DCISLobular CarcRecurrenceCancersTumorsTubularCancerDuctsPapillaryApocrineIntraductal carcinomaCribriformBiopsyEarliest stageMicroinvasionMetaplasticMastectomyPathologyPredictionCasesOutcomesAtypical ductalPure ductal carcLobularStage 0 breast cancerLesionsPatientsAssociated with invasiveAbnormal cellsInvasionClinicalEarliestManagementTreatmentHistopathologyEvolutionLymphHormone
DCIS33
- Ductal carcinoma in situ (DCIS), also known as intraductal carcinoma, is a pre-cancerous or non-invasive cancerous lesion of the breast. (wikipedia.org)
- DCIS has been classified according to the architectural pattern of the cells (solid, cribriform, papillary, and micropapillary), tumor grade (high, intermediate, and low grade), the presence or absence of comedo histology, or the cell type forming the lesion in the case of the apocrine cell-based in situ carcinoma, apocrine ductal carcinoma in situ. (wikipedia.org)
- Ductal carcinoma in situ (DCIS) literally means groups of "cancerous" epithelial cells which remained in their normal location (in situ) within the ducts and lobules of the mammary gland. (wikipedia.org)
- Although intraductal papillomas (IDPs) are benign, they are occasionally involved by a monomorphic, atypical cellular proliferation, morphologically identical to ductal carcinoma in situ (DCIS) or atypical ductal hyperplasia (ADH). (medscape.com)
- Determining the population most affected by atypical papilloma and ductal carcinoma in situ (DCIS) involving a papilloma is difficult, as series differ in their design and inclusion criteria for these lesions. (medscape.com)
- In addition, many cases of DCIS involving a papilloma are seen in association with ADH/DCIS in adjacent ductal spaces. (medscape.com)
- Ductal carcinoma in situ (DCIS) involving a papilloma grossly resembles an intraductal papilloma (IDP) (L/C ST) and thus appears as a lobulated, soft, tan mass within a cystic cavity. (medscape.com)
- Ductal carcinoma in situ (DCIS) is an intraductal neoplastic proliferation of epithelial cells that is separated from the breast stroma by an intact layer of basement membrane and myoepithelial cells. (nih.gov)
- Here we review the clinical challenge posed by DCIS, the contribution of the microenvironment and genetic aberrations to the progression from in situ to invasive breast cancer, the emerging evidence of the impact of intra-tumor genetic heterogeneity on this process, and strategies to combat this heterogeneity. (nih.gov)
- Ductal carcinoma in situ (DCIS) is noninvasive breast cancer that is limited to the inside of the ducts of the breast. (medscape.com)
- Women with low-grade DCIS are at higher risk of developing invasive breast cancer than women without DCIS, but are less likely to have a recurrence of the breast carcinoma or to develop new cancers than women with higher-grade DCIS. (medscape.com)
- Low-grade DCIS cells appear very much like normal breast cells or atypical ductal hyperplasia cells. (medscape.com)
- DCIS (ductal carcinoma in situ) is a non-invasive breast cancer. (komen.org)
- DCIS is also called intraductal (within the milk ducts) carcinoma. (komen.org)
- Ductal carcinoma in situ (DCIS) is the name for abnormal changes in the cells in the milk ducts of the breast. (canceraustralia.gov.au)
- Is Ductal Carcinoma In-Situ (DCIS) Breast Cancer or Abnormal Cells? (peoplebeatingcancer.org)
- You have been diagnosed with Ductal Carcinoma In-Situ aka DCIS aka pre-breast cancer. (peoplebeatingcancer.org)
- Will Ductal Carcinoma In-Situ (DCIS) Patients Accept Breast Cancer Risk? (peoplebeatingcancer.org)
- Increased use of screening mammography has resulted in a dramatic increase in the detection of ductal carcinoma in situ (DCIS). (medscape.com)
- BACKGROUND: Management of screen-detected ductal carcinoma in situ (DCIS) remains controversial. (ox.ac.uk)
- Ductal carcinoma in situ (DCIS), a known precursor lesion of invasive cancer of the female breast, is surrounded by a thick basement membrane and a layer of myoepithelial cells. (elsevierpure.com)
- The purpose of this study was to differentiate between high-grade and non-high-grade ductal carcinoma in situ (DCIS) of the breast on sonography. (elsevierpure.com)
