Dysfunction of the circadian pacemaker. Medical search. Frequent questions

Physiological studies have included retinal function relative to animal circadian rhythms, as well as the transplantation of neural circadian pacemakers in rodents. (sc.edu)
Notwithstanding the importance of these factors, the integrity of the visual and photic system remains the overriding component governing light's ability to entrain circadian rhythms. (biomedcentral.com)
Here, Meijer began her work on circadian rhythms alongside Ben Rusak. (wikipedia.org)
Meijer continues her study of circadian rhythms and chronobiology today as a Professor and Head of Neurophysiology Group at the Leiden University Medical Center in the Netherlands and a visiting professor in the Department of Ophthalmology at the University of Oxford in the United Kingdom. (wikipedia.org)
Meijer went on to characterize the baseline and light-induced activity of the mammalian SCN through long-term recordings in freely moving rats, which established the ability of the SCN to produce circadian rhythms in neural activity in vivo. (wikipedia.org)
Studying pathways for light input to the SCN, Meijer found that glutamate injections in the SCN produce phase shifts in the circadian activity rhythms of hamsters similar to those induced by light exposure, providing evidence that glutamate transmission mediates photic entrainment. (wikipedia.org)
We have a pacemaker (the suprachiasmatic nucleus) that regulates circadian rhythms in the brain and maintains a 24-hour cycle through a pathway involving the retina (back of eye) that is sensitive to light and dark, Dr. Nancy Foldvary-Schaefer, DO, MS , Director of the Sleep Disorders Center in Cleveland Clinic's Neurological Institute, explained. (healthline.com)
Living systems on earth are governed by many natural laws, but circadian rhythms play one of the most important roles in sustaining organisms, acting as the biological timekeepers that perpetuate life from mere seconds to the full Gregorian year. (frontiersin.org)
Mammalian circadian rhythms can be observed from the genetic level to the tissue level, and even to the macroscopic level, affecting behavior, biochemical and physiological processes. (frontiersin.org)
To garner a more comprehensive understanding of the effects of circadian rhythms on health and neurodegeneration, the underlying fundamental molecular mechanisms and interrelated processes must be explored ( Cox and Takahashi, 2019 ). (frontiersin.org)
Circadian rhythms, 24-hour internal clocks running in all cells, aid living organisms in acclimatizing their physiology and behavior to the day/night changes in light, temperature, accessibility of food, and other periodic ecological factors. (databasefootball.com)
The master circadian clock, or the central pacemaker of circadian rhythms, is the suprachiasmatic nucleus located in the hypothalamic region of the brain. (databasefootball.com)
Remarkably, the interaction between seizures and circadian rhythms occurs in a bi-directional manner. (databasefootball.com)
mood and cognitive performance and most apparently by sleep and wake cycle and circadian rhythms are influenced by the external environmental and social cues. (savedelicious.com)
According to the International Classification of Sleep disorders, the primary causality for obstinate sleep problems is thought to be the changes in the circadian timings or dysfunction between the external factors and visceral circadian rhythms. (savedelicious.com)
Circadian rhythms exist at all levels of complexity, from gene expression to rhythms in physiology, metabolism, and behavior. (achim-kramer-lab.de)
Circadian rhythms are endogenous oscillations whose period in constant conditions is close to 24h. (umass.edu)
Circadian Rhythms: Understanding the SCN Connectome. (umass.edu)
This alters exposure to the regular photoperiod ical studies of night shift work and cancer since and may disrupt circadian rhythms in humans. (who.int)
Are Biological Clocks And Circadian Rhythms The Same? (securepharmaonline.com)
While there is a prominent correlation between biological clocks and circadian rhythms, they are actually not the same thing. (securepharmaonline.com)
Biological clocks are the body's innate timing mechanism, which is essential for the regulation of all bodily processes, including circadian rhythms. (securepharmaonline.com)
It is these clocks that actually generate circadian rhythms and maintain their timings. (securepharmaonline.com)
In conclusion, we can say that the circadian rhythms are a consequence of the biological clocks. (securepharmaonline.com)
Hence, circadian rhythms are biological clocks but not all biological clocks are circadian rhythms. (securepharmaonline.com)
The circadian rhythms are designed to function in sync with the state of your body, to some extent. (securepharmaonline.com)
Circadian rhythms establish a link between your physical and mental systems, which are connected to a master clock, or the circadian pacemaker. (securepharmaonline.com)
It controls the circadian cycles and also influences many other physiological and behavioral rhythms occurring over a 24-hour period, which includes the sleep/wake cycle. (securepharmaonline.com)
Many other external cues apart from light, like temperature, exercise, and social interactions also have an influence on the circadian rhythms. (securepharmaonline.com)
The direct interconnection between CR and circadian rhythms has been evinced by the fact that Igf-1 expression is regulated by both CR and the circadian clock [ 14 ] . (encyclopedia.pub)
Circadian rhythms control daytime and nighttime changes in blood pressure. (nih.gov)
This study is examining the links between stress, loss of sodium through urine, and circadian rhythms in controlling blood pressure. (nih.gov)
Portacaval anastomosis disrupts circadian locomotor activity and pineal melatonin rhythms in rats. (hepatitiscentral.com)
11. Mason DJ, Tapp W. Measuring circadian rhythms. (hepatitiscentral.com)
13. Horne JA, Ostberg O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. (hepatitiscentral.com)
Disturbance of circadian rhythms underlies various metabolic diseases. (researchgate.net)
Constant light exposure (LL) is known to disrupt both central and peripheral circadian rhythms. (researchgate.net)
Here, we attempted to determine whether the effects of LL are different between various peripheral tissues and whether time-restricted feeding restores the circadian rhythms especially in white adipose tissue (WAT). (researchgate.net)
LL disrupted this pattern, causing disruptions in circadian rhythms of plasma levels of triglycerides (TG) and glucose. (researchgate.net)
LL eliminated the circadian rhythms of the expression of the clock genes as well as most of the genes involved in lipid metabolism in both liver and WAT. (researchgate.net)
Time-restricted feeding restored the circadian rhythms of most of the genes to various degrees in both liver and WAT. (researchgate.net)
In conclusion, LL disrupted the peripheral circadian rhythms more severely in liver than in WAT. (researchgate.net)
Time-restricted feeding restored the circadian rhythms in both tissues. (researchgate.net)
For stroke, different physiological activities such as sleep/wake cycles are disrupted due to alterations in circadian rhythms. (ijbs.com)
Thus, disrupted circadian rhythms may increase the severity and consequences of stroke, while readjustment of circadian clock machinery may accelerate recovery from stroke. (ijbs.com)
In this manuscript, we discuss the relationship between stroke and circadian rhythms, particularly on stroke development and its recovery process. (ijbs.com)
These observations suggest a link between circadian clock/rhythms and with onset, development, and recovery processes of stroke. (ijbs.com)
D. Ono, S. Honma and K. Honma, Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus. (atto.co.jp)

