• Presently found remarkable cytotoxic selectivity of acyclovir analogues against KB and HeLa tumor cells together with previously reported in the literature specific cytotoxic activity of acyclovir against murine leukemia L1210 cells seem to be encouraging for further investigation of this class of compounds in other tumor systems. (home.pl)
  • Benzoyl peroxide increases UVA-induced plasma membrane damage and lipid oxidation in murine leukemia L1210 cells. (harvard.edu)
  • Further, in the R1 and R2 sublines, no VCR dose-dependent cytotoxicity was apparent, and cell kill of greater than 40% was not achievable following a 3-hr drug exposure. (wikigenes.org)
  • We found that MMDX cytotoxicity for cultured M5076 tumor cells was potentiated 22-fold by preincubating the drug with NADPH-supplemented liver microsomes from untreated C57BL/6 female mice. (unboundmedicine.com)
  • Two compounds (of four selected), 8-bromoacyclovir and 1,N-2-ethenoacyclovir, having unsubstituted 9-[(2-hydroxyethoxy)methyl] chain, showed approximately 2-fold increase in their cytotoxicity against HeLa tumor cells in the presence of the induced microsomal generating system suggesting that their cytooxicity depends on the drug metabolic transformation into their active metabolites (intermediates) via MFO-system, and that structural unit of this chain is essential for abovementioned activation. (home.pl)
  • The rationale is based on a) evidence that, following drug-induced aplasia, resultant bone marrow proliferation in vivo corresponds temporally with induced humoral stimulatory activity, and on b) models that demonstrate increased cytotoxicity of β-cytosine arabinoside (Ara-C) to myeloblasts cultured in humoral stimulatory activity (HSA). (johnshopkins.edu)
  • Collectively these findings suggested that autophagy played a cytoprotective part in nedaplatin-induced cytotoxicity of HNE1/DDP and CNE2/DDP cells. (antiviralbiologic.com)
  • Adding lunasin to IL-12- or IL-2-stimulated NK cells demonstrated synergistic effects in the induction of IFNG and GZMB involved in cytotoxicity. (weeksmd.com)
  • M5076 tumors in C57BL/6 mice and to prolong survival of DBA/2 mice with disseminated L1210 leukemia. (unboundmedicine.com)
  • The in vivo antineoplastic activity of DAC administered as an i.v. infusion was evaluated in mice with murine L1210 leukemia by measurement of survival time, and in mice bearing murine EMT6 mammary tumor by excision of tumor after chemotherapy for an in vitro clonogenic assay. (biomedcentral.com)
  • In mice with L1210 leukemia and in mice bearing EMT6 tumors, the antineoplastic action of DAC also increased with the dose. (biomedcentral.com)
  • We also observed a correlation between in vitro and in vivo concentrations needed to produce optimal responses in mice with L1210 leukemia or with EMT6 tumor. (biomedcentral.com)
  • CD2F1 mice bearing L-1210 leukemia received a course of 60 mg Ara-C/kg every 8th hour (q.8 h) three times on day 0 and on another day in sequence (0.1 through 0.7). (johnshopkins.edu)
  • Typical orthotopic disease models include breast cancer, lung cancer, colon cancer, kidney cancer and diffuse large B-cell lymphoma (DLBCL), utilising mice, rats and hamsters as test subjects. (medicilon.com)
  • Although hydrazine sulfate is carcinogenic i.e., can cause cancer in some weanling mice given the drug in their drinking water since birth, there has never been a case of human cancer reported as a result of HS therapy . (hydrazinesulfate.org)
  • This is associated with increased tumourigenicity of ES cells in nude mice [25]. (lsd1receptor.com)
  • The reactivation of the TSGs ( p57KIP2 in HL-60 leukemic cells and p16CDKN2A in Calu-6 lung carcinoma cells) and the inhibition of global DNA methylation in HL-60 leukemic cells increased with DAC concentration. (biomedcentral.com)
  • The in vitro antineoplastic action of DAC correlated well with its inhibition of DNA methylation and reactivation of TSG in human neoplastic cells. (biomedcentral.com)
  • Recent research has shown that GPNA can inhibit multiple other amino acid transporters and that GPNA's inhibition of cell viability is likely due to off-target effects from the activity of the γ-Glutamyltransferase enzyme rather than the disruption of glutamine metabolism [ 12 ] . (encyclopedia.pub)
