-κB signaling is known to modulate activity of WNT and SHH signaling at early stages of hair follicle development, but these roles do not fully account for the phenotypes observed when this pathway is blocked. (biologists.org)
  • A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages," Journal of Investigative Dermatology , vol. 117, no. 1, pp. 3-15, 2001. (hindawi.com)
  • molecular
  • Although very much is known about how exactly secondary follicles steadily become preovulatory follicles, the molecular occasions mediating primordial follicle development and preliminary follicle development are less apparent. (careersfromscience.org)
  • The present study revealed previously unreported molecular mechanisms contributing to human DP properties and describes a useful technique for the investigation of human DP biology and hair follicle bioengineering. (biologists.org)
  • induction
  • Inactivation of the beta-catenin gene within DP of fully developed hair follicles results in dramatically reduced proliferation of the progenitors and their progeny that generate the hair shaft, and, subsequently, premature induction of the destructive phase of the hair cycle. (nih.gov)
  • germ
  • Newborn ovaries cultured in the current presence of -secretase inhibitors, substances that attenuate Notch signaling, acquired a marked decrease in primordial follicles weighed against vehicle-treated ovaries, and there is a corresponding upsurge in germ cells that continued to be buy Meisoindigo within nests. (careersfromscience.org)
  • During designed nest break down, germ cells are encapsulated by squamous somatic cells (pregranulosa cells) to create primordial follicles. (careersfromscience.org)
  • MOFs, that have several germ cells stuck within a follicle boundary (6,7), will also be seen in mouse ovary ethnicities treated with estradiol (11). (careersfromscience.org)
  • Hence, conversation between germ cells and pregranulosa cells is probable very important to orchestrating follicle set up. (careersfromscience.org)
  • exogenous
  • Furthermore, although TGFβ2 is not a direct LHX2 target gene, we find that exogenous TGFβ2 rescues the hair follicle phenotypes of LHX2 knockout skin explants, indicating that it operates downstream of LHX2. (biologists.org)
  • Exogenous estrogen reversed the increased basal level of IGF-1 binding protein-1 expression in SirT1 ko/ko mammary tissues, but not that of IκBα expression, suggesting that increased levels of estrogen enhanced the production of local IGF-1 and rescued ductal morphogenesis. (biomedcentral.com)
  • adult
  • In larval and adult tissues, dib expression is observed in the prothoracic gland and follicle cells of the ovaries respectively, two tissues known to synthesize ecdysteroids. (biologists.org)
  • development
  • These data support an operating function for Notch signaling in regulating primordial follicle development. (careersfromscience.org)
  • The early-migrating population distributes both dorsally and ventrally during normal development, while the late-migrating population is confined dorsally and forms much less cartilage and bone. (biologists.org)
  • Thus, the dorsal fate restriction of the late-migrating mesencephalic neural crest cell population in normal development is due to the presence of earlier-migrating neural crest cells, rather than to any change in the environment or to any intrinsic difference in migratory ability or potential between early- and late-migrating cell populations. (biologists.org)
  • These findings identify a novel NF-κB-LHX2-TGFβ2 signaling axis that is critical for primary hair follicle morphogenesis and may function more broadly in development and disease. (biologists.org)
  • In the skin, there is a complete lack of hair follicle development. (stanford.edu)
  • 2002
  • C. B. Barcaui, J. Pineiro-Maceira, and M. M. de Vaelar Alchorne, "Arrector pili muscle: evidence of proximal attachment variation in terminal follicles of the scalp," British Journal of Dermatology , vol. 146, pp. 657-658, 2002. (hindawi.com)
  • anagen
  • YFP (Green) was first detected at P3 in some but not all follicles (A,B) and increasing numbers of DP cells that express YFP were observed through the mid-anagen phase (C-F). By P7, virtually all DP cells express YFP (G, arrowheads). (nih.gov)
  • cells
  • During homeostasis, K79(+) cells line the hair follicle infundibulum, a domain we show to be multilayered, biochemically distinct and maintained by Lrig1(+) stem cell-derived progeny. (sigmaaldrich.com)
  • Follicles are made up of three MCM2 cells types: oocytes, encircling granulosa cells, and an exterior thecal cell level. (careersfromscience.org)
  • Follicle maturation proceeds until ovulation, when an egg or eggs experienced for fertilization are extruded in the ovary and the rest of the somatic cells from the follicle luteinize. (careersfromscience.org)
  • During early oogenesis, the cytokine-like molecule Unpaired (Upd) is secreted from the pair of anterior polar cells to activate the JAK/STAT pathway in the surrounding cells. (biologists.org)
  • onset
  • SirT1 deficiency deregulates the expression of IGF-1 binding protein-1 and attenuates the effect of IGF-1 signals, including estrogen-stimulated local IGF-1 signaling for the onset of ductal morphogenesis. (biomedcentral.com)
  • tissue
  • Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales. (biologists.org)
  • Drosophila
  • Probing mechanism, we discovered that these asymmetric cell divisions utilize an ancient mechanism that has been previously been described to characterize the differential specification of daughter cell fates that occurs in the early C. elegans embryo and Drosophila neuroblast. (rockefeller.edu)