Dual control cyclic amp receptor protein. Medical search. Frequent questions

Ste5 is a prototype of scaffold proteins that regulate activation of mitogen-activated protein kinase (MAPK) cascades in all eukaryotes. (bvsalud.org)
Protein kinase C regulates human pluripotent stem cell self-renewal. (rndsystems.com)
Specificity and mechanism of action of some commonly used protein kinase inhibitors. (rndsystems.com)
Identification of a novel inhibitor of mitogen-activated protein kinase kinase. (rndsystems.com)
Neuronal microtubule-associated protein 2D is a dual A-kinase anchoring protein expressed in rat ovarian granulosa cells. (nature.com)
Feliciello, A., Rubin, C. S., Avvedimento, E. V. & Gottesman, M. E. Expression of a kinase anchor protein 121 is regulated by hormones in thyroid and testicular germ cells. (nature.com)
PKA: a portrait of protein kinase dynamics. (nature.com)
Egan, J. J., Greenberg, A. S., Chang, M. K. & Londos, C. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. (nature.com)
GW786034 is a vascular endothelial growth factor receptor-focused multi-tyrosine kinase inhibitor involved in inhibiting the angiogenesis pathway. (gw786034inhibitor.com)
Activator of protein kinase A (cyclic AMP agonist). (biolog.de)
We utilize two complementary models, HEK293 cells and human iPSC-derived neurons, and delineate RBM12 as a novel repressor of the G protein-coupled receptor/cyclic AMP/protein kinase A (GPCR/cAMP/PKA) signaling axis. (sciety.org)
PEA treatment can activate the ERK1/2 MAP kinase and Akt proteins as determined by microfluorimetric measurements. (biomedcentral.com)
Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo. (rochester.edu)
however, recent investigations have shown that adenosine monophosphate-activated protein kinase-independent pathways can explain some of metformin's beneficial metabolic effects as well as undesirable side-effects. (cyberleninka.org)
AMPK is a highly conserved serine/threonine protein kinase composed of a catalytic a subunit and two regulatory p and y subunits, and is activated by an increased AMP : adenosine triphosphate (ATP) ratio in metabolic stress conditions, such as hypoxia or glucose depriva-tion5. (cyberleninka.org)
The inhibition of mitochondrial complex activity by metformin might be a mechanism of metformin-induced AMPK activation9, as intracellular ATP levels are decreased by the inhibition of mitochondrial complex activity and AMP levels are increased by the action of adenylate kinase converting two molecules of adenosine diphosphate (ADP) to ATP and AMP (Figure 1). (cyberleninka.org)
AMP molecules can then bind to the y subunit of AMPK and activate AMPK activity directly or by inhibiting dephosphorylation of AMPK phosphorylated by liver kinase B1 (LKB1) or calcium/calmodulin-dependent protein kinase kinase-ß (CAMKKß)10. (cyberleninka.org)
Decreased adenosine triphosphate (ATP) and increased adenosine monophosphate (AMP) content by metformin as a result of decreased mitochondrial complex activity contributes to adenosine monophosphate-activated protein kinase (AMPK) activation. (cyberleninka.org)
Risk factors for depression initiate an infection-like inflammation in the brain that involves activation microglial Toll-like receptors and glycogen synthase kinase-3β (GSK3β). (mdpi.com)
4] The ATP depletion is due to activation of Na+/K+ -ATPase, which, in turn, is a consequence of decreased phosphorylation by protein kinase C. Activation of the NMDA receptor is probably the cause of seizures in acute hyperammonemia. (medscape.com)
Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. (bvsalud.org)

Goupil S, Maréchal L, El Hajj H, Tremblay M-È, Richard FJ, Leclerc P (2016) Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. (plos.org)

Considerably higher resistance against cyclic nucleotide phosphodiesterases compared to dibutyryl- or 8-Br-cAMP (Cat. (biolog.de)
Sperm intracellular cAMP levels depend on the activity of adenylyl cyclases, mostly SACY, though transmembrane-containing adenylyl cyclases are also present, and on the activity of cyclic nucleotide phosphodiesterases (PDE) whose role is to degrade cAMP into 5'-AMP. (plos.org)

