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  • repress
  • In addition, in the nasopharyngeal carcinoma cell line, miR-20a and miR-20b has been shown to target the 3' UTR of vascular endothelial growth factor (VEGF) and repress the expression of VEGF, which is an important angiogenic factor. (wikipedia.org)
  • pathway
  • The E2F1 pathway mediated lethality in HPV-positive mice because deletion of E2F1 increased survival of mice ubiquitously expressing HPV oncogenes. (mdpi.com)
  • Our results indicate that HPV oncogenes activated the E2F1 pathway to cause lethality in normal mice and to suppress oral tumor growth. (mdpi.com)
  • These results suggest that selective modulation of the E2F1 pathway, which is activated in HPV tumors, may facilitate tumor regression. (mdpi.com)
  • miRNA
  • E2F1 somatic mutation within miRNA target site impairs gene regulation in colorectal cancer. (nih.gov)
  • Given this, the paralogs to the helicase core of the gene are associated with translation, transcription, nonsense-mediated mRNA decay, RNA decay, miRNA processing, RISC assembly, and pre-mRNA splicing. (wikipedia.org)
  • It is also required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC, and for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). (wikipedia.org)
  • tumor
  • E2F1 similarly functioned as a tumor suppressor in HPV-positive oral tumors as tumors grew faster with homozygous loss of E2F1 compared to tumors with heterozygous loss of E2F1. (mdpi.com)
  • LNGFR is a member of the tumor necrosis factor receptor (TNF receptor)superfamily - indeed, LNGFR was the first member of this large family of receptors to be characterized. (wikipedia.org)
  • inhibitory
  • Therefore, the major checkpoint in the cell cycle is the restriction (R) point between G1 and S phases, prior to DNA duplication, at which the cycle progresses depending on mitogenic or inhibitory factors such as DNA damage and signals from various signaling pathways. (antibodies-online.com)
  • genomic
  • Mov10 nteracts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. (wikipedia.org)
  • assay
  • This assay has high sensitivity and excellent specificity for detection of E2F1. (mybiosource.com)
  • MBS753168 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the E2F transcription factor 1 (E2F1) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • The assay sample and buffer are incubated together with E2F1-HRP conjugate in pre-coated plate for one hour. (mybiosource.com)
  • nerve growth factor r
  • The low-affinity nerve growth factor receptor (nerve growth factor receptor (TNFR superfamily, member 16), also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors that stimulate neuronal cells to survive and differentiate. (wikipedia.org)
  • reaction
  • NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between E2F1 and all the analogues, therefore, cross reaction may still exist in some cases. (mybiosource.com)
  • role
  • Raimondi S, Maisonneuve P, Lohr JM, Lowenfels AB: Early onset pancreatic cancer: evidence of a major role for smoking and genetic factors. (springermedizin.de)
  • Cells
  • In REF52 cells, overexpression of activator E2F1 is able to push quiescent cells into S phase. (wikipedia.org)