AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceHealth Care
Multiple Organ FailureSepsisSystemic Inflammatory Response SyndromeShock, HemorrhagicFatal OutcomeShock, SepticAPACHECritical IllnessThyroid CrisisPancreatitisIntensive CareInjury Severity ScoreHeart FailureIntensive Care UnitsWounds, NonpenetratingDisseminated Intravascular CoagulationPlasma ExchangeAcute DiseaseWounds and InjuriesMultiple TraumaTreatment OutcomeRespiratory Distress Syndrome, AdultAcute Kidney InjuryOrgan Dysfunction ScoresCritical CareTime FactorsAcute Lung InjuryRetrospective StudiesSeverity of Illness IndexProspective StudiesTrauma CentersHospital MortalityRespiration, ArtificialLungBurnsPostoperative ComplicationsDisease Models, AnimalInflammationLiverKidneyBiological MarkersProtein CLaparotomyErythrocyte TransfusionPrognosisShockTreatment FailureNecrosisPeritonitisErectile DysfunctionAortic Aneurysm, AbdominalCytokinesVentricular Dysfunction, LeftSurvival AnalysisSurvival RateMice, Inbred C57BLLength of StayRisk FactorsLiver TransplantationIntestinesHemorrhagePancreatitis, Acute NecrotizingOrgan TransplantationLipopolysaccharidesBlood TransfusionTumor Necrosis Factor-alphaInterleukin-6Liver FailureTissue and Organ ProcurementRats, WistarNeutrophilsTomography, X-Ray ComputedCross InfectionLiver Failure, AcuteRespiratory Insufficiency
SyndromeSepsisSepticRespiratory failureSeverePulmonaryLiverRenal failureSIRSMortalityProgressionMultisystemKidneysMulti-organ failureInjuryInflammatory responseOxygenInfectionVascularComplicationsCirculatoryKidneyExtracorporealTissuesCritically illShockScoresInfectionsPatientsBacteriaScoreBloodResponsesSystemsClinicalDiagnosis
Syndrome35
  • Multiple organ dysfunction syndrome (MODS) is altered organ function in an acutely ill patient requiring medical intervention to achieve homeostasis. (wikipedia.org)
  • Although Irwin and Rippe cautioned in 2005 that the use of "multiple organ failure" or "multisystem organ failure" should be avoided, both Harrison's (2015) and Cecil's (2012) medical textbooks still use the terms "multi-organ failure" and "multiple organ failure" in several chapters and do not use "multiple organ dysfunction syndrome" at all. (wikipedia.org)
  • citation needed] Sepsis is the most common cause of multiple organ dysfunction syndrome and may result in septic shock. (wikipedia.org)
  • Both SIRS and sepsis could ultimately progress to multiple organ dysfunction syndrome. (wikipedia.org)
  • Multiple organ dysfunction syndrome is well established as the final stage of a continuum: SIRS + infection → sepsis → severe sepsis → Multiple organ dysfunction syndrome. (wikipedia.org)
  • citation needed] Currently, investigators are looking into genetic targets for possible gene therapy to prevent the progression to multiple organ dysfunction syndrome. (wikipedia.org)
  • citation needed] This results in catastrophic immune response leading to multiple organ dysfunction syndrome. (wikipedia.org)
  • Multiple organ dysfunction syndrome (MODS) is the failure of two or more organs. (msdmanuals.com)
  • The systemic inflammatory response syndrome (SIRS) criteria were recently replaced by the quick Sequential Organ Failure Assessment (qSOFA) in 2016, allowing for quick bedside analysis of organ dysfunction in patients with suspected or documented infection. (medscape.com)
  • Multiple organ dysfunction syndrome (MODS) is characterized by progressive organ dysfunction in a severely ill patient, with failure to maintain homeostasis without intervention such as pressors or IV fluids. (medscape.com)
  • Secondary MODS is organ failure that has no attributable cause and is a consequence of the host's response (eg, acute respiratory distress syndrome [ARDS] in individuals with pancreatitis). (medscape.com)
  • Unfortunately, in a number of patients with AP, a host of inflammatory events can lead to organ dysfunction and failure, resulting in severe AP, organ failure that persists for at least 48 hours, and in more serious cases, multiple organ dysfunction syndrome (MODS). (carnegie-trust.org)
  • DIT results in TTP-like syndrome with hematologic phenotype of consumptive thrombocytopenia, microangiopathic hemolytic anemia , and multiorgan dysfunction syndrome. (symptoma.com)
  • There is a continuum of clinical manifestations from SIRS to sepsis to severe sepsis to septic shock to Multiple Organ Dysfunction Syndrome (MODS). (atsu.edu)
  • Most ARDS mortality is due not to respiratory failure, but to multiple organ dysfunction syndrome (MODS), with a number of failing organs implicated in the patient s death. (respiratory-therapy.com)
  • Postsplenectomy patients may experience hemophagocytic syndrome, acute renal failure, and generalized seizures. (medscape.com)