As in somatic cells, sperm intracellular cAMP concentration is regulated by the opposite action of two enzymes: the adenylyl cyclases (AC), which synthesize cAMP from ATP, and the phosphodiesterases (PDE), which break the phosphodiester bond of cAMP to form 5'-adenosine monophosphate (AMP). (plos.org)
3',5'-Cyclic-GMP Phosphodiesterases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "3',5'-Cyclic-GMP Phosphodiesterases" by people in this website by year, and whether "3',5'-Cyclic-GMP Phosphodiesterases" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "3',5'-Cyclic-GMP Phosphodiesterases" by people in Profiles. (umassmed.edu)

We measured this using an improved fluorescent reporter and by phosphorylation of endogenous cAMP-response-element binding protein (CREB). (nature.com)
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide exchange factors like EPAC. (plos.org)

On the horizon, novel insights into metabolism and energy homeostasis reveal guanosine 3′,5′-cyclic monophosphate (cGMP) signaling circuits as emerging targets for antiobesity pharmacotherapy. (eddoctor24h.com)
In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. (plos.org)
Cyclic AMP (adenosine 3', 5'-cyclic monophosphate) is an important player in sperm function. (plos.org)

Among PRRs, cyclic GMP-AMP synthase (cGAS) is a recently identiﬁed DNA sensor, which plays a pivotal role in recognizing cytosolic DNA [3]. (gw786034inhibitor.com)

To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (βARs), one that predominately recognizes neurons (βAR 248) and the other astrocytes (βAR 404), to characterize the microenvironments of DβH and βAR. (frontiersin.org)

Although a high level of PDE10A gene expression is observed in the testis, information on the identity of the isoforms or on the cell type that express the PDE10 protein is lacking. (plos.org)
Differential expression of polycytosine-binding protein isoforms in adrenal gland, locus coeruleus and midbrain. (rochester.edu)

Hormones mobilize intracellular second messengers and initiate signalling cascades involving protein kinases and phosphatases, which are often spatially compartmentalized by anchoring proteins to increase signalling specificity 1 . (nature.com)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)

Increased levels of this sugar inhibit the activity of the repressor by binding allosterically, resulting in a conformational change of the protein, which suppresses its interactions with RNA polymerase and DNA. (wikipedia.org)
Here we show that in adipocytes, chronically high insulin levels inhibit β-adrenergic receptors (but not other cAMP-elevating stimuli) from activating PKA. (nature.com)
Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1. (ox.ac.uk)

Excessive Ca 2 + entry through glutamate receptors activates a large array of potential neurotoxic mechanisms, which include activation of enzymes such as phospholipases, calpains and other proteases, protein kinases, nitric oxide synthetase, endonucleases, as well as reactive oxygen species (for review, see Sattler and Tymianski, 2000 ). (jneurosci.org)
In addition to its PRKA-dependent effects, different studies have clearly demonstrated that cAMP also activates EPAC ( E xchange P roteins directly A ctivated by c AMP) during capacitation and acrosome exocytosis [ 15 - 17 ]. (plos.org)

Additional analysis suggests Ssa1 is the major Hsp70 chaperone for the mating and invasive growth pathways and reveals several Hsp70-Hsp90 chaperone-network proteins required for mating morphogenesis. (bvsalud.org)
Chronically high insulin levels may disrupt the close apposition of β-adrenergic receptors and PKA, identifying a new mechanism for crosstalk between heterologous signal transduction pathways. (nature.com)
Dimethyl sulfoxide (DMSO) and fumarate reductase gene expression was down-regulated at least 2-fold in the mutant, which, showed lower or no reduction of these electron acceptors when compared to the wild type, suggesting both respiratory pathways are under EtrA control. (biomedcentral.com)
Such novel pathways include induction of mitochondrial stress, inhibition of mitochondrial shuttles, alteration of intestinal microbiota, suppression of glucagon signaling, activation of autophagy, attenuation of inflammasome activation, induction of incretin receptors and reduction of terminal endoplasmic reticulum stress. (cyberleninka.org)