  • In comparison with GPNA, V-9032 has approximately 100-fold increased potency in blocking cellular glutamine uptake, and inhibition of SLC1A5 with V-9032 was demonstrated to cause cell death, disrupt redox equilibrium, and result in disrupted development and progression of cancer [ 13 ] . (encyclopedia.pub)
  • While inhibition of ERK1/2 by MEK1/2 inhibitor U0126 could reduce the manifestation of LC3-II in nedaplatin-resistant NPC cells. (antiviralbiologic.com)
  • However conflicting evidence showed that inhibition of autophagy resensitized SKOV3/DDP cells (cisplatin-resistant ovarian malignancy cells) to cisplatin [15]. (antiviralbiologic.com)
  • 5-3 with inhibition activity against leukemia cell line L1210 at concentration 1.515 ppm. (univpancasila.ac.id)
  • The combination of both drugs could theoretically provide strong inhibition against viral RNA and DNA synthesis. (xiahepublishing.com)
  • The inhibition of P-gp and other ABC transporters can increase because the tumours have metastasized and/or have become resistant the intracellular concentration of cytotoxic drugs. (gotomydoctor.com)
  • consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
  • Furthermore, in tumour necrosis factor alpha (TNFa)-stimulated Ewing's sarcoma (ES) cells, NF-jB is reported to prevent activation of an apoptotic cascade through inhibition of c-Jun N-terminal kinase (JNK) [23] and upregulation of anti-oxidant enzymes [24]. (lsd1receptor.com)
  • However, relevant research has ebbed due to the limitation of these agents, which is the easy acquisition of tumor resistance by de novo glutamine synthesis in cancer or stromal cells. (encyclopedia.pub)
  • of nedaplatin in HNE1/DDP and CNE2/DDP cells suggesting that the resistance to TCS 5861528 nedaplatin-induced cell death was caused by enhanced autophagy in TCS 5861528 nedaplatin-resistant NPC cells. (antiviralbiologic.com)
  • Since autophagy is definitely substantially triggered in malignancy cells it may involve in drug resistance by facilitating malignancy cell survival during metabolic tensions caused by anticancer providers [13]. (antiviralbiologic.com)
  • Moreover the relationship between autophagy and drug-resistance is definitely complex since there exist some common regulatory elements including ROS [16 17 PI3K/Akt/mTOR pathway and ERK pathway [18]. (antiviralbiologic.com)
  • Tumor cell resistance to anthracyclines and epipodophyllotoxins can be due to reduced drug accumulation and/or alterations in the activity of topoisomerase II (TOPO II). (ucy.ac.cy)
  • Treatment of drug-resistant Caco-2 cells with the most active C. jambhiri and C. pyriformis compounds increased their sensitivity to doxorubicin and completely reversed doxorubicin resistance, which agrees with a decreased P- gp activity. (gotomydoctor.com)
  • an ATP-binding ), coumarins () and terpenoids cassette (ABC) transporter (150-170 kDa), which pumps out lipo- have been reported as philic agents from cells that have entered them by free diffusion agents for overcoming multidrug resistance, and could be used aloneat very low concentrations or in combination to reverse multidrugresistance in vitro. (gotomydoctor.com)
  • 2C-H was found to be inactive in NCI In Vivo Anticancer Drug Screens for tumor model L1210 Leukemia. (wikipedia.org)
  • Anticancer Drugs. (jenabioscience.com)
  • Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
  • 7. Mans DR Rocha A B, Schwartsmann G. Anticancer drug discovery and development in Brazil: Targeted plant collection as a rational strategy to acqvire candidate anticamcer compounds. (univpancasila.ac.id)
  • The purpose of this statement is to guide you, step by step, through the scientific development of hydrazine sulfate as an anticancer agent, the clinical trials and the high-level negative politics which came to surround this drug from the very beginning. (hydrazinesulfate.org)
  • abstract: PURPOSE:M30 and M65 ELISAs are proposed as surrogate biomarkers of tumour cell death in patients and are being applied increasingly in the pharmacodynamic (PD) evaluation of anticancer drugs during clinical trials. (shengsci.com)
  • Increasing the DAC concentration and duration of exposure produced a greater loss of clonogenicity for both human leukemic and tumor cell lines. (biomedcentral.com)