The suprachiasmatic nucleus (SCN) of the hypothalamus is thought to be the master pacemaker of this system. (nature.com)
1993]. There is evidence that the endogenous circadian pacemaker located in the suprachiasmatic nucleus is a wake-promoting system [Edgar et al. (psychiatrictimes.com)
The role of the suprachiasmatic pacemaker (SCN) in energy expenditure durning hibernation of golden-mantled ground squirrels. (sc.edu)
She discovered that synaptic and neural plasticity in the neuronal network of the suprachiasmatic nucleus (SCN) is required for regular seasonal adaptation of the circadian clock in animals. (wikipedia.org)
Alzheimer's patients exhibit high degradation of the suprachiasmatic nucleus (SCN), the central endogenous circadian timekeeper, and Parkinson's patients have highly disrupted peripheral clock gene expression. (frontiersin.org)
TRPM8 is expressed in the retina, specifically in cholinergic amacrine interneurons and in a subset of melanopsin-positive ganglion cells which project to the central pacemaker, the suprachiasmatic nucleus (SCN) of the hypothalamus. (painchannels.com)
In mammals, circadian clocks have been found in almost every cell, but they are organized hierarchically: A tiny brain structure, the suprachiasmatic nucleus (SCN) of the hypothalamus, is known to be the main pacemaker. (achim-kramer-lab.de)
A master pacemaker in the suprachiasmatic nucleus of the hypothalamus (SCN) is required not only for rhythmicity of sleep and wakefulness, but also to insure optimal physiological function as incompatible events are scheduled to occur at different phases. (umass.edu)
2018. Suprachiasmatic function in a circadian period mutant: Duper alters light- induced activation of vasoactive intestinal peptide cells and PERIOD1 immunostaining. (umass.edu)
A circadian pacemaker is a small group of nerve cells located in the suprachiasmatic nucleus (SCN), in the hypothalamus. (securepharmaonline.com)
The central circadian pacemaker in mammals is located in the hypothalamic suprachiasmatic nucleus (SCN), which controls peripheral circadian clocks. (ijbs.com)
Son, K. Kim, Effect of Mefloquine, a Gap Junction Blocker, on Circadian Period2 Gene Oscillation in the Mouse Suprachiasmatic Nucleus Ex Vivo . (atto.co.jp)

