Drugs or doses. Medical search. Frequent questions

Speaking on May 1 at Experimental Biology 2007, University of Kansas Medical Center scientist Dr. Gregory Reed reports a study that found daily use of ginseng or ginkgo biloba supplements at the recommended doses, or the combination of both supplements, are unlikely to alter the pharmacokinetics - by which drugs are absorbed, distributed, metabolized, and eliminated by the body - of the majority of prescription or over-the counter drugs. (news-medical.net)
Taken together, the five drugs in the cocktail provide measurements of the pathways that determine the pharmacokinetics of over 90 percent of prescription drugs. (news-medical.net)
This suggests, says Dr. Reed, that neither ginseng nor ginkgo biloba will affect the pharmacokinetics of the majority of prescription or over-the counter drugs. (news-medical.net)
Build clinical pharmacy skills and explore the complexities of drug dosing in renal disease with this pharmacokinetics course. (futurelearn.com)
On this course, you will learn the principles of pharmacokinetics and drug dose adjustment in patients with renal disease. (futurelearn.com)
The total daily dose of Copegus should be reduced for patients with creatinine clearance less than or equal to 50 mL/min, and the weekly dose of Pegasys should be reduced for creatinine clearance less than 30 mL/min as follows in Table 3 [ see Use in Specific Populations (8.7), Pharmacokinetics (12.3), and PEGASYS Package Insert ]. (hivandhepatitis.com)
The pharmacokinetics of abacavir (ABC) in African children living with HIV (CLHIV) weighing dose combinations (FDC) according to WHO weight bands dosing are limited. (bvsalud.org)

Oral colchicine has been used for many years as an unapproved drug with no FDA-approved prescribing information, dosage recommendations, or drug interaction warnings, the agency said in a news release, noting the development of new safety concerns. (medscape.com)
They recommend dosage reductions for women for a wide range of drugs. (sciencedaily.com)
This concern has prompted the Food and Drug Administration (FDA) to halve the recommended dosage for Sunovion's sleep aid Lunesta (eszopiclone). (healthline.com)
The doctor must determine whether the child needs the drug as well as the dosage. (minddisorders.com)
It may allow us to improve treatments by optimizing the drug dosage for each individual, and it's inexpensive, so everyone could benefit from this solution. (sflorg.com)
The ability to precisely measure drug dosage could also expand physicians' options for treating their patients. (sflorg.com)
This case offers an example of acute drug-induced liver injury occurring after a dosage increase of duloxetine. (psychiatrist.com)
These doses have not been studied in patients [ see Dosage and Administration (2.4), Use in Specific Populations (8.7), and Clinical Pharmacology (12.3) ]. (hivandhepatitis.com)

Patients should not stop taking oxazepam suddenly, especially if they are taking large doses. (minddisorders.com)
In a paper in today's issue of the journal Cancer Discovery , the researchers demonstrate that large doses of cyclophosphamide not only kill cancer cells directly, as has been known, but also spur an immune system attack on the cells. (dana-farber.org)

The 1 mg dose can be increased to 2 mg or 3 mg if needed, but the higher doses are more likely to result in next-day impairment of driving and other activities that require full alertness, said the FDA in a press statement. (healthline.com)
The risk of myopathy is also increased when simvastatin, especially at the higher doses, is used with certain drugs (see Simvastatin Dose Limitations below). (fda.gov)
Therefore, according to the authors, this could have dosing implications for both patients and prescribers because patients with a high BMI will be expected to require higher doses of warfarin to maintain effectiveness. (empr.com)

However, if it is almost time for your next dose, skip the missed dose and continue your dosing schedule. (medlineplus.gov)

Recent findings that the widely-used herbal supplement Saint John's wort could dramatically affect the absorption and metabolism of many prescription and non-prescription drugs raised concerns that other popular herbal supplements might cause similar changes, thus significantly altering drugs, therapeutic or toxic effects. (news-medical.net)
He does note, however, that the team did not investigate any possible effects of the herbal supplements on pharmacodynamic interactions: the way drugs produce desired therapeutic effects or cause adverse side effects. (news-medical.net)
A drug combination designed to enhance the immune system's ability to zero in and attack cancer cells has shown a pronounced therapeutic effect against cancer. (medindia.net)
The government has banned 14 fixed dose combination drugs including Nimesulide and Paracetamol dispersible tablets and Chlopheniramine Maleate and Codeine syrup citing there is "no therapeutic justification" for these medicines and that they may involve "risk" to people. (indiatimes.com)
Therefore, according to Kane-Gill, further studies are required to help guide clinical practitioners to be more vigilant for therapeutic failures and adverse drug reactions in these patients. (empr.com)
The expert committee said that there is "no therapeutic justification for this FDC (fixed dose combination) and the FDC may involve risk to human beings. (telegraphindia.com)
The ototoxicity of therapeutic drugs has been recognized since the nineteenth century. (cdc.gov)