  • Repeated attempts to reprogram epithelial cells were not successful. (biomedcentral.com)
  • The supernatant was discarded, and the cell pellet was suspended in Renal Epithelial Cell Growth Medium (REGM BulletKit, Lonza) and plated on gelatine-coated cell culture plates (Attachment Factor Protein, Life Technologies). (biomedcentral.com)
  • Intro Nasopharyngeal carcinoma (NPC) is definitely a type of cancer arising from the epithelial cells that collection the nasopharynx. (antiviralbiologic.com)
  • The Enteroendocrine System The ENS has roles in the motility of the gut, the absorption of nutrients, forex signal 24 rate of prolifer- ation of epithelial cells lining the GI tract, and the release of hormones and neuropeptides by enterochromaffin cells of the enteroendocrine system. (findbinaryoption.com)
  • Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
  • This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
  • The longest survival (250% of controls) was in animals whose second course began on day 3, the time of peak HSA as measured by DNA synthesis induced in L-1210 cells in culture. (johnshopkins.edu)
  • Autophagy is essential for survival differentiation development and homeostasis in eukaryotic cells. (antiviralbiologic.com)
  • NF-jB knockdown did not induce death under normal growth conditions, but did reduce TNFa-dependent cell survival. (lsd1receptor.com)
  • We measured its inhibitory activity on 17ß-HSD3 using microsomal fraction of rat testes as well as transfected LNCaP[17ß-HSD3] cells. (bvsalud.org)
  • The addition of a picolyl moiety at C-16 of RM-532-105 steroid core improves the 17ß-HSD3 inhibitory activity in the microsomal fraction of rat testes, but not in whole LNCaP[17ß-HSD3] cells. (bvsalud.org)
  • This mini review highlights the development of compounds that target cancer cells by taking advantage of redox or metabolic alteration in cancer cells. (degruyter.com)
  • Out of a series of twenty 8-substituted or/and 1,N-2-bridged (tricyclic) derivatives of acyclovir (a selective antiherpetic drug), known to be nontoxic to normal cells, seven compounds were found to exhibit moderate cytostatic activity in KB human tumor tissue culture system with ED50 activity values ranging from 0.052-0.094 x 10**-3 mole/l. (home.pl)
  • These enzymes are involved in untangling DNA during cell proliferation. (biomedcentral.com)
  • These studies demonstrated that the amount of proliferation of residual tumor and thereby sensitivity to cycle-active drugs given in sequence relates to the initial drug effect on tumor proliferation and the induction of humoral stimulation. (johnshopkins.edu)
  • In order to restrict the proliferation of glutamine-addicted cancer cells, researchers have created various drugs that target different stages in glutamine metabolism. (encyclopedia.pub)
  • 2008). Influence of drug-to-lipid ratio on drug release properties and liposome integrity in liposomal doxorubicin formulations. (ubc.ca)
  • By lowering the activation energy needed by cells to start metabolic reactions, enzymes allow biological systems to undertake necessary processes at the temperatures that exist inside the cell. (findbinaryoption.com)
  • Furthermore suppression of ROS could inhibit nedaplatin-induced ERK activation in HNE1/DDP cells indicating that ROS and ERK were involved in nedaplatin-induced autophagy. (antiviralbiologic.com)
  • Furthermore our results highlighted a potential approach to restore the level of sensitivity of cisplatin-resistant nasopharyngeal malignancy cells to nedaplatin in combination with autophagy inhibitors. (antiviralbiologic.com)
  • For instance upregulation of autophagy resulted in resensitization of H460/cis cells (cisplatin-resistant lung malignancy cells) to cisplatin-induced cell death [14]. (antiviralbiologic.com)
  • Nevertheless it is still unclear whether autophagy is definitely involved in nedaplatin-induced cell death in cisplatin-resistant NPC cells. (antiviralbiologic.com)
  • In the mean time autophagy was induced in HNE1/DDP cells and CNE2/DDP after they were exposed to nedaplatin. (antiviralbiologic.com)
  • The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80, Mol Cancer Ther 2007 Jan;6(1):370-9. (wayne.edu)
