Dysfunction diet induced metabolic syndrome is central obesity. Medical search. Frequent questions

The incidence of the insulin resistance syndrome has increased at an alarming rate worldwide, creating a serious challenge to public health care in the 21st century. (nih.gov)
We investigated whether exposure to POPs contributes to insulin resistance and metabolic disorders. (nih.gov)
Adult male rats exposed to crude, but not refined, salmon oil developed insulin resistance, abdominal obesity, and hepatosteatosis. (nih.gov)
Insulin resistance, metabolic syndrome, and prediabetes are closely related to one another and have overlapping aspects. (wikipedia.org)
Other signs of metabolic syndrome include high blood pressure, decreased fasting serum HDL cholesterol, elevated fasting serum triglyceride level, impaired fasting glucose, insulin resistance, or prediabetes. (wikipedia.org)
There is debate regarding whether obesity or insulin resistance is the cause of the metabolic syndrome or if they are consequences of a more far-reaching metabolic derangement. (wikipedia.org)
Rather than total adiposity, the core clinical component of the syndrome is visceral and/or ectopic fat (i.e., fat in organs not designed for fat storage) whereas the principal metabolic abnormality is insulin resistance. (wikipedia.org)
The continuous provision of energy via dietary carbohydrate, lipid, and protein fuels, unmatched by physical activity/energy demand, creates a backlog of the products of mitochondrial oxidation, a process associated with progressive mitochondrial dysfunction and insulin resistance. (wikipedia.org)
Central obesity is a key feature of the syndrome, as both a sign and a cause, in that the increasing adiposity often reflected in high waist circumference may both result from and contribute to insulin resistance. (wikipedia.org)
However, despite the importance of obesity, affected people who are of normal weight may also be insulin-resistant and have the syndrome. (wikipedia.org)
Along with physical examination, the authors determined albuminuria, calculated glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease (MDRD) formula, estimated insulin resistance markers (fasting plasma insulin and C-peptide concentrations and homeostatic model assessment (HOMA) index), as well as serum ADMA levels by enzyme immunoassay in all the patients. (nih.gov)
The syndromes of insulin resistance actually make up a broad clinical spectrum, which includes obesity, glucose intolerance, diabetes, and the metabolic syndrome, as well as an extreme insulin-resistant state. (medscape.com)
In clinical practice, no single laboratory test is used to diagnose insulin resistance syndrome. (medscape.com)
The mechanisms responsible for insulin resistance syndromes include genetic or primary target cell defects, autoantibodies to insulin, and accelerated insulin degradation. (medscape.com)
To determine the contribution of hepatic CB1 receptors to the other components of the metabolic syndrome (increased adiposity, dyslipidemia, insulin and leptin resistance), we analyzed the effects of a high-fat diet in mice with selective genetic ablation of hepatic CB1 receptors (LCB1 -/- mice) in comparison with wild-type (wt) and global CB1 knockout (CB1 -/-) mice. (nih.gov)
DCM is partially induced by chronic systemic inflammation, underpinned by a hostile environment due to hyperglycemia, hyperlipidemia, hyperinsulinemia, and insulin resistance. (frontiersin.org)
The increasing burden of environmental toxins, including persistent organic pollutants and heavy metals, can no longer be ignored as a key etiologic factor in the epidemic of obesity and diabetes, or what should be called "diabesity," the continuum of metabolic dysfunction mild insulin resistance to end-stage diabetes. (tringali-health.com)
The way toxins are linked to increases in metabolic syndrome is through their interference with glucose and cholesterol metabolism (which also induces insulin resistance). (tringali-health.com)
This means addressing and countering what he calls the "Four Horsemen"-heart disease, cancer, Alzheimer's (and related neurodegenerative diseases) and metabolic dysfunction (insulin resistance, Type 2 diabetes). (substack.com)
In the ER, sensing and adaptive measures are integrated and failure of the ER to adapt leads to aberrant metabolism, organelle dysfunction, insulin resistance, and inflammation. (molecularmetabolism.com)
Liu, J. # Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes. (xjtu.edu.cn)
A key contributor to metabolic diseases is chronic inflammatory responses that alter insulin sensitivity, lipid metabolism, atherosclerosis progression, and adipose tissue angiogenesis. (diabetesjournals.org)
For example, age-associated inflammation can lead to insulin resistance, impaired glucose metabolism, and dyslipidemia, all of which are components of metabolic syndrome [2]. (lifespan.io)
Metabolic syndrome has been linked to accelerated telomere attrition through increased oxidative stress, inflammation, and insulin resistance. (lifespan.io)
Insulin resistance, which is a hallmark of metabolic syndrome, has also been linked to telomere attrition, likely due to the role of insulin in promoting cell proliferation and DNA replication [13-15]. (lifespan.io)
These changes can contribute to insulin resistance and other metabolic abnormalities [16, 17]. (lifespan.io)
For example, the accumulation of misfolded or aggregated proteins can activate stress response pathways, such as the unfolded protein response (UPR), which can lead to insulin resistance and other metabolic abnormalities [20]. (lifespan.io)
At the core of Syndrome X, now much more commonly known as the metabolic syndrome, are dysregulations and dysfunctions involving glucose and insulin. (totalhealthmagazine.com)
In addition to participating in the development of many facets of the metabolic syndrome, impairment in insulin sensitivity also appears to be involved in the aging process by promoting inflammation, endothelial dysfunction (problems with the blood vessels), the production of advanced glycation end products (AGE) and oxidative stress. (totalhealthmagazine.com)
Normal levels of blood glucose and circulating insulin, meaning levels that do not lead to components of the metabolic syndrome, remain in dispute. (totalhealthmagazine.com)
Such observations lead to suspicions that minor insulin resistance predicts the early onset of many disturbed health parameters involved in the metabolic syndrome. (totalhealthmagazine.com)
In conclusion, eTRF showed greater benefits for insulin resistance and related metabolic parameters compared with mTRF. (nature.com)
Bin-Jaliah I, Maskell PD, Kumar P. Indirect sensing of insulin-induced hypoglycaemia by the carotid body in the rat. (springer.com)
Diabetes mellitus is a group of metabolic disease characterized by hyperglycemia resulting from defect in insulin secretion, insulin action or both. (powershow.com)
Abdominal obesity is typically associated with a statistically higher risk of heart disease , hypertension , insulin resistance , and type 2 diabetes (see below). (wikipedia.org)
[7] Metabolic syndrome is associated with abdominal obesity, blood lipid disorders, inflammation, insulin resistance, full-blown diabetes, and increased risk of developing cardiovascular disease. (wikipedia.org)
Central obesity is known to predispose individuals for insulin resistance. (wikipedia.org)
Insulin resistance is a major feature of diabetes mellitus type 2, and central obesity is correlated with both insulin resistance and T2DM itself. (wikipedia.org)
Type 2 diabetes (T2D) is a metabolic disorder characterized by a combination of insulin resistance, (especially in adipose tissue, skeletal muscles and the liver), and relative insulin secretion deficiency ( 1 ). (frontiersin.org)
For instance, women diagnosed with polycystic ovary syndrome typically have significant insulin resistance, regardless of body weight ( 9 ). (frontiersin.org)
In order to go a bit further in dissecting the cellular and molecular mechanisms possibly underlying "junk food"-induced cognitive decline, the authors focused on the insulin signaling pathway and its cerebral receptors. (plos.org)
It is likely that several molecular pathways are involved in the mechanisms underlying diet-induced changes on cognition and among them insulin may play a critical role. (plos.org)
It must be mentioned that hippocampal-dependent cognitive deficits induced by HFD have been attributed also to leptin, calcium dysregulation, inflammation, cellular stress, and impaired insulin signaling. (plos.org)
1 Metabolic syndrom is a combination of disorders that can lead to diabetes and cardiovascular disease, characterized by abnormal levels of fat and/or cholesterol in the blood and insulin resistance. (nih.gov)