Lipins also act in the nucleus as transcriptional co-activators with peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α) and peroxisome proliferator-activated receptor α to regulate target genes involved in fatty acid oxidation. (aocs.org)

Overactivation of NMDA receptors is believed to induce neuronal death by increasing phospholipid hydrolysis and subsequent degradation. (jneurosci.org)
Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate. (umassmed.edu)

Use knockout HEK293 cells to verify that RBM12 is novel repressor of the GPCR/cAMP pathway that extends to multiple GPCRs coupled to the stimulatory G protein (e.g. dopamine 1 receptor, beta-2 adrenergic receptor). (sciety.org)

We now investigated the effect of NMDA receptor overactivation on synthesis and degradation of major membrane phospholipids in the early stages of the excitotoxic process. (jneurosci.org)
Metabolic labeling experiments in whole cells showed that NMDA receptor overactivation does not modify the activity of phosphocholine or phosphoethanolamine cytidylyltransferases but strongly inhibits choline-ethanolamine phosphotransferase activity. (jneurosci.org)
These results show that membrane damage by NMDA is preceded by inhibition of phospholipid synthesis and not by phospholipid degradation in the early stages of the excitotoxic process, and that NMDA receptor overactivation decreases phosphatidylcholine and phosphatidylethanolamine synthesis by inhibiting choline-ethanolaminophosphotransferase activity. (jneurosci.org)
Acute ammonia intoxication in an animal model leads to increased extracellular concentration of glutamate in the brain and results in activation of the N -methyl D-aspartate (NMDA) receptor. (medscape.com)
sustained blocking of the NMDA receptor by continuous administration of antagonists dizocilpine (MK-801) or memantine prevents both phenomena, leading to significantly increased survival time in rats. (medscape.com)

Characterization of the brain penetrant neuropeptide Y Y 2 receptor antagonist SF-11. (rndsystems.com)

STP, serine/threonine protein phosphatase. (rupress.org)
The assessment of kinetic guidelines for wild-type and C299S mutant AKR1B10 shows that substitution of serine by cysteine at position 299 reduces the protein affinity for DL-glyceraldehyde and enhances its catalytic activity. (tam-receptor.com)

Sequence alignment of the protein encoded by etrA reveal that the four cysteine residues that form the [4Fe-4S] 2+ cluster in Fnr are conserved in EtrA [ 16 ]. (biomedcentral.com)
An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. (bvsalud.org)

cAMP-mediated stimulation of tyrosine hydroxylase mRNA translation is mediated by polypyrimidine-rich sequences within its 3'-untranslated region and poly(C)-binding protein 2. (rochester.edu)
Nicotinic and muscarinic acetylcholine receptors are essential for the long-term response of tyrosine hydroxylase gene expression to chronic nicotine treatment in rat adrenal medulla. (rochester.edu)

In contrast to Escherichia coli , the regulatory systems that control transcription of genes responsible for different respiratory processes are poorly understood in environmentally relevant Shewanella spp. (biomedcentral.com)
Despite the importance of the PAP reaction, identification of the genes responsible for encoding PAP enzymes remained elusive until 2006 when the yeast PAP was identified and was shown to be an orthologue of a family of three mammalian proteins called lipins [reviewed in 1]. (aocs.org)
The genome of E. coli MG1655 is 4,641,642 bp, corresponding to 4702 genes encoding 4328 proteins. (encyclopedia.pub)
The genome size of E. coli strain K-12 MG1655 is 4,641,652 bp, corresponding to 4702 genes encoding 4328 proteins, 228 RNA genes, and 146 pseudogenes. (encyclopedia.pub)

Dedication of IC50 of AKR1B10 inhibitors The em IC /em 50-value of the inhibitors were identified using the assay combination comprising 0.1 M sodium phosphate buffer (pH 7.5), 7.5 mM DL-glyceraldehyde, 0.2 mM NADPH, 0.3 M AKR1B10 wild-type protein and varying concentrations of inhibitors depending on their inhibition potency. (tam-receptor.com)

