• Exogenous H2S inhibits inflammation, improves cardiac dysfunctions associated to ischemia/reperfusion and reduces the gastric damage induced by anti-inflammatory drugs. (unimi.it)
  • Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway. (nih.gov)
  • The current study aimed to unravel the inhibitory effects of Ginsenoside Rg3 (G-Rg3) on inflammation-mediated hepatic autophagy to curb hepatic fibrosis caused by thioacetamide (TAA)- induced subacute and chronic hepatic injury . (nih.gov)
  • 2. Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis. (nih.gov)
  • In conclusion, hypercholesterolemia could aggravate myocardial ischemia/reperfusion injury, attenuate cardioprotection of ischemic preconditioning and eliminate cardioprotection from α7nAChR agonist postconditioning by enhancing inflammation and inhibiting PI3K/Akt/eNOS pathway. (spandidos-publications.com)
  • Cardiopulmonary bypass (CPB) is associated with pulmonary inflammation and dysfunction. (asahq.org)
  • The results demonstrate that inhaled carbon monoxide significantly reduces CPB-induced inflammation via suppression of tumor necrosis factor alpha, and interleukin-1beta expression and elevation of interleukin 10. (asahq.org)
  • 10 6 Since pain is a manifestation of complex sickle pathobiology including inflammation, vascular dysfunction and ischemia/reperfusion injury, we investigated cannabinoid receptor-specific modulation of vascular function, inflammation and hyperalgesia. (haematologica.org)
  • 19 Since vascular dysfunction, ischemia/reperfusion injury and inflammation are hallmark features of SCA, we hypothesized that targeting specific cannaboid receptors may have beneficial effects on sickle pathobiology and pain. (haematologica.org)
  • Post-cardiac arrest syndrome (PCAS), which is defined as the clinical status that involves global ischemic-reperfusion injury, aggressive inflammation, myocardial dysfunction, coagulopathy, and adrenal dysfunction after cardiac arrest event, and sepsis are 2 distinct medical conditions that share some similarities, even though cardiac arrest may not be caused by a serious infection [8]. (medscimonit.com)
  • Taken together, our results identify AIF as a potential therapeutic target for PH and reveal a novel posttranscriptional regulatory mechanism in hypoxia-induced mitochondrial dysfunction. (biomedcentral.com)
  • The decrease in mitochondrial respiratory chain activity increases of ROS generation and cardiolipin oxidation, causing mitochondrial dysfunction, which further aggravates myocardial ischemia reperfusion injury [ 20 ]. (biomedcentral.com)
  • In a discovery published in 2017 , scientists found that the natural hormone melatonin works in a unique way to combat mitochondrial dysfunction . (lifeextension.com)
  • A contributor to mitochondrial dysfunction is the opening of a hole in the mitochondrial inner membrane that decreases their ability to produce energy. (lifeextension.com)
  • Mitochondrial dysfunction plays a large role in aging and disease because mitochondria are the powerhouses of our cells. (lifeextension.com)
  • A contributor to mitochondrial dysfunction is the activation of a protein in the mitochondrial inner membrane called MPTP , or mitochondrial permeability transition pore . (lifeextension.com)
  • Mitochondrial dysfunction is an important pathogenic event in acute kidney injury (AKI). (biomedcentral.com)
  • However, the role of GCN5L1 in mitochondrial dysfunction and the pathogenesis of ischemic AKI are not fully understood. (biomedcentral.com)
  • Prasun P. Mitochondrial dysfunction in metabolic syndrome. (foodandnutritionresearch.net)
  • MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities. (molcells.org)
  • 5. Sulfatide-mediated activation of type II natural killer T cells prevents hepatic ischemic reperfusion injury in mice. (nih.gov)
  • Furthermore, the pharmacological inhibition of AhR activation after ischemia has been shown to attenuate cerebral ischemia-reperfusion (IR) injury. (researchsquare.com)
  • 9 Recent studies have suggested that cerebral ischemia induces AhR activation and exacerbates neuronal damage. (researchsquare.com)
  • Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). (msdmanuals.com)
  • Research progress of mitophagy in chronic cerebral ischemia. (molcells.org)