Although supplements made from P. johimbe bark extract would be expected to have low levels of yohimbine, the new study found high doses of the compound - up to 12 milligrams - in the supplements. (livescience.com)
The recommended dose of prescription yohimbine was 5 to 10 milligrams. (livescience.com)
There were no problems for people who had taken 20 milligrams of the drug for 10 days straight. (npr.org)
But for those taking doses of 50 milligrams, the fifth day "was a disaster, suddenly," he says. (npr.org)
The recommended starting dose of Lunesta has been decreased from 2 milligrams to 1 mg for both men and women. (healthline.com)
For the study, half of the participants were randomly assigned to receive a 0.3 milligrams per kilogram dose of psilocybin while the rest received a vitamin placebo (250 milligrams of niacin) known to produce a 'rush' that mimics a hallucinogenic drug experience. (technologynetworks.com)
Low-dose naltrexone refers to doses about 1/10th the size of the dose used normally, typically 4.5 mg or within a couple of milligrams of that value. (wikipedia.org)

An FDA analysis of safety data from reported adverse events, published literature, and company-sponsored pharmacokinetic and drug interaction studies has revealed cases of fatal colchicine toxicity in certain patients receiving standard doses of the drug concomitantly with other drugs such as clarithromycin. (medscape.com)
Pharmacokinetic modeling and simulation indicates that a dose of 200 mg daily in patients with severe renal impairment and a dose of 200 mg daily alternating with 400 mg the following day in patients with moderate renal impairment will provide plasma ribavirin exposure similar to patients with normal renal function receiving the approved regimen of Copegus. (hivandhepatitis.com)

When hypnotics are needed, the lowest dose possible should always be used, as with any medication. (healthline.com)
[3-19-2010] Based on review of data from a large clinical trial and data from other sources, the U.S. Food and Drug Administration (FDA) is informing the public about an increased risk of muscle injury in patients taking the highest approved dose of the cholesterol-lowering medication, Zocor* (simvastatin) 80 mg, compared to patients taking lower doses of simvastatin and possibly other drugs in the "statin" class. (fda.gov)
The shortage of pediatric medication in Canada last year led to a spike of dosing errors in children in Ontario, new research shows. (cp24.com)
The technology could be a step toward improving doctors' ability to administer precise medication doses. (sflorg.com)
Using data taken by the device within about 15 minutes after the medication was administered, the researchers reliably forecast how much of that drug would be effectively delivered to the animal's system in total. (sflorg.com)
The patch's measurement of peak drug concentration in the body - which occurs in the first 12 to 20 minutes after a dose is administered - could be used to predict how much of the medication is effectively delivered to the body over the course of an hour or more. (sflorg.com)
A study in which 24 trans women and 24 trans men who were taking gender-affirming hormone therapy were directly observed to take a daily dose of the standard formulation of the HIV prevention medication PrEP found that the levels of the two PrEP drugs tenofovir and emtricitabine were similar to the levels seen in similar cis men and women, and were all above levels associated with efficacy. (aidsmap.com)
Multi-dose drug dispensing, in which patients receive their medications packaged together for each dose (and not separated by individual medication), was associated with higher use of potentially inappropriate medications , but not with an increased rate of drug-drug interactions. (ahrq.gov)
STO: ORX) (OTCQX: ORXOY), today announces the submission of the New Drug Application (NDA) to the US Food and Drug Administration (FDA) for OX124, a high-dose rescue medication for opioid overdose with nasal delivery. (krqe.com)
In addition, development formulations of OX124 have in a previous exploratory clinical study (OX124-001) in healthy volunteers, demonstrated a more rapid absorption and higher bioavailability compared with the market leading naloxone rescue medication, even with the same dose as the comparator. (krqe.com)
With the submission of OX124 we are making good progress in expanding our commercial product portfolio in the US and this high-dose life-saving medication has the potential to curb the huge upturn in lethal overdoses seen over the past years and which is grounded in the wide spread of fentanyl. (krqe.com)
400 mg fixed dose tocilizumab holds out hope of extending the supply of life-saving medication and providing benefit to a larger number of severe COVID-19 patients. (vchri.ca)
Although randomized studies comparing tocilizumab doses require additional clinical consideration, this study adds to the body of observational data that demonstrates lower doses of tocilizumab - such as the 400 mg IV fixed dose strategy used in this study - increases the number of patients who will benefit from the medication in a climate of drug scarcity. (vchri.ca)
Low-dose naltrexone (LDN) describes the off-label, experimental use of the medication naltrexone at low doses for diseases such as Crohn's disease, Hashimoto's and multiple sclerosis, but evidence for recommending such use is lacking. (wikipedia.org)