  • Coma can occur, possibly as a consequence of severe sepsis, ARDS, or multiple organ dysfunction syndrome (MODS). (medscape.com)
  • Although most leptospirosis is mild, severe types of the disease can cause acute respiratory distress syndrome (ARDS), acute hepatic failure, acute kidney injury (AKI), and multiple organ dysfunction syndrome (MODS) [ 2 ]. (biomedcentral.com)
  • Extracorporeal blood purification is becoming increasingly important in intensive therapy for multiple organ dysfunction syndrome (MODS) and sepsis, considering all of their pathophysiological aspects. (oaepublish.com)
  • [ 1 ] up to 90% of the AKI in this group are part of a multiple organ dysfunction syndrome (MODS), indicating the severity of the patients' condition. (oaepublish.com)
  • The results show that the most common renal causes to perform haemodialysis are: haemolytic uremic syndrome (HUS), chronic renal failure, nephrotic syndrome and congenital bilateral nephrolithiasis. (signavitae.com)
  • For the others, the most common non-renal causes are multiple organ dysfunc-tion syndrome (MODS) that occurs as a result of cardiac insufficiency, hepatic in-sufficiency or after surgeries, as well as in hemato-oncologic diseases. (signavitae.com)
  • However, severe hyperbilirubinemia could induce oxidative stress and cell apoptosis, which cause respiratory failure, thrombocytopenia, and even neurological dysfunction, and consequently promote multiple organ dysfunction syndrome (MODS) and increase patient in-hospital mortality. (biomedcentral.com)
  • Inflammation produces inflammatory response and DIT orchestrates consumptive thrombocytopenia, microangiopathic hemolytic anemia, and multiorgan dysfunction syndrome (MODS). (biomedcentral.com)
  • ObjectiveThe aim of this study was to investigate (a) macrophage migration inhibitory factor (MIF) levels in polytrauma patients and rats after haemorrhagic shock (HS), (b) the potential of the MIF inhibitor ISO-1 to reduce multiple organ dysfunction syndrome (MODS) in acute (short-term and long-term follow-up) HS rat models and (c) whether treatment with ISO-1 attenuates NF-kappa B and NLRP3 activation in HS. (unito.it)
  • Serious AEs such as multiple organ dysfunction syndrome (MODS) and septic shock were commonly reported among patients who required invasive ventilation. (japsonline.com)
  • In addition, the illness takes a serious turn toward septic shock or multiple organ dysfunction syndrome (MODS). (japsonline.com)
  • Our current work focuses on determining the role of altered mitochondrial dynamics in sepsis-induced multi-organ dysfunction syndrome (MODS). (stanford.edu)
  • The spectrum of sepsis ranges from microbial invasion of the bloodstream or intoxication with early signs of circulatory compromise-including tachycardia, tachypnea, peripheral vasodilation, and fever (or hypothermia)-to full-blown circulatory collapse with multiple organ dysfunction syndrome (MODS) and death (see the image below). (medscape.com)
  • Pathogenesis of sepsis and multiple organ dysfunction syndrome (MODS). (medscape.com)
  • SDD treatment resulted in significant control of infectious episodes and multi-organ dysfunction syndrome (MODS). (medbc.com)
  • The primary outcome was clinical improvement, while the secondary outcomes were the development of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS), relief of epigastric abdominal pain, and length of hospital stay (LoH). (frontiersin.org)
  • Hydrogen inhalation therapy is a safe, reliable, and effective treatment for Multiple Organ Dysfunction Syndrome (MODS) induced by influenza and other viral infectious diseases. (drsircus.com)
  • [ 4 ] When fibrous dysplasia occurs in the setting of other extraskeletal abnormalities, skin pigmentation, and endocrine dysfunction, the resulting syndrome is named McCune-Albright syndrome . (medscape.com)
  • [ 6 ] Rarely, it can also be associated with solitary or multiple soft-tissue myxomas (Mazabraud syndrome). (medscape.com)
Sepsis10
  • The European Society of Intensive Care organized a consensus meeting in 1994 to create the "Sepsis-Related Organ Failure Assessment (SOFA)" score to describe and quantitate the degree of organ dysfunction in six organ systems. (wikipedia.org)
  • Sepsis is a response of the body's immune system that results in organ dysfunction or failure. (medscape.com)
  • A more detailed discussion of sepsis etiology in various organ systems is provided in Etiology . (medscape.com)
  • Sepsis-related multiple organ dysfunction is a common cause of death in the intensive care unit. (biomedcentral.com)