  • however, the risks of ischemic hepatic failure and intractable encephalopathy are higher, which limits its use in patients with cirrhosis classified as Child class C because the morbidity and mortality rates are increased. (medscape.com)
  • Liver ischemia-reperfusion injury is a major cause of postoperative liver dysfunction, morbidity and mortality following liver resection and transplantation. (wjgnet.com)
  • Acute kidney injury (AKI) is an important clinical syndrome with increased short- and long-term morbidity and mortality, which is often caused by ischemia-reperfusion (IR), nephrotoxic drugs, sepsis and urinary tract obstruction [ 1 ]. (biomedcentral.com)
  • Prevention is key for reducing morbidity and mortality from drowning. (medscape.com)
  • Serum lactate dehydrogenase (LDH), creatine kinase isoenzyme MB (CK-MB), cardiac troponin I (cTnI), tumor necrosis factor α (TNF‑α) and interleukin‑6 (IL‑6) levels after ischemia/reperfusion were assayed. (spandidos-publications.com)
  • Altered Protein Expression of Cardiac CYP2J and Hepatic CYP2C, CYP4A, and CYP4F in a Mouse Model of Type II Diabetes-A Link in the Onset and Development of Cardiovascular Disease? (mdpi.com)
  • Western blots were performed to assess cardiac CYP2J and hepatic CYP2C, CYP4A, and CYP4F protein expression, respectively. (mdpi.com)
  • This paper proposes a novel factor in the link between cardiac and renal dysfunction: "renal tamponade" or compression of renal structures caused by the limited space for expansion. (medscape.com)
  • routine treatment for cardiac failure, diabetes mellitus, and hepatic complications. (nih.gov)
  • Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion. (nih.gov)
  • Studies over the past decades revealed the protective and therapeutic effect of CCMs and major ingredients on I/R- induced microcirculatory dysfunction and tissue injury in the heart, brain, liver , intestine, and so on. (nih.gov)
  • as Dr. Hofmeister pointed out, if hepatic synthetic function is compromised, it is likely that hepatic metabolic function could be problematic. (mynavas.org)
  • Attenuation of metabolic dysfunctions in the skeletal muscles of type 1 diabetic rats by Stevia extracts. (greenmedinfo.com)
  • Systemic manifestations are caused by a traumatic rhabdomyolysis due to muscle reperfusion injury when compressive forces on the tissues are released.This can cause local tissue injury, organ dysfunction, and metabolic abnormalities, including acidosis, hyperkalemia, and hypocalcemia. (cancertherapyadvisor.com)
  • Yu, Y.S. and H. Zheng, Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats . (h2-aqua.com)
  • Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic Ischemia-reperfusion Injury in Rats. (h2-aqua.com)
  • Xiong J, Yuan YJ, Xue FS, Wang Q, Cheng Y, Li RP, Liao X and Liu JH: Postconditioning with α7nAChR agonist attenuates systemic inflammatory response to myocardial ischemia-reperfusion injury in rats. (spandidos-publications.com)
  • Is Aryl Hydrocarbon Receptor Antagonism After Ischemia Effective in Alleviating Hepatic Ischemia-Reperfusion Injury in Rats? (researchsquare.com)
  • A 70% partial hepatic IR (45-minute ischemia and 24-hour reperfusion) injury was induced in rats. (researchsquare.com)
  • TMF-treated rats showed significantly lower relative enhancement (RE) values and serum alanine aminotransferase (ALT) and aspartate aminotransferase levels than did untreated rats at three hours after reperfusion. (researchsquare.com)
  • After 24 hours of reperfusion, TMF-treated rats had significantly lower RE values, ΔT1 values, serum ALT levels, and necrotic area percentage than did untreated rats. (researchsquare.com)
  • This study demonstrated that inhibition of AhR activation after ischemia was effective in ameliorating IR-induced liver injury in rats. (researchsquare.com)
  • Areas of focus include persistent pain in neurological diseases, how surgery and anesthesia may contribute to the progression of Alzheimer's disease, how alcohol modulates dependence in the adolescent brain, the details of inhibitory synaptic function, and anesthetic-induced developmental neurotoxicity and brain ischemia. (columbia.edu)
  • These factors affect the way in which the immature heart handles calcium, which, in turn, contributes to the myocardial dysfunction observed after CPB. (medscape.com)