The new prescribing information for colchicine also contains data from clinical studies showing that substantially lower doses than usual provide equal efficacy for the treatment of gout with improved safety parameters. (medscape.com)
These two trials are part of a series of five trials evaluating the safety and efficacy of Stellarex .035″ low-dose [1] DCB to restore and maintain blood flow in the superficial femoral artery and popliteal arteries of patients with peripheral arterial disease. (philips.com)
Enhancing understanding of drug behaviour, toxicity, and efficacy in humans. (ddw-online.com)
trials are necessary to draw firm conclusions on the efficacy of [low-dose naltrexone]. (wikipedia.org)
Publication from the World Health Organization - WHO that brings information on antimalarial drug efficacy and drug resistance, challenges to monitoring drug efficacy and other subjects related to the. (bvsalud.org)

Patients should be informed of the risk for potentially fatal colchicine drug interactions that can occur at prescribed doses and with medications that are given for a short time, such as antibiotics. (medscape.com)
PGx applications have been characterized for a wide variety of drugs, such as analgesics, antidepressants, anticoagulants, proton pump inhibitors, and cardiovascular medications, that are prescribed to tens of millions of people in the United States. (cdc.gov)
Women are more likely than men to suffer adverse side effects of medications because drug dosages have historically been based on clinical trials conducted on men, suggests new research. (sciencedaily.com)
Researchers analyzed data from several thousand medical journal articles and found clear evidence of a drug dose gender gap for 86 different medications approved by the Federal Drug Administration (FDA), including antidepressants, cardiovascular and anti-seizure drugs and analgesics, among others. (sciencedaily.com)
Overall, in clinical practice, there remains uncertainty in how to dose certain medications in overweight and obese patients, especially with high-risk medications such as anticoagulants and sedatives. (empr.com)
Researchers found a twofold increase in calls to the Ontario Poison Centre for unintentional dosing errors of the medications for patients 18 years old or younger last fall, particularly in November 2022, compared to the four years prior. (cp24.com)
But predicting that margin is a persistent challenge because different people react differently to medications - even to the same dose. (sflorg.com)
This study is the first one to measure the blood levels of PrEP and GAT medications in transgender men, and adds to the body of knowledge of drug levels in transgender women. (aidsmap.com)
tell your doctor and pharmacist if you are allergic to trimethoprim, sulfa drugs, diuretics ('water pills', oral diabetes medications, or any other drugs. (medlineplus.gov)
There are prescription medications called "antiviral drugs" that can be used to treat flu illness. (cdc.gov)

In mouse models implanted with human lymphoma tissue, the researchers showed that high doses of the drug, but not normal doses, damaged tumor cells in a way that severely stressed the lymphoma cells. (medindia.net)
Why wouldn't CLDs cause side-effects at high doses when they occur even in normal doses? (thebulletin.ca)

You will learn how to calculate renal clearance, and how to recommend dosing regimen for patients with the disease. (futurelearn.com)
To evaluate the six-dose regimen of artemether-lumefantrine for treating uncomplicated falciparum malaria. (bvsalud.org)

Single-dose mass drug administration of azithromycin interfere with transmission by exoerythrocytic inhibition of (AZT) is underway to eliminate trachoma worldwide. (cdc.gov)
However AZT is highly effective against spective cohort of children and parents in Dodoma Province, Chlamydia trachomatis , the causative agent of trachoma, Tanzania, we quantified the temporal prevalence of malaria parasitemia by real-time PCR for 6 months after single-dose which causes blindness ( 5 , 6 ). (cdc.gov)
When combined with psychological counseling, a single dose of a mind-altering compound contained in psychedelic mushrooms significantly lessens mental anguish in distressed cancer patients for months at a time, according to results of a clinical trial led by researchers at NYU Langone Medical Center. (technologynetworks.com)
Those who initially received psilocybin took a single dose of placebo, and those who first took niacin, then received psilocybin. (technologynetworks.com)
[ 1 ] Although the majority of ingestions are ultimately benign, many ingestions can prove fatal with only a single dose of the agent ingested. (medscape.com)
Peramivir is given intravenously by a health care provider, and baloxavir is a pill given as a single dose by mouth. (cdc.gov)
Baloxavir is given in a single dose. (cdc.gov)

More than 60 years ago, British physician Denis Parsons Burkitt and his associates achieved one of the signal successes in cancer medicine when they cured children in sub-Saharan Africa with a form of lymphoma by treating them with high doses of the chemotherapy drug cyclophosphamide. (medindia.net)

Mild cases generally improve with discontinuation of the drug, while severe cases may require supportive therapy and treatment with an antimicrobial agent effective against C difficile. (drugs.com)
The study showed that compared to a placebo, Lunesta 3 mg was associated with severe next-morning psychomotor and memory impairment in both men and women, 7.5 hours after taking the drug. (healthline.com)
Subjects with moderate (n=17) or severe (n=14) renal impairment did not tolerate 600 mg or 400 mg daily doses of Copegus, respectively, due to Copegus-related adverse reactions, mainly anemia, and exhibited 20 to 30% higher ribavirin plasma exposures (despite frequent dose modifications) compared to subjects with normal renal function (creatinine clearance greater than 80 mL/min) receiving the standard dose of Copegus. (hivandhepatitis.com)
Tocilizumab, an immunosuppressive drug originally developed to treat severe forms of inflammatory arthritis, became scarce in early 2021 after it was discovered to be an effective treatment for life-threatening cases of COVID-19. (vchri.ca)