  • Blood samples were collected for 10 days after the first sepsis-induced organ dysfunction and after three and six months. (biomedcentral.com)
  • American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference, Definitions for sepsis and organ failure, and guidelines for the use of innovative therapies in sepsis. (jamanetwork.com)
  • The potential of new extracorporeal molecular technologies allows their successful use in severe cardiac and respiratory failure, acute kidney injury and hepatic dysfunction and in complex therapy for severe infections and sepsis and extreme metabolic violations. (oaepublish.com)
  • Adult and pediatric patients after cardiac surgery with cardiopulmonary bypass form a special cohort that often requires the application of various intra- and extracorporeal techniques due to the development of MODS, infections and sepsis in the postoperative period. (oaepublish.com)
  • In addition to protective "immune response", sepsis is characterized by destructive "endothelial response" of the host, leading to endotheliopathy and its molecular dysfunction. (biomedcentral.com)
  • Current Research and Scholarly Interests My laboratory is focused on understanding the cellular mechanisms which mediate end-organ failure in pediatric sepsis. (stanford.edu)
Septic3
  • He owns the absolute priority in the development and the introduction into the clinical practice of Russian clinics of modern methods of correction and maintaining homeostasis, including albumin dialysis, combined plasma filtration and adsorption, selective hemoperfusion, etc. at extremely severe contingent of patients of different age groups having multiple organ failure and septic complications after cardiac surgery. (oaepublish.com)
  • SIRS put patients at risk septic shock and multi-organ failure. (medicalspanish.org)
  • If left untreated, septic shock can lead to organ failure and, in severe cases, death. (clinicpark.com)
Respiratory failure7
  • Respiratory failure is common in the first 72 hours. (wikipedia.org)
  • The greater the number of organ failures, the higher the mortality risk, with the greatest risk associated with respiratory failure requiring mechanical ventilation. (medscape.com)
  • What Brower and his fellow researchers determined, essentially, was that traditional ventilation strategies, applied to ARDS patients, could cause additional lung injury and prevent recovery from acute respiratory failure. (respiratory-therapy.com)
  • In severe cases, damage to RBC membranes, decreased deformability, and cytoadherence to capillaries and venules lead to pulmonary edema and respiratory failure. (medscape.com)
  • 6. Presence of acute respiratory failure (Yes, No based on blood gases). (who.int)
  • Due to respiratory failure and the need for ventilatory support, intensive care units (ICUs) around the world became saturated. (japsonline.com)
  • Respiratory failure was the most common indication for mechanical ventilation. (ijccm.org)
Severe4
  • The project also aimed to identify the variables which most predicted the development of severe AP and MODS, to allow for the focusing of early medical interventions. (carnegie-trust.org)
  • Although most leptospirosis is mild, the severe form can cause multiple complications, with a fatality rate of over 50% even with ICU support. (biomedcentral.com)
  • The reported AEs ranged from mild to severe, including MODS. (japsonline.com)
  • range, 0 to 24, with higher scores indicating more severe organ dysfunction) from the preoperative score to the highest composite score through day 7 or the time of death or discharge. (johnshopkins.edu)
Pulmonary1
  • It usually begins with pulmonary failure, being followed by dysfunction of the CNS, liver, intestine, kidneys, and other organs that are not necessarily involved in the primary disease, nor do they appear in a predetermined order. (who.int)
Liver3
  • Subsequently, one might see liver failure (5-7 days), gastrointestinal bleeding (10-15 days) and kidney failure (11-17 days). (wikipedia.org)
  • Liver dysfunction leads to toxins escaping into the systemic circulation and activating an immune response. (wikipedia.org)
  • [ 5 ] Primary MODS is the direct result of identifiable injury or insult with early organ dysfunction (eg, renal failure due to a nephrotoxic agent or liver failure due to a hepatotoxic agent). (medscape.com)
Renal failure2
  • The main complications include jaundice, hemoglobinuria, and potential renal failure. (medscape.com)
  • There were 18 (52.9%) primary nephrologic pa-tients, while 16 (41.05%) were patients whose renal failure was caused by other etiology. (signavitae.com)
SIRS2
