• These results suggest that differential expression of Apaf-1 and caspase-3 genes may underlie regulation of apoptotic susceptibility during brain development, as well as after acute injury to mature brain, through the intrinsic pathway of caspase activation. (jneurosci.org)
  • Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)
  • Finally, our results suggest that one possible mechanism of this protective response lies in enhanced NPM-retinoblastoma tumor suppressor protein (pRB) interaction, leading to the relief of the repressive pRB-E2F1 circuitry and the consequent transcriptional activation of E2F1 and several downstream DNA repair genes. (edu.hk)
  • Both DP-1 and DP-2 synergistically interact with members of the E2F family of proteins, E2F-1, E2F-2, and E2F-3, to generate DNA binding complexes that specifically recognize the E2F site and functionally interact with E2F-1 in E2F site-dependent transcriptional activation of cellular genes. (ox.ac.uk)
  • By comparing FoxA1 binding sites in prostate cancer cell genomes, we defined a codependent set of FoxA1-MYBL2 and FoxA1-CREB1 binding sites within the regulatory regions of the Cyclin E2 and E2F1 genes that are critical for CRPC growth. (uthscsa.edu)
  • Based on the possible role of HMGB1 in the p53 network, investigattion on whether HMGB1 could regulate some potential downstream genes at the transcriptional level was carried out. (edu.hk)
  • To date, it is well known that lncRNAs participate in chromatin modifications and transcriptional and translational regulation of protein-encoding genes or regulate protein function and activity through specific binding [ 3 - 5 ]. (jcancer.org)
  • Like a transcription element, YAP mediates the manifestation of several growth-promoting or anti-apoptotic genes, including connective cells growth element (CTGF), cysteine-rich angiogenic inducer 61 (CYR61), cyclin E, E2F1, myc and survivin 7, 10C13. (colinsbraincancer.com)
  • Sarris ME, Moulos P, Haroniti A, Giakountis A, Talianidis I. (2016) Smyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver and colon cancer development. (forth.gr)
  • Here, we explored the mechanistic role of RIP140 in breast cancer and its involvement in estrogen receptor α (ERα) transcriptional regulation of gene expression. (aacrjournals.org)
  • The luciferase assay results demonstrated that HMGB1 does not regulate the p53 promoter directly but may affect the expression of p53 via its regulation on the MDM2 and the E2F1 promoters. (edu.hk)
  • However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)
  • Finally, we manually assembled a proposed regulation network model of subcutaneous preadipocyte differentiation base on the expression data, and suggested that E2F1 may serve as an important link between the processes of duck subcutaneous preadipocyte proliferation and differentiation. (biomedcentral.com)
  • Since the molecular mechanism underlying securin upregulation remains unclear, this study intended to investigate the association of securin upregulation with the Rb-E2F1 circuit and epigenetic histone (H3) modification patterns both globally and in the promoter region of the securin gene. (biomedcentral.com)
  • RAN-mediated pRb-inactivation induced securin upregulation, a putative E2F1 target, by inducing misregulation in chromatin remodeling in its promoter region, which led to transcriptional activation and subsequent development of chromosomal instability. (biomedcentral.com)
  • An HMGB1 expression plasmid together with the p53, the MDM2 or the E2F1 promoter-containing reporter plasmid were co-transfected into the MCF-7, the HMGB1 suppressed MCF-7 and the p53-null human osteosarcoma Saos-2 cell lines to examine the transcriptional effects of exogenous HMGB1 on these promoters. (edu.hk)
  • The action of HMGB1 on the MDM2 promoter is in a p53-dependent manner whereas its activation of the E2F1 promoter is p53-independent. (edu.hk)
  • Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. (tamu.edu)
  • Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. (abcam.com)
  • Additionally, BRDs contain several catalytic domains that enable them to act as methyltransferases, ATP-dependent re-modellers or histone acetyltransferases and helicases ( 8 ) Bromodomain and extra-terminal domain (BET) proteins are a family of transcriptional mediators that regulate gene expression ( 8 , 9 ). (frontiersin.org)
  • YAP, also called Yes-associated proteins 1, is usually an element of nuclear transcriptional complexes 9. (colinsbraincancer.com)
  • This proadifen-MTX synergism was also mediated by the inhibition of various cellular proteins engaged in apoptosis, including Mc-1, Bcl-xL, survivin and activation of procaspase-3. (spandidos-publications.com)
  • The mechanisms effecting establishment, maintenance, and modification of that specific physical conformation of CHROMATIN determining the transcriptional accessibility or inaccessibility of the DNA. (lookformedical.com)
  • Taken together, our data suggest that UASR1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. (jcancer.org)
  • Transcriptional modulation of oncogene and tumour suppressor gene expression by histone deacetylases, histone demethylases and histone methyltransferases. (sciforschenonline.org)
  • both E2F1 and c-Myc are stimulating factors of H19 expression, and the H19 lncRNA functions as a downstream effector of c-Myc and E2F1 in tumor development and progression [ 11 ]. (jcancer.org)
  • Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene. (wikipedia.org)
  • Arsenic-treated cells displayed increased multiple centrosome which is resulted from overexpressed Aurora-A. Furthermore, the transcription factor, E2F1, is responsible for Aurora-A overexpression after arsenic treatment. (tmu.edu.tw)
  • Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. (proteopedia.org)
  • It has long been known as an architectural transcription factor involved in gene activation as well as in other nuclear processes. (edu.hk)
  • Karagianni P, Moulos P, Schmidt D, Odom DT, Talianidis I. (2020) Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation. (forth.gr)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • Conclusion: We reveal that low dose of arsenic induced cell proliferation is through Aurora-A overexpression, which is transcriptionally regulated by E2F1 both in vitro and in vivo. (tmu.edu.tw)
  • controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. (proteopedia.org)
  • Messenger RNA and protein expression levels of Aurora-A were detected by reverse transcriptional-PCR and Western blotting, respectively. (tmu.edu.tw)
  • Injury-induced cytochrome c -specific cleavage of caspase-9 followed by activation of caspase-3 in mature brain correlated with marked increases in Apaf-1 and caspase-3 mRNA and protein expression. (jneurosci.org)
  • Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). (wuxibiortus.com)
  • DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1. (ncl.edu.tw)
  • We recently showed that NANOG-mediated induction of Aurora A kinase (AURKA), an upstream kinase for aPKCζ, and repression of Lethal Giant Larva 2 (LGL2 or LLGL2), an aPKCζ inhibitor, leads to aPKCζ upregulation and activation. (nature.com)
  • Immunohistochemistry data revealed hyperphosphorylation of Rb and upregulation of E2F1 in the RAN-treated samples. (biomedcentral.com)
  • Via dephosphorylation, calcineurin is the enzyme responsible for activating nuclear factor of activated T-cells (NF-AT), a T cell transcriptional regulatory factor. (medindex.am)
  • These results reveal a transcriptional regulatory mode of KRAS-driven malignant transformation and highlight miR-139-5p as a novel regulator of crosstalk between the Ras and Wnt signaling pathways in CRC. (thno.org)
  • Phosphorylation of RB1 disturbs its interaction with E2F1. (proteopedia.org)
  • As a consequence, the synthesis and release of Th1- (T helper 1) and Th2- (T helper 2) type cytokines, and other inflammatory mediators from T-cells and mast cells are blocked and the expression of signals essential for the activation of inflammatory T-lymphocytes is inhibited. (medindex.am)
  • Mechanistic investigations indicated that FoxA1, MYBL2, or CREB1 induction of histone H3 acetylation facilitated nucleosome disruption as the basis for codependent transcriptional activation and G 1 to S-phase cell-cycle transit. (uthscsa.edu)
  • Inevitably, there are fundamental and applied questions, such as those relating to transcriptional control of stem cell differentiation, intrinsic noise in gene expression, and the origins of disease, that may only be addressed at the single cell level. (justia.com)
  • This study aimed to explore adipogenic transcriptional dynamics before (proliferation) and after (differentiation) initial preadipocyte differentiation in ducks. (biomedcentral.com)
  • The major risk factors associated with HCC development and progression include chronic hepatitis B or C virus infections, high alcohol consumption, and activation of oncogenes [ 2 ]. (techscience.com)
  • Following activation, NK cells mediate killing of target cells through two major pathways that require direct contact between NK cells and their target cells ( 6 ). (frontiersin.org)
  • The transcriptional activity of YAP is usually subject to unfavorable rules by cytoplasmic sequestration or ubiquitin-mediated degradation. (colinsbraincancer.com)
  • With this research we display that PTPN14 binds to YAP and become a poor regulator of YAP-mediated transcriptional activity. (colinsbraincancer.com)
  • Snail expression, through AhR activation, is an epithelial-to-mesenchymal transition (EMT) determinant. (oncotarget.com)
  • This download generates activation of efficient ribonucleotides that are to the provirus of expression. (erik-mill.de)
  • Activation of YAP continues to be observed buy AdipoRon in higher than 60 percent of non-small cell lung malignancy cases 21. (colinsbraincancer.com)
  • Their function is regulated by the activation of a number of activating and inhibitory receptors that bind to specific ligands expressed on the surface of target cells. (frontiersin.org)
  • Further variety of the pathogenesis of heparin on food or eRF3 activation novo increases characterised for the unidentified blood, since responses between foreign mitochondria and the vacuolar agonist bind Generally previously often endocytosed. (erik-mill.de)
  • RIP140 is a transcriptional coregulator involved in energy homeostasis, ovulation, and mammary gland development. (aacrjournals.org)
  • Photoshop CS6 serial key is the activation code or software key for the program on a computer. (island-mljet.com)
  • ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition. (tamu.edu)
  • Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. (proteopedia.org)