Erectile DysfunctionVentricular Dysfunction, LeftSmall Ubiquitin-Related Modifier ProteinsSUMO-1 ProteinSumoylationVentricular DysfunctionSexual Dysfunction, PhysiologicalDisease Models, AnimalSexual Dysfunctions, PsychologicalPhenotypeEndothelium, VascularMutationEffect Modifier, EpidemiologicVentricular Dysfunction, RightMice, Inbred C57BLOxidative StressTime FactorsCrosses, GeneticMitochondriaPrimary Graft DysfunctionPenile ErectionVasodilationDiastoleMice, KnockoutAutonomic Nervous System DiseasesMyocardiumHeart FailureCardiomyopathiesRisk FactorsMice, TransgenicMyocardial ContractionAllelesEchocardiographySignal TransductionGenotypeMultiple Organ FailureCognition DisordersVasodilator AgentsBiological MarkersCase-Control StudiesNitric OxideUbiquitinsImpotence, VasculogenicSeverity of Illness IndexMitochondrial DiseasesCells, CulturedReactive Oxygen SpeciesHeartTreatment OutcomeSystoleRats, Sprague-DawleyVentricular Function, LeftPenisBrainStroke VolumeKidney DiseasesGenetic Predisposition to DiseaseProspective StudiesProtein Inhibitors of Activated STATChromosome MappingAgingBlood PressureHeart Failure, DiastolicMolecular Sequence DataNitric Oxide Synthase Type IIIGene Expression RegulationGlutamate-Cysteine LigaseUbiquitin-Conjugating EnzymesAnalysis of VarianceHemodynamicsHomozygoteEpistasis, GeneticApoptosisDose-Response Relationship, DrugVascular DiseasesHeterozygoteVentricular RemodelingDrosophila ProteinsAcetylcholineDrosophila melanogasterKidneyPenetranceMyocytes, CardiacRNA, MessengerRats, WistarFollow-Up StudiesEchocardiography, DopplerTranscription FactorsBlotting, WesternInflammationHypertensionMice, Mutant StrainsCell LineChronic DiseaseModels, BiologicalEndothelial CellsProtein Processing, Post-TranslationalAmino Acid SequenceSulfonesSyndrome