The drug manufacturer Purdue Pharmaceuticals resisted efforts to change the dosing recommendations for its long acting opioid OxyContin to protect its revenues, the Los Angeles Times has alleged in an investigative report published on 5 May. (bmj.com)
Follow the recommendations in the simvastatin label regarding drugs that may increase the risk for muscle injury when used with simvastatin (see Simvastatin Dose Limitations below). (fda.gov)
And whereas, on the basis of the recommendations of the Expert Committee and the Drugs Technical Advisory Board, the Central Government is satisfied that it is necessary and expedient in public interest to regulate by way of prohibition the manufacture for sale, sale and distribution for human use of the said drug in the country," the notification stated. (telegraphindia.com)
On August 9, 2011, the U.S. Food and Drug Administration (FDA) approved changes to the product label information for pegylated interferon alfa-2a (Pegasys) plus the Copegus brand of ribavirin, reflecting new dose recommendations for people with impaired kidney function. (hivandhepatitis.com)
The Committee made recommendations on residues of several veterinary drugs in food. (who.int)
The recommendations of the Committee are used by the Codex Alimentarius Commission for setting international standards, including limits on residues of veterinary drugs in foods. (who.int)

July 31, 2009 - The US Food and Drug Administration (FDA) has approved the first single-ingredient oral colchicine product ( Colcrys , Mutual Pharmaceutical Company, Inc) for the treatment of familial Mediterranean fever and acute gout flares. (medscape.com)
METHODS: This phase 1, double-blind, placebo-controlled, first-in-human study (NCT03809052) included a single ascending-dose phase (with a food-effect cohort) where participants across seven sequential cohorts were randomized 3:1 to receive oral GB1211 (5, 20, 50, 100, 200 or 400 mg) or placebo. (lu.se)

The dose of Copegus should not be further modified in patients with renal impairment. (hivandhepatitis.com)

The study also found that recommended doses can cause impairment to driving skills, memory, and coordination as long as 11 hours after the drug is taken. (healthline.com)
Recently, data from clinical trials and other types of studies have become available, which allowed the FDA to better characterize the risk of next-morning impairment with sleep drugs. (healthline.com)
In January 2013, the FDA announced a dose reduction for sleep drugs that contain the active ingredient zolpidem, such as Ambien and Ambien CR, because of the risk of next morning impairment. (healthline.com)
In the developed nations, and in some developing ones, the prescription of these drugs will trigger "ototoxicity monitoring" of patients to allow early detection of auditory effects and, when necessary, audiologic interventions to address the hearing impairment (AAA 2009). (cdc.gov)

No dose on non-dialysis days. (sunnybrook.ca)

Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with ertugliflozin. (medscape.com)

Cyclophosphamide dose in excess spurs immune system attack on the cells apart from killing the cancer cells directly, according to a new research published in the journal Cancer Discovery . (medindia.net)
At high doses, cyclophosphamide and other alkylating agents blur the line between chemotherapy and immunotherapy. (medindia.net)
Our results show that, at high doses, cyclophosphamide and other alkylating agents blur the line between chemotherapy and immunotherapy," said Dana-Farber's David Weinstock, MD, the senior author of the study. (medindia.net)
Cyclophosphamide was just the eighth anti-cancer drug to enter standard therapy when it was approved by the U.S. Food and Drug Administration in 1954. (medindia.net)
Cyclophosphamide and other alkylating agents are now used at lower doses to treat many types of cancer, including breast, ovarian, and pediatric cancers. (medindia.net)
In the new study, investigators focused on the effect of high doses of cyclophosphamide on macrophages - cells that, under the right conditions, eat infected cells or cells in the process of dying. (medindia.net)
Although high doses of cyclophosphamide and other alkylating agents may be too toxic for patients with diseases other than Burkitt lymphoma, researchers are investigating agents that mimic their ability to stress cancer cells, but with milder side effects. (medindia.net)

Women in the studies analyzed by Zucker and University of Chicago psychologist Brian Prendergast were given the same drug dose as the men, yet had higher concentrations of the drug in their blood, and it took longer for the drug to be eliminated from their bodies. (sciencedaily.com)
They found that the patch's measurements of drug concentrations correlated with those produced by conventional blood tests. (sflorg.com)
The low body mass and circulating blood volumes of children means that a single ingested dose of a substance may easily achieve concentrations in plasma or target tissues that far exceed concentrations in adults. (medscape.com)
The Committee also discussed procedures for assessing the effects of antimicrobial drug residues in food on the human intestinal microflora, including in vitro methods, such as determination of minimum inhibitory concentrations and continuous and semi-continuous culture systems, and in vivo methods, such as studies on conventional laboratory animals, human microflora associated with germ-free rodents, and volunteers. (who.int)