  • Studies were conducted in the leukemic mouse and rat to test the hypothesis that enhanced effects of drugs given in sequence relate to a predictable increase in tumor growth and sensitivity to cycle-active agents. (johnshopkins.edu)
  • In 1907 the zoologist Ross Granville Harrison demonstrated the growth of frog embryonic cells that would give rise to nerve cells in a medium of clotted lymph . (wikipedia.org)
  • The present study examined the role of CYP3A-mediated metabolism in the in vivo antitumor activity and host toxicity of MMDX in the mouse model and investigated the potential for increasing the therapeutic effectiveness of the drug by inducing its hepatic CYP-catalyzed activation. (unboundmedicine.com)
  • 2009) Synthesis of a Labeled RGD-Lipid, Its Incorporation into Liposomal Nanoparticles, and Their Trafficking in Cultured Endothelial Cells. (ubc.ca)
  • 2008) The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN. (ubc.ca)
  • 2006). Therapeutically Optimized Rates of Drug Release can be Achieved by Varying the Drug-to-Lipid Ratio in Liposomal Vincristine Formulations. (ubc.ca)
  • an enzyme linked immunosorbent assay (elisa) system to study specific anti-herpes simplex virus (hsv) antibody production in vitro by human peripheral blood mononuclear cells (pbmc) has been developed. (liverpool.ac.uk)
  • Peripheral blood mononuclear cells of healthy donors and post-transplant lymphoma patients were stimulated with or without lunasin in the presence of IL-12 or IL-2. (weeksmd.com)
  • In contrast, routinely administered chemotherapy drugs are commonly carcinogenic and can produce up to 26% of second cancers. (hydrazinesulfate.org)
  • Verapamil, phenothiazines, alkaloids like emetine and lobeline chemotherapy, but also to a broad spectrum of structurally and and other secondary functionally unrelated cytotoxic drugs as well. (gotomydoctor.com)
  • Phase II trial of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for untreated non-squamous non-small-cell lung cancer. (shengsci.com)
  • abstract: PURPOSE:We conducted a phase II trial to evaluate the efficacy and safety of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for advanced non-squamous non-small-cell lung cancer (NSCLC). (shengsci.com)
  • It is the most common cancer in children and accounts for the vast majority of all childhood leukemias. (lookformedical.com)
  • Cancer cells often maintain high basal level of ROS and are vulnerable to any further increase in ROS levels beyond a certain protective threshold. (degruyter.com)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
  • High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
  • Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
  • This is because cancer cells maintain high basal level of ROS, thus they are vulnerable to any further increase in ROS (Fig. 1 ). (degruyter.com)
  • ROS-modulation in normal vs. cancer cell. (degruyter.com)
  • We then assessed its metabolic stability as well as its cytotoxic effect against a panel of cancer cell lines. (bvsalud.org)
  • Interestingly, this structural modification enhances 3-fold the metabolic stability in conjunction with a significant cytotoxic effect against pancreatic, ovarian, breast, lung, and prostate cancer cells. (bvsalud.org)
  • Because cancer cells' reliance on glutamine metabolism is generally greater than in normal tissues, and glutamine deprivation in cancer cell cultures frequently results in cell death, scientists have explored depleting glutamine as a cancer therapy strategy. (encyclopedia.pub)
  • Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. (harvard.edu)
  • Inappropriate advertisement of laetrile as a cancer treatment resulted in a U.S. Food and Drug Administration investigation that culminated in charges and conviction of one distributor. (cancer.gov)
  • Court cases in Oklahoma, Massachusetts, New Jersey, and California challenged the FDA's role in determining which drugs should be available to cancer patients. (cancer.gov)
  • The only contrary results have been the National Cancer Institute-sponsored trials of hydrazine sulfate in which incompatible agents (medications) were used with the test drug. (hydrazinesulfate.org)
  • One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
  • Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
  • Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