Metabolic syndrome is associated with the risk of developing cardiovascular disease and type 2 diabetes. (wikipedia.org)
Metabolic syndrome can lead to several serious and chronic complications, including type-2 diabetes, cardiovascular diseases, stroke, kidney disease and nonalcoholic fatty liver disease. (wikipedia.org)
HPA-axis dysfunction may explain the reported risk indication of abdominal obesity to cardiovascular disease (CVD), type 2 diabetes and stroke. (wikipedia.org)
The metabolic syndrome requires aggressive control of cardiovascular and metabolic risk factors. (medscape.com)
Emphasis will be placed on basic and clinical mechanistic research that reflects expertise in both obesity and cardiovascular sciences. (nih.gov)
and the impact of obesity on the maturation of the cardiovascular system in young animals. (nih.gov)
RESEARCH OBJECTIVES Background The adult United States population, whose combined prevalence of overweight and obesity now exceeds 60 percent, is experiencing a mass exposure to obesity-related cardiovascular risk factors and will likely suffer the adverse clinical consequences in years to come. (nih.gov)
The residual independent effects of obesity on cardiovascular risk, however, detected in long-term prospective studies with decades of observation, suggest a role for less well-characterized mediators such as sleep-disordered breathing, autonomic dysregulation, and pro-thrombotic and pro-inflammatory states. (nih.gov)
We do not know what the consequences might be for the still-developing cardiovascular system if obesity is present during late stages of growth and maturation. (nih.gov)
The specific relationships between obesity and cardiovascular risk vary considerably with gender, race, and type of heart disease. (nih.gov)
Mechanistic Studies in Animals and Humans Because primary treatment and prevention of obesity often fail or are only partially successful, it is anticipated that the future will bring ever-increasing demands to treat the cardiovascular conditions attributable to obesity. (nih.gov)
Thus, in order to develop rational therapeutic approaches, we need to understand the basic biology of obesity-related cardiovascular disease. (nih.gov)
The Section on Neuroendocrinology focuses on the endocannabinoid system, which is involved in the regulation of appetite and the metabolism of lipids, and is therefore implicated in obesity, alcoholism and cardiovascular disease. (nih.gov)
The Section on Neuroendocrinology, Laboratory of Physiologic Studies, is focused on exploring the role of the endocannabinoid system in the regulation of appetitive functions, including alcohol drinking behavior, in lipid metabolism with emphasis on their role in obesity, and in cardiovascular functions. (nih.gov)
Metabolic syndrome represents a cluster of conditions such as obesity, hyperglycaemia, dyslipidaemia, and hypertension that can lead to type 2 diabetes mellitus and/or cardiovascular disease. (nature.com)
Obesity is a major contributor to metabolic diseases including type 2 diabetes, hypertension, and cardiovascular disease. (molecularmetabolism.com)
The global rise of metabolic disorders, such as obesity, type 2 diabetes, and cardiovascular disease, demands a thorough molecular understanding of the cellular mechanisms that govern health or disease. (molecularmetabolism.com)
The recognition of these lipids causes chronic low-level inflammation that contributes to disease progression of type 2 diabetes, metabolic syndrome, and cardiovascular disease. (diabetesjournals.org)
Central obesity, high triglycerides, low HDL cholesterol, high blood pressure, and elevated fasting glucose comprise a cluster of metabolic disorders that increase the risk of cardiovascular disease and type 2 diabetes and define metabolic syndrome [1]. (lifespan.io)
Downstream consequences of these dysfunctions include cardiovascular disease and cancer. (totalhealthmagazine.com)
Women with pregnancy-related complications (pre-eclampsia, gestational diabetes, pregnancy-induced hypertension) have a substantially higher risk for future cardiovascular disease and stroke. (heart.org)
Although only a Class IIa, Level of Evidence C recommendation, guidelines suggest that all women are evaluated for a history of pre-eclampsia/eclampsia and to document this history as a risk factor, then to evaluate and treat cardiovascular and stroke risk factors (hypertension, obesity, smoking, dyslipidemia). (heart.org)
Obesity is a major public health problem and a risk factor for type-2 diabetes, hypertension and cardiovascular disease [ 1 - 4 ]. (biomedcentral.com)
Evidences support the view that central obesity is an independently cardiovascular risk. (biomedcentral.com)
It is thought that leptin contributes to autonomic dysfunction and cardiovascular risks in type 1 and type 2 diabetes mellitus (T1DM and T2DM). (biomedcentral.com)
This raises the possibility that leptin might mediate the relationship between central obesity and the severity of cardiovascular autonomic neuropathy (CAN) in patients with well-controlled T2DM and prediabetes. (biomedcentral.com)
Based upon many cell-line studies, human clinical trials and animal models, it has been found that anthocyanins have anti-carcinogenic and anti-inflammatory activity, obesity control, cardiovascular disease prevention and diabetes relieving properties, all of which are likely to be associated with their potent antioxidant property. (oxfordvitality.co.uk)
Abdominal obesity has been strongly linked to cardiovascular disease , [1] Alzheimer's disease , and other metabolic and vascular diseases . (wikipedia.org)
Researchers first started to focus on abdominal obesity in the 1980s when they realized it had an important connection to cardiovascular disease, diabetes , and dyslipidemia . (wikipedia.org)
Abdominal obesity was more closely related with metabolic dysfunctions connected with cardiovascular disease than was general obesity. (wikipedia.org)
Abdominal obesity is linked with higher cardiovascular events among South Asian ethnic population. (wikipedia.org)
These alterations can manifest in humans as chronic health conditions, such as metabolic syndrome, 1 diabetes, cardiovascular disease, cancer, and intestinal disorders (Karlsson et al. (nih.gov)

