• Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death and is one of the most difficult-to-treat cancers. (biomedcentral.com)
  • The most common type of pancreatic tumor, Pancreatic Ductal Adenocarcinoma (PDAC), has distinctly poor patient outcomes due to its. (cancer.gov)
  • While single-cell transcriptomics has been used previously to study the cellular composition of primary tumor tissues of pancreatic ductal adenocarcinoma (PDAC), this study also used the technology to profile individual cells from dissociated primary tumors and biopsies of metastatic tissues, those cancerous lesions that have spread throughout the body from the primary tumor. (medicalxpress.com)
  • The partnership is designed to improve treatment response and survival rates of patients with pancreatic ductal adenocarcinoma (PDAC) tumors. (labpulse.com)
  • It will utilize PanCan's patient molecular and outcomes data and GeneCentric's RNA-based portfolio, which includes the PurlSt profiler that identifies PDAC subtypes. (labpulse.com)
  • The National Comprehensive Cancer Network recently recommended germline testing for all people newly diagnosed with pancreatic ductal adenocarcinoma (PDAC). (labpulse.com)
  • Objective: Most patients with pancreatic ductal adenocarcinoma (PDAC) will experience recurrence after resection. (nanostring.com)
  • Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human malignancies, with a 5-year survival rate of only 5% and a median survival of less than 6 months[ 1 ]. (oncotarget.com)
  • The plasticity and heterogeneity of fibroblasts in the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) has emerged as a key factor in determining tumor growth and therapeutic response. (elifesciences.org)
  • Cancer stemness has been proven to affect tumorigenesis, metastasis, and drug resistance in various cancers, including lung squamous cell carcinoma (LUSC). (biomedcentral.com)
  • Esophageal Squamous Cell Carcinoma (ESCC) and esophageal adenocarcinoma[ 2 , 3 ]. (ijpsonline.com)
  • Hepatocellular carcinoma (HCC), derived from hepatocytes, is the main histological subtype of primary liver cancer and poses a serious threat to human health due to the high incidence and poor prognosis . (biomedcentral.com)
  • Tamoxifen to block estrogen can result in remission and in ductal carcinoma in situ the recurrence drops by 50% in ER positive cases. (scirp.org)
  • PR is positive in about 70% of invasive ductal carcinoma, they are regulated by ER-α. (scirp.org)
  • Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung. (riken.jp)
  • Background: Breast's Invasive Ductal Carcinoma (IDC), which is the commonest type of malignancy in females worldwide, can be characterized using immunohistochemistry in view of personalized cancer therapy. (bvsalud.org)
  • Approximately 80% of all pancreatic cancers are adenocarcinomas, with only 2% of exocrine pancreatic tumors diagnosed as benign. (medscape.com)
  • from there, tumors can spread to nearby lymph nodes and to other areas of the body (liver, peritoneal cavity, intestine, or lungs). (medscape.com)
  • Researchers used a relatively new technique known as single-cell sequencing to genetically identify cell types, and subtypes, that occur in pancreatic tumors , and identify the various cells in the tumor 's stroma, a substance surrounding the tumor that can hide the cancer from the body's immune system. (medicalxpress.com)
  • The study, "Single-Cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions," was published in the scientific journal Genome Medicine . (medicalxpress.com)
  • It is the third-leading cause of cancer death in the U.S., following lung and colorectal cancers. (medicalxpress.com)
  • A wide range of emerging omics and multi-view clustering algorithms now provide unprecedented opportunities to further classify cancers into subtypes, improve the survival prediction and therapeutic outcome of these subtypes, and understand key pathophysiological processes through different molecular layers. (molcells.org)
  • Finally, we summarize the latest findings from large-scale multi-omics studies of various cancers and their implications for patient subtyping and drug development. (molcells.org)
  • Histologic and immunohistochemical evaluation revealed metastatic prostate adenocarcinoma with treatment-related neuroendocrine differentiation. (bvsalud.org)
  • Which of the following histologic subtypes of pancreatic cancer is the most common? (medscape.com)