  • Numerous vectors have been engineered for the sole purpose of killing cancer cells, and some have successfully suppressed malignant tumours. (weeksmd.com)
  • Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: long term antigen stability in cancer patient plasma. (shengsci.com)
  • Additionally Baf A1 enhanced reactive oxygen varieties (ROS) generation and apoptosis induced by nedaplatin in HNE1/DDP cells. (antiviralbiologic.com)
  • Radiation-induced red cell damage: role of reactive oxygen species. (harvard.edu)
  • The exact mechanism of fen-retinide-induced cell death is not fully understood, although it is reported to induce apoptosis indepen-dently of retinoic acid receptor expression [6-9], lacking the carboxyl group required for binding to these receptors [10]. (lsd1receptor.com)
  • More recently, fenretinide-induced apoptosis has been reported to be dependent on phosphorylation of nuclear factor-kappa B (NF-jB) in SH-SY5Y neuroblastoma cells [13]. (lsd1receptor.com)
  • The NF-jB family of transcription factors are involved in the regulation of several physiological processes such as inflammation, cell cycle regulation and apoptosis. (lsd1receptor.com)
  • Consistent with this hypothesis, NF-jB is constitutively acti-vated in a wide variety of tumours permitting cells to evade apoptosis [16-19,21,22]. (lsd1receptor.com)
  • Consequently, it indicates that therapy with autologous iPSc derivatives may face serious difficulties in their case, still, the first iPSc cell line from a person with FQAD was established. (biomedcentral.com)
  • Hence, dexamethasone and anticoagulants can be combined with a multi-drug therapy regimen for SARS-COV-2. (xiahepublishing.com)
  • And the truth is that every single, informed-consent, controlled clinical trial of hydrazine sulfate, performed in accordance with internationally accepted criteria and standards of scientific conduct without exception has indicated efficacy and safety of the drug. (hydrazinesulfate.org)
  • Cellular uptake and retention of VCR were 2- to 4-fold lower in the R1 and R2 sublines, compared with similarly treated S or R0 cells. (wikigenes.org)
  • Modulation of VCR uptake by 5 microM TFP in the S and R0 cells was 2-fold and it was 4- to 7-fold in the R1 and R2 sublines. (wikigenes.org)
  • it was reported that glycoprotein c of hsv-1 (gc-1) mediates the binding of c3b-coated erythrocytes to infected cells and has regulatory (decay-accelerating) activity for the alternative pathway c3 convertase of human complement. (liverpool.ac.uk)
  • Differential innate immune cell signatures and effects regulated by toll-like receptor 4 during murine lung tumor promotion. (harvard.edu)
  • Am J Physiol Lung Cell Mol Physiol. (harvard.edu)
  • Bilirubin is a chemical that is produced when old red blood cells break down. (webmd.com)
  • Stable urine primary cell cultures could not be obtained from the three remaining donors. (biomedcentral.com)
  • Growing viruses in cell cultures allowed preparation of purified viruses for the manufacture of vaccines . (wikipedia.org)
  • This vaccine was made possible by the cell culture research of John Franklin Enders , Thomas Huckle Weller , and Frederick Chapman Robbins , who were awarded a Nobel Prize for their discovery of a method of growing the virus in monkey kidney cell cultures. (wikipedia.org)
  • this study compared conventional viral isolation (vi) in cell cultures with a commercial product--virgo antigen detection system--for the identification and typing of herpes simplex virus (hsv). (liverpool.ac.uk)
  • Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. 2C-H exhibits agonist activity in vitro at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization. (wikipedia.org)
  • Clonogenic assays were performed on leukemic and tumor cell lines to evaluate the in vitro antineoplastic activity of DAC. (biomedcentral.com)
  • The effects of WR-1065 (2-((aminopropyl)amino)ethanethiol) on cell cycle progression, topoisomerase (topo) IIα activity, and topo IIα phosphorylation in Chinese hamster ovary (CHO) cells have been investigated. (ucy.ac.cy)
  • In addition, NK cells stimulated with lunasin plus cytokines displayed higher tumoricidal activity than those stimulated with cytokines alone using in vitro and in vivo tumor models. (weeksmd.com)
