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  • E2F1
  • Unlike E2F1 , E2F2 and E2F3 , which exhibit a cyclin A binding domain at their N-terminus, E2F4 has a truncated N-terminus and therefore does not harbor this domain (Beijersbergen et al. (atlasgeneticsoncology.org)
  • mice
  • Both the erythroid and the lymphoid defects in E2F4-deficient mice could be explained if the defect occurred at the level of the HSC, which gives rise to both lineages. (jimmunol.org)
  • molecular
  • This study identified ORC1 as a novel rate limiting factor und its regulation through E2F4 as a molecular mechanism involved in neuronal cell death after oxygen glucose deprivation. (fu-berlin.de)
  • signaling pathways
  • Therefore, the major checkpoint in the cell cycle is the restriction (R) point between G1 and S phases, prior to DNA duplication, at which the cycle progresses depending on mitogenic or inhibitory factors such as DNA damage and signals from various signaling pathways. (antibodies-online.com)
  • damage
  • Other, more hypothetical pathways are presented including the de novo production of new consensus binding motifs by oxidative damage/mutations and changes in promoter structure or sequence such that they acquire higher affinity for inappropriate transcription factors. (springer.com)
  • Evans MD, Cooke MS. Factors contributing to the outcome of oxidative damage to nucleic acids. (springer.com)
  • constitutively
  • AND-34, a novel GDP exchange factor, is expressed constitutively at significant levels in murine splenic B cells, but not in murine splenic T cells or thymocytes. (jimmunol.org)
  • Transcriptional
  • Components of the SWI-SNF apparatus are believed to bind to chromatin and relieve nucleosome-mediated repression of transcription, thus providing access to transcriptional activators ( 7 , 21 , 27 , 31 , 42 , 45 ). (asm.org)
  • reaction
  • We evaluated the role of long noncoding ribonucleic acid (lncRNA) in breast cancer cell lines by quantitative reverse transcription-polymerase change reaction. (cancerindex.org)
  • Mouse
  • We analyzed the impact of E2F4 deficiency on early steps in mouse hematopoietic development, and found defects in early hematopoietic progenitor cells that were propagated through common lymphoid precursors to the B and T lineages. (jimmunol.org)
  • This contrasts with current evidence from the mouse, where E2f4 seems to be more important. (zfin.org)
  • Show
  • Moreover, using a variety of double mutant combinations we show that E2f5 has a more prominent role in MCC development in the zebrafish than E2f4. (zfin.org)
  • complex
  • p130Cas and HEF1 are a structurally related pair of such docking molecules that localize to the focal adhesion complex, assembling members of adhesion and growth factor-related signaling cascades ( 10 , 11 ). (jimmunol.org)
  • found
  • Among these, E2F4 is found at high concentrations in hematopoietic cells ( 15 ). (jimmunol.org)
  • We found that while E2f4 is fully dispensable, E2f5 is essential for MCCs to form in the kidney tubules. (zfin.org)
  • However
  • However, E2F4 migrates as an heterogeneous set of bands between 57-64 kDa which are associated with extensive phosphorylations (Beijersbergen et al. (atlasgeneticsoncology.org)
  • However, the impact of E2F4 deficiency on thymocyte development has been controversial ( 15 , 17 ). (jimmunol.org)
  • signals
  • It is still unclear how environmental signals ( 1 ) and lineage-specific transcription factors work together to control the frequency with which dividing HSC either undergo self-renewal or commit to one or the other lineage. (jimmunol.org)