Abacavir drug exposures in African children under 14 kg using paediatric solid fixed dose combinations according to World Health Organization weight bands. (bvsalud.org)

Our study demonstrates that consumers in the U.S.A. are unable to obtain adequate safety information from the overwhelming majority of yohimbine supplement brands offered for sale," the researchers wrote in their article, published today (Sept. 22) in the journal Drug Testing and Analysis. (livescience.com)
Researchers discovered, for example, that while high doses are much more effective against certain cancers than low doses, they inflict about the same amount of DNA damage, suggesting that something else comes into play at high doses. (medindia.net)
PrEP drugs and sex hormones are metabolised in different ways so there is no reason to expect significant interactions, the researchers say. (aidsmap.com)
Vancouver, B.C. - Scarcity of a drug central to the treatment of critically ill COVID-19 patients inspired British Columbia researchers to develop a novel dosing strategy that resulted in more people being treated with smaller doses of a life-saving drug. (vchri.ca)
However, currently no drugs are indicated for the treatment of agitation, so "clinicians use multiple classes of compounds with limited empirical data and no instructions for use," write the researchers. (medscape.com)
Researchers have also examined "ultra-low-doses" of naltrexone at microgram, nanogram, and picogram doses, that are co-administered with opioid analgesics with the goal of increasing pain relief and reducing side effects. (wikipedia.org)

Subscribe to AHFS Clinical Drug Information to get direct access to integrated drug shortages content, plus comprehensive and actionable drug information. (ashp.org)

The Infants' Concentrated Drops have been specifically designed for use only with enclosed dosing device. (theodora.com)

HONOLULU, Hawaii - The atypical antipsychotic brexpiprazole ( Rexulti , Otsuka and Lundbeck) is safe and effective for treating agitation in patients with dementia related to Alzheimer's disease (AD) - at least at its highest dose, new research suggests. (medscape.com)

suggested that reductions in alaria can be treated or prevented with the broad- malaria prevalence associated with AZT MDA might have spectrum antimicrobial drugs tetracycline or azithro- contributed to observed decreases in overall deaths ( 10 ). (cdc.gov)
Dose reductions or interruption of colchicine therapy should be considered in patients with normal renal and hepatic function who require concomitant treatment with a P-glycoprotein or strong cytochrome P 450 isoenzyme 3A4 inhibitor. (medscape.com)
HA403 trade name] is not indicated in children weighing less than 35 kg as appropriate dose reductions for the weight of the child cannot be made. (who.int)

When it comes to prescribing drugs, a one-size-fits-all approach, based on male-dominated clinical trials, is not working, and women are getting the short end of the stick," said study lead author Irving Zucker, a professor emeritus of psychology and of integrative biology at UC Berkeley. (sciencedaily.com)
Dose Finding in Drug Development introduces the drug development process, the design and the analysis of clinical trials. (chipsbooks.com)
The agency is also reviewing data from other clinical trials, observational studies, adverse event reports, and data on prescription use of simvastatin to better understand the relationship between high-dose simvastatin use and muscle injury (see Data Summary below). (fda.gov)
Accurate dose prediction for clinical trials is essential to ensure patient safety and trial success. (ddw-online.com)
This new whitepaper from the Jackson Laboratory discusses evidence-based selection of starting doses in first-in-human clinical trials through the utilisation of humanised mouse models. (ddw-online.com)
The significance of selecting appropriate starting doses in clinical trials. (ddw-online.com)

These data suggested that drug interactions affecting the gastrointestinal absorption and/or hepatic metabolism of colchicine play a central role in the development of toxicity, the FDA said. (medscape.com)
The prescription drug cocktail was again administered and blood and urine samples taken in order to determine the absorption and metabolism of these drugs in the presence of either or both of the herbal supplements. (news-medical.net)
The submission is supported by data from the pivotal study in healthy volunteers, OX124-002, where OX124 showed a significantly faster and higher absorption of naloxone compared to intramuscular dosing with an injection reference product. (krqe.com)

A rise and fall of alkaline phosphatase, AST (aspartate transaminase), and ALT (alanine transaminase) correlated with an increase in duloxetine dose and subsequent discontinuation. (psychiatrist.com)

This study to some extent addresses concerns raised by a couple of other studies which had suggested that both levels of gender-affirming hormones and levels of PrEP could be lower in trans people taking PrEP, due to drug-drug interactions. (aidsmap.com)