DIAGNOSES: The patient had a history of poorly controlled diabetes for the past 2 years and central retinal vein occlusion of the same eye for the past 2 weeks. (bvsalud.org)
Increased rates of co-morbidities such as type 2 diabetes and hepatic damage in overweight adolescents indicate that the young are not protected from the metabolic perturbations that accompany excess adipose tissue stores. (nih.gov)
Obesity during pregnancy has been directly linked to obstetric complications including gestational diabetes, HTN, hematomas, pre-eclampsia, and congenital defects. (mdpi.com)
Obesity-associated type 2 diabetes is rapidly increasing throughout the world. (biomedcentral.com)
We know that diet, exercise, and lifestyle are factors when it comes to your risk of diabetes. (tringali-health.com)
Today, rates of metabolic syndrome (a cluster of conditions that occur together, increasing your risk of heart disease, stroke and type 2 diabetes) continue to rise. (tringali-health.com)
Mitochondrial dynamic regulation in obesity, diabetes, NALFD and other accociated metabolic syndromes. (xjtu.edu.cn)
Diabetes is a common metabolic syndrome which leads to dire complications that are known to cause 3.2 million deaths in America every year. (alldaychemist.com)
This cardio-metabolic syndrome leads to serious heart problems and diabetes. (alldaychemist.com)
ABSTRACT The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. (who.int)
This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. (who.int)
Replication studies identify several genetic variants in Arabs with obesity-linked diabetes. (who.int)
For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. (who.int)
Gaps exist in our information about diabetes and obesity in Arabpopulations in relation to ethnic-specific cut-off points for diagnosis and treatment of diabetes. (who.int)
Algoblan A, Alalfi M, Khan M. Mechanism linking diabetes mellitus and obesity. (springer.com)
Causal genetic variants of obesity and type-2 diabetes have been identified through candidate gene, family-based linkage and large scale association analyses. (biomedcentral.com)
It is now recognised that epigenetics plays a significant role in complex disease, and provides mechanisms whereby environmental factors can influence complex diseases such as obesity and type-2 diabetes [ 17 , 18 ]. (biomedcentral.com)
Children with severe obesity are at greater risk than others for hypertension, type 2 diabetes, metabolic syndrome, non-alcoholic fatty liver disease, atherosclerosis, and adult obesity. (jomes.org)
Pediatric obesity is associated with numerous comorbidities, such as type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, non-alcoholic fatty liver disease (NAFLD), obstructive sleep apnea, polycystic ovary syndrome (PCOS), and psychiatric problems in childhood. (jomes.org)
Obesity management for the treatment of type 2 diabetes: standards of medical care in diabetes-2020. (foodandnutritionresearch.net)
describe how low skeletal muscle mass and abdominal obesity additively increase the risk of incident type 2 diabetes, independently from glycometabolic parameters. (tomwademd.net)
Mongraw-Chaffin and coauthors find a strong graded association of body mass index and diabetes with self-reported COVID-19 that suggests obesity and diabetes might play a role in risk for symptomatic SARS-CoV-2 infection, beyond their co-occurrence with socioeconomic factors. (tomwademd.net)
Visceral and central abdominal fat and waist circumference show a strong association with type 2 diabetes . (wikipedia.org)
You are more likely to develop type 2 diabetes if you are 45 years old or older, have a family history of diabetes, or are overweight or have obesity. (nih.gov)
Polycystic ovary syndrome, gestational diabetes mellitus (GDM), and the age of menopause are three major woman-specific risk factors of T2D. (frontiersin.org)
Introduction Bariatric surgery offers the most effective treatment for obesity, ameliorating or even reverting associated metabolic disorders, such as type 2 diabetes. (bmj.com)

Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). (wikipedia.org)
The investigation included 86 patients (64 men and 22 women aged 44 +/- 11 years) with abdominal obesity. (nih.gov)
According to a study published in a journal of the American College of Cardiology, abdominal obesity is a prime reason behind the high prevalence of metabolic syndrome in US population. (alldaychemist.com)
Abdominal obesity , also known as central obesity and truncal obesity , is the human condition of an excessive concentration of visceral fat around the stomach and abdomen to such an extent that it is likely to harm its bearer's health. (wikipedia.org)

The most important risk factors are diet (particularly sugar-sweetened beverage consumption), genetics, aging, sedentary behavior or low physical activity, disrupted chronobiology/sleep, mood disorders/psychotropic medication use, and excessive alcohol use. (wikipedia.org)
These metabolic disorders can further complicate bone health and impede healing processes 5 . (nature.com)
The endoplasmic reticulum (ER) is a key organelle for cellular function and metabolic adaptation and, therefore disturbed ER function, known as "ER stress," is a key feature of metabolic disorders. (molecularmetabolism.com)
As ER stress remains a poorly defined phenomenon, this review provides a general guide to understanding the nature, etiology, and consequences of ER stress in metabolic disorders. (molecularmetabolism.com)
We discuss the implications of ER stress in metabolic disorders by reviewing evidence implicating ER phenotypes and organelle communication, protein quality control, calcium homeostasis, lipid and carbohydrate metabolism, and inflammation as key mechanisms in the development of ER stress and metabolic dysfunction. (molecularmetabolism.com)
Immune system dysfunction has been recognized to contribute to metabolic disorders for some time. (diabetesjournals.org)
These manifest as central obesity (excessive fat around the belly), high blood pressure and blood fat disorders-especially hypertriglyceridemia and low levels of HDL cholesterol. (totalhealthmagazine.com)
The lipocalin-2 (LCN2) cytokine, primarily known as a protein of the granules of human neutrophils, has been recently reported to be implicated in metabolic and inflammatory disorders. (biomedcentral.com)
Impact of diet, obesity or systemic metabolic disorders on myocardial metabolism mitochondrial function, or the response to ischemia/reperfusion. (nih.gov)
Therefore, it is not surprising that disrupted circadian rhythmicity, a prominent feature of modern-day society, promotes the development and/or progression of a wide variety of diseases, including inflammatory, metabolic, and alcohol-associated disorders. (nih.gov)

This condition is also associated with a special upregulation in the expression of pro-inflammatory adipokines [ 9 ] and increase in the generation of free radicals and other reactive species, leading to increased oxidative stress, production of cell adhesion molecules, and microcirculation dysfunction [ 10 ]. (biomedcentral.com)

These syndromes may also be associated with immunological diseases and may exhibit distinct phenotypic characteristics. (medscape.com)
Ethnopharmacological relevance: Tea ( Camellia sinensis ) has been consumed for centuries as a traditional remedy for various metabolic diseases. (cabi.org)
Mitochondrial targeted therapeutic against metabolic and aging associated diseases. (xjtu.edu.cn)
Although TLRs are classically associated with infectious insult, it is now clear that they are key regulators of inflammatory responses observed during metabolic diseases ( 5 ). (diabetesjournals.org)
The loss of proteostasis, which can occur due to genetic and environmental factors, is associated with several age-related diseases, including metabolic syndrome [19]. (lifespan.io)
In particular, western-style diets, which include fat-rich food and snacks that are consumed around the clock, play a causative role in the development of some chronic diseases 2 . (nature.com)
Herein, we review in a concise manner the pathways linking CB chemoreceptor dysfunction to the pathogenesis of metabolic diseases and describe the methods available to evaluate CB chemosensitivity, postulated to be directly related to metabolic dysfunction. (springer.com)
Specifically, he's attempting to understand and popularize understanding of the mechanisms driving the diet-derived explosion in so-called chronic diseases (or diseases of civilization). (heartandsoilsupplements.com)