  • The highest mortality rates (38% and 45%, respectively) were noted for patients with a SIRS score of 4 on day 2 or 3, suggesting the importance of failure of early resuscitation to ameliorate the proinflammatory response in critically ill patients. (jamanetwork.com)
  • For patients with MAP, aggressive hydration protocol may be more effective than standard hydration protocol at lowering SIRS and MODS rates, relieving epigastric abdominal pain, and shortening the LoH. (frontiersin.org)
Mortality4
  • Even then, the mortality rate in patients afflicted with MODS is around 30%, with the rate increasing as more organs are involved. (healthwire.co)
  • BackgroundThe MODS caused by an excessive systemic inflammatory response following trauma is associated with a high morbidity and mortality. (unito.it)
  • More importantly, uncontrolled systemic inflammation is a major role in the emergence of organ failure, a condition that was previously associated with a higher risk of mortality ( 9 ). (frontiersin.org)
  • Studies have also shown that fluid resuscitation is beneficial for lowering mortality and the occurrence of complications such as pancreatic necrosis and organ failure ( 10 ). (frontiersin.org)
Progression1
  • The results of treatment, particularly in children, considering their anatomical and physiological features, are related to the severity and progression of organ failure, the indications that are found, the choice of method, and the timely initiation of blood purification. (oaepublish.com)
Multisystem2
  • Multisystem organ failure is defined as an illness in which two or more organ systems are not able to function without assistance or intervention. (healthwire.co)
  • He said, "The causes of multisystem organ failure are still not fully understood but it may occur due to a variety of known reasons. (healthwire.co)
Kidneys1
  • Fluid removal from certain organs, such as blood from the heart, kidneys, and other vital organs can lead to hypoxia or an episode of oxygen deprivation which starts to damage those organs. (medicalspanish.org)
Multi-organ failure3
Injury7
  • This results in tissue injury and organ dysfunction. (wikipedia.org)
  • The Resolution of Organ Injury in Acute Pancreatitis (RESORP) study, aims to investigate the long-term outcomes of patients diagnosed with AP. (carnegie-trust.org)
  • The aim of this process is to maintain tissue integrity in a steady state and restore the integrity of the organ after injury. (biomedcentral.com)
  • This is mechanically rough on the lungs and can set up additional lung injury and, for that matter, contribute to MODS. (respiratory-therapy.com)
  • ConclusionOur results point to a role of MIF in the pathophysiology of trauma-induced organ injury and dysfunction and indicate that MIF inhibitors may be used as a potential therapeutic approach for MODS after trauma and/or haemorrhage. (unito.it)
  • Absence of TNFR signaling leads to a decreased local and systemic inflammatory response with diminished organ injury. (aai.org)
  • [ 1 ] Neurogenic bladder is a term applied to urinary bladder malfunction due to neurologic dysfunction emanating from internal or external trauma, disease, or injury. (medscape.com)
Inflammatory response1
  • Prolonged inflammatory response may lead to persistent or progressive fibrosis impairing the function of an organ. (biomedcentral.com)
Oxygen2
  • Shock is a life-threatening condition in which blood flow to the organs is low, decreasing delivery of oxygen and thus causing organ damage and sometimes death. (msdmanuals.com)
  • Shock is a medical emergency caused by your organs not getting enough blood and oxygen. (merckmanuals.com)
Infection3
  • The immune system responds by releasing chemicals to fight the infection, but in some cases, an excessive immune response can occur, damaging organs and tissues. (clinicpark.com)
  • Given that these enhanced responses are triggered by failed attempts to control the infecting virus, VAED typically presents with symptoms related to the target organ of the infection pathogen. (cov19longhaulfoundation.org)
  • Age-specifc prevalence of Epstein-Barr In immunocompromised persons, solid organ and virus infection among individuals aged 6-19 years in the United States and factors affecting its acquisition. (ehd.org)
Vascular2
  • The vascular system, the heart, the red blood cells, vessel walls, and multiple organs are crumbling under a tidal wave of spike proteins. (drsircus.com)
  • It often manifests with multiple vascular nodules on the skin and other organs. (bvsalud.org)
Complications1
Circulatory2
  • Early clinical manifestations begin with inflammation and progress to circulatory organ dysfunction associated with significant hematopathologic changes. (biomedcentral.com)