Antibody-AdV complexes can provoke inflammatory cytokine and chemokine responses in macrophages via the intracellular antibody receptor TRIM21 [56-59]. (genemedi.com)

regulator (FNR, oxygen starvation), the ferric uptake regulator (Fur, iron starvation) www.selleckchem.com/products/azd6738.html and the superoxide response protein (SoxR, oxidative stress). (thrombin-inhibitor.com)

Ammonia is a product of the metabolism of proteins and other compounds, and it is required for the synthesis of essential cellular compounds. (medscape.com)

Hexon and penton structures form the capsid of AdV, and fiber protein mediates the binding of the virion to the cell surface and is a major determinant of viral tropism. (genemedi.com)

As ASFV is a nucleocytoplasmic virus and mainly completes viral replication and assembly in the cytoplasm [21], it is hypothesized that ASFV may encode early proteins to prevent the sensing of foreign DNA from being recognized by cytosolic DNA receptors, especially cGAS. (gw786034inhibitor.com)

For this repressor protein to function properly, the operon also contains a histone binding site to facilitate this process. (wikipedia.org)
Activity of this repressor protein is controlled based on the levels of D-galactose in the cell. (wikipedia.org)

however, limited anaerobic growth and nitrate reduction occurred, suggesting that multiple regulators control nitrate reduction in this strain. (biomedcentral.com)

Clopidogrel exerts its antiplatelet effect by inhibiting the binding of adenosine diphosphate (ADP) to its receptor (P2Y12) and consequent ADP-mediated platelet activation [ 3 ]. (hindawi.com)

This binding process leads to the release of IL-1α and activation of IL-1 receptor, promoting chemokines production and attracting other innate immune cells to kill AdV infected MFs [61]. (genemedi.com)
Furthermore, we determined that changes in pAkt immunoreactivity elicited by PEA were not mediated by activation of cannabinoid receptor type 2 (CB2), thus indicating a novel mechanism of action. (biomedcentral.com)

Several transcriptional and post-transcriptional regulatory mechanisms control the preferential use of glucose over other sugars. (encyclopedia.pub)
For example, it has been reported that metformin-induced suppression of glucose production is more pronounced in AMPKa1a2-null hepatocytes compared with control cells7. (cyberleninka.org)

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring. (rndsystems.com)
In agreement with its activity as an RNA-binding protein, loss of RBM12 leads to altered gene expression, including that of multiple effectors of established significance within the receptor pathway. (sciety.org)

Rare, protein-truncating variants substantially increase the risk for mental illnesses like schizophrenia. (sciety.org)

GalT encodes for the protein galactosyltransferase which catalyzes the transfer of a galactose sugar to an acceptor, forming a glycosidic bond. (wikipedia.org)

First, we performed quality control, dimensionality reduction, clustering, and annotation of the data through the Seurat R package (v4.0.5). (hindawi.com)
Inhibition kinetics of daunorubicin reduction by AKR1B10 The inhibition kinetics of daunorubicin reduction by histagged AKR1B10 wild-type protein was monitored spectrophotometrically, by measuring decrease in the absorbance of the cofactor NADPH at 340 nm (Balendiran and Rajkumar, 2005, Martin et al. (tam-receptor.com)

The HAD domain-containing proteins catalyze hydrolase or phosphohydrolase reactions. (aocs.org)

It has been postulated that DP96R is a potential immune evasion protein, although its mechanism of action remains virtually unknown [9,22]. (gw786034inhibitor.com)
The abundance of other NAE species, such as palmitoylethanolamine (PEA), together with their largely unknown function and receptors, has prompted us to examine the neuroprotective properties and mechanism of action of PEA. (biomedcentral.com)

Lipin-1 and -2 have a second function as transcriptional co-activators acting in a complex with transcriptional regulators called peroxisome proliferator-activated receptor-coactivator-1α (PGC-1α) and peroxisome proliferator-activated receptor-α (PPARα) [1,3] (Fig. 1). (aocs.org)
Stress-induced catecholaminergic function: transcriptional and post-transcriptional control. (rochester.edu)