- Microcalcifications with associated ductal changes (11 of 31 [35.5%]) were the most common sonographic findings in high-grade DCIS. (elsevierpure.com)
- BACKGROUND: A better definition of biomarkers and biological processes related to local recurrence and disease progression is highly warranted for ductal breast carcinoma in situ (DCIS). (lu.se)
- Adjuvant radiotherapy and hormonotherapy after breast-conserving surgery (BCS) in ductal carcinoma in situ ( DCIS ) have been shown to reduce the risk of local recurrence . (bvsalud.org)
- Ductal carcinoma in situ (DCIS) is a noninvasive condition. (healthline.com)
- Ductal carcinoma in situ (DCIS) is a pre-cancerous lesion that may give rise to IDC. (cancerbiomed.org)
- SLNB is often not performed but may be done in some cases if an initial core biopsy showed DCIS, because more extensive sampling may show invasive carcinoma. (medscape.com)
- Ductal carcinoma in situ (DCIS) is a cancer that forms in the milk ducts of the breast. (medicalnewstoday.com)
- Stage 0 is also called ductal carcinoma in situ (DCIS). (mskcc.org)
- We therefore examined factors associated with =5% weight gain over 2-year follow-up of a cohort of newly diagnosed early-stage invasive breast cancer (EIBC) and ductal carcinoma in situ (DCIS) patients and age-matched controls without a breast cancer history. (cdc.gov)
- Breast cancers include invasive breast cancer, ductal carcinoma in situ (DCIS), and other in situ excluding lobular carcinoma in situ (LCIS). (cdc.gov)
- Let's go into a very important area-ductal carcinoma in situ (DCIS), which I think you would prefer to have renamed and re-identified. (medscape.com)
Lobular Carc4
- Lobular carcinoma in situ (LCIS) is noninvasive breast cancer that arises from the lobule at the terminal end of the duct and shows a rather diffuse distribution throughout the breast, which explains its presentation as a nonpalpable mass in most cases (see the images below). (medscape.com)
- Lobular carcinoma in situ (LCIS) is cancer that grows in the milk-producing glands of your breast. (healthline.com)
- The percentage of breast cancer cases diagnosed in situ (excluding lobular carcinoma in situ) increased from 1.3% in 1981 to 11.9% in 2000. (cdc.gov)
- breast cancer in situ (BCIS) (excluding lobular carcinoma in situ [13-15]) is the earliest stage of localized breast cancer and is diagnosed almost exclusively by mammography ( 16 ). (cdc.gov)
Recurrence3
- Analysis of Local Recurrence Risk in Ductal Carcinoma In Situ and External Validation of the Memorial Sloan Kettering Cancer Center Nomogram. (bvsalud.org)
- In another study comparing different types of mastectomy, Son et al found that among 300 patients who underwent SSM (17.3%), total SSM (39.7%), or simple mastectomy (43%), for invasive lobular carcinoma, time to local recurrence and positive margin rates did not differ by surgical method. (medscape.com)
- Tamoxifen to block estrogen can result in remission and in ductal carcinoma in situ the recurrence drops by 50% in ER positive cases. (scirp.org)
Cancers8
- Breast cancers usually are epithelial tumors of ductal or lobular origin. (medscape.com)
- While breast cancer can develop in several different tissue types within the breast, most cancers can be classified as either ductal carcinomas, which starts in the ducts, or lobular carcinomas, which starts in the lobule glands. (mdanderson.org)
- Ductal and lobular carcinoma cancers can be further divided into non-invasive and invasive breast cancer, depending on if they have spread to the surrounding tissue. (mdanderson.org)
- In situ cancers. (webmd.com)
- Tubular carcinomas account for approximately 8-27% of all breast cancers, though this type is rare in males. (medicalnewstoday.com)
- Papillary carcinomas are another rare form of IDC, accounting for under 1-2% of invasive breast cancers. (medicalnewstoday.com)
- Most breast cancers are carcinomas-These tumors grow out of the surface or lining of the glandular tissue of the breast. (epnet.com)
- In situ cancers are treated where the tumor is and offer the best chance for a cure. (epnet.com)
Tumors3