Circadian melatonin disruption can be used as an indicator of delirium. (greenmedinfo.com)
Disruption of melatonin circadian rhythm production is frequent among RRMS patients and seemingly related to higher disability and fatigue scores. (greenmedinfo.com)
However, modern life constantly challenges our internal clock, which can lead to circadian rhythm disruption. (achim-kramer-lab.de)
Today, it is undeniable that circadian rhythm disruption is associated with many common diseases, including sleep disorders, psychiatric and neurodegenerative diseases, metabolic and cardiovascular disorders, immune system dysfunctions, as well as cancer. (achim-kramer-lab.de)
ii) Disruption of the circadian clock by artificial light, shift work, travel across time zones, social jet lag, and daylight saving time changes has been associated with a variety of common diseases. (achim-kramer-lab.de)
We have found that disruption of the circadian clock in any of several cell types in identified hypothalamic circuits alters timing of the LH surge. (umass.edu)
For Volume 124, the scope of the system- cancer in humans and cancer in experimental atic review encompassed a comprehensive animals formed the basis of the Working Group's search of the literature, focusing on an agent evaluation of "shift work that involves circadian name reflecting variations on "night shift work", disruption" as Group 2A. (who.int)
The chronic circadian disruption caused by shift work, jetlag, and/or irregular sleep-wake cycles has long-term health consequences. (ijbs.com)
Circadian disruption can be caused by environmental influences such as shift work or travel across time zones. (ijbs.com)
These findings may have real-world implications for circadian disruption induced by exposure to brief light stimuli at night. (jci.org)

Rodents serve as vital experimental models for circadian timing since they mirror in close detail the human circadian system. (sc.edu)
We investigated the response of the human circadian pacemaker to a single 15-second or 2-minute light pulse administered during the biological night. (jci.org)

Meijer's studies of cryptochrome-deficient mice (a photoreceptor which regulates entrainment by light) revealed that they show no neuronal activity in the SCN because the circadian rhythm is generated from a transcription-translation feedback loop, which includes both positive and negative feedback via certain circadian clock genes. (wikipedia.org)
A set of core genes constitutes this transcriptional pathway that forms the identity of the endogenous circadian pacemaker. (frontiersin.org)
The CLOCK/BMAL1 heterodimer activates the transcription of Per/Cry genes, and the production and resulting phosphorylation of PER/CRY inhibit the CLOCK/BMAL1 heterodimer, reducing the transcription of Per/Cry forming the negative feedback loop required to maintain circadian rhythmicity at a basic molecular level. (frontiersin.org)
Over the past three decades, the molecular mechanism of circadian rhythm generation has been uncovered and the associated genes and gene variants have been identified. (achim-kramer-lab.de)
Cells throughout the brain and periphery express core circadian clock genes that engage in feedback loops to insure temporal coordination. (umass.edu)
We use molecular genetics to achieve conditional deletion of critical circadian clock genes in specific neurons of female mice. (umass.edu)
Further, the postprandial release of insulin resets peripheral clocks by regulating the expression of core circadian genes. (encyclopedia.pub)
Here, we assessed the combined effect of diet composition and feeding time on (1) body composition, (2) energy balance, and (3) circadian expression of hepatic clock and metabolic genes. (researchgate.net)
Although every system in the body has a circadian rhythm, one manifestation is the sleep-wake cycle, and it is estimated that between 10 and 20 percent of genes oscillate in a circadian fashion. (medlink.com)
Rhythmicity of the circadian system is a 24-hour period, driven by transcription-translation feedback loops of circadian clock genes. (ijbs.com)
Moreover, the immunological processes that affect the evolution and recovery processes of stroke are regulated by the circadian clock or core-clock genes. (ijbs.com)

