Jensen and Bauner-Osborne (2004) Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescense-based membrane potential assay. (tocris.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Tissue homogenates, cell lysates and other biological fluids. (lotuskringpoeldijk.nl)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Excitatory Amino Acid Transporter 2 (EAAT2) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (lotuskringpoeldijk.nl)
The dependence of EAAT3 internalization on the DAT also suggests that the two transporters might be internalized together. (wikipedia.org)
The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse? (wikipedia.org)
Neuronal glutamate transporter1
Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1" (PDF). (wikipedia.org)
High affinity glutamate transporter2
The neuronal and epithelial human high affinity glutamate transporter. (wikipedia.org)
Glutamate is incorporated into these cell types through a high affinity glutamate transporter located in the plasma membrane. (org.es)
Glutamate14
Excitatory amino acid transporter 3 is a member of the high-affinity glutamate transporters which plays an essential role in transporting glutamate across plasma membranes in neurons. (wikipedia.org)
In the brain, excitatory amino acid transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. (wikipedia.org)
Glutamate transporters , also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. (tocris.com)
Functions of glutamate transporters include regulation of excitatory neurotransmission , maintenance of low ambient extracellular glutamate concentrations (protects against neurotoxicity) and providing glutamate for metabolism through the glutamate-glutamine cycle. (tocris.com)
Overactivity of glutamate transporters has been implicated in the pathophysiology of schizophrenia and other mental illnesses, whilst underactivity is seen in ischemia and traumatic brain injury. (tocris.com)
Tocris offers the following scientific literature for Glutamate (EAAT) Transporters to showcase our products. (tocris.com)
Glutamate is the main excitatory neurotransmitter in the mammalian central nervous system and is removed from the synaptic cleft by sodium-dependent glutamate transporters. (johnshopkins.edu)
We have used a yeast two-hybrid screen to identify interacting proteins that may be involved in regulating EAAT4-the glutamate transporter expressed predominately in the cerebellum-or in targeting and/or anchoring or clustering the transporter to the target site. (johnshopkins.edu)
Here we report the identification and characterization of two proteins, GTRAP41 and GTRAP48 (for glutamate transporter EAAT4 associated protein) that specifically interact with the intracellular carboxy-terminal domain of EAAT4 and modulate its glutamate transport activity. (johnshopkins.edu)
Glutamate (Fig. 1) is believed to be the major excitatory neurotransmitter in the retina. (org.es)
Glutamate is incorporated into the vesicles by a glutamate transporter located in the vesicular membrane. (org.es)
This transporter selectively accumulates glutamate through a sodium-independent, ATP-dependent process (Naito and Ueda, 1983, Tabb and Ueda, 1991, Fykse and Fonnum, 1996), resulting in a high concentration of glutamate in each vesicle. (org.es)
Neuroactive glutamate is classified as an excitatory amino acid (EAA) because glutamate binding onto postsynaptic receptors typically stimulates, or depolarizes, the postsynaptic cells. (org.es)
Glutamate transporters maintain the concentration of glutamate within the synaptic cleft at low levels, preventing glutamate-induced cell death (Kanai et al. (org.es)
Neurotransmitter transporters1
However, the subcellular co-localization of the two neurotransmitter transporters remains to be established definitively by high resolution electron microscopy. (wikipedia.org)
EAAC14
GLAST and GLT-1 are localized primarily in astrocytes 6, 7 , whereas EAAC1 (refs 8, 9), EAAT4 (refs 9, 10, 11) and EAAT5 (ref. 5) are neuronal. (johnshopkins.edu)
Studies of EAAT4 and EAAC1 indicate an extrasynaptic localization on perisynaptic membranes that are near release sites 8-10 . (johnshopkins.edu)
GLAST and GLT-1 are localized primarily in astrocytes6, 7, whereas EAAC1 (refs 8, 9), EAAT4 (refs 9, 10, 11) and EAAT5 (ref. 5) are neuronal. (johnshopkins.edu)
Studies of EAAT4 and EAAC1 indicate an extrasynaptic localization on perisynaptic membranes that are near release sites8-10. (johnshopkins.edu)
L-Aspartic acid is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. (sigmaaldrich.com)
Functions1
Some neuroactive compounds are amino acids, which also have metabolic functions in the presynaptic cell. (org.es)
Release1
Neurotransmitter molecules can also bind onto presynaptic autoreceptors and transporters, regulating subsequent release and clearing excess neurotransmitter from the cleft. (org.es)
Human5
The neuronal and epithelial human high affinity glutamate transporter. (wikipedia.org)
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Thymosin Beta 4, Y-Chromosomal (Tb4Y) in serum, plasma and other biological fluids. (1elisakits.com)
Description: Quantitative sandwich ELISA for measuring Human Thymosin beta-4, Y-chromosomal (TMSB4Y) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Thymosin Beta 4 (Tb4) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Thymosin Beta 4 (Tb4) in samples from serum, plasma or other biological fluids. (1elisakits.com)
Plasma4
Excitatory amino acid transporter 3 is a member of the high-affinity glutamate transporters which plays an essential role in transporting glutamate across plasma membranes in neurons. (wikipedia.org)
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Fatty Acid Binding Protein 4, Adipocyte (FABP4) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. (lotuskringpoeldijk.nl)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Fatty Acid Binding Protein 4, Adipocyte (FABP4) in serum, plasma, tissue homogenates and other biological fluids. (lotuskringpoeldijk.nl)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Fatty Acid Binding Protein 4, Adipocyte (FABP4) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (lotuskringpoeldijk.nl)