Aconitases (Acn) are iron sulfur proteins that catalyse the reversible isomerization of citrate and isocitrate GSK J4 cell line via the intermediate cis-aconitate in the Krebs cycle. (thrombin-inhibitor.com)

The reason is because many immune-related receptors and molecules are extensively produced by these cells, not only during disease but also during physiological processes ( 3 , 9 ). (frontiersin.org)

Current understanding of the regulation and functions of AcnA and AcnB in dual Acn bacteria is based on a model developed in Escherichia coli. (thrombin-inhibitor.com)
Thus, the work reported here provides a second example of the regulation and function of AcnA and AcnB proteins in a dual Acn bacterium. (thrombin-inhibitor.com)

Inhibition of TGF-β1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-β1-Induced EMT in Renal Fibrosis. (rndsystems.com)

The mammalian immune system utilizes pattern recognition receptors (PRRs) to detect pathogen-associated molecular patterns (PAMPs) from invading pathogens and activate the host innate immune response [1,2]. (gw786034inhibitor.com)

Arachidonylethanolamide (AEA) is a well characterized NAE that is an endogenous ligand at cannabinoid and vanilloid receptors, but it exists in small quantities relative to other NAE types. (biomedcentral.com)

Fish were acclimated to one of three temperatures (15, 25 or 30°C) and sampled at one of two treatments (control or after CTmax), following which we assessed differential gene expression and gene ontology in muscle. (bvsalud.org)
Furthermore, the most consistent gene ontology pattern that emerged following both acclimation and CTmax was upregulation of transcripts involved in "protein folding", which also include heat shock proteins. (bvsalud.org)

In addition to innate immune responses in circulation, AdV virions can also be trapped by splenic macrophages (MFs) of the MARCO subset via the binding of fiber knob of the capsid to integrin b3 receptor [60]. (genemedi.com)
ASFV utilizes multiple self-encoding proteins to evade the host's innate and adaptive immune responses [9e13]. (gw786034inhibitor.com)

Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture. (ox.ac.uk)

For most serotypes, adenovirus infection is mediated by the high-affinity binding of the fiber-knob region to a receptor of target cell, named as the coxsackie-Ad receptor (CAR), which mainly determines the viral tropism [44]. (genemedi.com)
Transient IL-10 receptor blockade can enhance CD8(+) T cell responses to a simian adenovirus-vectored HIV-1 conserved region immunogen. (ox.ac.uk)
The aggregative enzyme (ACA) is activated following cAMP-binding to the G-protein coupled cell surface cAMP receptor (cAR1). (biomedcentral.com)
This group also found that while both receptor subtypes were seen in the membranes and cytoplasm of cell bodies, the β 2 receptor subtype, but not the β 1 , was localized to the nucleus. (frontiersin.org)

Heat shock proteins (HSPs) are inducible molecular chaperones, which help mitigate protein damage resulting from increased temperatures. (bvsalud.org)

Our differential expression analyses also revealed induction of many different heat shock proteins, including hsp70, hsp90, hsp40 and other small HSPs, after both acute and chronic temperature increase in white muscle. (bvsalud.org)

Organisms4

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes22

Information Science3

Kinase21

Phosphodiesterase1

Nucleotide phosphodiesterases2

Phosphodiesterases4

Phosphorylation5

Monophosphate3

Synthase1

Beta-adrenergic1

Isoforms2

Phosphatases2

Inhibit3

Activates2

Pathways4

Activator1

Hydrolysis2

Dopamine1

NMDA5

Characterization1

Serine2

Residues2

Tyrosine2

Genes4

Inhibitors1

Chemokine1

Oxidative stress1

Metabolism1

Mediates1

Cytosolic1

Repressor2

Nitrate reduction1

Adenosine diphosphate1

Activation2

Glucose2

Pathway2

Variants1

Galactosyltransferase1

Reduction2

Phosphohydrolase1

Mechanism of act2

Transcriptional2

Reversible1

Molecules1

Regulation2

Role1

Mammalian1

Endogenous1

Gene2

Innate2

Activity1

Cell4

Molecular1

Induction1