- Apocrine ductal carcinoma in situ (ACDIS) is a very rare breast carcinoma which is regarded as a variant of the ductal carcinoma in situ breast tumors. (wikipedia.org)
- ACDIS tumors have microscopic histopathology features that are similar to pure apocrine carcinoma of the breast tumors but differ from them in that they are completely localized, i.e. have not invaded nearby tissues or metastasized to distant tissues. (wikipedia.org)
- Tumors of medullary carcinomas are soft and fleshy. (medicalnewstoday.com)
Tubular5
- Tubular carcinomas are forms of IDC that usually measure 1 centimeter or under . (medicalnewstoday.com)
- A tubular carcinoma is made of tubules, which are tube shaped structures. (medicalnewstoday.com)
- Tubular carcinomas respond well to treatment and are a less aggressive form of invasive breast cancer. (medicalnewstoday.com)
- The degree of positivity (score of 0 - 5) and staining intensity (0 - 3) [5] varies, but even in cases with negative results involving tubular or lobular carcinoma, the results must be reconfirmed. (scirp.org)
- Medullary, mucinous, and tubular carcinomas -These are 3 relatively slower-growing types of breast cancer. (epnet.com)
Cancer22
- In situ means "in place" and refers to the fact that the abnormal cells have not moved out of the mammary duct and into any of the surrounding tissues in the breast ("pre-cancerous" refers to the fact that it has not yet become an invasive cancer). (wikipedia.org)
- Polyphenolics from mango (Mangifera indica L.) suppress breast cancer ductal carcinoma in situ proliferation through activation of AMPK pathway and suppression of mTOR in athymic nude mice. (oregonstate.edu)
- The objective of this study was to assess the underlying mechanisms of mango polyphenol decreased cell proliferation and tumor volume in ductal carcinoma in situ breast cancer. (oregonstate.edu)
- This data demonstrates that each member of the NRG family of ligands is present in pre-invasive ductal breast cancer and that they may be involved in regulating cell behaviour. (kent.ac.uk)
- Apocrine carcinoma is a very rare form of female breast cancer. (wikipedia.org)
- Breast cancer usually begins either in your glands that make milk (called lobular carcinoma ) or the ducts that carry it to the nipple (called ductal carcinoma ). (webmd.com)
- Noninvasive breast cancer is also known as breast cancer in situ. (healthline.com)
- Invasive ductal carcinoma (IDC) is the most common type of breast cancer. (healthline.com)
- The most common histological subtype of breast cancer is invasive ductal carcinoma (IDC) 1 , 2 . (cancerbiomed.org)
- however, patients with LCIS have about a 5% 5-y risk and a 20-30% lifetime risk of developing invasive breast cancer, which may be ipsilateral or contralateral and may be ductal or lobular in origin. (medscape.com)
- Medullary carcinoma is a rarer form of IDC, accounting for around 5% of all breast cancer cases. (medicalnewstoday.com)
- Medullary carcinomas usually do not grow quickly or spread outside the breast, so it is generally easier to treat this type than other forms of breast cancer. (medicalnewstoday.com)
- 1997). Comparison of Risk Factors for Ductal Carcinoma in Situ and Invasive Breast Cancer. (cdc.gov)
- Ductal Carcinoma in situ which is low stage breast cancer. (selfgrowth.com)
- A prospective study of weight gain in women diagnosed with early-stage invasive breast cancer, ductal carcinoma in situ, and women without breast cancer. (cdc.gov)
- Women with LCIS have a higher risk of having breast cancer (usually invasive lobular carcinoma) over the next 20 years. (epnet.com)
- Ductal carcinoma -This is the most common form of breast cancer. (epnet.com)
- En dépit des controverses concernant le dépistage universel du cancer du sein, un tel programme au niveau national est nécessaire en Arabie saoudite. (who.int)
- The most common kinds of breast cancer in men are the same kinds in women-invasive ductal carcinoma, invasive lobular carcinoma, and ductal carcinoma in situ. (cdc.gov)
- From 1991 through 1995, mammography screening had increased in rural ZIP codes (7% of breast cancer diagnosed in situ). (cdc.gov)
