ApoptosisRats, Inbred F344Apoptosis Regulatory ProteinsCaspasesCaspase 3Inhibitor of Apoptosis ProteinsProto-Oncogene Proteins c-bcl-2F FactorF2-IsoprostanesDNA Fragmentationbcl-2-Associated X ProteinIn Situ Nick-End LabelingX-Linked Inhibitor of Apoptosis ProteinCell Line, TumorApoptosis Inducing FactorCell SurvivalSignal TransductionCASP8 and FADD-Like Apoptosis Regulating ProteinCaspase 9Caspase InhibitorsCaspase 8Enzyme ActivationMitochondriaCell LineFas Ligand ProteinTumor Suppressor Protein p53Cytochromes cTumor Cells, CulturedCells, Culturedbcl-X ProteinAnnexin A5Flow CytometryCell ProliferationProstaglandins FAmino Acid Chloromethyl KetonesBlotting, WesternCysteine Proteinase InhibitorsTransfectionProto-Oncogene ProteinsCell CycleEnzyme InhibitorsAntineoplastic AgentsPoly(ADP-ribose) PolymerasesFluorodeoxyglucose F18Time FactorsRNA, MessengerJurkat CellsTNF-Related Apoptosis-Inducing LigandReactive Oxygen SpeciesCell DivisionRNA, Small InterferingCarrier ProteinsCaspase 7Amino Acid SequenceHL-60 CellsDown-RegulationMembrane Potential, MitochondrialUp-RegulationCell DeathDose-Response Relationship, DrugTumor Necrosis Factor-alphaGenes, bcl-2Gene Expression RegulationDNA-Binding ProteinsPhosphorylationProtein Bindingbcl-2 Homologous Antagonist-Killer ProteinMembrane GlycoproteinsNecrosisCytochrome c GroupProto-Oncogene Proteins c-aktGene Expression Regulation, NeoplasticMyeloid Cell Leukemia Sequence 1 ProteinProton-Translocating ATPasesBH3 Interacting Domain Death Agonist ProteinNF-kappa BDNA DamageTranscription FactorsGene ExpressionStaurosporineReverse Transcriptase Polymerase Chain ReactionMice, Inbred C57BLCell Cycle Proteinsbcl-Associated Death ProteinAntineoplastic Agents, PhytogenicRecombinant ProteinsDrug SynergismRNA InterferenceCeramidesReceptors, TNF-Related Apoptosis-Inducing LigandProtein-Serine-Threonine KinasesCaspase 2Mice, KnockoutHeLa CellsOxidative StressMice, NudeImmunohistochemistryFas-Associated Death Domain ProteinNeoplasm ProteinsMice, Inbred BALB C