A supplement often touted for revving up sex lives actually contains doses of a supposedly natural compound that are so high that the product essentially acts like a drug, with potentially dangerous side effects, according to a new study. (livescience.com)
The new study shows one example of why this regulation should change - some supplements contain doses of active ingredients that are as high as those in drugs, Cohen said. (livescience.com)
Study participants were given a drug dose that was too high, the companies delayed alerting authorities, and Biotrial did not react quickly enough after the first participant got sick, the report said. (npr.org)
Despite the fact that he was experiencing stroke-like symptoms, five other healthy volunteers received a sixth dose of the experimental medicine at the highest dose used in the study the next morning. (npr.org)
The study was the first one to try the drug in humans. (npr.org)
Healthy volunteers were recruited to test preliminary doses for the drug and its safety in a so-called phase 1 study . (npr.org)
For decades, women were excluded from clinical drug trials based, in part, on unfounded concerns that female hormone fluctuations render women difficult to study, Zucker said. (sciencedaily.com)
The dose change is based, in part, on findings from a study of 91 healthy adults, ages 25 to 40. (healthline.com)
T his is the second column from the drugs team at Release, where every other month we are putting forward a new case study from our advocacy work to share with others in the sector. (drinkanddrugsnews.com)
Treatment with a new class of drugs, called senolytics, in donors improved the physical fitness of the recipients, a new study has shown. (medicaldaily.com)
In another study, Julia A. Mueller, MD, of the Mayo Clinic in Jacksonville, FL, and colleagues evaluated the impact of body mass index (BMI) on total weekly dosing of warfarin, the most common treatment for venous thromboembolism and other hypercoagulable conditions. (empr.com)
In this retrospective study, the investigators evaluated 831 patients and found a significant correlation between BMI and total weekly dosing of warfarin. (empr.com)
The study, published Wednesday in the New England Journal of Medicine, examined the effect of the shortage of children's ibuprofen and acetaminophen, which forced parents to crush up pills of the drugs intended for adults in order to treat their children. (cp24.com)
What our research does is shine some light on the issue of drug shortages and the potential consequences associated with them,' said Dr. Jonathan Zipursky, the lead author of the study and a clinical pharmacologist and toxicologist at Sunnybrook Health Sciences Centre in Toronto. (cp24.com)
The emerging microbial antibiotic resistance crisis is in part rooted in ineffective use of antibiotics, including poor choices of drugs," said Stanford University pediatric pulmonologist Carlos Milla, a co-author of the study. (sflorg.com)
This is not the first study to show that the higher the dose of CLDs, the greater the risk of side-effects and I'm sure it will not be the last study to show this relationship. (thebulletin.ca)
Multi-dose drug dispensing and inappropriate drug use: a nationwide register-based study of over 700 000 elderly. (ahrq.gov)
Johnell K, Fastbom J. Multi-dose drug dispensing and inappropriate drug use: A nationwide register-based study of over 700,000 elderly. (ahrq.gov)
Inappropriate drug use in the elderly: a nationwide register-based study. (ahrq.gov)
Published in the Journal of Psychopharmacology , the study showed that one-time treatment with the hallucinogenic drug psilocybin-whose use required federal waivers because it is a banned substance-quickly brought relief from distress that then lasted for more than six months in 80 percent of the 29 study subjects monitored, based on clinical evaluation scores for anxiety and depression. (technologynetworks.com)
Now, a new study published by Chen and his team in The Lancet Regional Health - Americas , found that a lower, fixed-dose tocilizumab strategy is both clinically and economically effective. (vchri.ca)
To date, this study is the most comprehensive comparison of physiological parameters and clinical outcomes between fixed and weight-based dosing," says Dr. Sophie Stukas, the study's co-first author and associate research scientist at the University of British Columbia (UBC) Faculty of Medicine. (vchri.ca)
However, post hoc subgroup analyses of just those who received the study drug at 2 mg/day did show a significantly greater improvement in CMAI score over those who received placebo. (medscape.com)
The full study-drug group also demonstrated significant superiority on the "key" secondary endpoint of Clinical Global Impression-Severity of Illness (CGI-S) score, as related to agitation. (medscape.com)
Those receiving the study drug at 2 mg/day had a significantly greater improvement in CMAI score. (medscape.com)
Otsuka and Lundbeck recently announced that, on the basis of talks with the US Food and Drug Administration (FDA), they will initiate a third phase 3 study during the first half of 2018 that will focus on the higher dose. (medscape.com)
Further clinical study is required to investigate clinical implications and safety of the proposed alternative ABC doses. (bvsalud.org)
In 2017, Raknes and Småbrekke published a drug utilization cohort study on Norwegian patient and prescriber characteristics, and dispense patterns, following a 2013 television documentary on low-dose naltrexone. (wikipedia.org)
RESULTS: All 78 participants received at least one GB1211 dose ( n = 58) or placebo ( n = 20) and completed the study. (lu.se)

Realizing population health benefits from emerging PGx applications requires sifting through the available research studies to identify the gene-drug pairs with convincing scientific evidence for improving health outcomes. (cdc.gov)
Advantages of refining dosing strategies, minimising risks, and improving trial outcomes. (ddw-online.com)