- From 1996 through 2000, mammography use was fairly homogeneous across the entire county (13%-14% of breast cancer diagnosed in situ). (cdc.gov)
- The percentage of breast cancer cases diagnosed in situ increased in the state and in all areas of Dane County from 1981 through 2000. (cdc.gov)
Ducts2
- It's called "in situ" (which means "in place") because the abnormal cells have not left the milk ducts to invade nearby breast tissue outside the milk ducts. (komen.org)
- Invasive, or infiltrating, ductal carcinoma (IDC) develops in the milk ducts of the breast, then spreads to surrounding breast tissue. (medicalnewstoday.com)
Papillary3
- Cases of papillary carcinomas often occur in postmenopausal females. (medicalnewstoday.com)
- A papillary carcinoma is made up of small, finger-like protrusions. (medicalnewstoday.com)
- Papillary carcinomas have a medium level of growth. (medicalnewstoday.com)
Apocrine3
- [7] Cytologically, the cells of apocrine carcinoma are relatively large, granular, and it has a prominent eosinophilic cytoplasm. (wikipedia.org)
- [8] When apocrine carcinoma is tested as a "triple negative" , it means that the cells of the patient cannot express the estrogen receptor , progesterone receptor , or HER2 receptor. (wikipedia.org)
- A rare case of apocrine carcinoma of the breast: Cytopathological and immunohistopathological study. (wikipedia.org)
Intraductal carcinoma1
- Intraductal carcinoma, comedo type. (medscape.com)
Cribriform2
- Histopathology of the cribriform type of breast ductal carcinoma in situ. (wikipedia.org)
- Cribriform carcinomas form in the stroma, or connective tissues, of the breast. (medicalnewstoday.com)
Biopsy1
- According to the investigators, this suggested that such biopsy is less appropriate in patients with pure ductal carcinoma in situ than it is in those with microinvasion. (medscape.com)
Microinvasion1
- A retrospective study by Hotton et al of patients with ductal carcinoma in situ who were treated with simple mastectomy found a low rate of positive sentinel lymph node biopsies in persons without microinvasion. (medscape.com)
Mastectomy1
- Scholars@Duke publication: Recurrent ductal carcinoma in situ after total mastectomy. (duke.edu)
Pathology1
- Pathology of Ductal Carcinoma In situ of the Breast: A Heterogeneous. (annals.edu.sg)
Prediction1
- Prediction of Upstaging in Ductal Carcinoma in Situ Based on Mammographic Radiomic Features. (cdc.gov)
Cases2
- In this study we examined using immunohistochemical staining expression of NRG1alpha, NRG1beta, NRG2alpha, NRG2beta, NRG3 and NRG4 in sixty cases of pre-invasive ductal carcinoma in situ of the breast representing different degrees of differentiation. (kent.ac.uk)
- Fifty-seven lesions (75.0%) were identified on sonography, which revealed a mass in 30 cases, microcalcifications in 20, ductal changes in 4, and architectural distortion in 3. (elsevierpure.com)
Outcomes1
Atypical ductal1
- On average, 80% of atypical ductal hyperplasias are associated with ER overexpression [ 7 - 9 ]. (hindawi.com)
Pure ductal carc1
- A clinically distinct subgroup of pure ductal carcinoma in situ presents as an extensive, high-grade lesion, which nevertheless lacks invasion. (duke.edu)
Lobular13
- Breast cancers usually are epithelial tumors of ductal or lobular origin. (medscape.com)
- Lobular carcinoma in situ (LCIS) is noninvasive breast cancer that arises from the lobule at the terminal end of the duct and shows a rather diffuse distribution throughout the breast, which explains its presentation as a nonpalpable mass in most cases (see the images below). (medscape.com)
- Breast cancer evolves from normal epithelium of the terminal duct or lobular unit through a series of increasingly abnormal proliferative lesions beginning with atypical hyperplasia, to premalignant in situ disease, to malignant and increasingly invasive neoplasia [ 1 - 3 ]. (hindawi.com)
- Patients with lobular carcinoma in situ have abnormal cells that look like cancer cells growing in the lining of the milk-producing glands-or lobules-of a breast. (moffitt.org)
- However, having lobular carcinoma in situ increases a patient's risk of developing invasive breast cancer later. (moffitt.org)