The core circadian molecular machinery gives rise to endogenous timekeeping activity. (frontiersin.org)

Dr. DeCoursey's research emphasizes the physiological, ecological and behavioral aspects of mammalian daily (circadian) rhythmicity. (sc.edu)
Neurodegenerative disorders have been shown to exhibit substantial interconnectedness with circadian rhythmicity. (frontiersin.org)
The cellular stress and subsequent DNA damage signaling imposed by hyperactivity of these multiple molecular systems in addition to aberrant circadian rhythmicity lead to extensive protein aggregation such as α-synuclein pre-formed fibrils (α-Syn PFFs), suggesting a specific molecular pathway linking circadian rhythmicity, PARP1/E3 ligase activity, and Parkinson's disease. (frontiersin.org)
Clinical implications of circadian rhythmicity. (hepatitiscentral.com)

A number of neurological conditions may be worsened by changes in the circadian clock via the SCN pacemaker. (ijbs.com)

As chief of the division of sleep and chronobiology in the department of psychiatry at the University of Pennsylvania School of Medicine, David F. Dinges, Ph.D., focuses on ways sleep and the endogenous circadian pacemaker interact to control wakefulness and waking neurobehavioral functions such as physiological alertness, attention, cognitive performance, fatigue, mood, neuroendocrine profiles, immune responses and health. (psychiatrictimes.com)
The SCN assumes the role as the central pacemaker, and through a series of genetic feedback loops and highly coordinated neuronal innervation, endogenous timekeeping activity arises, giving way to the production of circadian rhythm. (frontiersin.org)
They are generated by an internal timing system - an endogenous circadian clock - that allows organisms to anticipate daily changes in their environment. (achim-kramer-lab.de)
It is now clear that synchronization between endogenous circadian and exogenous environmental cycles is critical for health and well-being. (achim-kramer-lab.de)

Taken together, the present findings indicate that age-related circadian disorganization in entrainment to light, stress, and exercise is due to sympathetic dysfunctions in peripheral organs, while meal timing produces effective entrainment of aged peripheral circadian clocks. (nature.com)
23 Despite these apparent relationships between circadian rhythm and peripheral clock function in aged mice, no study to date has examined changes in the coordination of the SCN with peripheral clocks in aging. (nature.com)
Neural pacemakers or "living clocks" impart an adaptive time structure to organisms through the synchronization of the internal, neural timing component with environmental time by specific synchronizing agents, especially the solar day-night cycle. (sc.edu)
Ecological and behavioral studies have addressed the adaptive value of circadian clocks. (sc.edu)
Experimental studies of rodent biological clocks hold out hope for understanding and correcting human dysfunctions such as jet lag, shift worker sleep problems, and insomnia of the elderly. (sc.edu)
She is known for her extensive studies of photic and non-photic effects on the mammalian circadian clocks. (wikipedia.org)
In addition to still unraveling neuronal mechanisms of circadian clocks and their applications to health, Meijer's lab now studies the effects of modern lifestyles on our circadian rhythm and bodily functions. (wikipedia.org)
Meijer is a major contributor to the topic of circadian clocks and neuronal organization. (wikipedia.org)
However, you should know that not all biological clocks are circadian. (securepharmaonline.com)

This indicates the importance of circadian rhythm in the sleep patterns in aging. (savedelicious.com)
One obvious indication of the importance of circadian organization is the deleterious effects of jet lag and schedule changes experienced by shift workers: many illnesses are aggravated, including mental illness, diabetes, and heart disease. (umass.edu)

As such, these results offered evidence for the role of classical photoreceptors in transmitting light information to the SCN, which showed that the mammalian circadian clock receives input from photopigments beyond melanopsin. (wikipedia.org)