The drug should be discontinued if seizures occur. (drugs.com)
Hearing loss can occur after ingestion of certain drugs due to their effects on the peripheral auditory system or central nervous system. (cdc.gov)

CrCl 29 mL/min or less: The dose should be 50% of the standard dose at the same dosing interval and duration. (drugs.com)

He said drug shortages remain a concern. (cp24.com)
To help alleviate shortages of the crucial drug, Vancouver Coastal Health Research Institute researcher Dr. Luke Chen proposed a unique strategy - providing patients with smaller, fixed doses of the drug, rather than the standard weight-based dose strategy. (vchri.ca)
When supply shortages of tocilizumab hit, British Columbia adopted Chen's strategy and switched to fixed dosing 400 mg IV for patients weighing more than 50 kg. (vchri.ca)
In the context of ongoing drug shortages, a fixed-dose 400 mg of tocilizumab may be a practical, feasible and economical option. (vchri.ca)

The nonfatal drug overdose data on this dashboard come from CDC's Drug Overdose Surveillance and Epidemiology ( DOSE ) system, which captures electronic health record information in syndromic surveillance systems. (cdc.gov)
Drug Overdose Surveillance and Epidemiology (DOSE) System. (cdc.gov)

No dose adjustment recommended. (pediatriconcall.com)

Prescription records show that he was taking eight doses of amphetamines, nine of tranquillisers, 16 of two different barbiturates, two anti-seizure tablets, two anticonvulsant pills, two painkillers and three sleeping pills. (telegraph.co.uk)
The drugs of abuse that are potentially fatal include all amphetamines (including methamphetamine and MDMA) and opiates. (medscape.com)

None of the other 90 volunteers exposed to the drug at lower doses experienced any problems. (npr.org)
With this safety concern in mind, the Food and Drug Administration (FDA) is requiring a lower starting dose for this insomnia drug. (healthline.com)
The FDA is requiring Sunovion to change the drug label and lower the current recommended starting dose. (healthline.com)
Using lower doses means less drug will remain in the body in the morning hours. (healthline.com)
Oxazepam and other benzodiazepines should never be combined with alcohol or other drugs that depress (lower the activity of) the central nervous system. (minddisorders.com)
Be aware of the potential increased risk of muscle injury with the 80 mg dose of simvastatin compared to lower doses of simvastatin and possibly other statin drugs. (fda.gov)
Ribavirin plasma exposures were approximately 20% lower in subjects with ESRD on HD compared to subjects with normal renal function receiving the standard 1000/1200 mg Copegus daily dose. (hivandhepatitis.com)

Monotherapy with AZT is not typically used dose AZ MDA on prevalent malaria infections in a large pro- to treat malaria. (cdc.gov)
AZT mg/kg) 7 days apart reduced malaria rates by half when mass drug administration caused a transient, 1-month anti- measured at 1 time point in children 5-14 years of age ( 9 ). (cdc.gov)

All doses were administered in the fasted state except in the food-effect cohort where doses were given 30 min after a high-fat meal. (lu.se)

It became a mainstay of cancer treatment after Burkitt and others used high doses to cure children with what's now known as Burkitt lymphoma - which had a 100% mortality rate at the time - sometimes with only one dose. (medindia.net)

While previous studies have developed protocols for the dosing of warfarin, few studies have evaluated the impact of BMI on warfarin dosing due to risk of adverse events associated with underdosing and overdosing. (empr.com)

It's different dosing and a different compound, but obviously it has similarities to the parent compound," he said. (medscape.com)

The Washington Manual , www.unboundmedicine.com/washingtonmanual/view/Davis-Drug-Guide/109510/all/Equianalgesic_Dosing_Guidelines. (unboundmedicine.com)
Vallerand AHA, Sanoski CAC, Quiring CC. Equianalgesic Dosing Guidelines. (unboundmedicine.com)
A recent systematic review that assessed the cost-effectiveness of pharmacogenetic testing for drugs with existing guidelines concluded that most studies favored pharmacogenomic testing. (cdc.gov)
The Clinical Pharmacogenetics Implementation Consortium (CPIC®) is an international consortium that aims to address barriers to the clinical implementation of tests by creating, curating, and posting guidelines and evidence levels for gene-drug pairs . (cdc.gov)

Such a barrier felt contrary to the basic premise of OST, which is to prescribe in place of street opioids at an adequate dose to alleviate all withdrawal symptoms, as well as the basic premise of harm reduction, which is to meet people where they are at. (drinkanddrugsnews.com)
Both doses demonstrated comparable reduction of inflammation and improvement on lung function," says Chen. (vchri.ca)

