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  • Virtual Embryo
  • To understand how morphology controls biological functions, and, ultimately, how multicellular systems self-organize, we aim at integrating molecular, cellular and multicellular levels of description (see Fig. 1) into a new and versatile simulation framework for embryo morphogenesis: Virtual Embryo. (college-de-france.fr)
  • These replicas can then be interfaced via a 3D Virtual Embryo module to a model organism database (Aniseed) that allows one to relate the geometrical properties of cells and cell contacts to additional parameters such as cell lineage, cell fates, or the underlying genetic program. (edu.au)
  • Second, the 3D Virtual Embryo software proposes a panel of mathematical shape descriptors to precisely quantify cellular geometries and generate a 3D identity card for each embryonic cell. (edu.au)
  • tissues
  • In particular, the interplay between cell contractility, cell-cell adhesion, molecular expression and fate specification remains poorly understood in early embryos and small tissues. (college-de-france.fr)
  • Schematic illustration of the multiple spatiotemporal scales implicated in the morphogenesis of early embryos or small tissues. (college-de-france.fr)
  • Gustav Jacob Born was an experimental embryologist whose original work with amphibians served as the platform for his wax-plate method of embryo modeling, heteroblastic (different tissues) and xenoplastic (similar species) transplantation methods, environmental influences on sex ratio studies, and proposed function of the corpus luteum. (asu.edu)
  • The neural crest is transient structure of the vertebrate embryo that develops at the margin of the central nervous system At cephalic level, the neural crest generates most of the skeletal tissues encasing the developing forebrain and provides the prosencephalon with functional vasculature and meninges. (cnrs.fr)
  • tissue
  • In the last ten years, his research has extended to the investigation of how tissue morphogenesis and homeostasis are determined by cell behaviour. (cnic.es)
  • Using tissue transposition and molecular analyses in avian embryos, we reconcile these findings by demonstrating that classical manipulation experiments, which form the basis of the prepatterning model, involved transplantation of a local signaling center, the isthmic organizer. (sciencemag.org)
  • avian
  • Cellular death in morphogenesis of the avian wing' (1962), by John W. Saunders Jr., et al. (asu.edu)
  • Noden grafted first-arch neural crest precursors posteriorly to new locations in avian embryos, and these ectopic crest cells gave rise to duplications of first-arch skeletal derivatives, such as the quadrate and Meckel's cartilage. (sciencemag.org)
  • zebrafish
  • Our goal is to understand how such interactions determine the self-organization of cell communities in the nervous system of the zebrafish embryo. (nih.gov)
  • Under the guidance of Dr. John Kuwada he showed how axon tracts established in the zebrafish brain by early developing neurons serve as a scaffold to guide growth cones of later developing neurons. (nih.gov)
  • After a short second postdoctoral position with Dr. Wolfgang Driever, where he did a genetic screen to identify zebrafish with an aberrant pattern of early neurons, he established his Unit in the Laboratory of Molecular Genetics at NICHD in 1997. (nih.gov)
  • dorsal
  • Circumferential actin filament bundles form in all five rows of hypodermal cells (one dorsal, two lateral, and two ventral) at the start of elongation and appear to contract to generate the force that transforms the shapes of the hypodermal cells and the embryo. (wormbook.org)
  • hmp-1 mutants form the normal pattern of hypodermal cells but arrest elongation at an early stage (1.25- to 1.5-fold) and develop abnormal lumps in the dorsal hypodermis. (wormbook.org)
  • Curiously, the primary defect in hmp-1 embryos appears to be failure of the dorsal hypodermis to elongate. (wormbook.org)
  • vitro
  • Landrum Brewer Shettles is remembered as an important contributor to early in vitro fertilization research in the United States as well as a prolific author on the subject of choosing a child's sex before conception. (asu.edu)
  • She experimented by culturing mouse eggs and successfully developing them into embryos, leading to advancements with in vitro fertilization. (asu.edu)
  • Whilst no such precursors could be identified by immunoprecipitation of in vivo labeled embryo lysates, immunoprecipitation of in vitro translation products suggested such precursors (ca 40 x 10(3) kD) might exist. (duke.edu)
  • vivo
  • Dr. Torres described how his group's work has "established the first technique for the in vivo microscopy of the developing heart in mouse embryos, and this has enabled us to propose a new model of the formation of the heart tube. (cnic.es)
  • mechanisms
  • His major contributions include the understanding of how gene activities regulate regionalization processes in the developing embryo and the discovery of mechanisms involved in quality control and organ regeneration. (cnic.es)
  • microscopy
  • This line of research has involved the introduction of new techniques, including new genetic and methodological tools for 3-dimensional microscopy of the developing embryo. (cnic.es)
  • stem cells
  • The outlined invention presents a new concept of culturing stem cells, embryoid bodies (EB) and embryos in a controllable 3D niche comprising a mixture of biodegradable scaffolds, supportive cells and feeding capillaries. (pharmalicensing.com)
  • Cellular
  • Bonner's studies of cellular slime molds have shed light on some of the big questions of biology including the origins of multicellularity and the nature of morphogenesis. (asu.edu)
  • postdoctoral
  • The Life Sciences Research Foundation is pleased to announce recipients of three-year postdoctoral fellowships who will begin their training as early as June 2009. (lsrf.org)
  • processes
  • However, UC Santa Barbara professor Otger Campàs, who holds a Duncan & Suzanne Mellichamp Chair in Systems Biology and Bioengineering, has made great strides in our understanding of a different, yet essential, aspect of this problem: the mechanical and physical processes that shape embryos. (satoshinakamotoblog.com)
  • organism
  • John Craig Venter helped map the genomes of humans, fruitflies, and other organisms in the US in the late 1990s and early 2000s, and he helped develop an organism with a synthetic genome. (asu.edu)
  • reproductive
  • Papanicolaou's work helped improve the reproductive health of women by providing an effective means of identifying precancerous cells and improving the likelihood of early treatment and survival of cervical cancer. (asu.edu)
  • Intrauterine insemination (IUI), also known as artificial insemination, is one of the earliest and simplest assisted reproductive technologies (ART). (asu.edu)
  • whereby
  • This article describes a process whereby image stacks gathered from live or fixed ascidian embryos are digitalized and segmented to produce 3D embryo replicas. (edu.au)
  • mechanical
  • Decyphering it necessitates to resolve the mechanical balance of the embryo with the myosin force-production as a source term. (newton.ac.uk)
  • epiblast
  • Reintroduction of Myo/Nog cells into the epiblast of ablated embryos restores normal patterns of BMP signaling, morphogenesis and skeletal myogenesis, and inhibits the expression of cardiac markers in the somites. (bepress.com)
  • second
  • The second child of Lilly Marguerite Stehli and Paul Bonner, John Tyler was born 12 May 1920 in New York City and spent his early years in Locust Valley, Long Island (late 1920s), France (1930), and London (1932). (asu.edu)
  • block
  • We have isolated several zygotic lethal mutations in a gene named hmp-1 (humpback) that seem to specifically block elongation of the embryo. (wormbook.org)
  • animals
  • Injection of anti-sense RNA made from this cDNA into the gonads of wild-type animals produces the Hmp-1 phenotype in embryos, indicating that this cDNA encodes hmp-1. (wormbook.org)