Accordingly, the cytoplasmic-to-nuclear ratio of late viral mRNA was reduced in G(1) cells infected with the mutant viruses compared to that in G(1) cells infected with the wild-type virus. (nih.gov)
Furthermore, cells infected during S phase with the E1B 55-kDa- or E4 orf6-mutant viruses synthesized more late viral protein than did cells infected during G(1). (nih.gov)
It appears that ribavirin causes HEV mutagenesis in treated patients, and distinct mutants within the viral population occur during ribavirin therapy. (medscape.com)