Pancreatic ductal adenocarcinoma (PDAC) accounts for about 95% of pancreatic cancer cases and is considered the most aggressive type of pancreatic cancer [ 2 ]. (oncotarget.com)
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death and is one of the most difficult-to-treat cancers. (biomedcentral.com)
What makes the response of PDAC to immunotherapy different from the responses of other solid tumors is the specific host tissue. (biomedcentral.com)
Ductal adenocarcinoma of the pancreas (PDAC) accounts for more than 85% of PC and is an aggressive malignancy characterized by a high rate of distant metastasis and recurrence. (alfaoncology.com)
Histopathological grading of PDAC serves as an important factor in prognostication, judged by criteria involving the presence of mucins, nuclear polymorphism, the number of mitoses, and the comparison of the tubular structure and solid growth. (alfaoncology.com)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a very dense and highly organized tumor microenvironment (TME) consisting of extracellular matrix (ECM) proteins, cancer-associated fibroblasts (CAFs), pancreatic stellate cells (PSCs), and immune cells. (mdpi.com)
The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) is the major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong inherent chemotherapy resistance as well as establishing an immunosuppressive tumor microenvironment (TME). (biomed.news)
Tumors6
Recent evidence demonstrated that galectin-9 is highly expressed in a wide range of human malignancies including the most aggressive tumors, such as high-grade glioblastomas and pancreatic ductal adenocarcinomas, as well as common malignancies such as breast, lung and colorectal cancers. (bmj.com)
Our aims were to elucidate whether T cells can induce galectin-9 secretion in human cancer cells derived from solid malignant tumors and whether this soluble form displays higher systemic immunosuppressive activity compared with the cell surface-based protein. (bmj.com)
Results We discovered that T lymphocytes induce galectin-9 secretion in various types of human cancer cells derived from solid malignant tumors. (bmj.com)
Breast cancers usually are epithelial tumors of ductal or lobular origin. (medscape.com)
Triphasic pancreatic-protocol computed tomography is the best initial diagnostic test for pancreatic cancer, and on this modality these tumors appear as a hypodense solid mass. (coek.info)
A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)
Pancreatic cancer1
The third leading cause of cancer-related deaths in the United States is pancreatic cancer, more than 95% of which is pancreatic ductal adenocarcinoma (PDA). (bvsalud.org)
Microscopically, fungating or polypoid carcinomas are well-differentiated adenocarcinomas, commonly papillary type. (poznayka.org)
Transmembrane2
MUC16, a transmembrane mucin, facilitates pancreatic adenocarcinoma progression and metastasis. (oncotarget.com)
Here we report the impact of mucin 1 (MUC1), a transmembrane glycoprotein, on proliferation and functional activity of MDSCs. (bvsalud.org)
Extracellular matrix2
Among them, cancer-associated fibroblasts (CAFs) are responsible for the production of extracellular matrix and regulation of tumor behavior, forming a physical barrier for drug delivery and leading to medication resistance. (alfaoncology.com)
As the major non-neoplastic component of the pancreatic tumor microenvironment (TME), CAFs not only promote the formation of the desmoplastic stroma by secreting extracellular matrix proteins but also regulate cancer progression by influencing cytokines/chemokine production. (alfaoncology.com)
Macroscopically, ulcerative carcinomas are poorly-differentiated adenocarcinomas, which invade deeply into the stomach wall. (poznayka.org)
Invasive2
In spite of their aggressive biologic behavior, some ductal adenocarcinomas show bland nuclear features, making the distinction of benign lesion from an invasive carcinoma difficult, particularly on small biopsy specimens (Fig. 1). (coek.info)
As such, galectin-9 and regulatory pathways controlling its production should be considered as key targets for immunotherapy in a large number of cancers. (bmj.com)
However, solid tumor cells at rest are known to secrete either very low amounts of galectin-9 or, in most of the cases, do not secrete it at all. (bmj.com)
carcinoma contains abundant pools of mucin in which are seen a small number of tumor cells, sometimes having signet-ring appearance. (poznayka.org)
Malignant3
Background/Aim: Uterine mesonephric-like adenocarcinoma (MLA) is a rare malignant tumor of the female genital tract. (iiarjournals.org)
The term mesonephric-like adenocarcinoma (MLA) has been suggested for a malignant tumor arising in the uterine corpus and the adnexa. (iiarjournals.org)
Progression1
DCIS is divided into comedo (ie, cribriform, micropapillary, solid) and noncomedo subtypes.This division provides additional prognostic information on the likelihood of progression or local recurrence (see the images below). (medscape.com)
Abundant1
Histologically, most ductal adenocarcinomas are composed of glandlike structures embedded in an abundant desmoplastic stroma. (coek.info)
Tissue1
We observed similar metabolic alterations that correlated with MUC16 expression in primary tumor tissue specimens from human pancreatic adenocarcinoma cancer patients. (oncotarget.com)
Functional1
The revealed key factors in the design and optimization of 3D DNA nanoframes for functional liposome production could benefit the fields of nanotechnology and molecular medicine. (biomed.news)
Molecular1
Despite small molecular mucolytics having the ability to break the disulfide bonds of mucins, offering a potential way to overcome the airflow obstruction and airway infection, these mucolytics have limited therapeutic effects in vivo. (biomed.news)
It is often an area of ill-defined thickening in the breast , in contrast to the dominant lump characteristic of ductal carcinoma . (lookformedical.com)
Human1
Methods A wide range of human cancer cell lines derived from solid tumours, keratinocytes and primary embryonic cells were employed, together with helper and cytotoxic T cell lines and human as well as mouse primary T cells. (bmj.com)
Protein4
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. (lookformedical.com)
SENT-seq quantifies how dozens of LNPs deliver DNA barcodes and mRNA into cells, the subsequent protein production and the transcriptome, with single-cell resolution. (biomed.news)
For several reasons there is a growing interest in the scientific community in immunoglobulin Y as antibiotic alternative and their oral administration in the polyclonal antibody (pAb) format, to maintain animal health and performance, do not require IgY purification for large-scale production, resulting in protein impurities and high concentration of biotin in the samples. (preprints.org)
With purified recombinant protein production and peptide synthesis to display limited/selected epitopes, intrinsic factors that can affect the functioning of resulting antibodies can be more easily selected for. (preprints.org)
Patients1
Increased creatinine production and reduced renal clearance in patients with chronic kidney disease (CKD) are likely to lead to accumulation of inflammatory factors in the body. (xiahepublishing.com)
Formation1
The positively charged nanogels effectively inhibit the formation of large aggregates of mucin in vitro, probably thanks to the formation of an ionic interaction between CS-Arg and mucin, as well as the breakage of disulfide bonds in mucin by the reductive TCEP. (biomed.news)