Design: To address the influence of systemic dyslipidemia on ethanol-induced liver disease, chronic-binge ethanol feeding was applied to female C57BL/6J (wild type) mice and mice deficient for the low-density lipoprotein receptor (Ldlr-/-), which display a human-like lipoprotein profile with elevated cholesterol and triglyceride levels in circulation. (bvsalud.org)
Innate immunity is now known to impact tissue metabolic responses with members of the Toll-like receptor 2 and 4 (TLR 2/4) family implicated in dyslipidemia. (diabetesjournals.org)

citation needed] Recent research indicates prolonged chronic stress can contribute to metabolic syndrome by disrupting the hormonal balance of the hypothalamic-pituitary-adrenal axis (HPA-axis). (wikipedia.org)
He does an exceptional job of weaving all the common threads together for these 4 chronic conditions, such as how metabolic dysfunction is a key underpinning across the board. (substack.com)
Chronic inflammation, which is a hallmark of metabolic syndrome, can also contribute to genomic instability through the release of cytokines and other molecules that can damage DNA and increase the risk of mutation [9]. (lifespan.io)
Some people also use guarana to treat low blood pressure and chronic fatigue syndrome (CFS), and to prevent malaria and dysentery. (rxlist.com)
Despite professional society guidelines recommending that obesity be treated as a chronic disease by emphasizing the use of lifestyle modification in conjunction with pharmacotherapy, antiobesity medications are uncommonly prescribed in most clinical practices. (tomwademd.net)
In addition, D1 activity is also lower in females, making women more prone to tissue hypothyroidism, with resultant depression, fatigue, fibromyalgia, chronic fatigue syndrome, and obesity despite having normal TSH levels. (restorativemedicine.org)

It is, however, unclear as to the extent to which adipose tissue contributes quantitatively to the elevated circulating levels of these factors in obesity and whether there is a generalised or local state of inflammation. (cambridge.org)
I/R-induced cardiac inflammation was also ameliorated by CaMKII-δ9 inhibition, and compared with the previously well-studied CaMKII-δ2, CaMKII-δ9 overexpression caused more profound cardiac inflammation. (stanford.edu)
Short-term moderate CR decreases obesity, increases the thermogenesis, and inhibits inflammation in a mouse model of obesity, probably via the activation of the AMPK/SIRT1 pathway in WAT and liver. (foodandnutritionresearch.net)

in addition to the central role of lipid storage, it has a major endocrine function secreting several hormones, notably leptin and adiponectin, and a diverse range of other protein factors. (cambridge.org)
However, many other factors appear to increase a person's predisposition to obesity, including endocrine disruptors (eg, bisphenol A [BPA]), gut microbiome, sleep/wake cycles, and environmental factors. (msdmanuals.com)
Booth A, Magnuson A, Fouts J, Foster MT. Adipose tissue: an endocrine organ playing a role in metabolic regulation. (springer.com)
Adipose tissue is an endocrine organ [ 5 ] and plays a fundamental role in obesity-related metabolic dysfunction [ 6 ]. (biomedcentral.com)
Currently, adipose tissue is recognized as a complex and dynamic endocrine organ in the body that not only stores energy, but also regulates energy homeostasis, cellular reactions, and metabolic homeostasis [ 4 ]. (biomedcentral.com)
Today I link to the web page, An Endocrine Society Thematic Issue: Obesity 2023 . (tomwademd.net)
In Endocrine Reviews , Akalestou and others survey mechanisms of weight loss after obesity surgery, which include changed food selection. (tomwademd.net)
Circulating levels of liver-derived miRNAs normalized along with the endocrine and metabolic recovery of bariatric surgery, independent of the fat percentage reduction. (bmj.com)

The mechanisms of the complex pathways of metabolic syndrome are under investigation. (wikipedia.org)
There are multiple mechanisms linking metabolic syndrome and the primary hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, altered proteostasis, and disabled macroautophagy [5]. (lifespan.io)
Several mechanisms have been proposed to explain the relationship between the loss of proteostasis and metabolic syndrome. (lifespan.io)
Environmental factors can influence obesity by epigenetic mechanisms. (biomedcentral.com)
MetS with central obesity is associated with an imbalance of homeostatic mechanisms, leading to adipose tissue dysfunctionality characterized by altered secretion of adipokines. (biomedcentral.com)
o Mechanisms for myocardial cell dysfunction, death (apoptosis/necrosis) and autophagy. (nih.gov)
Li and colleagues identify mechanisms that may account for the weight-loss-inducing effects of berberine. (tomwademd.net)

To define the clinical significance of asymmetric dimethylarginine (ADMA) and that of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism as factors of endothelial dysfunction (ED) in the development of early kidney injury in obese patients. (nih.gov)
Research should also assess the value of biomarkers of endothelial dysfunction during the course of oral contraceptive use and arterial thrombotic event. (heart.org)

Obesity is a prime reason behind the problems of metabolism. (alldaychemist.com)
Sedentary living, lack of exercise, genetics, junk food are few factors that can induce obesity which can further hamper the process of metabolism. (alldaychemist.com)
Increased energy expenditure in the liver and brown adipose tissue could potentially be manipulated to modulate and improve metabolism in obesity. (foodandnutritionresearch.net)
We aim to explore the anti-obesity effects of short-term moderate CR by improving energy metabolism via the SIRT1/AMPK pathway in white adipocytes and liver in a mouse model of obesity. (foodandnutritionresearch.net)

The parsimonious view is that the increased production of inflammatory cytokines and acute-phase proteins by adipose tissue in obesity relates primarily to localised events within the expanding fat depots. (cambridge.org)
It provides a strong basis for future work and offers additional evidence for the role of DNA methylation of adipose tissue in obesity. (biomedcentral.com)

