• Disorder
  • Fabry disease is a genetic lysosomal storage disorder caused by defects in the GLA gene on the X chromosome, leading to a deficiency in alpha-galactosidase A. This leads to an accumulation of glycosphingolipids in multiple tissues and cell types, with subsequent organ dysfunction related to direct deposition of the glycosphingolipids as well as inflammation and/or fibrosis related to these deposits. (cancertherapyadvisor.com)
  • history
  • Criteria for preoperative exclusion included chronic renal insufficiency (plasmatic creatinine concentration more than 2 mg/kg), history of hematologic disorders, hepatic dysfunction (active hepatitis, cirrhosis), history of pulmonary embolism, deep venous thrombosis, and cerebrovascular injury. (asahq.org)
  • result
  • Anything that causes a rapid drop in blood pressure , such as a heart attack or an insulin reaction in a diabetic, can result in fainting or near fainting. (encyclopedia.com)