We are studying the regulation of intra- and intercellular processes which generate high-amplitude circadian oscillations with biochemical, genetic, molecular- and cell-biological methods. (achim-kramer-lab.de)
Ongoing projects in the lab include the characterization of molecular and cell biological mechanisms essential for the dynamics of circadian oscillations and thereby for physiology and behavior (funding by Deutsche Forschungsgemeinschaft TRR168 ). (achim-kramer-lab.de)
Next to light/dark phases, feeding patterns constitute the most essential element entraining daily oscillations, and therefore, timely and appropriate restrictive diets have a great capacity to restore the circadian rhythm. (encyclopedia.pub)

Physiological events that show day-night fluctuations in mammals are controlled by an internal circadian clock system. (nature.com)
Our group is engaged in understanding the molecular basics of the circadian clockwork in mammals and their impact on physiological and behavioral processes. (achim-kramer-lab.de)

Entrainment or phase adaptation is an important function of the circadian clock system that allows the adjustment of circadian dynamics in response to external stimuli. (nature.com)
Ocular pathology lessens light's efficacy to maintain optimal circadian entrainment. (biomedcentral.com)

Diversity of function of SCN pacemakers in behavior and ecology of 3 species of sciurid rodents. (sc.edu)
The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder. (nature.com)
For example, we have created novel reporter cells that allow us to study the dynamic behavior of clock proteins using single cell fluorescence microscopy to better understand the cell biology of the circadian clock. (achim-kramer-lab.de)
The circadian timing system and the organization of sleep-wake behavior. (hepatitiscentral.com)

Much less is known regarding effects of age-related photic impairment on circadian rhythm functions. (biomedcentral.com)
There are suggestions that several ophthalmic diseases could attenuate photic transmission to the circadian pacemaker. (biomedcentral.com)
Building upon this finding, Meijer later demonstrated the presence of glutamate receptors within the retinohypothalamic tract of brown Norwegian rats through the use of immunogold labeling, providing molecular evidence that glutamate acts as a neurotransmitter in the transduction of photic signals to the circadian clock. (wikipedia.org)
Phase resetting in duper hamsters: Specificity to photic zeitgebers and circadian phase. (umass.edu)

The ability of the circadian clock to adapt to environmental changes is critical for maintaining homeostasis, preventing disease, and limiting the detrimental effects of aging. (nature.com)
Additionally, Meijer and colleagues demonstrated the mechanisms behind synchronization and plasticity of the SCN circadian pacemaker which allows the circadian clock to respond to changes in the length of day. (wikipedia.org)
Specifically, they found that a phase shift in one's circadian clock due to different patterns of light exposure results in metabolic disorders and obesity. (wikipedia.org)
Previously, melanopsin expressed in intrinsically photosensitive retinal ganglion cells was thought to be the primary photopigment involved in light input to the circadian clock. (wikipedia.org)
An important factor which plays a vital role in everyone's sleep is circadian rhythm, a 24 hour internal biological clock, which is also known as the circadian pacemaker. (savedelicious.com)
We have discovered a novel circadian mutation called duper, which causes the circadian clock to run fast and reduces jet lag 4-fold. (umass.edu)
We are working to determine the relative contributions of circadian function in vasopressin, VIP, kisspeptin and GnRH neurons in order to reveal the loci at which the clock controls ovulation. (umass.edu)
The circadian rhythm is a collection of physical and mental changes that follow a 24-hour cycle, and are a part of the body's internal clock. (securepharmaonline.com)
The circadian rhythm is an intrinsic body clock that modulates a variety of physiologic processes to anticipate upcoming events and physiologically prepares for those events. (medlink.com)
Khan S, Siddique R, Liu Y, Yong VW, Xue M. Towards improving the prognosis of stroke through targeting the circadian clock system. (ijbs.com)
Adaptation to these environmental cues requires intrinsic regulators, which have long been identified as the circadian system and modulated by the circadian clock ( 1 ). (ijbs.com)
This circadian clock contains components including Period circadian homologues ( PER1, PER2, PER3 ), Cryptochrome (CRY1, CRY2), circadian locomotor output cycle kaput ( CLOCK ), NPAS2 , and brain and muscle ARNT-like protein 1( BMAL1 ), which play a critical role in rhythm generation and determine the circadian rhythm across the 24 hour light/dark cycles ( 2 ). (ijbs.com)
Suh and K. Kim, Identification and Validation of Cryptochrome Inhibitors That Modulate the Molecular Circadian Clock. (atto.co.jp)