Also alarming are the ever rising rates of overweight and obesity in children and adolescents, which have tripled over the last 30 years. (nih.gov)
Although undernutrition is often associated with refugee status, concerns are increasing about overweight/obesity among refugees resettling to developed countries. (cdc.gov)
7 - 9 Overweight and obesity are frequently assumed to be associated with assimilation to a U.S. lifestyle (increased availability of high-calorie foods, reduced physical activity), compounded by lack of nutritional education. (cdc.gov)
However, one study identified a population of African children who had a high prevalence of overweight/obesity at the time of arrival, 5 and other data have identified overweight/obesity and associated medical consequences in the newly arriving Iraqi population. (cdc.gov)
10 This trend may reflect the overall rising global prevalence of overweight/obesity and/or the changing socioeconomic status of newly arriving refugees. (cdc.gov)
13 - 16 Children with severe obesity have more adverse cardiometabolic risks than children who are overweight or have mild to moderate obesity. (jomes.org)
Fifty overweight people (BMI 28-36) using a key ingredient in ZipSlim®, along with a lower calorie diet (1350 calories for women/1850 calories for men), lost 30 pounds in just 13 weeks, compared to just 10 pounds for those following the lower calorie diet alone. (beyondslim.com)

Treatment options for severe pediatric obesity include lifestyle modification therapy, pharmacotherapy, and metabolic and bariatric surgery. (jomes.org)
We sought to determine the effects of bariatric surgery on circulating microRNAs (miRNAs) that have been implicated in the metabolic cross talk between the liver and adipose tissue. (bmj.com)

6 - 8 Low socioeconomic status (SES) significantly affects pediatric obesity. (jomes.org)

Since 1975, the prevalence of obesity has increased by 2% per decade, unabated despite new and more stringent guidelines set by WHO, CDC, and other public health organizations. (mdpi.com)

Adult obese subjects instructed in dietary management and treated with "anorectic" drugs lose more weight on the average than these treated with placebo and diet, as determined in relatively short-term clinical trials. (nih.gov)
Western medicine, unlike, for instance, traditional Chinese and Indian medicine, tends to pursue and treat the various arms of the metabolic syndrome as distinct clinical entities. (totalhealthmagazine.com)
This quantitative competition permits planning diverse diets to meet a desired surrogate clinical outcome. (nih.gov)
Demographic (169 men and 92 postmenopausal women) and clinical (metabolic syndrome (MS), triglyceride (TG) and C-reactive protein (CRP) levels) characteristics were collected to assess independent factors of CAD (CAD: 188 and non-CAD: 73) and serum LCN2 levels by multiple logistic regression and multivariate stepwise regression analyses, respectively. (biomedcentral.com)

Adipocyte- derived angiotensinogen and angiotensin II are of interest because the renin/angiotensin/aldosterone system plays a major role in the pathophysiology of hypertension and related sequelae such as cardiac hypertrophy, diastolic dysfunction and heart failure. (nih.gov)
CaMKII (Ca2+/calmodulin-dependent kinase II) plays a central role in cardiac ischemia/reperfusion (I/R) injury-an important therapeutic target for ischemic heart disease. (stanford.edu)
Severe complications such as cardiac problems, kidney dysfunction and retinopathy have disturbed the lives of people of every race. (alldaychemist.com)

Notably, insights into the biology of the secretion of the hormone leptin from adipocytes and its action in the central nervous system have contributed to our understanding of the regulation of energy balance. (nih.gov)
In mammalian biology, ER is a phenotypically and functionally diverse platform for nutrient sensing, which is critical for cell type-specific metabolic control by hepatocytes, adipocytes, muscle cells, and neurons. (molecularmetabolism.com)

Body mass index and osteoporosis increased the likelihood to have sarcopenia, but hypertension and healthy diet decreased it. (biomedcentral.com)

For example, high-fat diets have been shown to induce changes in DNA methylation patterns that lead to altered gene expression in a way that favors metabolic syndrome [18]. (lifespan.io)

However, metabolic pathways and immune responses are even more integrated than simple TLR recognition of excess lipid compounds. (diabetesjournals.org)

CB1 deficient mice are resistant to obesity and the associated hormonal/metabolic alterations induced by a high-fat diet even though their total caloric intake does not differ from the intake of wild-type mice that do become obese on the same diet. (nih.gov)
Liver lipidomics analysis reveals the anti-obesity and lipid-lowering effects of gypnosides from heat-processed Gynostemma pentaphyllum in high-fat diet fed mice. (cabi.org)
Male C57BL/6 mice were randomized into two groups receiving either a standard or a high-fat diet (HFD) for 8 weeks to induce obesity. (foodandnutritionresearch.net)
The HFD-induced obese mice were further randomized into two groups: HFD group or CR group (received 75% of the food eaten by HFD group). (foodandnutritionresearch.net)
report on studies with male mice indicating that the metabolic benefits of intermittent fasting result in part from promotion of histone acetylation in lipid oxidation genes of muscle and adipose tissue. (tomwademd.net)
Ultrasound aggression in mice was induced and the molecular and cellular changes were studied. (hormonesmatter.com)
2016). As part of this study, mice were exposed either to normal food or to high-fat food for several days -just imagine something like a diet based on tasty, saucy, fat burgers for weeks and weeks. (plos.org)
Interestingly -and luckily- such deleterious effects of a high-fat diet on memory processes were entirely abolished once mice were re-exposed (dietary reversal) to a normal and healthy diet, which strongly indicates that cognitive dysfunctions induced by "junk food" may be somehow reversible. (plos.org)
Update on the New Diet (NTP-2000) for Rats and Mice in NTP Toxicology and Carcinogenesis Studies. (nih.gov)

and it has a distinct anti-obesity effect. (biomedcentral.com)
Anti-obesity effects of spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1. (foodandnutritionresearch.net)