  • The terms bacteremia , viremia, fungemia, and parasitemia refer to bloodstream invasions (BSIs) that may be associated with fever but have no other signs or symptoms of circulatory compromise or end-organ malperfusion or dysfunction. (medscape.com)
Kidney1
  • Kidney and other organs: Clots present here can result in kidney failure or failure of the organ where the clot is present. (symptoma.com)
Extracorporeal1
  • Various extracorporeal blood purification techniques directly affect the molecular and electrolyte composition of blood and influence all structures of the human body, which can allow us to correct, recover, replace and maintain homeostasis in MODS. (oaepublish.com)
Tissues2
  • The clinical manifestations of leptospirosis vary depending on organs and tissues involved. (biomedcentral.com)
  • The clinical manifestations of leptospirosis are complicated because of the difference of impaired organs or tissues. (biomedcentral.com)
Critically ill2
  • The most popular hypothesis by Deitch to explain MODS in critically ill patients is the gut hypothesis. (wikipedia.org)
  • In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. (springer.com)
Shock2
  • Very low blood pressure can cause damage to organs, a process called shock. (msdmanuals.com)
  • Shock is caused by your organs (such as your brain, heart, and lungs) shutting down because they aren't getting enough blood. (merckmanuals.com)
Scores4
  • Subset analysis of multiple organ dysfunction (MOD) scores for the same groups depicted in Figure 5. (jamanetwork.com)
  • Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. (springer.com)
  • MODS scores can be used to assess the presence and severity of organ dysfunction on admission and throughout the stay [ 9 ]. (springer.com)
  • However, some authors have voiced their concern regarding using organ dysfunction scores in specific subpopulations [ 9 ]. (springer.com)
Infections1
  • Gram-negative infections in MODS patients are relatively common, hence endotoxins have been advanced as principal mediator in this disorder. (wikipedia.org)
Patients2
  • Some of these patients recovered within weeks, others progressed to MODS and resulted in short-term death. (biomedcentral.com)
  • 2. Patients who at the time of admission to the intensive care unit are in multiple organ dysfunction. (who.int)
Bacteria2
  • El choque séptico se refiere a infecciones de la sangre (por un virus, hongo o bacteria) que es tan grave que causa un efecto significativo en los niveles de fluidos del cuerpo. (medicalspanish.org)
  • Ticks (Acari: Ixodidae and Argasidae) transmit multiple and diverse pathogens (including bacteria, protozoa, and viruses), which cause a wide range of human and animal diseases, including rickettsial diseases, caused by bacteria in the order Rickettsiales. (cdc.gov)
Score1
  • Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. (bjan-sba.org)
Blood3
  • This may lead to essential organs being starved of important blood supply, resulting in the organs failing to function, leading to MODS. (healthwire.co)
  • Multiple organ support therapy is the aim of introducing and applying blood purification today. (oaepublish.com)
  • When your body can't get enough blood to your organs, those organs start shutting down. (merckmanuals.com)
Responses2
  • Indeed, it has been suggested that progressive fibrosis is a central mechanism of organ failure, which is related to the host's inflammatory responses and subsequent fibroblast response [ 11 ]. (biomedcentral.com)
  • Since it contains inflammation-causing cells, it will go on to create inflammatory responses in other organs. (medicalspanish.org)
Systems3
  • We often think that various organs and various systems within our body are independent of each other. (healthwire.co)
  • If 5 organ systems are affected, the chances of survival are less than 5%", he added. (healthwire.co)
  • Multiple Organ Dysfunction (MOD) will be considered as: Acute, progressive, sequential or simultaneous and potentially reversible impairment of functions in various interdependent organ systems (2 or more previously healthy organs and systems far from the site of the condition of origin). (who.int)
Clinical1
  • This clinical form is characterized by single or multiple lesions that are usually located in the lower extremities and affects elderly men 28 . (bvsalud.org)
Diagnosis1
  • Awareness, diagnosis, and control of tickborne rickettsial diseases are most effectively addressed by considering the intersecting components of human, animal, and environmental health that collectively form the foundation of One Health ( 1 ), an approach that integrates expertise from multiple disciplines and facilitates understanding of these complex zoonoses. (cdc.gov)