Disturbances in circadian rhythm-the approximately 24-hour cycles that are endogenously generated by an organism-can be categorized into 2 main groups: transient disorders (eg, jet lag or a changed sleep schedule due to work, social responsibilities, or illness) and chronic disorders (eg, delayed sleep-phase syndrome [DSPS], advanced sleep-phase syndrome [ASPS], and irregular sleep-wake cycle). (medscape.com)

Even though your circadian system may be promoting wakefulness at the right time of day, if you have too great a sleep debt, your ability to function will be compromised. (psychiatrictimes.com)
Circadian rhythm partly determines the time of sleep and wakefulness and any changes in the preferred time of sleep and wakefulness are gradually delayed as we grow old(Dijk, Duffy, & Czeisler, 2000). (savedelicious.com)

A recent study, investigating adolescents and young adults ages 12-20 years from the Missouri School for the Blind, found significantly greater circadian dysfunction (e.g., more daytime napping and variable timing of awakening), among patients with optic diseases relative to those without such diseases [ 29 ]. (biomedcentral.com)
this increases exposure to daytime light and promotes robust circadian alignment," said Dr. Melissa Knauert , associate professor of pulmonary medicine at Yale School of Medicine. (healthline.com)

The diagnosis of circadian rhythm disorders is primarily based on a thorough history. (medscape.com)
Thus any changes in the system of circadian timing or misalignments in the circadian rhythm and the external cues may result in Circadian rhythm sleep disorders(CRSD) (Lu & Zee, 2006). (savedelicious.com)
Detection of autonomic dysfunction may therefore be helpful in diagnosing PD in the early or pre-motor stages, and/or in differentiating it from other parkinsonian disorders, such as multiple system atrophy and progressive supuranuclear palsy. (bmj.com)
The division aims to foster collaborative research into sleep, sleep disorders, and circadian biology, to educate physicians and the lay public, to influence public policy, and to set new standards of clinical practice, aiming, as its website ( www.hms.harvard.edu/sleep ) declares, to create "a model program in sleep and circadian biology. (harvardmagazine.com)

Circadian misalignment reduces glucose tolerance, providing a mechanism to help explain the increased diabetes risk in shift workers. (greenmedinfo.com)

Can free-living, wild species of rodents such as chipmunks, antelope squirrels, or golden-mantled squirrels survive in natural habitat without their neural circadian pacemaker? (sc.edu)
Meijer has made notable contributions to the understanding of the neural and molecular mechanisms of circadian pacemakers. (wikipedia.org)
Applying techniques in neurophysiology to the study of circadian systems, Meijer pioneered the use of in vitro and in vivo electrophysiological recordings to characterize the neural basis of circadian light responses in the mammalian SCN. (wikipedia.org)

Although numerous studies exist analyzing the mechanisms of neurodegeneration and circadian rhythm function independently, molecular mechanisms establishing specific links between the two must be explored further. (frontiersin.org)
Thus, in this review, we explore the possible intersecting molecular mechanisms between circadian rhythm and neurodegeneration, with a particular focus on Parkinson's disease. (frontiersin.org)
Therefore, there is an urgent need to reveal the underlying molecular mechanisms leading to the sensory dysfunction characteristic of CIPN. (painchannels.com)

In general, most physiological processes are regulated by the circadian system, which is modulated by environmental cues such as exposure to light and/or dark, temperature, and the timing of sleep/wake and food intake. (ijbs.com)
In humans, a single light exposure of 12 minutes and multiple-millisecond light exposures can shift the phase of the circadian pacemaker. (jci.org)

Actigraphy: a means of assessing circadian patterns in human activity. (hepatitiscentral.com)

The circadian rhythm plays a chief role in the adaptation of all bodily processes to internal and environmental changes on the daily basis. (encyclopedia.pub)
We focus on immunological and/or molecular processes linking stroke and the circadian system and suggest the circadian rhythm as a target for designing effective therapeutic strategies in stroke. (ijbs.com)

iii) In addition to the therapeutic and preventive aspects, circadian diagnostics serves to reduce circadian rhythm disturbances in shift workers, e.g., by a shift schelule oriented to the chronotype, as well as to develop treatment strategies for patients with circadian rhythm disturbances. (achim-kramer-lab.de)

