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  • proliferation
  • The retinoblastoma protein (pRb), in its hyperphosphorylated form, releases E2 promoter binding factor-1 (E2F1), which drives cell proliferation. (aacrjournals.org)
  • lncRNA-HIT promotes cell proliferation of non-small cell lung cancer by association with E2F1. (nih.gov)
  • Study demonstrated that CDCA3 may target p21 to promote colorectal cancer (CRC) cell proliferation and tumorigenesis, at least partially in an E2F1-mediated manner, and that CDCA3 may serve as a potential prognostic and therapeutic target of CRC. (nih.gov)
  • Combined, these data identify Brm as a major effector of serum androgen-induced proliferation in the prostate that is disrupted in human disease, and indicate that loss of Brm confers a proliferative advantage in prostate cancer. (aacrjournals.org)
  • endogenous
  • This process is reversible through ablation of endogenous E2F1 in highly aggressive skin cancer cells, leading to increased TXNIP and E-Cadherin and loss of mesenchymal markers SNAI2, ZEB1, and Vimentin 9 , 17 . (nature.com)
  • tumors
  • We integrate gene expression profiles of cancer cell lines from two E2F1-driven highly aggressive bladder and breast tumors, and use network analysis methods to identify the tumor type-specific core of the network. (nature.com)
  • Our integrative network-based methodology, exemplified in the case of E2F1-induced aggressive tumors, has the potential to support the design of cohort- as well as tumor type-specific treatments and ultimately, to fight metastasis and therapy resistance. (nature.com)
  • Enforced E2F1 expression in advanced tumors and metastases of different kinds of cancers correlates with pronounced resistance towards therapy and poor patient prognosis 14 , 15 . (nature.com)
  • melanoma
  • As a direct target of E2F1, enforced expression of miR-224 / 452 in melanoma cells stimulates a mesenchymal phenotype by repressing the metastasis suppressor TXNIP associated with changes in the actin cytoskeleton towards an enhanced invasive cell behavior. (nature.com)
  • expression
  • To control this process, it is increasingly apparent that the specificity of SWI/SNF function is dictated by biochemical diversity in subunit composition, and that imbalances in subunit expression can induce significant, often tissue-specific biological consequence ( 3 , 5 - 8 ). (aacrjournals.org)
  • regulatory
  • Network hubs, feedback, and feedforward loops, the regulatory motifs often encountered in cancer networks, are able to induce a complex regulatory behavior that evades the use of conventional data analysis tools for their understanding 6 , 7 . (nature.com)
  • TXNIP in turn controls E2F1 activity in a negative regulatory loop. (nature.com)
  • E2F1 regulates glucose metabolism by increasing anaerobic glycolysis and identified the key regulatory enzyme, PFKFB3, as E2F1 target gene responsible for mTORC1 activation. (ssrn.com)
  • target
  • E2F1 somatic mutation within miRNA target site impairs gene regulation in colorectal cancer. (nih.gov)
  • growth
  • SFN at concentrations of 5 - 20 μM induced a dose-dependent suppression of growth in cell lines MDAH 2774 and SkOV-3 with an IC50 of ~8 μM after a 3 day exposure. (biomedcentral.com)
  • activation
  • Based on the metabolic function of E2F1, we hypothesize that glucose catabolism driven by E2F1 could participate on mTORC1 activation. (ssrn.com)
  • results
  • Overall, our results further increase the knowledge of the radiation-induced p53 network of the embryonic brain and provide more evidence concerning the importance of p53 and its transcriptional targets during mouse brain development. (biologists.org)