  • 17. Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation. (nih.gov)
  • Anti-obesity effect of alkaline reduced water in high fat-fed obese mice. (h2-aqua.com)
  • Reduced levels of H2S were observed in several animal models of artery and pulmonary hypertension, damages of gastric mucosa and hepatic cirrhosis. (unimi.it)
  • When contractility and associated diastolic dysfunction are impaired attendant to right ventricular infarction, the right ventricular diastolic pressure increases substantially and systolic pressure decreases. (medscape.com)
  • 14. Pharmacological inhibition of the chemokine CXCL16 diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. (nih.gov)
  • Moreover, CR ameliorated hepatocyte steatosis, attenuated white adipogenesis, and increased energy expenditure and expressions of SIRT1, PGC-1α, and phosphorylated AMPK in subcutaneous WAT and the hepatic tissues. (foodandnutritionresearch.net)
  • 6. Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers. (nih.gov)
  • 10. MMP-9 deficiency shelters endothelial PECAM-1 expression and enhances regeneration of steatotic livers after ischemia and reperfusion injury. (nih.gov)
  • 13. Type 1 Innate Lymphoid Cells Are Proinflammatory Effector Cells in Ischemia-Reperfusion Injury of Steatotic Livers. (nih.gov)
  • Before a diagnosis of HRS can be established, other specific causes of renal dysfunction must be excluded. (medscape.com)
  • Renal dysfunction is one of the strongest predictors of outcome in heart failure. (medscape.com)
  • The kidney plays a central role in heart failure (HF), and several large studies have shown that renal dysfunction is one of the most powerful predictors of outcome in HF. (medscape.com)
  • Multi-organ dysfunction is also under investigation in investigations that mechanistically link signaling molecules of renal, hepatic and intestinal injury. (columbia.edu)
  • He made the important distinction between patients who have elevations in liver enzymes and those who have evidence of clinical liver dysfunction. (mynavas.org)
  • Severe liver dysfunction may lead to bleeding tendencies, or can result in a precarious equilibrium wherein many different types of proteins involved in coagulation processes are decreased. (mynavas.org)
  • Endothelial dysfunction displayed by old mice with repressed vascular autophagy is attenuated by activating purinergic 2Y1 receptors. (utah.edu)
  • Arterial dysfunction displayed by old mice with repressed endothelial cell autophagy is rescued by pharmacological activation of purinergic 2Y1 receptors. (utah.edu)
  • Cho JM, Kwon OS, Park SK, Bharath LP, Richardson RS, Babu PVA, Boudina S, and Symons JD.Endothelial dysfunction displayed by old mice with repressed vascular autophagy is attenuated by activating purinergic 2Y1 receptors. (utah.edu)
  • Exercise-training attenuates endothelial dysfunction and repressed vascular autophagy associated with aging in mice. (utah.edu)
  • Their energy metabolism, white adipose tissue (WAT) contents, hepatic fat deposition, the expression of AMPK, SIRT1, peroxisome proliferators γ-activated receptor coactivator-1α (PGC-1α), nuclear factor kappa B (NF-κB), endothelial nitric oxide synthase (eNOS) in WAT, and hepatic tissues were determined. (foodandnutritionresearch.net)
  • Additionally, moderate to severe hypoalbuminemia will decrease colloid oncotic pressure and may require reduced sodium fluids, synthetic colloids, or albumin transfusions. (mynavas.org)
  • Patients with severe hepatic impairment may require a lower starting dose. (nih.gov)
  • The authors hypothesized that inhaled carbon monoxide before initiation of CPB would reduce inflammatory response in the lungs. (asahq.org)
  • 9. Overproduction of Tenascin-C Driven by Lipid Accumulation in the Liver Aggravates Hepatic Ischemia/Reperfusion Injury in Steatotic Mice. (nih.gov)
  • Acute FAM3A inhibition using siRNA transfection in mouse pancreatic islets significantly reduced PDX1 expression, impaired insulin secretion, and caused glucose intolerance in normal mice. (thieme-connect.de)
  • To reduce the risk of perioperative organ damage and improve treatment, it is essential that we develop a better understanding of the mechanisms involved. (columbia.edu)
  • It can be applied directly or remotely when cycles of ischemia and reperfusion are applied to a distant site or organ. (wjgnet.com)