Duper: a mutation that shortens hamster circadian period.J. Biol. (umass.edu)

Chemogenetics allows us to silence neurons at specific loci and at particular times of day in order to determine when and where circadian signals control neuroendocrine function. (umass.edu)
Central control of circadian phase in arousal-promoting neurons. (umass.edu)

We also examined whether ophthalmic dysfunction influences relationships between ambient illumination and melatonin. (biomedcentral.com)
The circadian rhythm influences many aspects of physiology. (medlink.com)

Non-alcoholic cirrhosis associated with neuropsychological dysfunction in the absence of overt evidence of hepatic encephalopathy. (hepatitiscentral.com)

Notably, Meijer is the 2016 recipient of the Aschoff and Honma Prize, one of the most prestigious international prizes in the circadian research field. (wikipedia.org)

Since the previous "transmeridian travel", or "circadian disrup- evaluation, new data have become available for tion", and standardized terms for each of the these areas and for carcinogen mechanisms, and relevant outcomes (cancer and mechanisms). (who.int)

What impact does the deletion of the pacemaker have on time-dependent functions such as hibernation of ground squirrels? (sc.edu)

Therefore, discerning how the circadian system and seizures influence each other is of great interest in understanding not only the pathophysiological features of epilepsy but also for developing new therapeutic strategies. (databasefootball.com)
Non-motor features of Parkinson's disease (PD) are increasingly being defined and include dysfunction of the autonomic nervous system. (bmj.com)
Lack of sleep may be related to obesity, diabetes, immune-system dysfunction, and many illnesses, as well as to safety issues such as car accidents and medical errors, plus impaired job performance and productivity in many other activities. (harvardmagazine.com)

In fact, the etymology of the word circadian suggests its Latin origin- 'circa diem' - meaning around the day. (securepharmaonline.com)

A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. (lookformedical.com)

Pineal calcification may contribute to melatonin deficiency and circadian timing irregularities. (greenmedinfo.com)

The aim of this review is to describe aspects of autonomic dysfunction, including symptoms, assessment and pathophysiology, resulting from autonomic impairment in PD and other parkinsonian syndromes. (bmj.com)

In January 2014, the FDA approved the melatonin receptor agonist tasimelteon (Hetlioz) as the first treatment for non-24- hour sleep-wake disorder ("non-24"), a chronic circadian disorder that affects the timing of sleep, in individuals who are completely blind. (medscape.com)
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by motor dysfunction (parkinsonism) and several non-motor features. (bmj.com)
Prior names include delayed sleep phase syndrome and circadian rhythm sleep disorder, delayed sleep phase type. (medlink.com)
The circadian rhythm in delayed sleep-wake phase disorder is shifted later when compared to the social norms. (medlink.com)
In patients with delayed sleep-wake phase disorder, the circadian rhythm is delayed when compared to the typical day-night schedule, and therefore, sleep onset and the natural wake time is delayed, usually by more than 2 hours, in relation to conventional or socially acceptable time. (medlink.com)

Another critical function that is regulated by the circadian pacemaker is the discharge of luteinizing hormone from the anterior pituitary that triggers ovulation. (umass.edu)

Anatomy38

Organisms19

Diseases50

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Psychiatry and Psychology8

Phenomena and Processes44

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science2

Health Care15

Rhythms48

Suprachiasmatic12

Disruption10

Human circadian2

Genes11

Core circadian1

Rhythmicity4

Changes in the circadian1

Endogenous4

Clocks9

Importance of circadian2

Mammalian circadian1

Oscillations3

Mammals2

Entrainment2

Behavior4

Photic4

Clock13

Cycles1

Wakefulness2

Daytime2

Disorders4

Misalignment1

Neural3

Molecular mechanisms3

Exposure2

Patterns1

Processes2

Shift1

Biol1

Neurons2

Influences2

Hepatic1

20161

Mechanisms1

Deletion1

System3

Latin1

Neuronal1

Pineal1

Impairment1

Disorder5

Discharge1