- Accounting for about 10% of invasive breast cancers, invasive lobular carcinoma is the second-most common type of breast cancer. (moffitt.org)
- Invasive lobular carcinoma has the potential to spread to lymph nodes and other parts of the body. (moffitt.org)
- How fast this type of cancer spreads can be affected by the details of each patient's case, but some forms of invasive lobular carcinoma can be quite aggressive. (moffitt.org)
- Lobular carcinoma starts in the parts of the breast, called lobules, which produce milk. (medlineplus.gov)
- Breast cancer usually begins either in your glands that make milk (called lobular carcinoma ) or the ducts that carry it to the nipple (called ductal carcinoma ). (webmd.com)
- If you have been diagnosed with Ductal Carcinoma in Situ or Lobular Carcinoma in Situ and are seeking expert care, don't hesitate to schedule a consultation with Dr. Lindsay Keith. (lindsaykeith.com)
- Invasive lobular carcinoma (ILC) starts in the lobules and can spread to other parts of the body. (healthline.com)
- I was diagnosed with LCIS - Lobular Carcinoma In-Situ, (via mammogram showing calcification, and a stereotactic biopsy) had my first oncology appointment today. (cancer.org)
Stage 0 breast cancer1
- When abnormal cells are detected in the lining of a milk duct but haven't spread beyond that, cancer specialists refer to the condition as ductal carcinoma in situ , also known as stage 0 breast cancer. (moffitt.org)
Lesions3
- Corben AD and Brogi E. Chapter 21: Ductal Carcinoma In Situ and Other Intraductal Lesions: Pathology, Immunohistochemistry, and Molecular Alterations. (cancer.org)
- We sought to evaluate differences between those ductal carcinomas in situ presenting as large versus small lesions while controlling for high-grade, to determine whether there exist phenotypic and genetic differences between the 2 groups. (duke.edu)
- A more thorough evaluation of these differences could help identify the likelihood of recurrence or progression for in situ lesions. (duke.edu)
Patients1
- Background: To determine the clinical presentation of patients presenting with isolated ductal carcinoma in situ at a single tertiary center in the Cape Town, South Africa. (aku.edu)
Associated with invasive1
Abnormal cells1
Invasion1
- In situ carcinoma is characteristically contained within the epithelium, with the basement membrane intact, and without any signs of invasion [ 4 ]. (hindawi.com)
Clinical4
- In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Ductal Carcinoma in Situ of the Breast. (ductalcarcinoma-info.com)
- These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Ductal Carcinoma in Situ of the Breast. (ductalcarcinoma-info.com)
- We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Ductal Carcinoma in Situ of the Breast every 3 months. (ductalcarcinoma-info.com)
- This is an evidence-map of ductal carcinoma in situ treatment options and impacts on patient-centered and clinical options. (rand.org)
Management4
- Rosso KJ, Weiss A, Thompson AM. Are There Alternative Strategies for the Local Management of Ductal Carcinoma in Situ? (bcm.edu)
- Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK Sloane Project. (bcm.edu)
- The Biology and Management of Ductal Carcinoma in Situ of the Breast. (bvsalud.org)
- A Nationwide Cross-Sectional Survey of UK Breast Surgeons' Views on the Management of Ductal Carcinoma In Situ. (ox.ac.uk)
Treatment2
- The Landmark Series-Ductal Carcinoma in Situ: The Evolution of Treatment. (ductalcarcinoma-info.com)
- 15. [The consensus conference on the treatment of in situ ductal carcinoma of the breast, April 22-25, 1999]. (nih.gov)
Histopathology2
- Histopathology of the cribriform type of breast ductal carcinoma in situ. (wikipedia.org)
- The patient underwent an elective excisional biopsy for a palpable mass, with histopathology revealing a complex fibroadenoma with a nidus of ductal carcinoma in-situ. (ijcto.org)
Evolution1
- In summary, we have developed a novel method for single cell DNA sequencing, which preserves spatial context, and applied this method to understand clonal evolution during the transition between carcinoma in situ to invasive ductal carcinoma. (tmc.edu)