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  • interacts
  • We recently showed that a novel disulfide reductase, TRP14, inhibits tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation, and we identified the dynein light chain LC8, which interacts with the NF-kappaB inhibitor IkappaBalpha, as a potential substrate of TRP14. (mendeley.com)
  • intracellular
  • and Uma Santhanam, Ph.D., director of cell biology and clinical efficacy, who presented their research at the American Academy of Dermatology 's Summer Conference in their posters: "Dynein is necessary for intracellular transport of both nutrients and autophagosomes in human dermal fibroblasts,' and "A role for autophagy in skin aging. (skininc.com)
  • Dynein may be involved in some aspects of dynein-related intracellular transport and motility. (novusbio.com)
  • Kinesins and cytoplasmic dyneins play essential roles in intracellular transport such as axonal transport and in the formation of the spindle apparatus and the separation of the chromosomes during mitosis and meiosis. (wikipedia.org)
  • cilia and flagella
  • Dynein transports various cellular cargos , provides forces and displacements important in mitosis , and drives the beat of eukaryotic cilia and flagella . (wikipedia.org)
  • Axonemal dynein, found in cilia and flagella, is crucial to cell motility, for example in spermatozoa, and fluid transport, for example in trachea. (wikipedia.org)
  • complexes
  • In panel C, BICD2 -N is coprecipitated with dynein and dynactin and enhances coprecipitation of the two complexes with each other (vertical arrows below the blots). (nih.gov)
  • homology
  • Model for the motor component of dynein heavy chain based on homology to the AAA family of oligomeric ATPases. (ebi.ac.uk)
  • motor
  • Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. (shakes.cz)
  • The 380kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. (ebi.ac.uk)
  • While numerous cellular processes require cytoplasmic dynein, the mechanisms that target and regulate this microtubule motor remain largely unknown. (plos.org)
  • Cytoplasmic dynein is the major microtubule minus-end-directed cellular motor. (nih.gov)