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  • E2F3
  • a) Normal thyroid tissues from retinoblastoma gene (Rb1)+/+ (left column), Rb1D326V/+ (middle column) or Rb1+/− (right column) mice were stained with anti-E2F1 (upper section), anti-E2F2 (middle section) and anti-E2F3 (lower section) antibody using HRP chromogenic substrate, DAB (brown-colored staining). (nih.gov)
  • b) The positive-cell ratio was analyzed in C-cells stained with anti-E2F1 (upper graph), anti-E2F2 (middle graph) or anti-E2F3 (lower graph) antibody. (nih.gov)
  • For this purpose, we performed IHC to evaluate the level of E2F and found that E2F1, E2F2 and E2F3 were decreased in the thyroid C-cells of the mutant Rb1+/− mice (Fig.3a). (nih.gov)
  • This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. (nih.gov)
  • Mouse embryos lacking E2F1, E2F2, and one of the E2F3 isoforms, can develop normally when either E2F3a or E2F3b, is expressed. (wikipedia.org)
  • Thus
  • Thus, E2F2 converted PC12-derived neurons from a reversible to a 'terminally' differentiated, NGF-dependent state, analogous to postmitotic sympathetic neurons. (umassmed.edu)
  • mice
  • The occurrence and severity of collagen-induced arthritis were decreased in E2f2 -KO mice compared with WT mice. (biomedcentral.com)
  • roles
  • This study aimed to elucidate this mechanism and confirm the pathological roles of E2F2 in rheumatoid arthritis (RA). (biomedcentral.com)
  • role
  • This study confirms the pathological role of E2F2 in RA and found that the E2F2-STAT1/MyD88-Akt axis is closely related with the inflammatory phenotype in RASFs. (biomedcentral.com)
  • progression
  • The factors that trigger the progression from clinically and body weight-stable CHF to cardiac cachexia, however, remain poorly understood. (hindawi.com)
  • control
  • It is still unclear how environmental signals ( 1 ) and lineage-specific transcription factors work together to control the frequency with which dividing HSC either undergo self-renewal or commit to one or the other lineage. (jimmunol.org)