  • 2005). Investivgation of factors responsible for cell line cytoplasmic expression differences. (ubc.ca)
  • BAY 11-7082 decreased cell viability, which was accompanied by caspase-3 cleavage. (lsd1receptor.com)
  • The lifespan of most cells is genetically determined, but some cell-culturing cells have been "transformed" into immortal cells which will reproduce indefinitely if the optimal conditions are provided. (wikipedia.org)
  • Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (lookformedical.com)
  • It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. (lookformedical.com)
  • BAY 11-7082-induced cell death through an NF-jB-independent mechanism and enhanced cell death when combined with fenretinide. (lsd1receptor.com)
  • of cell death [7]. (lsd1receptor.com)
  • In this study we have investigated the role of NF-jB in fenretinide-induced cell death and the importance of NF-jB in ESFT. (lsd1receptor.com)
  • His original idea, presented in 1902, was called totipotentiality: "Theoretically all plant cells are able to give rise to a complete plant. (wikipedia.org)
  • We have observed that DAC reduced the in vitro clonogenic potential in a dose-dependent manner of both human and murine leukemia and tumor cell lines. (biomedcentral.com)
  • trifluorothymidine (tft) is known to be concentrated in herpes simplex virus (hsv) infected cells in vitro in the form of phosphorylated derivatives. (liverpool.ac.uk)
  • The laboratory technique of maintaining live cell lines (a population of cells descended from a single cell and containing the same genetic makeup) separated from their original tissue source became more robust in the middle 20th century. (wikipedia.org)
  • In the United States, researchers must file an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) to conduct drug research in human subjects. (cancer.gov)
  • infection of human epidermoid carcinoma no. 2 cells with herpes simplex virus type 1 (hsv-1) leads to a reorganization of antigens associated with both the small and heterogeneous nuclear ribonucleoprotein complexes (snrnp and hnrnp). (liverpool.ac.uk)
  • It must be emphasized that no medical journal on earth of high repute or not would publish an article and editorial based on one case , calling attention of the medical profession and public to the potential toxicity of a drug gaining in common usage, without incontrovertible, verifiable, air-tight evidence that the patient in question ever took the drug in the first place. (hydrazinesulfate.org)
  • 1 referred to leukemia dosages (≥ 3 mg/kg/day) of TG for the treatment of SARS-COV-2 and reasoned that due to the short time period the level of toxicity would be minimal. (xiahepublishing.com)
  • Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. (wikipedia.org)
  • [12] He suggested that the potentialities of individual cells via tissue culture as well as that the reciprocal influences of tissues on one another could be determined by this method. (wikipedia.org)
  • It has been used for a range of diseases in the past, such as leukemia and inflammatory bowel disease, and can be repurposed for other diseases, such as SARS-COV-2. (xiahepublishing.com)
  • LBN rats bearing acute myelocytic leukemia (AML) were treated with 100 mg Ara-C/kg q.8 h six times begining on day 0 and on other days in sequence (0.1 through 0.12). (johnshopkins.edu)
  • To this end, we attempted to develop an induced pluripotent stem cell (iPSc) model to study this disease and verify whether reprogramming technology can be used in the future to treat patients with FQAD and their other disorders in which autologous-induced pluripotent stem cells and their derivatives may be used. (biomedcentral.com)
  • The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
  • Cellular accumulation of DOX was 20 and 50% lower in the R1 and R2 sublines, respectively, compared with similarly treated S or R0 cells. (wikigenes.org)
  • The presence of 5 microM TFP, by competing for efflux, enhanced VCR retention 1.5-fold in S and R0 cells and 2- to 4-fold in the R1 and R2 sublines. (wikigenes.org)
  • 2007) Characterization of the Drug Retention Properties and Pharmacokinetic Properties of Liposomal Nanoparticles Containing Dihydrosphingomyelin. (ubc.ca)
  • 2006). Formation of drug-arylsulfonate complexes inside liposomes: a novel approach to improve drug retention. (ubc.ca)