  • With a prevalence of 80-85%, ductal adenocarcinomas are far more common than all other histologic subtypes of pancreatic cancer. (medscape.com)
  • In a widely used mouse model of breast cancer, mammary gland-specific expression of the polyoma middle T (PyMT) oncoprotein under the control of the MMTV promoter/enhancer in transgenic mice (MMTV-PyMT) results in widespread transformation of the mammary epithelium and subsequent development of multifocal mammary adenocarcinomas and metastatic lesions in the lymph nodes and in the lungs [ 2 ]. (biomedcentral.com)
  • ABSTRACT: We describe FDG PET/CT findings in a case of isolated skull metastasis with spiculated periosteal reaction from rectal mucinous adenocarcinoma 8 years after proctectomy. (bvsalud.org)
  • We present 68Ga-PSMA-11 PET/CT findings in a case of isolated parietal peritoneal metastasis from prostate adenocarcinoma 35 months after radical prostatectomy. (bvsalud.org)
  • This case demonstrates the usefulness of 68Ga-PSMA-11 PET/CT in identifying atypical metastasis from prostate adenocarcinoma. (bvsalud.org)
  • Breast cancer in PyMT mice is particularly noted by its short latency, high penetrance, and a high incidence of lung metastasis [ 3 ]. (biomedcentral.com)
  • We intended to develop a clinically applicable stemness subtype classifier that could assist physicians in predicting patient prognosis and treatment response. (biomedcentral.com)
  • Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies. (wikipedia.org)
  • Compared with lung adenocarcinoma (LUAD), there are still few effective targeted treatment options for LUSC in the clinic [ 6 ]. (biomedcentral.com)
  • Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung. (cancer.gov)
  • Patients in the stemness subtype B group with higher mRNAsi scores exhibited better overall survival (OS) than those in the stemness subtype A group. (biomedcentral.com)
  • Although the death rate of lung cancer has declined over the past few decades, the average five-year survival rate for LUSC is only between 20% and 30% [ 5 ]. (biomedcentral.com)
  • In recent years, advances in cancer immunotherapy have extended overall survival (OS) in select non-small cell lung cancer (NSCLC) patients with positive PD-L1 expression. (biomedcentral.com)
  • Therefore, a subtype classifier based on specific characteristics for survival prediction and therapy response estimation is the first step toward personalized cancer treatment for LUSC patients. (biomedcentral.com)
  • Some authors excluded cystosarcoma phyllodes from their studies due to its epithelial components, but others do not distinguish between other subtypes of breast sarcoma and cystosarcoma because of similar survival and clinical course. (oap-bioscience.org)
  • Immunotherapy prediction demonstrated that stemness subtype A has a better response to immune checkpoint inhibitors (ICIs). (biomedcentral.com)
  • Furthermore, the drug response prediction indicated that stemness subtype A had a better response to chemotherapy but was more resistant to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). (biomedcentral.com)
  • Multi-omics approaches have been applied to numerous clinical studies for better identification of clinical subtypes or drug resistance, prediction of effective combination therapies, and identification of predictive biomarkers to increase the response rate to targeted treatments. (molcells.org)
  • Next, we identified 190 stemness-related differentially expressed genes (DEGs) that could categorize LUSC patients into two stemness subtypes. (biomedcentral.com)
  • Finally, we constructed a nine-gene-based classifier to predict patients' stemness subtype and validated it in independent GEO validation sets. (biomedcentral.com)
  • From the abstract: 'Neoadjuvant or adjuvant immunotherapy can improve outcomes in patients with resectable non-small-cell lung cancer (NSCLC). (cdc.gov)
  • Researchers examined plasma samples of 37 lung cancer patients and 71 asymptomatic age, gender, and smoking-history matching controls. (labpulse.com)
  • In this review, we will look at the biomarkers that prove to be valuable tools for the personalization of cancer therapeutics among lung and breast cancer patients. (scirp.org)
  • Given our current knowledge of the heterogeneity of tumor types and subtypes, the ICGC set a goal of coordinating approximately 50 projects, each of which will generate the genomic analyses on approximately 500 cancer samples of each class. (wikipedia.org)