There is neither specific evidence which clearly establishes the mechanism whereby amphetamines produce mental and behavioral effects in children, nor conclusive evidence regarding how those effects relate to the condition of the central nervous system. (nih.gov)
Other central nervous system actions or metabolic effects, may be involved, for example. (nih.gov)
Nonlocalizing (soft) neurological signs, learning disability, and abnormal EEG may or may not be present, and a diagnosis of central nervous system dysfunction may or not be warranted. (nih.gov)
Caffeine works by stimulating the central nervous system (CNS), heart, and muscles. (rxlist.com)
It is made in the central nervous system and the gastrointestinal nerve complex. (hormonesmatter.com)
The symptoms of serotonin syndrome arise as a result of an over-abundance of its release from the nervous system into the blood and can be mild to severe, depending on the amount of serotonin in circulation. (hormonesmatter.com)
C87124 Central Nervous System Signs and Symptoms C96388 NICHD Childhood Immunization Terminology C1455 Conjugate Vaccine Conjugate Vaccine A category of vaccines created by covalently attaching an antigen from an organism to a carrier protein from the same organism to aid in the delivery of the immunogen. (nih.gov)
High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system. (ac.ir)

Sprague-Dawley rats were exposed for 28 days to lipophilic POPs through the consumption of a high-fat diet containing either refined or crude fish oil obtained from farmed Atlantic salmon. (nih.gov)
10 rats were fed a normal basal diet (Cr), 30 rats fed a high-fat diet (HFD) for 14 weeks during the entire study. (biomedcentral.com)
Chis B, Chis A, Muresan A, Fodor D. Q10 Coenzyme Supplementation can Improve Oxidative Stress Response to Exercise in Metabolic Syndrome in Rats. (ac.ir)

We've placed too much emphasis on obesity per se, without zooming in on metabolic dysfunction which can occur in people who are lean (approximately 33 million of the 100 million Americans with metabolic dysfunction are non-obese). (substack.com)
Research design and methods We measured 30 miRNAs in 155 morbidly obese patients and 47 controls and defined associations between miRNAs and metabolic parameters. (bmj.com)
Conclusions Since liver miRNAs play a crucial role in the regulation of hepatic biochemical processes, future studies are warranted to assess whether they may serve as determinants or mediators of metabolic risk in morbidly obese patients. (bmj.com)

Our findings revealed that CB1 receptors and endocannabinoids are present in the liver where their activation promotes lipogenesis and inhibits lipid oxidation, thus contributing to the development of high-fat diet-induced fatty liver (Osei-Hyiaman et al. (nih.gov)

However, the impact of other TLR proteins on metabolic regulation has remained poorly understood. (diabetesjournals.org)
Differential methylation is found within genes associated with obesity, epigenetic regulation and development, such as CETP , FOXP2 , HDAC4 , DNMT3B , KCNQ1 and HOX clusters. (biomedcentral.com)
Exercise-Induced Mitochondrial Biogenesis: Molecular Regulation, Impact of Training, and Influence on Exercise Performance. (ac.ir)

The key sign of metabolic syndrome is central obesity, also known as visceral, male-pattern or apple-shaped adiposity. (wikipedia.org)

Levels of HILPDA were markedly induced by fatty acids in several hepatoma cell lines. (molecularmetabolism.com)
May 2017) Nonalcoholic fatty liver disease was not originally included in metabolic syndrome manifestations. (totalhealthmagazine.com)
According to some authorities, non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. (totalhealthmagazine.com)
Obesity and nonalcoholic fatty liver disease: from pathophysiology to therapeutics. (foodandnutritionresearch.net)

Loss of estrogen function leads to the development of metabolic dysfunction that spans numerous tissues. (medscape.com)
Research shows that Western diet habits are a factor in development of metabolic syndrome, with high consumption of food that is not biochemically suited to humans. (wikipedia.org)

In this review, we explore the concept that estrogens are critical for defining metabolic function in adipose and hepatic tissues and also the possibility that exercise training should be considered a substitute for estrogen replacement therapy in women with impairments in estrogen levels. (medscape.com)
The goal of this review is to highlight recent findings concerning changes in metabolic function in adipose and hepatic tissue under conditions of reduced estrogen levels. (medscape.com)
Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits. (xjtu.edu.cn)

Myocardial injury instigated from myocarditis, myocardial infarction (MI), or metabolic stress triggers the innate and adaptive immune response in the heart. (frontiersin.org)

Read our special collection of journal articles, published in 2022-2023, focused on obesity! (tomwademd.net)