First, the people running the trial gave extremely high doses of the drug - about 40 times the amount that they expected was needed to quell pain. (npr.org)
Today, doctors shy away from prescribing some drugs that can be highly effective at the proper dose but toxic or even fatal at a dose that's too high. (sflorg.com)
For instance, out of 1700 patients taking high dose CLDs, only one patient would be hospitalized for acute kidney injury. (thebulletin.ca)
So for 20 years I've used high doses of vitamin C available in health food stores. (thebulletin.ca)
For people at high risk of serious flu complications, treatment with an antiviral drug can mean the difference between having a milder illness versus a very serious illness that could result in a hospital stay. (cdc.gov)

Ellis Unger, M.D., director of the Office of Drug Evaluation in the FDA's Center for Drug Evaluation and Research, said in a press statement,"To help ensure patient safety, healthcare professionals should prescribe, and patients should take, the lowest dose of a sleep medicine that effectively treats their insomnia. (healthline.com)

The scientists found no significant differences between those who received one, both, or none of the ginseng and ginkgo biloba supplements in how their bodies absorbed or metabolized any of the five prescription drugs. (news-medical.net)
Overall, they were found to experience adverse drug reactions nearly twice as often as men. (sciencedaily.com)
We were blindsided by the drug shortage and we found ourselves as parents looking for drugs from other places or trying to follow guidance to divide pills that were intended for adults,' he said. (cp24.com)
But equally important, they found that the higher the dose the greater the destruction of muscle tissue. (thebulletin.ca)

After 3 doses of duloxetine 40 mg, her dose was subsequently increased from 40 mg to 60 daily (day 4 at 9 am ) to target residual depressive symptoms. (psychiatrist.com)
Patients should be monitored carefully for dose-related adverse reactions, particularly nervous system symptoms (see sections 4.3 and 4.4). (who.int)
Antiviral drugs can lessen fever and other symptoms, and shorten the time you are sick by about one day. (cdc.gov)

Pharmacogenomics (PGx) combines the sciences of pharmacology and genomics to assess how to use information about a person's genetic makeup, or genome, to choose the drugs and drug doses that are likely to work best for that particular person. (cdc.gov)
Both novice and expert consumers used the active ingredients to assess drug similarity, indicating that the information was accessible. (acrwebsite.org)
However, only medically trained experts used this information to assess the risks of taking two drugs concurrently, indicating that they understood its diagnosticity or relevancy. (acrwebsite.org)

A real-world, multicenter assessment of drugs requiring weight-based calculations in overweight, adult critically ill patients. (empr.com)

More concretely, the barrier is also contrary to the guidance of the 'orange book', which advises in chapter 4 that, for patients on OST who are having to buy street opioids, prescribers could 'increase dose, if inadequate' - something that can only be arranged in a medical review. (drinkanddrugsnews.com)

The first randomized controlled trial assessed flexible dosing of brexpiprazole at 0.5 mg to 2 mg per day vs placebo. (medscape.com)
The second trial, which compared brexpiprazole at a fixed dose with placebo, met the primary endpoint. (medscape.com)
In the multiple ascending-dose phase, participants received 50 or 100 mg GB1211 or placebo twice daily for 10. (lu.se)

Multiple studies have shown that low-dose naltrexone has promise as a treatment for chronic pain, some autoimmune disorders and cancers. (wikipedia.org)

The authors investigate whether the consumers utilized the active ingredients listed on the package and recognized the risks of double dosing when using two drugs with the same active ingredient. (acrwebsite.org)

The participants were given a ,cocktail, of five drugs, each drug in the cocktail chosen because it provides a measure of the activity of a key drug metabolism pathway. (news-medical.net)
Thank you for sharing this Drug Metabolism & Disposition article. (aspetjournals.org)
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Bulletin Editor August 28, 2017 Comments Off on Proper dose of cholesterol-lowering drugs? (thebulletin.ca)

Anatomy13

Organisms14

Diseases21

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment91

Psychiatry and Psychology3

Phenomena and Processes37

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Named Groups1

Health Care34

Pharmacokinetics7

Dosage8

Large Doses2

Higher doses3

Skip1

Therapeutic7

Milligrams7

Pharmacokinetic2

Medication14

Efficacy5

Medications10

Normal doses2

Regimen2

Single-dose7

Chemotherapy drug1

Severe4

Recommendations6

Oral2

Patients with renal1

Impairment4

Dialysis1

Hypoglycemia1

Cyclophosphamide7

Concentrations4

Paediatric1

Researchers6

Integrated drug shortages1

Infants1

Suggests1

Reductions3

Clinical trials6

Absorption3

Discontinuation1

Interactions1

Study29

Outcomes2

Occur2

CrCl1

Shortages4

Overdose2

Adjustment recommended1

Amphetamines2

Lower7

Malaria2

Cohort1

Lymphoma1

Adverse events1

Compound1

Guidelines4

Reduction2

High5

Insomnia1

Found4

Symptoms3

Assess3

Adult1

Prescribers1

Placebo3

Cancers1

Active ingredient1

Metabolism3

20171