  • The company has touted the results of a study showing that the test detected stage I/II pancreatic ductal adenocarcinoma with 99% specificity and 89% sensitivity. (labpulse.com)
  • The test detected pancreatic ductal adenocarcinoma with 99% specificity and 89% sensitivity in stage I/II when excluding individuals with low levels of CA 19-9, an antigen released by pancreatic cancer cells. (labpulse.com)
  • The images in the slide are of cytologic samples from fine-needle aspiration (FNA) of pancreatic adenocarcinomas: (A) well-differentiated tumor, (B) moderately differentiated tumor, (C) moderately to poorly differentiated tumor, and (D) poorly differentiated tumor. (medscape.com)
  • Presented at the International Association for the Study of Lung Cancer (IASLC) 2020 World Conference, the test uses methylation status measurement of the tumor-derived portion from cell-free DNA (cfDNA) in plasma for patient classification. (labpulse.com)
  • Distinct cell types and subtypes were identified in the analysis, including tumor cells, endothelial cells, cancer associated fibroblasts, and immune cells, and the expression levels of various genes in the individual cell populations correlated with patient clinical outcomes. (medicalxpress.com)
  • Most ductal adenocarcinomas are tough and gritty gray-white clumps that mainly metastasize in the head of the pancreas. (medscape.com)
  • Introduction: Lung inflammation, also known as pneumonitis, is a condition characterized by the inflammation of lung tissue. (biogenex.com)
  • It is well recognized, however, that cancer is highly heterogeneous and hundreds of types/subtypes can be defined. (wikipedia.org)
  • Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. (who.int)
  • According to the World Health Organization classification, there are 2 subtypes of intrahepatic cholangiocarcinoma, small duct (SD) and large duct (LD), each with distinct clinicopathologic features. (medscape.com)
  • Each subtype has distinct imaging characteristics, as well as a variety of benign and malignant mimics, making accurate diagnosis of cholangiocarcinoma through imaging challenging. (medscape.com)
  • Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. (who.int)
  • The primary jejunal tumor showed inhomogeneous enhancement on contrast-enhanced CT and intense FDG uptake on PET/CT mimicking adenocarcinoma or gastrointestinal stromal tumor. (bvsalud.org)
  • Immune infiltration analysis (ESTIMATE and ssGSEA algorithms) methods were used to investigate the immune infiltration status of different subtypes. (biomedcentral.com)
  • Severe lung damage resulting from COVID-19 involves complex interactions between diverse populations of immune and stromal cells. (nanostring.com)
  • Existing immune treatments that work well against skin cancer and lung cancer do not work in pancreatic cancer. (ox.ac.uk)
  • The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma . (medscape.com)
  • Estrogen receptor positive luminal B is the second most common but the least studied subtype of breast cancer. (biomedcentral.com)
  • Breast cancer is the 2nd leading cause of cancer death (the most common is lung cancer) in the overall female population but is the leading cause of cancer death in Black women. (msdmanuals.com)
  • Depending on the expression status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), it can be classified into four molecular subtypes: luminal A, luminal B, HER2-positive, and basal-like (or triple-negative) breast cancer. (biomedcentral.com)
  • Not only are transgenes expressed at a level different from that of the same oncogenes in human breast cancer, but also throughout the ductal tree [ 6 ] they do not target the cell types that are the cells of origin in human breast cancer. (biomedcentral.com)
  • Levels of glutathione S transferase pi mRNA in human lung cancer cell lines correlate with the resistance to cisplatin and carboplatin. (riken.jp)
  • [3] A general rule for the genetic onset of pancreatic cancer is that multiple combinations of genetic mutations are present in adenocarcinomas. (medscape.com)
  • Aruj Chawla, DO discusses a study that brings about a novel method to analyze vascular involvement in pancreatic ductal adenocarcinomas. (arrs.org)
  • Opium use and risk of lung cancer: A multicenter case-control study in Iran. (who.int)
  • Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. (cancer.gov)