Obesity affects 13% of adults 2 , and has gathered increasing attention with accumulating evidence linking obesity to compromised bone quality, coupled with osteoporosis and increased risk of bone fractures in the elderly demographic 3 . (nature.com)
Prevalence of obesity and severe obesity among adults: United States, 2017-2018. (msdmanuals.com)
Many studies have reported that SES is associated with a risk of obesity in both adults and children because it can influence lifestyle factors such as food choices and physical activities. (jomes.org)
Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009-2016. (beyondslim.com)
Nearly 35% of adults over the age of 20 and 50% of adults over the age of 60 have a metabolic syndrome, which may lead to serious health problems. (plos.org)

5 , 6 Indeed, according to recent reports, reduced physical activity due to school closures during the COVID-19 pandemic is aggravating obesity and glucose intolerance in children and adolescents with obesity. (jomes.org)

Do Toxins Cause Metabolic Syndrome? (tringali-health.com)
Some researchers have suggested that toxins may cause metabolic syndrome by linking the rise to the increasing prevalence of obesity in babies. (tringali-health.com)
They deliver great taste, but have a potency to cause metabolic syndromes. (alldaychemist.com)

In conclusion, the ER is intricately linked to a wide spectrum of cellular functions and is a critical component in maintaining and restoring metabolic health. (molecularmetabolism.com)
Cellular metabolic and immune responses are coordinated in such a manner as to ensure that immune cells have sufficient energy to carry out their cellular function ( 10 ). (diabetesjournals.org)

Given that obesity is epidemic and tied to impaired cognition, understanding the long-term impact of a high-fat diet (HFD) on the hippocampus -a key brain structure involved in learning and memory processes- is of paramount importance, especially in children and adolescents. (plos.org)

2. Attention Deficit Disorder with Hyperactivity as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate to severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. (nih.gov)
Oxaliplatin is a chemotherapy drug that can induce severe acute neuropathy in patients within hours of treatment. (researchgate.net)
Childhood obesity has been increasing steadily in recent decades, and severe childhood obesity has emerged as a major public health problem both nationally and internationally. (jomes.org)
The consequences of severe childhood obesity are more devastating than those of mild to moderate obesity. (jomes.org)
Accurately assessing and diagnosing a child with severe obesity is the key to implementing successful therapy. (jomes.org)
A detailed and accurate patient history and physical examination are important to discriminate monogenic obesity and metabolic syndrome diagnoses from severe obesity without an underlying cause. (jomes.org)
Although progress has been made, safe and effective treatment for severe pediatric obesity is still challenging. (jomes.org)
Public health organizations also need to make efforts to encourage and normalize healthy eating habits and exercise to prevent severe obesity in childhood. (jomes.org)
1 , 2 Although recent data suggest that the increase in pediatric obesity has slowed and its overall prevalence has begun to stabilize, severe pediatric obesity continues to increase consistently. (jomes.org)
3 , 4 The overall prevalence of severe pediatric obesity in Korea increased from 1.2%-1.8% in 2001 to 2.1%-2.4% in 2013-2014. (jomes.org)
Early signs of vascular dysfunction and subclinical atherosclerosis have also been reported in children with severe obesity. (jomes.org)

It is marked by myocardial remodeling, including fibrosis, hypertrophy, and cell death, leading to diastolic dysfunction with or without systolic dysfunction. (frontiersin.org)

These alterations can occur in response to environmental factors such as diet, physical activity, and exposure to toxins. (lifespan.io)
Several studies have suggested that epigenetic alterations play a role in metabolic syndrome and that metabolic syndrome in a vicious cycle drives further alterations in the epigenome. (lifespan.io)

Causes of obesity are probably multifactorial and include genetic predisposition. (msdmanuals.com)
The prevalence of obesity continues to increase worldwide due to complex behavioral, genetic, and environmental factors. (molecularmetabolism.com)

Alzheimer's disease and dementia) in metabolic syndromes. (plos.org)

Long-term dietary habits are determinants of metabolic health 1 . (nature.com)

Obesity, a multifactorial metabolic disorder, is rapidly increasing in western and developing countries. (plos.org)

this may have implications for the progress of obesity related problems. (biomedcentral.com)

11 Several factors have been identified that increase the risk of obesity among refugees, including length of stay in the host country 12 - 14 , level of acculturation to U.S. lifestyles 15 - 17 , existing cultural beliefs and values 18 , and poor quality of housing. (cdc.gov)

Anatomy14

Organisms9

Diseases67

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment67

Psychiatry and Psychology10

Phenomena and Processes64

Anthropology, Education, Sociology and Social Phenomena5

Technology, Industry, Agriculture10

Information Science3

Named Groups5

Health Care42

Geographicals11

Insulin44

Cardiovascular32

Diabetes27

Abdominal obesity4

Disorders10

Increased oxidative stress1

Diseases8

Dyslipidemia2

Chronic6

Inflammation3

Endocrine8

Mechanisms7

Endothelial dysfunction2

Metabolism4

Adipose tissue in obesity2

Overweight7

Bariatric surgery2

Socioeconomic status1

Prevalence of obesity has increased1

Clinical4

Cardiac3

Adipocytes2

Hypertension1

Shown to induce1

Pathways1

Mice9

Anti-obesity2

Nervous system8

Rats3

Obese3

High-fat diet-induced1

Regulation3

Adiposity1

Fatty4

Development of metabolic2

Hepatic3

Myocardial infarction1

20231

Adults5

Glucose intolerance1

Cause metabolic3

Cellular2

Epidemic1

Severe11

Diastolic1

Alterations2

Genetic2

Alzheimer's1

Determinants1

Multifactorial1

Implications1

Risk of obesity1