This study provides the first in vivo evidence of trapped SD proteins in clathrin-coated pits at the plasma membrane when this pathway is disrupted. (sdbonline.org)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)
Vesicular transport2
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported. (lookformedical.com)
Regulates4
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
2011). Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. (sdbonline.org)
SH3-containing GRB2-like protein 3-interacting protein 1 (Sgip1) is a brain-enriched protein that regulates clathrin-mediated endocytosis and interferes with the internalization of cannabinoid receptor 1. (bvsalud.org)
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. (lookformedical.com)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines. (sdbonline.org)
Proteins fated to be internalized by clathrin-mediated endocytosis require an endocytic motif, where AP-2 or another adaptor protein can bind and recruit clathrin. (bvsalud.org)
An adaptor protein complex found primarily on perinuclear compartments. (lookformedical.com)
BIN11
A ubiquitous splice form of amphiphysin-2 (BIN1) that does not contain clathrin or adaptor interactions is highly expressed in muscle tissue and is involved in the formation and stabilization of the T-tubule network. (wikipedia.org)
PI(4,5)P 2 interacts with various ion channels and receptors to regulate membrane signaling but its nanoscale distribution and association with these proteins remain elusive. (jneurosci.org)
Auxilin4
This study implicates the Drosophila GAK homolog, auxilin (aux) , in a broad spectrum of parkinsonian-like symptoms. (sdbonline.org)
The SD protein endocytosis and recycling pathway was found to contain clathrin , dynamin , AP-2 complex, like-AP180 (Lap) , auxilin and Hsc70-4 (the endocytosis part) followed by Rab11 and the exocyst complex (the recycling part). (sdbonline.org)
Using the Drosophila nephrocyte as a genetic screen platform, most genes involved in endocytosis and cell trafficking were screened, and the key components were identified of the cell trafficking pathway required for SD protein endocytosis and recycling. (sdbonline.org)
Disrupting any component in this pathway led to disrupted SD on the cell surface and intracellular accumulation of mislocalized SD proteins. (sdbonline.org)
All genes in this SD protein endocytosis and recycling pathway, as well as SD proteins themselves, are highly conserved from flies to humans. (sdbonline.org)
Thus, these results suggest that the SD proteins in human kidney undergo the same endocytosis and recycling pathway to maintain the filtration structure, and mutations in any genes in this pathway could lead to abnormal SD and renal diseases. (sdbonline.org)
high bacteria are as proteins of pathway ATM rise, either as acids for greenhouse initiation or for the dehydrogenase of binding eIF2 disorders. (evakoch.com)
After vascular complex pathway is caused on a Electrical snRNP, MAML( other) radicals direct in brain with cyclin C, including protein of followed high-affinity ligands in TAD and PEST cilia of NICD1 by CDK8. (evakoch.com)
DAVID Pathways, a functional annotation tool, helped identify a set of 11 genes from a single cluster associated with the endocytosis pathway related to insulin resistance. (bvsalud.org)
Enzymes1
There are other acetyltransferases of cheap enzymes signaling available( clathrin-dependent), lymphoblastic and online( sterol). (evakoch.com)
Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth. (sdbonline.org)
Phosphatidylinositol-4,5-bisphosphate (PI(4,5)P 2 ) plays an essential role in neuronal activities through interaction with various proteins involved in signaling at membranes. (jneurosci.org)
However, the distribution pattern of PI(4,5)P 2 and the association with these proteins on the neuronal cell membranes remain elusive. (jneurosci.org)
Kinase3
Cyclin-G-associated kinase (GAK) , a PD susceptibility gene identified through genome-wide association studies (GWAS), is a ubiquitous serine/threonine kinase involved in clathrin uncoating (see DrosophilaClathrin heavy chain ), though its PD-related function remains elusive. (sdbonline.org)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. (sdbonline.org)
During this process, Rab7 promotes the assembly of HOPS, which mediates lysosomal tethering with endosomes by pairing an R-SNARE on a lysosome (VAMP7 or VAMP8) with three Q-SNAREs on an endosome (syntaxin-7, VTI1b, syntaxin-8). (biomedcentral.com)
Translocation2
They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION. (lookformedical.com)
TRPML1-mediated lysosomal calcium release can also dephosphorylate TFEB and promote its nuclear translocation and regulate lysosome biogenesis, autophagy, and lipid metabolism. (biomedcentral.com)
Subunit2
Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals. (sdbonline.org)
The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found. (lookformedical.com)
Localization1
indicating their potential role as an anchor for these proteins to regulate their localization and dynamics during synaptic transmission. (jneurosci.org)
Receptors1
Insulin receptors are regulated by endocytosis, a process that removes receptors from the cell surface to be marked for degradation or for re-use. (bvsalud.org)
Genes1
OBJECTIVES: Our goal was to discover insulin-resistance-related genes that play key roles in endocytosis which could serve as potential biological targets to enhance insulin sensitivity. (bvsalud.org)
Interaction1
Amphiphysin is a brain-enriched protein with an N-terminal lipid interaction, dimerisation and membrane bending BAR domain, a middle clathrin and adaptor binding domain and a C-terminal SH3 domain. (wikipedia.org)
AMPH1
Amphiphysin is a protein that in humans is encoded by the AMPH gene. (wikipedia.org)
Reduced aux expression further enhances and accelerates alpha-Syn-mediated DA neuron loss. (sdbonline.org)
Alternative splicing can often result in the expression of distinct protein isoforms from a single gene, with specific composition and properties. (bvsalud.org)
Several research groups have studied the physiological importance of Sgip1, and four Sgip1 protein isoforms have been described to date, while the NCBI Gene database predicts the expression of 20 splice variants from the Sgip1 gene in mice. (bvsalud.org)
Structure3
SD proteins are known to undergo endocytosis and recycling to maintain the integrity of the filtration structure. (sdbonline.org)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
The Ark1/Prk1 family of protein kinases. (sdbonline.org)
A family of large adaptin protein subunits of approximately 100 kDa in size. (lookformedical.com)
A family of medium adaptin protein subunits of approximately 45 KDa in size. (lookformedical.com)
Early1
In download Dopamine in the Pathophysiology and Treatment of Schizophrenia: to find the place of here shown early ligands, Rev clusters between the synthesis and storage-inducing resulting body homodimer protein proteins( suggested in Li et al. (evakoch.com)