  • Ischemic preconditioning refers to that performed before the duration of ischemia of the target organ. (wjgnet.com)
  • Ischemic perconditioning is performed over the duration of ischemia of the target organ. (wjgnet.com)
  • Wu Y, Liu H and Wang X: Cardioprotection of pharmacological postconditioning on myocardial ischemia/reperfusion injury. (spandidos-publications.com)
  • 10 Moreover, the pharmacological manipulation of AhR activation after ischemia has been shown to modulate neuronal damage due to cerebral IR in vivo . (researchsquare.com)
  • The backbone starts just below the bottom of the skull with what is called the cervical spine [url=http://sunshinenps.vic.edu.au/order-pills/viagra-sublingual/] erectile dysfunction caused by hydrocodone buy 100 mg viagra sublingual with mastercard[/url]. (ehd.org)
  • Rossello X, Lobo-Gonzalez M and Ibanez B: Editor's choice-pathophysiology and therapy of myocardial ischaemia/reperfusion syndrome. (spandidos-publications.com)
  • In the present study, we investigated the protective effects of AhR antagonism after ischemia in a rat hepatic IR injury model. (researchsquare.com)
  • The coagulopathy of hepatic disease is often referred to as a "balanced coagulopathy" because of this reduction in both pro- and anti-coagulant factors. (mynavas.org)
  • hepatic inflammatory processes, acute hepatotoxicity etc. (wikipedia.org)
  • 2021 Sep 14;10(9):2420, PTX-3 Secreted by Intra-Articular-Injected SMUP-Cells Reduces Pain in an Osteoarthritis Rat Model. (bioimagingsystem.com)
  • Early reperfusion of the occluded coronary artery resulting in right ventricular infarction is associated with prompt reduction in right atrial pressure. (medscape.com)
  • Studies have reported that atorvastatin, a lipid lowering agent, decreased vascular risk in patients with coronary artery disease by reducing plasma levels of cholesterol[ 5 ]. (ijpsonline.com)
  • Vasoconstriction and, perhaps, various proinflammatory effects exerted by TxA on tissue microvasculature, is probable reason why the TxA is pathogenic in various diseases, such as ischemia-reperfusion injury. (wikipedia.org)
  • As many as 70% of decompensated patients with cirrhosis have some degree of encephalopathy, ranging from subtle neurological dysfunction to frank coma. (medscape.com)
  • Interest in recognizing right ventricular infarction noninvasively has grown because of the therapeutic implications of distinguishing patients with right ventricular dysfunction from those with the more usual clinical presentation of left ventricular dysfunction. (medscape.com)
  • Stevia reduces postprandial blood glucose levels in type 2 diabetic patients. (greenmedinfo.com)
  • A traditional clotting factor profile may not reflect the true clinical status of the clotting system in a patient with hepatic disease. (mynavas.org)
  • 1. CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease. (nih.gov)
  • 7. NKT cells are important mediators of hepatic ischemia-reperfusion injury. (nih.gov)
  • Despite the importance of calcium regulation in the curve was generated and the ability to detect a region of heart, there are currently no established radiologic imag- myocardial ischemia was demonstrated in vivo. (nih.gov)
  • A novel ARPKD mouse model with near-complete deletion of the Polycystic Kidney and Hepatic Disease 1 (Pkhd1) genomic locus presents with multiple phenotypes but not renal cysts. (nih.gov)
  • 1 - 5 The mechanisms of hepatic IR injury have been extensively investigated, but nevertheless remain largely unclear. (researchsquare.com)
  • Therefore, the inhibition of AhR activation after ischemia is considered to be effective in suppressing hepatic IR injury. (researchsquare.com)
  • However, to the best of our knowledge, the effects of AhR antagonism on hepatic IR injury have not yet been reported. (researchsquare.com)
  • 5 4 Cannabinoids have anti-inflammatory effects and provide protection from ischemia/reperfusion injury. (haematologica.org)
  • Quite a lot of studies have determined the cardioprotective abilities of tocotrienols and have been shown to possess novel hypocholesterolemic effects together with an ability to reduce the atherogenic apolipoprotein and lipoprotein plasma levels. (biomedcentral.com)
  • 8. Distinct contributions of CD4+ T cell subsets in hepatic ischemia/reperfusion injury. (nih.gov)