• The expression of DMDL protein is not restricted to smooth and skeletal muscle, however, since relatively large amounts are present in transformed brain cell lines of both glial and Schwann cell origin. (rupress.org)
  • Within the brain, dystrophin is enriched at the postsynaptic regions of specific subsets of neurons, while the distribution of DRP is yet to be described. (rupress.org)
  • In order to utilize the protein-building instructions they carry, exons are first transcribed into a final genetic blueprint called messenger RNA. (eurekalert.org)
  • However, the genes involved must be able to function if certain exons are removed from the protein recipe. (news-medical.net)
  • The latter study showed that it is possible to correct the genetic error in the cells that no longer produce dystrophin protein, and inject corrected cells stimulating the regeneration of muscles. (stemcellsgroup.com)
  • Recently, Dystrophin has also been found to act as a scaffold for several signaling molecules, but the roles of dystrophin -mediated signaling pathways remain unknown. (jneurosci.org)
  • This alternate translational control element is encoded within the dystrophin gene itself, in a region of the gene that evolution has highly conserved," Dr. Flanigan said. (eurekalert.org)
  • We examined the optimal conditions for protein extraction, total protein determination, antibody detection upon Western blotting and relative dystrophin quantification techniques. (exonskipping.eu)
  • Spindles were serially-sectioned in transverse and longitudinal planes, and they were double-labelled with an antibody to dystrophin and with a 200 kD neurofilament protein antibody which revealed their sensory innervation. (ubc.ca)
  • Members of the dystrophin family of proteins perform a critical role in the maintenance of membrane-associated complexes at points of intercellular contact in vertebrate cells. (nih.gov)
  • The results of this study suggest that dystrophin is not an integral part of the subsynaptic sensory-membrane in equatorial regions of normal intrafusal fibers, and, that the neurotrophic effect of sensory innervation is not the principle cause of this unique arrangement of dystrophin in equatorial regions. (ubc.ca)
  • Scientists say the new strategy enhances the accuracy for surgical-like editing of the human genome, correcting mistakes in the DNA sequence that cause devastating diseases like DMD, a deadly condition caused by defects in the dystrophin gene. (news-medical.net)
  • Kunkel with a six-foot-long map showing a portion of the area where the dystrophin gene is located within the human genome. (harvardmagazine.com)
  • Under normal conditions, the messenger RNA is marked at its very beginning by a special molecular cap that is critical for recruiting ribosomes, the cellular structures responsible for translation of the gene into a protein. (eurekalert.org)
  • Short-term synaptic facilitation of evoked transmitter release is decreased in the mutants, suggesting that the absence of dystrophin results in increased probability of release. (jneurosci.org)