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  • promoters
  • Prevention of E2F-binding correlated with a failure to acetylate H4 on target promoters, and inability to enter the cell cycle upon mitogenic stimulation. (rero.ch)
  • Furthermore, the coactivator complex targeted most, if not all, promoters investigated in this study, establishing Tip60 recruitment and H4 acetylation as a common feature of E2F-dependent coactivation. (rero.ch)
  • The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. (wikipedia.org)
  • cyclin
  • p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the G1/S checkpoint of the cell cycle. (wikipedia.org)
  • When Rb is phosphorylated by cyclin D and E-dependent kinases during the G1 phase of the cell cycle, Rb can not block E2F-dependent transcription, and the cell can progress to the DNA synthetic phase(S phase). (wikipedia.org)
  • subunit
  • Physiological E2F is a heterodimer composed of an E2F subunit together with a DP subunit. (creativebiomart.net)
  • E2F and Myc associate with TRRAP, a subunit of distinct macromolecular complexes that contain the histone acetyltransferases (HATs) Gcn5/PCAF or Tip60. (rero.ch)
  • histone
  • This was accompanied by localized changes in histone acetylation, centered to the E2F binding sites. (rero.ch)
  • target genes
  • Firstly, I used chromatin immunoprecipitation (CHIP) to show that E2F recruits a TRRAP/Tip60 complex to its target genes. (rero.ch)
  • pathways
  • Among its related pathways are IL-2 Pathway and E2F transcription factor network . (genecards.org)
  • Therefore, the major checkpoint in the cell cycle is the restriction (R) point between G1 and S phases, prior to DNA duplication, at which the cycle progresses depending on mitogenic or inhibitory factors such as DNA damage and signals from various signaling pathways. (antibodies-online.com)
  • cell
  • Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. (wikipedia.org)
  • The E2F transcription factors are involved in mediating the cell cycle, which could be a potential link to the hypothesized role of TTC39C in anaphase. (wikipedia.org)
  • cyclins
  • Taxi has not restriction point and transition at G1/S. Three been shown to bind directly to Taxi-responsive novel types of putative mammalian G1 cyclins were isolated by using human cDNA libraries to transactivation occurs through indirect effects of complement CLN-deficient yeast and designated Taxi on transcription factors which bind to the as cyclins C, D, and E . (internetpdfarticles.com)
  • however, when phosphorylated by Cln3-Cdk1, Whi5 is ejected from the nucleus, allowing for transcription of the G1/S regulon, which includes the G1/S cyclins Cln1,2. (wikipedia.org)
  • vivo
  • This suggests that factors in addition to Dorsal and Dri are required for the efficient recruitment of Gro in vivo. (sdbonline.org)
  • vitro
  • The (-13910) region, in particular, has been shown to function in vitro as an enhancer element capable of differentially activating transcription of LCT promoter. (wikipedia.org)
  • progression
  • E2F is required for G1 S progression of proliferating cells and normal morphology and survival of post-mitotic, differentiating cells. (wikipedia.org)